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compositionComposition:ACECLOFENAC-100MG+TIZANIDINE-2MG
prescription
Prescription Medicine
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Zerodol-MR Tablet is used to relieve pain and inflammation linked to conditions such as osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, muscle pain, tooth pain, bone and joint pain, and headache. It helps relax tight, stiff muscles, reducing discomfort. Reducing pain and swelling makes movement easier. This helps improve daily activity and overall physical comfort.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Veda Maddala , M Pharmacy
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More about the Product

Composition :

ACECLOFENAC-100MG+TIZANIDINE-2MG

Manufacturer/Marketer :

Ipca Laboratories Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Zerodol-MR Tablet

Zerodol-MR Tablet is a prescription medication used to treat painful muscle spasms associated with various bone, joint, or muscle conditions. It helps reduce muscle stiffness, relieves moderate-to-severe pain, and restores physical mobility. This medication is typically prescribed for short-term relief during acute flare-ups of muscle pain or injury.

To get the best results, you should take it consistently at the exact times recommended by your doctor. It is highly recommended to take this tablet with food or a glass of milk to prevent stomach irritation. Combining this medical treatment with gentle stretching exercises and adequate rest can significantly improve your recovery process.

While taking you might experience mild side effects such as drowsiness, dizziness, or a dry mouth. These symptoms are generally temporary and tend to go away as your body adjusts to the medicine. However, if you experience serious symptoms like yellowing of your skin or eyes, severe stomach pain, or an irregular heartbeat, contact your doctor immediately.

Before starting this medicine, you must tell your doctor if you have a history of liver disease, kidney problems, or stomach ulcers. Do not take this if you have severe liver damage, active bleeding disorders, or if you are currently taking certain antidepressant or blood pressure medications. Talk to your doctor or pharmacist to ensure this medicine is safe for your specific health profile.

Drinking alcohol while taking it can severely increase drowsiness and raise the risk of liver damage, so it must be avoided entirely. If you are pregnant, breastfeeding, or an older adult, consult your doctor before using this medication, as special precautions may be needed. This medicine is generally not recommended for children unless prescribed by a doctor. The safety and appropriate dose should be decided by a healthcare professional. 

Uses of Zerodol-MR Tablet

Your doctor may prescribe this medication to manage several musculoskeletal issues. The primary uses include:

  • Painful muscle spasms: Zerodol-MR Tablet relaxes tight, cramping muscles and blocks pain pathways, helping you move more comfortably.
  • Lower back pain: It relieves acute, severe back pain caused by muscle strains, injuries, or joint stiffness in the spine.
  • Neck pain and stiffness: This medicine reduces muscle tension in the neck and shoulders, helping restore a normal range of motion.
  • Post-operative pain: It helps manage painful muscle spasms and localised discomfort that can occur after orthopaedic surgeries.

Key Benefits

This medicine brings several key health benefits:

  • Relieves muscle tightness and pain: Zerodol-MR Tablet provides dual-action relief by targeting both physical muscle tightness and the accompanying pain.
  • Supports faster recovery: This combined action allows you to recover faster from acute muscle injuries and return to your daily activities with minimal discomfort.
  • Improves movement and sleep: Secondly, by relaxing the affected muscles, this medication helps restore flexibility and physical movement. It also aids in improving your sleep quality, which is often disrupted by painful, night-time muscle spasms.
Side effects of Zerodol-MR Tablet
  • Avoid driving or operating machinery or activities that require high focus until you know how the medication affects you.
  • Maintain a fixed sleeping schedule, create a relaxing bedtime routine and ensure your sleeping space is comfortable to maximize your sleep quality.
  • Limit alcohol and caffeine as these may worsen drowsiness and disturb sleep patterns.
  • Drink plenty of water as it helps with alertness and keeps you hydrated and for overall well-being.
  • Moderate physical activity can improve energy levels, but avoid intense workouts right before bedtime.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
Here are the steps to Dry Mouth (xerostomia) caused by medication:
  • Inform your doctor about dry mouth symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Drink plenty of water throughout the day to help keep your mouth moist and alleviate dry mouth symptoms.
  • Chew sugar-free gum or candies to increase saliva production and keep your mouth moisturized.
  • Use saliva substitutes, such as mouthwashes or sprays, only if your doctor advises them to help moisturize your mouth and alleviate dry mouth symptoms.
  • Avoid consuming smoking, alcohol, spicy or acidic foods, and other irritants that may aggravate dry mouth symptoms.
  • Schedule regular dental check-ups to keep track of your oral health and handle any dry mouth issues as they arise.
Here are the 7 step-by-step strategies to manage the side effect of "inability to sleep" caused by medication usage:
  • Prepare for a restful night's sleep: Develop a calming pre-sleep routine, like reading or meditation, to help your body relax and prepare for sleep.
  • Create a sleep-conducive Environment: Make bedroom a sleep haven by ensuring it is quiet, dark and calm.
  • Follow a Sleep Schedule: Go to bed and get up at the same time every day to help regulate your body's internal clock and increase sleep quality.
  • Try relaxing techniques like deep breathing, mindfulness meditation and any others.
  • Limit stimulating activities before bedtime: Avoid stimulating activities before bedtime to improve sleep quality.
  • Monitor Progress: Keep track of your sleep patterns to identify areas for improvement.
  • Consult a doctor if needed: If these steps don't improve your sleep, consult a doctor for further guidance and therapy.
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.

Directions for Use

  • Zerodol-MR Tablet can be taken with food to avoid stomach upset.
  • It is usually taken twice daily or as prescribed by your doctor.
  • Swallow Zerodol-MR Tablet as a whole with a glass of water.
  • Do not break, chew, or crush it.

How Zerodol-MR Tablet Works

Zerodol-MR Tablet contains two active medicines that work together to relieve pain and stiffness. Tizanidine is a central alpha-2 adrenergic agonist that works in the brain and spinal cord to calm overactive nerve signals that cause muscles to tighten. This helps stiff, cramping muscles relax and improves movement. Aceclofenac is a pain-relieving medicine that mainly blocks the COX-2 enzyme, reducing the production of chemicals called prostaglandins that cause pain, swelling, and inflammation. Together, these two medicines help break the cycle of muscle spasm and pain, providing effective relief.
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Alcohol

Unsafe

Avoid consumption of alcohol while taking Zerodol-MR Tablet as it may cause increased drowsiness. It may also increase the risk of stomach bleeding.

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Pregnancy

Caution

Please consult your doctor if you have any concerns regarding this; your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

Consult your doctor if you are breastfeeding; your doctor will decide whether Zerodol-MR Tablet can be taken by breastfeeding mothers or not.

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Driving

Caution

Zerodol-MR Tablet may cause dizziness. Do not drive or operate machinery unless you are alert.

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Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have liver problems or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney problems or any concerns regarding this.

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Children

Unsafe

Zerodol-MR Tablet is not recommended for children as safety and effectiveness are not established.

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Heart

Unsafe

Zerodol-MR Tablet is contraindicated in patients with heart conditions. Please seek medical advice before using this medicine.

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Geriatrics

Caution

Zerodol-MR Tablet should be given to elderly patients only if prescribed by a doctor. If you have any concerns about using Zerodol-MR Tablet in geriatrics, please consult your doctor.

What if I have taken an overdose of Zerodol-MR Tablet

If you suspect an overdose, seek emergency medical attention immediately. Symptoms of an overdose may include extreme drowsiness, confusion, slow breathing, or severe dizziness.

Diet & Lifestyle Advise

  • Stay well hydrated: Stay well hydrated by drinking plenty of water throughout the day, which helps maintain proper muscle function.
  • Avoid strenuous activities: Avoid heavy lifting, sudden twisting movements, or strenuous exercise that could reinjure your healing muscles.
  • Use warm or cold therapy: Apply a warm compress or a cold pack to the painful area for 15 to 20 minutes at a time to soothe sore muscles naturally.
  • Avoid alcohol and limit caffeine: Avoid alcohol and limit caffeine, as both can worsen dehydration and increase the drowsiness caused by this medication.
  • Do gentle stretches: Incorporate gentle, doctor-approved stretches once your acute pain begins to subside to help prevent future muscle stiffness.

Health Queries

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What other medications can I take for severe pain when turning my neck to one side, since taking Zerodol MR this morning has not provided any relief?

Vikas Singh

Vikas Singh

M Pharmacy

Since Zerodol MR contains an anti-inflammatory and a muscle relaxant, please avoid taking other oral painkillers right now to prevent side effects. Instead, you can safely apply a warm compress or a topical pain-relief gel containing diclofenac to your neck. Gentle range-of-motion movements within a pain-free limit can also help. If the pain remains severe, spreads down your arm, or is accompanied by numbness, please consult your doctor for a physical evaluation.

I have a very painful and swollen area on the back of my shoulder. What medicine should I take?

Chandrakanta Jena

Chandrakanta Jena

Pharm D

A very painful and swollen area on the back of your shoulder may be due to a muscle strain, skin infection, boil, abscess, inflamed cyst, or an injury. The correct treatment depends on the cause, so it is best to have the area examined by a doctor before taking medicine. For mild pain, paracetamol may provide temporary relief if it is safe for you to take. Avoid squeezing, pressing or massaging the swollen area, especially if it is red, warm or contains pus. Seek medical attention promptly if the swelling is rapidly increasing, you develop fever, severe pain, redness spreading around the area, pus, or difficulty moving your shoulder.

Can a right lower wisdom tooth that is still trapped under the gum cause soreness under my ear when I open my mouth?even if the tooth itself doesn't hurt?and can this issue also cause the lymph nodes in my neck to swell, and would a medication like Zerodol MR help treat it?

Vikas Singh

Vikas Singh

M Pharmacy

Yes, an impacted wisdom tooth can definitely cause soreness near your ear and swollen lymph nodes, even without direct tooth pain. This happens because inflammation can easily spread to surrounding tissues, muscles, and nerves. Zerodol MR (aceclofenac and tizanidine) can help temporarily ease the discomfort and jaw stiffness. However, it only manages the symptoms rather than curing the root cause. I gently recommend visiting a dentist soon to evaluate the tooth, as you may need a definitive treatment or antibiotics if there is an underlying infection.

Why is the salivary gland near my right jaw feeling sore and irritated when I open my mouth, and why isn't Chymoral plus working to relieve this pain when a similar issue after a past wisdom tooth removal went away with Zerodol MR?

Vikas Singh

Vikas Singh

M Pharmacy

Your jaw and salivary gland soreness might stem from a blocked duct, mild infection, or jaw muscle tension, which is different from post-surgical healing. Zerodol MR (which contains aceclofenac and the muscle relaxant tizanidine) worked well before because it relieved muscle spasms. Chymoral plus (containing trypsin-chymotrypsin) focuses more on reducing swelling and may not ease muscle stiffness or salivary duct issues. I suggest applying a warm compress, staying well-hydrated, and seeing a dentist or doctor soon to identify the exact cause.

Can my breastfeeding wife be successfully treated for the shooting nerve pain running from her waist down her left leg, and is it safe for her to take Nuerokind injections, Omonacortil, Zerodol MR, Vitamin D3, and Gemcal while nursing, given that her X-ray is normal?

Veda Maddala

Veda Maddala

M Pharmacy

Regarding her medications: Vitamin D3, Gemcal, and Nuerokind injections are safe and beneficial. However, Omonacortil (prednisolone) requires careful doctor supervision, and Zerodol MR (aceclofenac and tizanidine) is generally not recommended while nursing because tizanidine can cause infant drowsiness. Please consult her doctor to substitute Zerodol MR with safer alternatives like paracetamol, and consider gentle physical therapy.

Why does my mother's left hip and leg pain get worse early in the morning despite taking Zerodol MR and Diclowin Plus for muscle spasms, and how can we safely manage this pain?

Vikas Singh

Vikas Singh

M Pharmacy

It is very common for hip and joint pain to feel worse in the morning due to overnight inactivity and joint stiffness. Since she is taking both Zerodol MR and Diclowin Plus, please be cautious as both contain similar pain-relieving medications (NSAIDs), which can increase the risk of stomach upset when taken together. To help her find relief safely, try applying a warm compress to her hip before she gets out of bed and encourage gentle, slow stretching. Please consult her doctor to review these medications and find a safer, more targeted treatment plan for her.

Could taking Zerodol MR cause pain when I urinate or a urinary tract infection, and what medicine can I take to treat it?

Veda Maddala

Veda Maddala

M Pharmacy

Hello. I understand this must be uncomfortable. Zerodol MR, which contains aceclofenac and tizanidine, does not typically cause a urinary tract infection (UTI), though tizanidine can sometimes cause mild urinary side effects. Painful urination in young men is less common and could indicate an infection or irritation that needs specific attention. It is very important not to self-medicate with antibiotics without a diagnosis. I highly recommend drinking plenty of water and seeing a healthcare professional for a simple urine test. They can safely identify the exact cause and prescribe the correct generic medication to help you feel better soon. Take care.

Is it safe to take Bluvit-D3, Zerodol MR, and B colen all at the same time?

G.santoshini Reddy

G.santoshini Reddy

M Pharmacy (Pharmaceutics)

Hello. It is generally safe to take Bluvit-D3 (vitamin D3), Zerodol MR (aceclofenac and tizanidine), and B colen (vitamin B-complex) together, as there are no known harmful interactions between them. To protect your stomach, I highly recommend taking Zerodol MR after a meal. You can take your vitamins as prescribed. If you experience any mild stomach upset or drowsiness, please let your doctor know. Rest assured, these medicines can safely work together to help you recover.

What could be causing my neck pain to come back after getting temporary relief from Zerodol MR, and what should I do next?

Dr. S Aneela

Dr. S Aneela

M. Pharm (Pharmacology)., PhD

Zerodol MR, which contains aceclofenac and tizanidine, temporarily relieves pain and muscle spasms but does not cure the underlying issue. The return of your pain could be due to ongoing muscle strain, poor posture, or a joint or nerve issue in your neck. For now, try applying a warm compress and avoiding sudden neck movements. Please consult your doctor or a physical therapist for a thorough evaluation. They can help identify the root cause and recommend targeted exercises to help you find lasting relief.

Why is my right buttock and knee pain getting worse when I sit, bend, or sleep, even though my spine X-ray was normal and I am taking Zerodol MR?

Y. Lakshmi Thulasi

Y. Lakshmi Thulasi

Pharm-D (Post baccalaureate)

I hear how frustrating this persistent pain is, especially when your X-ray came back normal. While X-rays are great for showing bones, they can miss soft tissue issues like pinched nerves, discs, or muscle tightness. Your symptoms?pain in the buttock and knee worsened by sitting or bending?could point to sciatic nerve irritation or a muscle issue like piriformis syndrome. While Zerodol MR (aceclofenac and tizanidine) helps with inflammation and muscle relaxation, it may not address the root nerve irritation. I gently recommend consulting your doctor for a physical exam or perhaps an MRI, and discussing physical therapy. Rest assured, with the right targeted approach, you can find relief.
health query

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How Soon It Starts Working

  • The time required for Zerodol-MR Tablet to start to work: The effect of Zerodol-MR Tablet is observed within 30 to 60 minutes of administration.
  • The time for which the effects of Zerodol-MR Tablet last: Zerodol-MR Tablet effect lasts for 8 to 12 hours.

What if you forget to take Zerodol-MR Tablet

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed one and continue with your regular schedule. Do not take a double dose to make up for a missed one.

Storage

• Store the tablets at room temperature, ideally between 15°C and 30°C (59°F to 86°F).

Drug Warnings

  • Avoid driving or operating machinery: Do not drive, operate heavy machinery, or perform tasks that require full mental alertness until you know how this medicine affects you, as it can cause significant drowsiness.
  • Stand up slowly: Stand up slowly from a sitting or lying position to prevent sudden drops in blood pressure, which can cause dizziness or fainting.
  • Watch for signs of liver problems: Check your skin and the whites of your eyes regularly for any yellowing, which could indicate liver stress.
  • Inform your healthcare providers: Inform any surgeon, dentist, or healthcare provider that you are taking Zerodol-MR Tablet before undergoing any medical or dental procedures.
  • Do not share your medicine: Never share this medication with anyone else, even if they have similar symptoms of muscle pain or stiffness.
  • Do not stop suddenly: If you have been taking this medicine at high doses or for a long time, do not stop it suddenly without your doctor's advice. Stopping tizanidine abruptly may cause your muscle spasms to return and, in some people, lead to withdrawal effects such as high blood pressure and a fast heartbeat. Aceclofenac does not carry this withdrawal risk. 

Drug-Drug Interactions

verifiedApollotooltip
  • Blood thinners and pain relievers (like warfarin, aspirin, or ibuprofen): They may increase the risk of stomach ulcers or bleeding when taken with blood thinners (like warfarin) or other pain relievers (like aspirin or ibuprofen).
  • Blood pressure medicines, sleeping pills, or anxiety medicines: They can cause a severe drop in blood pressure or extreme sleepiness if taken with certain blood pressure medications, sleeping pills, or anxiety treatments.
  • CYP1A2 inhibitors (a group of medicines that affect how your body breaks down tizanidine): For example, ciprofloxacin or fluvoxamine can greatly increase the amount of tizanidine in your blood, raising the risk of severe drowsiness, dizziness, low blood pressure, and slow heart rate. Tell your doctor if you are taking these medicines, as they should not be taken together with tizanidine. 
Tizanidine + AceclofenacCiprofloxacin
Critical
Tizanidine + AceclofenacSaquinavir
Critical

Drug-Drug Interactions

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Tizanidine + AceclofenacCiprofloxacin
Critical
How does the drug interact with Zerodol-MR Tablet:
Coadministration of Ciprofloxacin with Tizanidine and Aceclofenac together can increase the risk of side effects.

How to manage the interaction:
Using Ciprofloxacin with Tizanidine and Aceclofenac together is avoided, as it can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience drowsiness, weakness, sweating, or palpitations, contact the doctor immediately. Do not discontinue any medications without consulting the doctor.
Tizanidine + AceclofenacSaquinavir
Critical
How does the drug interact with Zerodol-MR Tablet:
Combining Tizanidine and Aceclofenac with Saquinavir can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Tizanidine and Aceclofenac with Saquinavir is not recommended, as it can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhoea or vomiting, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
Tizanidine + AceclofenacDronedarone
Critical
How does the drug interact with Zerodol-MR Tablet:
Coadministration of Tizanidine and Aceclofenac with Dronedarone can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Tizanidine and Aceclofenac with Dronedarone is generally avoided as it can result in an interaction, but it can be taken when prescribed by a doctor. Contact your doctor immediately if you experience sudden dizziness, shortness of breath, palpitations, or chest pain. Do not discontinue any medications without consulting a doctor.
Tizanidine + AceclofenacFluvoxamine
Critical
How does the drug interact with Zerodol-MR Tablet:
Taking Fluvoxamine with Tizanidine and Aceclofenac it can increase the risk of side effects.

How to manage the interaction:
Although Fluvoxamine with Tizanidine and Aceclofenac is not recommended, they can be taken together if prescribed by a doctor. However, contact your doctor immediately if you experience drowsiness, dizziness, low blood pressure, slurred speech, confusion, or severe weakness. Do not stop using any medications without consulting a doctor.
Tizanidine + AceclofenacPimozide
Critical
How does the drug interact with Zerodol-MR Tablet:
Coadministration of Pimozidew with Tizanidine and Aceclofenac may cause a rise in potassium levels in your blood.

How to manage the interaction:
Although taking Pimozidew with Tizanidine and Aceclofenac can result in an interaction, they can be taken together if prescribed by a doctor. However, consult your doctor immediately if you experience sudden dizziness, lightheadedness, shortness of breath, or heart palpitations. Do not discontinue using any medications without consulting a doctor.
Tizanidine + AceclofenacCisapride
Critical
How does the drug interact with Zerodol-MR Tablet:
Coadministration of Tizanidine and Aceclofenac with Cisapride can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Tizanidine and Aceclofenac with Cisapride is avoided as it can result in an interaction, but it can be taken if your doctor has advised it. Contact your doctor immediately if you experience sudden dizziness, shortness of breath, palpitations, or vomiting. Do not discontinue any medications without consulting your doctor.
Tizanidine + AceclofenacZiprasidone
Critical
How does the drug interact with Zerodol-MR Tablet:
Co-administration of Tizanidine and aceclofenac with Ziprasidone can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Tizanidine and aceclofenac with Ziprasidone is not recommended, as it can result in an interaction, but it can be taken if a doctor has advised it. However, contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhea, or vomiting. Do not discontinue any medications without consulting a doctor.
Tizanidine + AceclofenacAmlodipine
Severe
How does the drug interact with Zerodol-MR Tablet:
Co-administration of Tizanidine and Aceclofenac with Amlodipine can increase the risk or severity of developing side effects like low blood pressure.

How to manage the interaction:
Although co-administration of amlodipine with tizanidine and Aceclofenac can result in an interaction, it can be taken if a doctor has advised it. However, if you experience headache, dizziness, or irregular heart rate while taking these drugs, contact the doctor immediately. Use caution while getting up from a sitting or sleeping position, and avoid driving or using dangerous machinery. Do not discontinue any medications without consulting the doctor.
Tizanidine + AceclofenacPindolol
Severe
How does the drug interact with Zerodol-MR Tablet:
Combining Tizanidine and Aceclofenac with Pindolol can lower your blood pressure.

How to manage the interaction:
Taking Tizanidine and Aceclofenac with Pindolol together can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like headache, dizziness, lightheadedness, fainting, and changes in pulse or heart rate, contact your doctor immediately. Avoid driving or operating hazardous machinery until you know how the medications affect you, use caution when getting up from a sitting or lying position, and do not discontinue any medications without consulting your doctor.
Tizanidine + AceclofenacAciclovir
Severe
How does the drug interact with Zerodol-MR Tablet:
Concomitant use of Aciclovir with Tizanidine and Aceclofenac can increase the effects and levels of Tizanidine. This can result in low blood pressure, especially when standing up from sitting or lying.

How to manage the interaction:
Coadministration of Aciclovir with Tizanidine and Aceclofenac can result in an interaction, but it can be taken if your doctor has advised it. Contact a doctor immediately if you experience dizziness, excessive sweating, palpitations, and irregular heart rhythm. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Food: Food can affect how tizanidine is absorbed, and the effect may vary depending on the formulation. Take this medicine consistently, either always with food or always without food, as advised by your doctor, to help reduce the risk of side effects such as drowsiness, dizziness, or low blood pressure. 
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANALGESICS]

FAQs

Zerodol-MR Tablet is used to treat pain and inflammation associated with musculoskeletal and joint disorders.
Zerodol-MR Tablet contains Tizanidine and Aceclofenac. Tizanidine works on the centres of the spinal cord and brain. This helps relieve muscle stiffness and improve muscle movements. Aceclofenac works by blocking the effect of prostaglandins, thereby reducing mild to moderate pain and inflammation.
Zerodol-MR Tablet is used to reduce and relieve pain and inflammation associated with osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. Arthritis is the tenderness and swelling in the joints.
Diarrhoea may be a side effect of Zerodol-MR Tablet . Drink enough fluids and eat non-spicy food if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience severe diarrhoea, consult your doctor. Do not take anti-diarrheal medicine on your own.
Taking Zerodol-MR Tablet can elevate symptoms of gastric ulcer and bleeding. So, talk to your doctor before taking Zerodol-MR Tablet if you have gastrointestinal bleeding or other bleeding problems like haemophilia before using Zerodol-MR Tablet .
Zerodol-MR Tablet and Hifenac-MR are similar, as they relieve pain and inflammation but differ in their active components.
Yes, Zerodol-MR Tablet is a painkiller. However, it is not intended for all types of pain. Use it as prescribed to avoid side effects.
Zerodol-MR Tablet contains Aceclofenac and Tizanidine, making it effective for pain relief and muscle relaxation. Zerodol-SP, on the other hand, includes Aceclofenac, Paracetamol, and Serratiopeptidase, which help reduce pain, inflammation, and swelling. Both should be used as directed by a doctor.
Diabetic patients can use Zerodol-MR Tablet , but it should be taken with caution as it may impact blood sugar levels. Therefore, please consult a doctor before using Zerodol-MR Tablet to ensure its safety for your condition. Regular monitoring of blood sugar is recommended.
You are recommended to consult a doctor before taking Zerodol-MR Tablet with paracetamol or other medicines to avoid potential interactions.
Yes, the use of Zerodol-MR Tablet can cause nausea and vomiting. Take it with food or milk, or with antacids, to prevent nausea. Avoid consuming fried or fatty foods with Zerodol-MR Tablet . If vomiting occurs, drink plenty of water or other fluids by taking small, frequent sips. If vomiting persists, consult your doctor.
Zerodol-MR Tablet usually starts working within 20-30 minutes of taking it, though the onset may vary depending on individual health conditions.
Zerodol-MR Tablet contains aceclofenac and tizanidine as its active components.
Do not take higher than the recommended dose of Zerodol-MR Tablet as it can lead to increased side effects. Therefore, do not exceed the recommended dose. If your symptoms worsen, please consult your doctor.
Store Zerodol-MR Tablet at room temperature in a cool and dry place as advised on the label. Protect from light and moisture. Keep it out of reach of children.
Zerodol-MR Tablet is safe when used as per the dose and duration advised by a doctor.
Zerodol-MR Tablet is contraindicated in individuals with known allergies to its ingredients, or patients with high blood pressure, heart problems, stomach ulcers, bleeding disorders, inflammatory bowel disease, high cholesterol, diabetes, asthma, or liver and kidney issues. Zerodol-MR Tablet is not recommended for children, and you should consult your doctor if you are pregnant or breastfeeding.
You are recommended not to stop taking Zerodol-MR Tablet without consulting your doctor as stopping it suddenly can cause adverse effects. Therefore, continue taking Zerodol-MR Tablet for the duration prescribed and if you experience any difficulty while taking Zerodol-MR Tablet , consult your doctor so that the dose may be reduced gradually.
Take Zerodol-MR Tablet as directed by your doctor. Swallow Zerodol-MR Tablet whole with a glass of water; do not crush, chew, or break it.
If you miss a dose of Zerodol-MR Tablet , take it as soon as you remember and if it is the time for the next dose, skip the missed dose and continue with the regular dose. Avoid taking double dose to make up for the missed one.
Zerodol-MR Tablet may cause side effects such as nausea, vomiting, stomach pain, diarrhoea, loss of appetite, and heartburn. These do not require any medical treatment as they will gradually reduce over time. Consult a doctor if these side effects persist for longer durations.
It is highly recommended to take Zerodol-MR Tablet with food or a glass of milk. Taking it on an empty stomach increases the risk of indigestion and stomach upset. Talk to your doctor or pharmacist if you experience persistent stomach discomfort.
Yes, drowsiness and dizziness are common side effects of this medication due to its muscle-relaxing properties. Avoid driving or operating machinery until you know how this medicine affects you. Talk to your doctor if the sleepiness is severe.
No, you must avoid drinking alcohol while taking this medicine. Alcohol can dangerously increase drowsiness, cause a severe drop in blood pressure, and increase the risk of liver damage. Talk to your doctor if you have concerns about alcohol use.
This medication is generally not recommended during pregnancy or breastfeeding unless specifically deemed necessary by your doctor. It may pose risks to the developing baby. Talk to your doctor to discuss safer alternatives.
You should avoid taking other pain relievers alongside Zerodol-MR Tablet , as this significantly increases the risk of stomach irritation and bleeding. Talk to your doctor or pharmacist before combining any pain medications.
Older adults may be more sensitive to the side effects of this medication, particularly dizziness, drowsiness, and stomach issues, which can increase the risk of falls. Talk to your doctor to determine if this is the safest option for you.
Dry mouth is a common side effect of the muscle relaxant component in this medicine. You can manage this by sucking on sugar-free candies, chewing sugar-free gum, or taking frequent sips of water. Talk to your doctor or pharmacist if this symptom becomes severe or bothersome.

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Reference

  1. Electronic Medicines Compendium (EMC). Pil.4240 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  2. Drugs.com Clinical Review Team. Tizanidine Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  3. Tizanidine hydrochloride. 1996. [Accessed on 02 Apr. 20191]Check here
  4. DailyMed DailyMed. [Accessed on 23 Apr. 2019]Check here
  5. Pareek A, Chandurkar N, Chandanwale AS, et al. 2009. [Accessed on 16 Sep. 2024]Check here
  6. Shirin Ghanavatian, Armen Derian. Tizanidine. NIH National Library of Medicine, National center for biotechnology information. May 2022. [Accessed on 5th June 2026]Check here
  7. Health Products Regulatory Authority (HPRA). 2188598.Ppa0465 168 001.A8263158 055A 45A9 A0C4 78A88025A375.000001Zanaflex Combined Pil.170214 Human Medicine Product Information. Dublin, Ireland: HPRA; 2024. [Accessed on 02 Jun. 2026]Check here

Country of origin

India

Manufacturer/Marketer address

142 AB, Kandivli Industrial Estate, Kandivli (West), Mumbai - 400 067, Maharashtra
Other Info - ZER0001

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