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compositionComposition:IDARUBICIN-5MG
prescription
Prescription Medicine
info
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ZAVEDOS INJECTION 5MG is used to treat cancer. It contains Idarubicin, which belongs to the class of anthracycline topoisomerase inhibitors. It inhibits the topoisomerase II enzyme by intercalating the DNA base pairs. This causes double helix DNA to be uncoiled, destroying DNA and RNA synthesis. Thus, ZAVEDOS INJECTION 5MG stops the multiplication of abnormal cells, leads to the growth of cells in an unbalanced way and causes cancer cell death. ZAVEDOS INJECTION 5MG is used in combination with other medicines for the treatment of acute myeloid leukaemia.

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Written By Dr. Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

IDARUBICIN-5MG

Manufacturer/Marketer :

Pfizer Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About ZAVEDOS INJECTION 5MG

ZAVEDOS INJECTION 5MG is a chemotherapy medication injected into a vein to treat acute myeloid leukemia, which is a type of blood cancer. It works by stopping cancer cells from growing and multiplying, helping to bring the disease into remission.

Because this medicine is given as an injection or infusion in a hospital or clinic, medical professionals will manage your schedule. Consistency is vital, and your healthcare team will plan your cycles carefully. Since it is injected, food intake does not directly affect how the drug is absorbed, but staying hydrated and eating small, frequent meals can help manage nausea.

Common side effects include nausea, temporary hair loss, and a decrease in blood cell counts, which can increase your risk of infections. You must consult your doctor immediately if you face specific serious side effects, such as signs of an infection (like a fever) or if you experience unusual chest pain.

Do not take this if you have severe liver damage, severe kidney damage, or severe heart problems, such as a recent heart attack or abnormal heart rhythms. It is also not suitable for individuals with severely weakened bone marrow function. Talk to your doctor before starting this medicine if you have any history of heart disease.

This medicine can interact with other cancer treatments, vaccines, and certain drugs that affect your heart or liver. Avoid live vaccines during treatment, and talk to your doctor if you are pregnant, breastfeeding, or planning a pregnancy, as this medicine can harm an unborn baby.

Uses of ZAVEDOS INJECTION 5MG

ZAVEDOS INJECTION 5MG is used to treat certain types of blood cancers by slowing or stopping the growth of cancer cells. Your doctor may prescribe it for the following conditions:

  • Acute Myeloid Leukemia: ZAVEDOS INJECTION 5MG is used in combination with other chemotherapy drugs to treat this type of blood cancer, helping to destroy leukemia cells and restore normal blood cell production in the bone marrow.
  • Acute Lymphocytic Leukemia: In certain cases, doctors may prescribe this medicine to treat acute lymphocytic leukemia when other primary treatments have not worked.

Key Benefits

Using ZAVEDOS INJECTION 5MG as prescribed helps treat certain types of leukaemia by slowing the growth of cancer cells. Here are the key benefits you can expect:

  • Helps destroy leukaemia cells: Targets rapidly dividing cancer cells, helping reduce their number in the blood and bone marrow.
  • Supports healthy blood cell production: As abnormal cells decrease, the bone marrow can gradually produce healthy red blood cells, white blood cells, and platelets.
  • Works well with combination therapy: When used with other chemotherapy medicines, ZAVEDOS INJECTION 5MG helps improve treatment effectiveness and supports better disease control.
Side effects of Zavedos Injection 5mg
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
  • Severe leukopenia needs immediate medical attention if the levels of WBC drop.
  • Boost your immunity by including immune-rich foods and stay hydrated.
  • Get sufficient sleep and manage stress, which helps improve white blood cell count.
  • Consult your doctor for effective treatment to improve your blood cell count and get regular body checks to monitor changes in the count.
  • Try to prevent the factors that cause severe leukopenia and may lead to impaired immunity.
  • Eat well-cooked food to minimize infection risk.
  • Practice good hand hygiene to prevent infections.
  • Avoid crowds and people with illnesses to reduce exposure.
  • Wear a mask when necessary to lower infection risk.
  • Rest adequately to support your body's healing process.
  • Stay hydrated by drinking plenty of water.
  • Regularly monitor blood cell counts for changes.
  • Seek immediate medical help if symptoms like fever, chills, or fatigue occur.
  • Consult your doctor right away if concerning symptoms arise.
  • Follow your doctor's guidance on managing myelosuppression and infection prevention.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Heart failure needs immediate medical attention. To manage this effect, the doctor's instructions must be followed strictly.
  • Take care of change in your weight as there can be sudden changes.
  • Rest and refrain from physical activity, and restart after a few days.
  • Reduce your salt intake and control your diet with the help of a dietician.
  • Track your symptoms and keep your follow-up appointments to manage severe side effects.
  • Eat protein-rich foods like fish, poultry, eggs, and legumes.
  • Include foods with minerals and vitamins essential for hair health.
  • Join a support group to connect with others experiencing hair loss.
  • Openly discuss your feelings about hair loss.
  • Consider covering up with wigs, hats, or scarves.
  • Be patient and avoid seeking miracle cures.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication to ensure safety.
  • ZAVEDOS INJECTION 5MG will be administered by the doctor or healthcare professional.
  • Do not self-administer.

How ZAVEDOS INJECTION 5MG Works

ZAVEDOS INJECTION 5MG contains idarubicin, an anthracycline chemotherapy medicine that helps treat certain types of leukaemia. It works by binding to the DNA of cancer cells and blocking an enzyme called topoisomerase II, which is needed for DNA replication and repair. This prevents the cancer cells from growing and dividing, causing them to die. As a result, ZAVEDOS INJECTION 5MG helps reduce the number of leukaemia cells and supports the recovery of healthy blood cell production.
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Alcohol

Unsafe

Avoid consumption of alcohol with ZAVEDOS INJECTION 5MG as it may increase the risk of liver damage.

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Pregnancy

Unsafe

It is not recommended for use in pregnancy as it may harm your foetus. If you are pregnant or planning pregnancy, inform your doctor before receiving ZAVEDOS INJECTION 5MG. Use effective contraception to avoid pregnancy while on treatment with this medicine.

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Breast Feeding

Unsafe

It is not recommended for use in breastfeeding as it may pass into breast milk and harm your infant. Because of the possibility of major adverse events in nursing infants from the medicine, women should quit nursing prior to taking the drug and refrain from breastfeeding during treatment and for 14 days after the final dosage.

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Driving

Unsafe

ZAVEDOS INJECTION 5MG causes dizziness and may alter the ability to drive or operate machines. Hence, avoid driving or operating machines after taking ZAVEDOS INJECTION 5MG.

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Liver

Caution

If you have a pre-existing or a history of liver disease, inform your doctor before receiving ZAVEDOS INJECTION 5MG. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition. Your doctor may also suggest liver function tests while on treatment with ZAVEDOS INJECTION 5MG.

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Kidney

Caution

If you have a pre-existing or a history of kidney disease, inform your doctor before receiving ZAVEDOS INJECTION 5MG. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition. Your doctor may also suggest renal function tests while on treatment with ZAVEDOS INJECTION 5MG.

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Children

Unsafe

ZAVEDOS INJECTION 5MG is not recommended for use in children as the safety and efficacy have not been established.

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Heart

Caution

ZAVEDOS INJECTION 5MG should be used with caution and under medical supervision in patients with heart problems. Therefore, please consult your doctor before using ZAVEDOS INJECTION 5MG.

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Geriatrics

Caution

ZAVEDOS INJECTION 5MG should be used with caution in elderly individuals and only under medical supervision. Please consult your doctor before starting treatment with ZAVEDOS INJECTION 5MG.

What if I have taken an overdose of ZAVEDOS INJECTION 5MG

Because this medicine is prepared and given by trained medical staff, an overdose is extremely rare. However, if an accidental overdose occurs, it can cause severe bone marrow suppression and heart complications. Your medical team will monitor you closely and provide immediate supportive treatment if needed.

Diet & Lifestyle Advise

  • Follow a clean, fully cooked diet: To protect your immune system when your white blood cell count is low, avoid raw foods, unpasteurized dairy, and unwashed fruits or vegetables.
  • Stay well-hydrated: Drink plenty of fluids, such as water or clear broths, to help your kidneys flush out the waste products from destroyed cancer cells.
  • Eat small, frequent meals: If you experience nausea, eating smaller portions throughout the day rather than three large meals can help maintain your nutrition and energy levels.
  • Maintain excellent oral hygiene: Use a soft-bristled toothbrush and a mild, alcohol-free mouthwash to prevent mouth sores and infections.
  • Avoid crowds and sick people: Because your body's ability to fight infections will be reduced, try to steer clear of crowded public spaces and anyone who is currently unwell.

Health Queries

What are the common symptoms of Acute Myeloid Leukemia (AML)? Is AML curable, and what is the typical life expectancy or prognosis with and without treatment?

Dr. S Aneela

Dr. S Aneela

M. Pharm (Pharmacology)., PhD

Hello, Acute Myeloid Leukemia is a fast-growing cancer that affects blood cell production. Common symptoms may include severe fatigue, frequent infections, fever, easy bruising or bleeding, bone pain, and shortness of breath. With modern treatments such as chemotherapy, targeted therapy, and stem cell transplant, many patients achieve remission and some may be cured, depending on age, overall health, and the leukemia subtype. Without treatment, AML can progress quickly, so early diagnosis and prompt care are very important. A hematologist or oncologist can guide the best treatment plan based on detailed testing and individual health needs.
health query

Have a query?

How Soon It Starts Working

The time required for ZAVEDOS INJECTION 5MG to start to work: The exact onset time of ZAVEDOS INJECTION 5MG has not been clinically established. The time for which the effects of ZAVEDOS INJECTION 5MG last: The duration of ZAVEDOS INJECTION 5MG’s effect is clinically not established.

What if you forget to take ZAVEDOS INJECTION 5MG

Since this medication is injected by healthcare professionals in a hospital or clinic, it is highly unlikely that you will miss a dose. However, if you miss a scheduled appointment for your injection, contact your healthcare provider immediately to reschedule.

Storage

•Store unopened vials of ZAVEDOS INJECTION 5MG in a refrigerator at 2°C to 8°C in their original packaging to protect them from light. Do not freeze.

Drug Warnings

  • Watch the injection site closely: Let your nurse or doctor know immediately if you feel any burning, stinging, pain, or redness around the IV line during the injection. Leaking can cause severe tissue damage.
  • Monitor your temperature daily: A fever is a medical emergency when you are on this medicine. Contact your healthcare team right away if your temperature rises.
  • Expect urine discolouration: Do not be alarmed if your urine turns a reddish colour for a day or two after your injection; this is a harmless side effect of the medicine clearing your body.
  • Avoid contact with body fluids: Since the drug remains in your system for a few days, flush the toilet twice after use and wash your hands thoroughly to protect others in your household.
  • Have regular heart checks: Your doctor will schedule regular tests, such as echocardiograms, to monitor your heart health before and during your treatment cycles.

Drug-Drug Interactions

verifiedApollotooltip
  • Other heart-affecting cancer treatments or chest radiotherapy: May increase the risk of heart damage when used together with ZAVEDOS INJECTION 5MG.
  • Live vaccines or immunosuppressive medicines: May increase the risk of serious infections and should generally be avoided during treatment.
IdarubicinPimozide
Critical
IdarubicinSparfloxacin
Critical

Drug-Drug Interactions

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IdarubicinPimozide
Critical
How does the drug interact with Zavedos Injection 5mg:
Taking Zavedos Injection 5mg and Pimozide together can increase the chance of a serious abnormal heart rhythm.

How to manage the interaction:
Taking Zavedos Injection 5mg and Pimozide together is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
IdarubicinSparfloxacin
Critical
How does the drug interact with Zavedos Injection 5mg:
Co-administration of Sparfloxacin with Zavedos Injection 5mg may prolong the QT interval.

How to manage the interaction:
Taking Zavedos Injection 5mg with Sparfloxacin is not recommended, please consult a doctor before taking it.
IdarubicinAnagrelide
Severe
How does the drug interact with Zavedos Injection 5mg:
Taking Zavedos Injection 5mg and Anagrelide together can increase the chance of a serious abnormal heart rhythm. If you suffer from any cardiac conditions, or electrolyte disturbances (such as magnesium or potassium deficiency brought on by severe or prolonged diarrhea or vomiting), you may be at higher risk.

How to manage the interaction:
Taking Zavedos Injection 5mg and Anagrelide together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
IdarubicinCitalopram
Severe
How does the drug interact with Zavedos Injection 5mg:
Taking Zavedos Injection 5mg and Citalopram together can increase the chance of a serious abnormal heart rhythm. If you suffer from any cardiac conditions, or electrolyte disturbances (such as magnesium or potassium deficiency brought on by severe or prolonged diarrhea or vomiting), you may be at higher risk.

How to manage the interaction:
Taking Zavedos Injection 5mg and Citalopram together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
IdarubicinSaquinavir
Severe
How does the drug interact with Zavedos Injection 5mg:
Taking Zavedos Injection 5mg and Saquinavir together can increase the chance of a serious abnormal heart rhythm. If you suffer from any cardiac conditions, or electrolyte disturbances (such as magnesium or potassium deficiency brought on by severe or prolonged diarrhea or vomiting), you may be at higher risk.

How to manage the interaction:
Taking Zavedos Injection 5mg and Saquinavir together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
IdarubicinBCG vaccine
Severe
How does the drug interact with Zavedos Injection 5mg:
Taking BCG vaccine with Zavedos Injection 5mg can increase the risk of infection or may reduce the effectiveness of the vaccine.

How to manage the interaction:
Although there is a possible interaction between Zavedos Injection 5mg and BCG vaccine, you can take these medicines together if prescribed by your doctor. If you notice any unusual symptoms, it's important to contact a doctor right away. Do not discontinue any medications without consulting the doctor.
IdarubicinAdalimumab
Severe
How does the drug interact with Zavedos Injection 5mg:
Combining Zavedos Injection 5mg and Adalimumab can increase the risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, Zavedos Injection 5mg can be taken with Adalimumab if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not discontinue any medications without a doctor's advice.
IdarubicinInfliximab
Severe
How does the drug interact with Zavedos Injection 5mg:
When Zavedos Injection 5mg is taken with Infliximab, can increase the risk or severity of developing serious infections.

How to manage the interaction:
Taking Zavedos Injection 5mg with Infliximab together can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience symptoms of fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in sputum, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
IdarubicinVandetanib
Severe
How does the drug interact with Zavedos Injection 5mg:
Taking Zavedos Injection 5mg and Vandetanib together can increase the chance of a serious abnormal heart rhythm. If you suffer from any cardiac conditions, or electrolyte disturbances (such as magnesium or potassium deficiency brought on by severe or prolonged diarrhea or vomiting), you may be at higher risk.

How to manage the interaction:
Taking Zavedos Injection 5mg and Vandetanib together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
IdarubicinIbutilide
Severe
How does the drug interact with Zavedos Injection 5mg:
Taking Zavedos Injection 5mg and Ibutilide together can increase the chance of a serious abnormal heart rhythm. If you suffer from any cardiac conditions, or electrolyte disturbances (such as magnesium or potassium deficiency brought on by severe or prolonged diarrhea or vomiting), you may be at higher risk.

How to manage the interaction:
Taking Zavedos Injection 5mg and Ibutilide together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
  • There are no specific food interactions known to affect this injected medicine directly, but it is best to avoid alcohol as it can place extra strain on your liver.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTINEOPLASTIC]

FAQs

ZAVEDOS INJECTION 5MG is used to treat Acute Myeloid Leukemia.
ZAVEDOS INJECTION 5MG contains Idarubicin, which belongs to the class of anthracycline topoisomerase inhibitors. It inhibits the topoisomerase II enzyme by intercalating the DNA base pairs. This causes double helix DNA to be uncoiled, destroying DNA and RNA synthesis.
Yes, ZAVEDOS INJECTION 5MG is a vesicant. Vesicants are drugs that can cause severe tissue damage and blistering if they leak out of the vein during administration (a process known as extravasation). Always ensure ZAVEDOS INJECTION 5MG should be administered by trained healthcare professionals to minimize risks.
The side effects of ZAVEDOS INJECTION 5MG include nausea, vomiting, mouth ulcers, loss of appetite, diarrhoea, dizziness, weakness, stomach pain, headache, pale skin, difficulty urinating, fever, and pain at the injection site. Consult the doctor if any of these symptoms persist or worsen.
This medicine is injected directly into a vein as an infusion by a healthcare provider in a hospital or specialised clinic. Talk to your doctor if you have questions about your specific treatment schedule.
Yes, temporary hair loss is a very common side effect of this chemotherapy medicine. Your hair will typically begin to grow back after your treatment cycles are completed. Talk to your doctor or nurse about managing this change.
This medicine has a natural reddish color, which can tint your urine pink or red for up to 48 hours after your injection. This is a normal, harmless occurrence as your body eliminates the drug. Talk to your doctor if this lasts longer than a few days.
You should avoid receiving live vaccines during your treatment, as your weakened immune system may not be able to handle them safely. Always consult your healthcare team before getting any vaccine. Talk to your doctor for a safe vaccination schedule.
This medicine temporarily lowers the number of white blood cells, red blood cells, and platelets in your body, which can increase your risk of infections, fatigue, and bleeding. Your medical team will monitor your blood counts regularly. Talk to your doctor about how to protect yourself during this time.
Since this medicine can cause severe fatigue, nausea, or dizziness, it is highly recommended that you arrange for someone else to drive you home after your appointment. Talk to your doctor about how this medication might affect your daily activities.
This class of medication can sometimes affect the heart muscle, especially at higher cumulative doses. Your doctor will run regular tests to monitor your heart function throughout your treatment. Talk to your doctor if you experience chest pain, shortness of breath, or a rapid heart rate.
No, you should not breastfeed while receiving this medicine, as it can pass into breast milk and potentially harm your baby. Talk to your doctor about safe feeding alternatives for your infant.

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Country of origin

India

Manufacturer/Marketer address

The Capital, 1802, 18th Floor , Plot No. C-70, ‘G’ Block , Bandra Kurla Complex, Bandra East , Mumbai – 400051.
Other Info - ZAV0003
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