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compositionComposition:PHENOXYBENZAMINE-50MG
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Prescription Medicine
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Zaxyben 50mg Injection is an antihypertensive medicine used in the treatment of hypertension (high blood pressure) caused by phaeochromocytoma (tumour of the adrenal glands). This medicine works by opposing certain hormones produced by the tumour of the adrenal gland and thus relaxes and widens blood vessels and lowers increased blood pressure. It is advised to avoid alcohol consumption as it can worsen the condition.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

PHENOXYBENZAMINE-50MG

Manufacturer/Marketer :

Molekule (India) Pvt Ltd

Consume Type :

Parenteral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Zaxyben 50mg Injection

Zaxyben 50mg Injection is an injectable medication primarily used to control episodes of dangerously high blood pressure and sweating in people with a rare tumour of the adrenal gland called pheochromocytoma. This medication is typically given to prepare patients safely for surgery to remove the tumour or to manage symptoms when surgery is not an option. It works by relaxing blood vessels so that blood can flow more easily.

Because Zaxyben 50mg Injection is given as an injection into a vein, it is administered by a healthcare professional in a hospital or clinic setting. The frequency of your doses will be carefully timed by your medical team to ensure consistent blood pressure control leading up to your procedure. To support your treatment, your doctor may recommend lifestyle adjustments such as monitoring your daily fluid intake and keeping a close eye on your salt consumption.

While receiving this medication, you may experience mild side effects like a stuffy nose, mild dizziness when standing up, or a faster heart rate. These effects often occur as your body adjusts to the relaxed blood vessels. However, you must inform your healthcare provider immediately if you experience severe dizziness, fainting, or signs of an allergic reaction.

Before starting treatment with Zaxyben 50mg Injection, tell your doctor if you have a history of heart disease, kidney issues, or poor blood circulation to your brain. Do not take this medicine if you have a known allergy to any of its ingredients, or if you have a condition where a sudden drop in blood pressure could be highly dangerous, such as coronary artery disease.

This injection can interact with alcohol, which can cause your blood pressure to drop to dangerously low levels, and certain medications like other blood pressure drugs can worsen this effect. If you are pregnant, breastfeeding, or are an older adult, it is vital to discuss the unique risks and benefits with your doctor before receiving this treatment.

Uses of Zaxyben 50mg Injection

A healthcare professional may prescribe Zaxyben 50mg Injection to manage symptoms caused by adrenal gland tumours that produce excess hormones. These include:

  • Pheochromocytoma Surgery Preparation: Helps control severe spikes in blood pressure and excessive sweating before and during the surgical removal of adrenal gland tumours.
  • Long-term Management of Inoperable Adrenal Tumours: In cases where surgery is not possible, this injection helps manage and control symptoms caused by excessive hormone release from the tumour.

Key Benefits

Zaxyben 50mg Injection helps stabilise blood pressure and control symptoms caused by excess hormone release, making treatment and surgery safer. Key benefits include:

  • Stabilises Blood Pressure: Zaxyben 50mg Injection provides crucial stabilisation for patients facing high-stress medical procedures. By blockading the chemical signals that cause blood vessels to tighten, it prevents sudden, life-threatening surges in blood pressure.
  • Supports Safer Surgery: For patients preparing for surgery, this medication provides reassurance by making the surgical procedure significantly safer and reducing the stress placed on the heart. It also helps relieve highly uncomfortable symptoms like severe sweating and a pounding heart, allowing patients to feel more comfortable and physically prepared for their recovery.

Directions for Use

  • Zaxyben 50mg Injection is administered by healthcare professionals through an intravenous (IV) injection, typically in a hospital setting.
  • The dosage and frequency are determined by your doctor, based on your condition and response to treatment.
  • Do not attempt to self-administer this injection, as improper use may lead to serious side effects.
  • Follow your healthcare provider’s instructions about the medication and any steps to track your progress or precautions during treatment.

How Zaxyben 50mg Injection Works

This medicine contains phenoxybenzamine. It works by targeting specific receptors in the body called alpha receptors, which are found on the walls of your blood vessels. Under normal circumstances, stress hormones like adrenaline attach to these receptors and cause the blood vessels to narrow, which raises your blood pressure. By binding irreversibly to these alpha receptors, Zaxyben 50mg Injection blocks adrenaline from attaching to them. This action keeps the blood vessels relaxed until the body produces new alpha receptors, helping lower blood pressure and prevent sudden spikes caused by adrenal gland tumours.
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Alcohol

Unsafe

Avoid consumption of alcohol while on treatment with Zaxyben 50mg Injection as it may increase the risk of dangerously low blood pressure.

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Pregnancy

Consult your doctor

Zaxyben 50mg Injection is not recommended for pregnant women unless clearly necessary. Therefore, if you are pregnant or planning pregnancy, please inform your doctor before receiving Zaxyben 50mg Injection.

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Breast Feeding

Consult your doctor

Zaxyben 50mg Injection is usually not recommended for breastfeeding mothers. Therefore, please inform your doctor if you are a breastfeeding mother before receiving Zaxyben 50mg Injection.

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Driving

Caution

Zaxyben 50mg Injection may cause dizziness or light-headedness in some people. Therefore, avoid driving if you feel dizzy or lightheaded after taking Zaxyben 50mg Injection.

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Liver

Caution

Inform your doctor if you have a history of liver diseases/conditions. The dose may be adjusted by your doctor as required.

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Kidney

Caution

Inform your doctor if you have a history of Kidney diseases/conditions. The dose may be adjusted by your doctor as required.

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Children

Caution

Zaxyben 50mg Injection is not recommended for children unless advised by the doctor.

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Heart

Consult your doctor

Please consult your doctor before using Zaxyben 50mg Injection if you have pre-existing heart problems. Your doctor will prescribe Zaxyben 50mg Injection if the benefits outweigh the risks.

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Geriatrics

Consult your doctor

Please consult a doctor before administering Zaxyben 50mg Injection to geriatric patients. Your doctor will prescribe Zaxyben 50mg Injection if the benefits outweigh the risks.

What if I have taken an overdose of Zaxyben 50mg Injection

An overdose of this medication can cause a dangerous drop in blood pressure and a very rapid heart rate. Because this medicine is given under close medical supervision, your team will monitor you continuously to prevent this. If you suspect you have received too much or experience severe lightheadedness or fainting after an injection, notify your healthcare provider or seek emergency medical care immediately.

Diet & Lifestyle Advise

  • Stay hydrated: Drink plenty of fluids as directed by your doctor to help prevent your blood pressure from dropping too low when you stand up.
  • Change positions slowly: To avoid dizziness or fainting, take your time when moving from a lying or sitting position to a standing position.
  • Avoid sudden temperature changes: Extremely hot baths, showers, or hot weather can widen your blood vessels further, increasing the risk of dizziness and fainting.
  • Monitor your blood pressure: Keep a daily log of your blood pressure readings at home as recommended by your healthcare team to track how well the treatment is working.
  • Limit salt intake if advised: Discuss your daily sodium intake with your doctor, as maintaining the right balance of salt and water is crucial during this treatment.
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How Soon It Starts Working

The time required for Zaxyben 50mg Injection to start to work: Zaxyben 50mg Injection ideally shows its action within 2 hours after administration. The time for which the effects of Zaxyben 50mg Injection last: The effect of Zaxyben 50mg Injection lasts for 24 hours.

What if you forget to take Zaxyben 50mg Injection

Since this medication is administered by healthcare professionals in a clinical setting, missing a dose is highly unlikely. However, if you miss a scheduled appointment for your injection, contact your healthcare provider immediately to reschedule. Do not attempt to receive a double dose to make up for a missed one.

Storage

•Keep the medication in its original carton to protect it from light.•Do not freeze the medication.

Drug Warnings

  • Inspect the Solution: Always inspect the injection vial before use; the solution should be clear and free of particles or discolouration.
  • Rotate Injection Sites: Ensure the injection site is rotated regularly if you are receiving multiple infusions to prevent tissue irritation or vein damage.
  • Avoid Driving or Operating Machinery: This medication can cause severe drowsiness or dizziness. Do not drive, operate heavy machinery, or perform dangerous tasks until you know how the medicine affects you.
  • Inform Your Surgical Team: Alert your surgical team that you are receiving Zaxyben 50mg Injection, as it can interact with anaesthetics used during surgery.
  • Monitor the Injection Site: Watch for irritation, swelling, redness, or pain at the injection site, and report these symptoms to your nurse or doctor promptly.

verifiedApollotooltip
  • Blood Pressure-Lowering Medicines: Taking Zaxyben 50mg Injection with other blood pressure-lowering medicines, such as beta-blockers or calcium channel blockers, may cause your blood pressure to fall too low.
  • Erectile Dysfunction Medicines: Taking medicines such as sildenafil or tadalafil with this injection can trigger a sudden, severe drop in blood pressure.
  • Nasal Decongestants and Cold Remedies: Some nasal decongestants or cold remedies may reduce the effectiveness of Zaxyben 50mg Injection.

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  • Alcohol: Consuming alcohol while taking this medication can significantly increase the risk of extreme dizziness, fainting, and severely low blood pressure.

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ALPHA BLOCKERS]

FAQs

Zaxyben 50mg Injection is an antihypertensive medicine used in the treatment of hypertension (high blood pressure) caused by phaeochromocytoma (tumour of the adrenal glands).
Zaxyben 50mg Injection contains Phenoxybenzamine that works by opposing the action of certain hormones produced by the adrenal gland tumor that constricts and narrows blood vessels. Thereby, it relaxes and widens blood vessels and lowers high blood pressure.
You are not recommended to take Zaxyben 50mg Injection with atenolol as it may increase orthostatic hypotensive effects of Zaxyben 50mg Injection such as dizziness, fainting, or lightheadedness. However, please consult a doctor before taking other medicines with Zaxyben 50mg Injection.
Zaxyben 50mg Injection should be used with caution in patients suffering from kidney problems as it may increase the risk of adverse effects. Therefore, if you have any kidney disease, inform your doctor before taking Zaxyben 50mg Injection.
Zaxyben 50mg Injection may cause dizziness in some patients. Therefore, it is advised to get up slowly from a sitting or lying position to avoid such side effects. Also, if you feel dizzy after taking Zaxyben 50mg Injection, avoid driving or operating heavy machinery.
Zaxyben 50mg Injection should be taken for as long as it has been prescribed by the doctor. The dose and duration will be determined by the doctor based on your medical condition.
People who are allergic to any of the components in this medicine should not take Zaxyben 50mg Injection. It is also not recommended in conditions where a fall in blood pressure may be undesirable.
Zaxyben 50mg Injection reduces blood pressure and increases the release of the chemical messenger (noradrenaline) which results in reflex tachycardia (fast heart rate). Let the doctor know if you experience a fast heart rate.
Zaxyben 50mg Injection is used for the treatment of hypertension associated with the rare adrenal gland tumour, pheochromocytoma.
Zaxyben 50mg Injection helps to lower the elevated blood pressure caused by pheochromocytoma. It is an adrenal gland tumour that causes adrenal glands to release large amounts of chemicals called catecholamines into the blood, which raises blood pressure. Zaxyben 50mg Injection lowers blood pressure by blocking alpha receptors.
Yes, Zaxyben 50mg Injection may affect sex life. It may cause sexual dysfunction like ejaculation failure during intercourse. Consult the doctor if you have any concerns.
The symptoms of an overdose of Zaxyben 50mg Injection include vomiting, fast heart rate, fainting, or dizziness. Consult the doctor if you experience any of these symptoms.
Zaxyben 50mg Injection starts working in an hour. However, it might take a few hours to notice the effects of the medicine.
The side effects of Zaxyben 50mg Injection include vomiting, nausea, dizziness, blocked nose, light-headedness, tachycardia, tiredness, ejaculation failure during intercourse, and narrowing of the pupil of the eye. Consult the doctor if any side effects persist or worsen.
No, Zaxyben 50mg Injection is an injection that must be prepared and given by a trained healthcare professional in a hospital or clinic setting. This ensures your blood pressure and heart rate are monitored closely during the infusion. Talk to your doctor if you have questions about your treatment schedule.
You should avoid alcohol while receiving Zaxyben 50mg Injection. Alcohol relaxes your blood vessels further, which can combine with the medication to cause a dangerous drop in blood pressure, leading to severe dizziness or fainting. Talk to your doctor if you need help managing this.
No, Zaxyben 50mg Injection does not cure or shrink adrenal gland tumours (pheochromocytoma). Instead, it manages the dangerous high blood pressure and other symptoms caused by the tumour, often to make surgical removal safer. Talk to your doctor about your long-term treatment plan.
You should avoid driving, riding a bike, or operating machinery immediately after receiving this injection. The medication can cause dizziness, lightheadedness, and blurred vision, which makes these activities unsafe. Talk to your doctor about when it is safe for you to drive again.
Some patients may experience a stuffy nose or mild nasal congestion due to the relaxation of blood vessels in the nasal passages. However, if you experience sudden difficulty breathing, wheezing, or throat swelling, seek emergency medical care immediately as this could be an allergic reaction.
Zaxyben 50mg Injection is generally only used during pregnancy if the potential benefits outweigh the risks to the unborn baby, as it can affect blood pressure and blood flow. If you are pregnant, planning to become pregnant, or breastfeeding, discuss your options thoroughly. Talk to your doctor to make an informed decision.

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Country of origin

India
Other Info - ZAXY240
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