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compositionComposition:METOCLOPRAMIDE-5MG
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Prescription Medicine
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Zerinorm 5mg Syrup is used to prevent nausea and vomiting caused by chemotherapy, radiotherapy, and which might occur after migraine. Additionally, it is also used to treat gastro-oesophageal reflux disease (GERD), diabetic gastroparesis (delayed gastric emptying in people with diabetes), heartburn, ulcers and sores in the oesophagus. It contains Metoclopramide, which works by increasing the motility of the upper gastrointestinal tract; this allows faster transit of food and reduces the symptoms of GERD and gastric emptying. It also works on the part of the brain that controls vomiting, thereby helping in preventing nausea and vomiting. In some cases, it may cause common side effects such as restlessness, fatigue, drowsiness, diarrhoea, weakness, and lassitude (lack of energy). Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

METOCLOPRAMIDE-5MG

Consume Type :

Oral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Zerinorm 5mg Syrup

Zerinorm 5mg Syrup is an oral prescription medication used to treat certain conditions of the stomach and intestines. It is primarily prescribed to relieve symptoms of slow stomach emptying in people with diabetes, and to treat severe heartburn caused by acid reflux when other treatments have not worked. It is also commonly used to prevent nausea and vomiting.

To get the best results, you should take Zerinorm 5mg Syrup consistently at the exact times prescribed by your doctor, usually 30 minutes before meals and at bedtime. Taking it on an empty stomach helps your body absorb the medicine properly so it can work when food enters your stomach. Making simple changes, like eating smaller, more frequent meals, can also help improve your digestive symptoms while using this medicine.

While taking Zerinorm 5mg Syrup, you may experience mild side effects such as drowsiness, tiredness, or restlessness. However, you must contact your doctor immediately if you notice muscle twitching, uncontrolled movements of your face or limbs, or severe mood changes. These can be signs of serious neurological issues that require prompt medical attention.

Before starting Zerinorm 5mg Syrup, tell your doctor if you have a history of depression, high blood pressure, asthma, or kidney disease. Do not take this if you have a history of seizure disorders, bleeding or blockages in your stomach or intestines, or a rare adrenal gland tumor.

This medicine can interact with other drugs that make you sleepy, such as sleeping pills or muscle relaxants, and drinking alcohol while taking it can make drowsiness much worse. Smoking may also reduce the effectiveness of this medicine by altering how fast your stomach empties. If you are pregnant, breastfeeding, or an older adult, you should discuss the risks and benefits with your doctor before taking Zerinorm 5mg Syrup.

Uses of Zerinorm 5mg Syrup

Zerinorm 5mg Syrup is used in the prevention of Nausea, Vomiting, gastroesophageal reflux disease (GERD), and diabetic gastroparesis (delayed gastric emptying in people with diabetes). The detailed uses of Zerinorm 5mg Syrup are as follows:

  • Diabetic gastroparesis: Helps relieve symptoms like nausea, vomiting, feeling full too quickly, and stomach bloating caused by delayed stomach emptying in people with diabetes.
  • Gastroesophageal reflux disease (GERD): Provides short-term relief for chronic heartburn when other medications do not work, by helping clear stomach acid more quickly.
  • Prevention of nausea and vomiting: Helps control nausea and vomiting caused by medical procedures, chemotherapy, or certain illnesses

Key Benefits

  • Zerinorm 5mg Syrup provides relief from persistent nausea and vomiting, allowing you to keep food and fluids down and maintain proper nutrition.
  • Speeding up the movement of food through your digestive tract relieves the uncomfortable sensations of bloating, painful fullness, and early satiety after eating.
  • It helps reduce severe heartburn and acid reflux symptoms, making it easier to sleep and go about your daily activities without pain.

Directions for Use

  • Take this medicine by mouth, usually 30 minutes before meals and at bedtime, as directed by your doctor.
  • Swallow the tablet whole with a full glass of water. Do not crush, chew, or break the tablet unless your doctor or pharmacist tells you to do so.
  • If you are using an oral liquid form, measure the dose carefully using a special medical measuring device or spoon, not a regular household spoon.
  • Always follow your doctor's exact instructions regarding how long to take this medication. It is usually prescribed for short-term use, typically not exceeding 12 weeks.

How Zerinorm 5mg Syrup Works

Zerinorm 5mg Syrup works by acting on receptors in the brain and digestive system. It blocks dopamine (D2) receptors in the brain to help prevent nausea and vomiting. It also activates serotonin (5-HT4) receptors, which improves the movement of the stomach and intestines, helping food move more quickly into the small intestine. In addition, it has a weak blocking effect on serotonin (5-HT3) receptors, which further helps reduce nausea. Together, these actions speed up stomach emptying, reduce acid reflux, improve digestion, and effectively relieve nausea and vomiting.
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Alcohol

Unsafe

Avoid consumption of alcohol while taking Zerinorm 5mg Syrup as it may make some side effects worse such as increased sleepiness and drowsiness.

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Pregnancy

Consult your doctor

Consult your doctor before taking Zerinorm 5mg Syrup if you are pregnant; your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Consult your doctor

Consult your doctor before taking Zerinorm 5mg Syrup if you are breastfeeding.

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Driving

Unsafe

Zerinorm 5mg Syrup may cause dizziness, drowsiness and fatigue. Do not drive or operate machinery until you know how Zerinorm 5mg Syrup affects you.

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Liver

Caution

Dose adjustment may be needed. Consult your doctor before taking Zerinorm 5mg Syrup if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed. Consult your doctor before taking Zerinorm 5mg Syrup if you have kidney impairment or any concerns regarding this.

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Children

Caution

Zerinorm 5mg Syrup are not recommended for children due to the risk of tardive dyskinesia, extrapyramidal symptoms as well as risk of methemoglobinemia in neonates.

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Heart

Caution

Zerinorm 5mg Syrup should be administered with caution in patients with heart problems. Please inform your doctor about any existing heart problems before using Zerinorm 5mg Syrup.

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Geriatrics

Caution

Zerinorm 5mg Syrup should be administered with caution in elderly patients. If you have any concerns, please consult your doctor.

What if I have taken an overdose of Zerinorm 5mg Syrup

If you suspect an overdose, seek emergency medical care or call a poison control centre immediately. Symptoms of an overdose may include severe drowsiness, confusion, muscle spasms, or uncontrolled movements.

Diet & Lifestyle Advise

  • Eat smaller, more frequent meals (five to six times a day) instead of three large meals to reduce the workload on your stomach.
  • Choose low-fat and low-fiber foods, as fat and fiber can slow down stomach emptying and worsen your symptoms.
  • Sit upright for at least two hours after eating to prevent stomach acid and food from flowing back up into your throat.
  • Avoid foods and beverages that can worsen heartburn, such as caffeine, chocolate, spicy foods, tomatoes, and citrus fruits.
  • Stay hydrated by sipping small amounts of water or clear liquids throughout the day, especially if you have been experiencing vomiting.
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Have a query?

How Soon It Starts Working

  • The time required for Zerinorm 5mg Syrup to start to work: Zerinorm 5mg Syrup ideally shows its action within 30 to 60 minutes after administration.
  • The time for which the effects of Zerinorm 5mg Syrup last: The effect of Zerinorm 5mg Syrup lasts for 1 to 2 hours.

What if you forget to take Zerinorm 5mg Syrup

If you miss a dose of Zerinorm 5mg Syrup, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • FDA Boxed Warning: Do not take Zerinorm 5mg Syrup for longer than 12 weeks unless your doctor advises otherwise. Long-term or high-dose use increases the risk of tardive dyskinesia, a serious and sometimes permanent disorder causing involuntary muscle movements.
  • Watch for unusual movements of the face, tongue, mouth, eyes, arms, or legs. Stop the medicine and contact your doctor immediately if these occur.
  • Zerinorm 5mg Syrup may cause drowsiness or dizziness. Avoid driving, operating machinery, or doing activities that require alertness until you know how it affects you.
  • Avoid or limit alcohol while taking this medicine, as it can increase drowsiness and other side effects.
  • Zerinorm 5mg Syrup usually starts working within 30–60 minutes after an oral dose. Its stomach-emptying (prokinetic) effect lasts for about 1–2 hours per dose, although the overall treatment benefit depends on your condition and the duration of therapy.
  • Take this medicine exactly as prescribed and do not exceed the recommended dose or duration without consulting your doctor.

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Drug-Drug Interactions

  • Combining Zerinorm 5mg Syrup with antipsychotic medications or certain antidepressants can significantly increase the risk of serious muscle spasms and movement disorders.
  • Using this medicine with strong pain relievers (like opioids) or anticholinergic drugs can reduce its effectiveness in emptying your stomach.
  • Taking it with sedatives, sleeping pills, or anxiety medications can lead to extreme drowsiness and slowed breathing.

Drug-Food Interactions

  • Drinking alcohol while taking Zerinorm 5mg Syrup can intensify drowsiness, dizziness, and coordination issues.

Drug-Disease Interactions

  • Parkinson's disease: May worsen symptoms like muscle stiffness and tremors.
  • Seizure disorders: Can increase the frequency or severity of seizures.
  • Stomach bleeding, blockages, or tears: Can worsen these dangerous intestinal conditions by increasing gut contractions.
  • Kidney or liver disease: May require a lower dose to avoid buildup of the medication in your body.

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIEMETICS, GASTROPROKINETIC AGENTS]

FAQs

Zerinorm 5mg Syrup belongs to a group of medicines called anti-emetics and prokinetic agents used to prevent nausea and vomiting caused by chemotherapy and radiotherapy, which might occur after migraines. Zerinorm 5mg Syrup is also used to treat gastro-oesophageal reflux disease (GERD), diabetic gastroparesis (delayed gastric emptying in people with diabetes), heartburn, ulcers and sores in the oesophagus.
Zerinorm 5mg Syrup works by increasing the motility of the upper gastrointestinal tract; this allows faster transit of food and reduces the symptoms of GERD and gastric emptying. It also works on the part of the brain that controls vomiting, thereby helps in preventing nausea and vomiting.
Take Zerinorm 5mg Syrup only for as long as the doctor has prescribed it for you. Do not take Zerinorm 5mg Syrup for more than three months as it might increase the risk of tardive dyskinesia (movement disorder), which is often irreversible. The risk of developing tardive dyskinesia increases with the total dosage and duration of treatment.
Diarrhoea might be a side-effect of Zerinorm 5mg Syrup. Drink enough fluids and eat non-spicy food if you experience diarrhoea. Consult your doctor if the condition persists or worsens.
Maintain a minimum gap of 6 hours between each dose. Do not take another dose of Zerinorm 5mg Syrup even in case of vomiting and rejection of dose to avoid an overdose.
Zerinorm 5mg Syrup may cause uncontrollable movements such as shaking, tics, twisting movements, muscle stiffness and rigidity. Consult your doctor if you experience these symptoms.
Take Zerinorm 5mg Syrup 30 minutes before food, preferably at bedtime or as advised by the doctor.
Before starting Zerinorm 5mg Syrup, inform the doctor if you have heart problems, diabetes, depression, high blood pressure, breast cancer, seizures, liver or kidney problems, Parkinson's disease, methemoglobinemia (blood disorder); if you are taking levodopa or if you have had gastrointestinal surgery in the last 3-4 days.
No, Zerinorm 5mg Syrup should not be taken after meals. It works best when taken on an empty stomach.
Zerinorm 5mg Syrup is not known to cause constipation. Drink enough fluids and eat fibre-rich food if you have constipation. Consult the doctor if the condition persists or worsens.
Zerinorm 5mg Syrup is not indicated for the treatment of morning sickness. It is used to treat nausea, vomiting, gastroesophageal reflux disease (GERD), and diabetic gastroparesis (delayed gastric emptying in people with diabetes). Talk to the doctor if you have morning sickness; the doctor will prescribe appropriate medicine based on your condition.
Zerinorm 5mg Syrup can be taken with ranitidine if prescribed by the doctor. No interaction has been reported between both these medicines.
Zerinorm 5mg Syrup may cause side effects such as restlessness, fatigue, drowsiness, diarrhoea, weakness, and lassitude (lack of energy). Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if the side effects persist or worsen.
Zerinorm 5mg Syrup usually begin to work within 30 to 60 minutes after taking them. The effects typically last for about 1 to 2 hours. Talk to your doctor if you do not notice an improvement in your symptoms.
If you notice any unusual, uncontrolled muscle movements, especially in your face, tongue, or limbs, stop taking the medicine and contact your doctor immediately. This could be a sign of a serious side effect. Talk to your doctor right away.
You should only take Zerinorm 5mg Syrup during pregnancy if your doctor determines that the benefits outweigh the potential risks to the baby. If you are pregnant or planning to become pregnant, talk to your doctor.
No, Zerinorm 5mg Syrup is generally not recommended for use longer than 12 weeks. Prolonged use increases the risk of developing tardive dyskinesia, a serious and potentially irreversible movement disorder. Talk to your doctor about your treatment duration.

Disclaimer

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Country of origin

India
Other Info - ZERI868
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