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compositionComposition:ANIDULAFUNGIN-100MG
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Zanidurix Combipack Injection 1's is used to treat invasive candidiasis (a type of fungal infection). It contains Anidulafungin, which works by preventing the normal development of fungal cell walls by making them fragile or unable to grow. Thus, it kills fungus and helps to treat fungal infections. Common side effects of this medication may include nausea, diarrhoea, hypokalaemia (low blood potassium), headache, vomiting, or difficulty breathing.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

ANIDULAFUNGIN-100MG

Manufacturer/Marketer :

Cipla Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-28

Return Policy :

Not Returnable

About Zanidurix Combipack Injection 1's

Zanidurix Combipack Injection 1's is an injectable medicine used to treat serious fungal infections in the blood or other parts of the body. It belongs to a group of medicines called antifungals, which specifically target and destroy fungal cells to help your body clear the infection. It is highly effective in treating deep-tissue fungal conditions that require medical intervention.

This medicine is usually given once a day. Because it is injected directly into a vein, it bypasses your digestive system, meaning food intake does not affect how it works. To help your body recover faster, it is highly recommended to stay well-hydrated, get plenty of rest, and eat a balanced diet during your treatment course. 

During treatment, your doctor will monitor your progress to make sure the infection is responding well. Depending on your condition, you may need blood tests, including blood cultures, to confirm the infection has cleared and to check your liver function. Some people begin to feel better within a few days, but it is important to complete the full course of treatment prescribed by your doctor, even if your symptoms improve sooner.

The length of treatment depends on the type and severity of your infection. For bloodstream Candida infections, treatment often continues for at least 2 weeks after your last positive blood culture and after your symptoms have improved. Your doctor will decide the right treatment duration for you. Your doctor will monitor how well the medicine is working during your treatment. If the infection does not improve as expected, additional tests may be performed, and your doctor may adjust your treatment plan or switch you to a different antifungal medicine if needed

While Zanidurix Combipack Injection 1's is highly effective, some people may experience mild side effects like diarrhoea, nausea, or low potassium levels. However, you should contact your doctor immediately if you notice serious signs such as yellow skin or eyes, dark urine, or trouble breathing, as these can point to more severe complications.

Talk to your doctor before starting this medicine if you have a history of liver problems. If this medicine is prescribed for a child, the dose is carefully calculated according to the child's body weight and medical condition. Zanidurix Combipack Injection 1's may be used in children aged 1 month and older when recommended by a doctor. Your child's healthcare team will carefully monitor their treatment to help ensure it is safe and effective. Your doctor will decide the most appropriate dose. Do not take this medicine if you are allergic to Zanidurix Combipack Injection 1's. Also tell your doctor if you have ever had an allergic reaction to other echinocandin antifungal medicines, such as caspofungin or micafungin, as similar reactions may occur. Your healthcare team will review your medical history to ensure this treatment is suitable for you. 

Let your healthcare provider know about all other medicines you are taking, as some substances may interact. Always consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding before starting your treatment with Zanidurix Combipack Injection 1's.

Uses of Zanidurix Combipack Injection 1's

Your doctor may prescribe Zanidurix Combipack Injection 1's to help manage the following conditions:

  • Candidemia: Zanidurix Combipack Injection 1's is used to treat serious blood infections caused by the yeast Candida, helping to clear the fungus from your bloodstream.
  • Invasive Candidiasis: This medicine helps clear deep-tissue fungal infections that can affect your internal organs, such as your abdomen or heart.
  • Esophageal Candidiasis: Zanidurix Combipack Injection 1's is prescribed to treat fungal infections of the food pipe (esophagus), making swallowing easier and resolving painful fungal overgrowth.

Key Benefits

When used as directed as part of your treatment plan, this medicine may provide the following benefits:

  • Treats Serious Fungal Infections: Receiving Zanidurix Combipack Injection 1's helps you recover from deep-seated fungal infections, which can otherwise cause severe systemic illness. By clearing the infection from your bloodstream and organs, it helps reduce high fevers, chills, and other severe symptoms associated with fungal overgrowth, paving the way for a smoother recovery.
  • Targets Fungus, Not Healthy Cells: Another major benefit of this medicine is its targeted action. It targets a part of fungal cells called the cell wall, which is not found in human cells. This allows the medicine to attack the fungus while reducing effects on healthy human cells, although side effects can still occur.
Side effects of Zanidurix Combipack Injection
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.
  • Wear compression garments like stockings, sleeves, or gloves to apply pressure and help stop fluid from building up, especially after the swelling goes down.
  • Move around and do exercises to help the fluid circulate, especially in swollen limbs. Ask your doctor for specific exercises.
  • Raise the swollen area above your heart level several times a day, even while sleeping, to help reduce swelling.
  • Gently massage the swollen area with firm but not painful pressure.
  • Keep the swollen area clean and moisturized to prevent injury and infection.
  • Reduce salt intake to help prevent fluid from building up and worsening the swelling, as advised by a doctor.
  • If the swelling does not get better after a few days of home treatment or worsens, consult your doctor right away.
  • Talk to your doctor about oral potassium supplements.
  • Eat potassium rich foods such as bananas, avocados, oranges, dark leafy greens, beans and peas, fish, spinach, milk and tomatoes.
  • Maintain your magnesium levels and general health by drinking lots of water.
  • Maintain a diet high in magnesium-rich foods such as spinach, almonds, chickpeas and brown rice.
  • Limit your alcohol intake because too much of it lowers your magnesium levels.
  • Plan blood testing on a regular basis to monitor magnesium levels.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication.
  • Zanidurix Combipack Injection 1's will be administered by a nurse or doctor.
  • Do not self-administer.

How Zanidurix Combipack Injection 1's Works

Fungal cells have a strong outer protective layer called a cell wall, which they need to survive, maintain their shape, and multiply. Zanidurix Combipack Injection 1's contains anidulafungin, which works by blocking an enzyme called 1,3-beta-D-glucan synthase, which helps build the fungal cell wall. Without this component, the fungal cell wall becomes weak and fragile. Because the cell wall is damaged, the fungal cells cannot hold themselves together against bodily fluids and eventually burst. This effectively stops the fungus from growing and spreading, allowing your body's natural immune system to easily clear the remaining infection.
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Alcohol

Consult your doctor

The interaction of alcohol with Zanidurix Combipack Injection 1's is unknown. If you have any concerns regarding this, please discuss them with your doctor.

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Pregnancy

Consult your doctor

It is unknown how Zanidurix Combipack Injection 1's affects pregnant women. Therefore, it is not recommended for use during pregnancy. However, if you are pregnant or planning pregnancy, inform your doctor before receiving Zanidurix Combipack Injection 1's.

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Breast Feeding

Consult your doctor

It is unknown how Zanidurix Combipack Injection 1's affects breastfeeding women. Therefore, take your doctor’s advice before receiving Zanidurix Combipack Injection 1's while breast-feeding.

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Driving

Caution

The effect of Zanidurix Combipack Injection 1's on driving is unknown. Drive only if you are alert after taking Zanidurix Combipack Injection 1's.

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Liver

Consult your doctor

If you have any concerns regarding the use of Zanidurix Combipack Injection 1's in patients with liver problems, please discuss them with your doctor.

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Kidney

Consult your doctor

If you have any concerns regarding the use of Zanidurix Combipack Injection 1's in patients with kidney problems, please discuss them with your doctor.

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Children

Consult your doctor

If you have any concerns regarding the use of Zanidurix Combipack Injection 1's for children, please consult a doctor.

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Heart

Consult your doctor

Please consult your doctor before receiving Zanidurix Combipack Injection 1's if you have pre-existing heart problems. Your doctor will prescribe Zanidurix Combipack Injection 1's if the benefits outweigh the risks.

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Geriatrics

Consult your doctor

Please consult a doctor before administering Zanidurix Combipack Injection 1's to geriatric patients. Your doctor will prescribe Zanidurix Combipack Injection 1's if the benefits outweigh the risks.

What if I have taken an overdose of Zanidurix Combipack Injection 1's

Because this medicine is prepared and given by medical professionals, an overdose is highly unlikely. If you suspect you have received too much of this medicine or feel unusually unwell after an infusion, seek immediate medical attention or contact emergency services.

Diet & Lifestyle Advise

  • Stay Well Hydrated: Drink plenty of fluids, especially water, to keep your body hydrated and support your kidneys and liver during recovery.
  • Eat a Nutritious Diet: Eat a nutrient-dense diet rich in vitamins and minerals to help support your immune system while it fights the infection.
  • Prioritise Sleep and Recovery: Get adequate sleep and rest, as physical recovery from a systemic fungal infection requires significant energy.
  • Keep the Catheter Site Clean: If you have an intravenous catheter, keep the area clean and dry as instructed by your nurse to prevent secondary bacterial skin infections.
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How Soon It Starts Working

The time required for Zanidurix Combipack Injection 1's to start to work: Zanidurix Combipack Injection 1's ideally shows its action within 1 hour after administration. The time for which the effects of Zanidurix Combipack Injection 1's last: The duration of action for Zanidurix Combipack Injection 1's is unknown.

What if you forget to take Zanidurix Combipack Injection 1's

Since this medicine is given by a healthcare professional, it is unlikely that you will miss a dose. However, if you miss an appointment or suspect a dose was skipped, contact your clinic or healthcare provider immediately to reschedule your treatment.

Storage

• Store unopened vials of Zanidurix Combipack Injection 1's powder in a refrigerator between 2°C to 8°C (36°F to 46°F). 

Drug Warnings

  • Inspect the Vial Before Use: Inspect the liquid in the vial before it is injected; it must be clear and free of any visible particles. Do not use if it looks cloudy or discoloured.
  • Report Infusion Reactions Immediately: Tell your healthcare provider immediately if you feel warm, itchy, dizzy, or short of breath while the medicine is being injected so they can adjust the infusion rate.
  • Liver Health Monitoring: Ensure your doctor knows if you have any history of liver issues, as they may want to perform regular blood tests to check your liver health during treatment.
  • Monitor the Injection Site: Make sure the injection site is clean, and report any pain, redness, or swelling around the needle or catheter site immediately.

Drug-Drug Interactions

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  • Tell Your Doctor About All Medicines: Zanidurix Combipack Injection 1's has a low risk of drug interactions, but some medicines, such as cyclosporine, may increase the amount of Zanidurix Combipack Injection 1's in your body. Your healthcare team will review all your prescription medicines, over-the-counter medicines, vitamins, herbal products, and supplements to make sure your treatment is safe.
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

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No clinically significant food interactions are known with Zanidurix Combipack Injection 1's when used as directed.

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIFUNGALS]

FAQs

Zanidurix Combipack Injection 1's is used to treat Invasive candidiasis.
Zanidurix Combipack Injection 1's contains Anidulafungin, which works by preventing the normal development of fungal cell walls by making them fragile or unable to grow. Thus, Zanidurix Combipack Injection 1's kills fungus and helps to treat fungal infections of blood or other internal organs.
Invasive candidiasis is not contagious. However, the yeast itself can travel from person to person and on surfaces. It can be spread through healthcare workers' hands or contaminated medical devices.
Zanidurix Combipack Injection 1's may cause headache as a common side effect. However, if the condition persists or worsens, please consult a doctor.
The common side effect of Zanidurix Combipack Injection 1's nausea, diarrhoea, hypokalaemia (low blood potassium), headache, vomiting, or difficulty breathing. Most of these side effects of Zanidurix Combipack Injection 1's gradually resolve over time and do not require medical attention. However, if the side effects worsen or persist, please consult your doctor.
Zanidurix Combipack Injection 1's is given directly into a vein as a slow intravenous infusion by a healthcare provider. Talk to your doctor for more details.
Yes, in some cases, a home-health nurse can administer this infusion if you are stable and your home environment is suitable. Talk to your doctor to see if this is an option for you.
No, Zanidurix Combipack Injection 1's is an antifungal medicine, not an antibiotic. It is specifically designed to treat fungal and yeast infections rather than bacterial infections. Talk to your doctor if you have questions about your prescription.
The duration of your treatment depends on how severe your infection is and how quickly you recover. Your doctor will determine the exact length of your treatment course. Talk to your doctor for more information.
It is best to avoid alcohol during treatment, as both alcohol and this medicine can affect your liver function. Talk to your doctor or pharmacist for specific advice.
In some cases, this medicine can affect liver function. Your doctor may perform routine blood tests to monitor your liver health. Talk to your doctor if you notice yellowing of your skin or eyes.
Inform your nurse or doctor immediately. They can slow down the infusion rate to help relieve these symptoms. Talk to your doctor if you have concerns.
This medicine should only be used during pregnancy or breastfeeding if the potential benefits outweigh the risks. Talk to your doctor to understand what is safest for you and your baby.

Disclaimer

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Country of origin

India

Manufacturer/Marketer address

Cipla House, Peninsula Business Park, Ganpatrao Kadam Marg, Lower Parel, Mumbai-400013.
Other Info - ZAN0389
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