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  3. Zambri 10mg Tablet

Zambri 10mg Tablet, Pack of 1 Tablet
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Written By Lakshmithulasi Yarragunta ,
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Zambri 10mg Tablet is used to treat pulmonary arterial hypertension (high blood pressure in the lungs). It contains Ambrisentan, which works by widening the blood vessels and improving blood flow. In some cases, this medicine may cause side effects such as headache, dizziness, breathlessness, runny nose, feeling sick, diarrhoea, and fatigue. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Composition :

AMBRISENTAN-10MG

Manufacturer/Marketer :

Zydus Cadila

Consume Type :

ORAL

Return Policy :

Not Returnable

About Zambri 10mg Tablet

Zambri 10mg Tablet is used to treat high blood pressure in the arteries of the lungs (pulmonary arterial hypertension). Hypertension is a medical condition in which the blood exerts high pressure (force exerted by circulating blood) against the walls of blood vessels. This condition makes the heart work harder in pumping blood to the whole body. Pulmonary hypertension affects the arteries in the lungs and the right side of the heart.

Zambri 10mg Tablet contains ‘Ambrisentan,’ which belongs to the class of ‘endothelin receptor blockers’. Ambrisentan works by inhibiting the action of Endothelin, a natural substance that constricts blood vessels and raises blood pressure. Zambri 10mg Tablet widens the constricted pulmonary arteries (blood vessels that carry blood from the heart to the lungs) and increases blood supply to the lungs, thus lowering the blood pressure.

In some cases, Zambri 10mg Tablet can cause side effects like headache, dizziness, palpitations, breathlessness, runny nose, feeling sick, diarrhoea, and fatigue. These side effects are not familiar to everyone and vary individually. If you notice any side effects that are not manageable, please consult your doctor.

Please inform your doctor if you are using any prescription or non-prescription drugs, including vitamins and herbal products. Let your doctor know if you have any allergic reactions to Zambri 10mg Tablet or any other medicines before starting Zambri 10mg Tablet. Inform your doctor if you have low blood pressure, lung, heart, kidney or liver problems, and anaemia (lack of blood cells). It is advised to consult a doctor if you are a pregnant or breastfeeding mother. Do not stop taking Zambri 10mg Tablet without consulting your doctor, since it may worsen your condition and increase the risk of future heart problems. Do not consume alcohol with Zambri 10mg Tablet as it may increase the risk of low blood pressure.

Uses of Zambri 10mg Tablet

Zambri 10mg Tablet is used in the treatment of Pulmonary arterial hypertension. The detailed uses of Zambri 10mg Tablet are as follows:<br/> • Treatment of Pulmonary Arterial Hypertension: Zambri 10mg Tablet is used to treat Pulmonary Arterial Hypertension (PAH) by increasing blood supply to the lungs, thus lowering the blood pressure.<br/> • Decreases High Blood Pressure in Lung Arteries: Zambri 10mg Tablet helps reduce high pressure in the arteries between the heart and lungs.<br/> • Improves Exercise Tolerance: Zambri 10mg Tablet improves stamina and physical activity capacity in PAH patients.<br/> • Lowers Disease Progression: Zambri 10mg Tablet slows the advancement of symptoms linked to PAH. <br/> • Reduces Heart Strain: Zambri 10mg Tablet reduces the workload on the heart by widening blood vessels in the lungs.<br/>

Directions for Use

  • Take Zambri 10mg Tablet with or without food, or as advised by a doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication to improve effectiveness.
  • Swallow Zambri 10mg Tablet as a whole with a glass of water.
  • Do not crush, chew, or break it.

Medicinal Benefits

Zambri 10mg Tablet is an anti-hypertensive medicine that treats high blood pressure in the arteries of the lungs (pulmonary arterial hypertension (PAH)). It contains ‘Ambrisentan,’ an endothelin receptor blocker. Zambri 10mg Tablet works by inhibiting the action of Endothelin, a natural substance that constricts blood vessels and raises blood pressure. In people with PAH, the pulmonary arteries get narrower, making the heart work harder to pump blood through them. Zambri 10mg Tablet widens these constricted arteries and makes it easier for the heart to pump blood, thus lowering the blood pressure.

How Zambri 10mg Tablet Works

Zambri 10mg Tablet contains Ambrisentan, which belongs to the class of endothelin receptor blockers. Ambrisentan works by inhibiting the action of Endothelin, a natural substance that constricts blood vessels and raises blood pressure. Zambri 10mg Tablet widens the constricted pulmonary arteries (blood vessels that carry blood from the heart to the lungs) and increases blood supply to the lungs, thus lowering the blood pressure.

Storage

• Store in a cool and dry place away from sunlight.• Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Zambri 10mg Tablet
  • Wear compression garments like stockings, sleeves, or gloves to apply pressure and help stop fluid from building up, especially after the swelling goes down.
  • Move around and do exercises to help the fluid circulate, especially in swollen limbs. Ask your doctor for specific exercises.
  • Raise the swollen area above your heart level several times a day, even while sleeping, to help reduce swelling.
  • Gently massage the swollen area with firm but not painful pressure.
  • Keep the swollen area clean and moisturized to prevent injury and infection.
  • Reduce salt intake to help prevent fluid from building up and worsening the swelling, as advised by a doctor.
  • If the swelling does not get better after a few days of home treatment or worsens, consult your doctor right away.
  • A blocked nose can be relieved by drinking more water, which helps clear fluids.
  • Use saline nasal spray available over the counter to relieve blockage or blow harder to remove the mucus.
  • Use nasal strips that can be placed on the nose to widen nostrils and increase airflow.
  • Keep a humidifier around to moisten air at home/workplace.
  • Avoid diet rich in salt and carbohydrates
  • Drink plenty of water and stay hydrated.
  • Exercise regularly and maintain a healthy lifestyle.
  • Take potassium rich foods like potatoes, spinach, tomatoes, sea food and dairy products.
  • Take beverages containing caffeine like coffee and tea.
  • High levels of liver enzymes need immediate medical attention.
  • Watch your diet and consume low-fat foods, like green leafy vegetables, fish, whole grains, nuts, etc.
  • Regularly do strengthening exercises to control your cholesterol levels.
  • Avoid drinking alcohol as it can affect your liver.
  • Focus on losing weight as it can help control cholesterol and maintain liver enzymes.
  • Practice yoga and meditation to improve liver functioning and overall health.
  • Stay hydrated by taking fluids like water, juices and soups etc.
  • Eat fruits and vegetables which contain vitamins.
  • Take iron rich food like dry fruits, green leafy vegetables and sea food etc.
  • Reduce intake of milk, cheese, yogurt, soy, chocolate, ice cream, Grapes, Popcorn, canned salmon, pomegranate.
  • Regular exercise like walking, jogging is helpful.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
Managing Low Blood Pressure Triggered by Medication: Expert Advice:
  • If you experience low blood pressure symptoms like dizziness, lightheadedness, or fainting while taking medication, seek immediate medical attention.
  • Make lifestyle modifications and adjust your medication regimen under medical guidance to manage low blood pressure.
  • As your doctor advises, regularly check your blood pressure at home. Record your readings to detect any changes and share them with your doctor.
  • Fluid intake plays a vital role in managing blood pressure by maintaining blood volume, regulating blood pressure, and supporting blood vessel function. Drinking enough fluids helps prevent dehydration, maintain electrolyte balance, and regulate fluid balance.
  • Take regular breaks to sit or lie down if you need to stand for long periods.
  • When lying down, elevate your head with extra pillows to help improve blood flow.
  • Avoid heavy exercise or strenuous activities that can worsen low blood pressure.
  • Wear compression socks as your doctor advises to enhance blood flow, reduce oedema, and control blood pressure.
  • If symptoms persist or worsen, or if you have concerns about your condition, seek medical attention for personalized guidance and care.

What if I have taken an overdose of Zambri 10mg Tablet

Avoid exceeding the recommended dose as it could lead to an overdose. Symptoms of overdose may include sweating, confusion, blurred vision, dizziness, light-headedness when getting up suddenly from a sitting/lying position, or faintness. If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Brief your medical history if you have heart failure, liver or kidney diseases, lung conditions (pulmonary fibrosis), anaemia, oedema (fluid retention) and hypotension (low blood pressure) before starting Zambri 10mg Tablet. Zambri 10mg Tablet is contraindicated during pregnancy since it has harmful effects on the foetus. Consult your doctor before using Zambri 10mg Tablet if you are a breastfeeding mother. Complete the course strictly as suggested by the doctor, even if you feel better, to avoid disease recurrence. Do not drive or operate machinery since Zambri 10mg Tablet may cause side effects like dizziness and weakness, affecting your ability to concentrate and drive. Avoid consumption of alcohol with Zambri 10mg Tablet as it may increase the risk of low blood pressure. Zambri 10mg Tablet is not recommended in patients younger than 18 years of age.

Drug-Drug Interactions

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AmbrisentanCiclosporin
Severe
AmbrisentanLeflunomide
Severe

Drug-Drug Interactions

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AmbrisentanCiclosporin
Severe
How does the drug interact with Zambri 10mg Tablet:
When Zambri 10mg Tablet is taken with cyclosporine, this increases the blood levels of Zambri 10mg Tablet. This can increase the risk of serious side effects such as liver problems, anemia, and fluid accumulation (particularly in the lungs).

How to manage the interaction:
Co-administration of ciclosporin with Zambri 10mg Tablet can result in an interaction, but it can be taken if a doctor has advised it. If you experience any of these symptoms such as fever with shivering, pain in your joints, swelling, bleeding or bruising easily, a rash or itchy skin, not feeling hungry, feeling tired, dark color urine, looking pale, dizziness, gaining weight suddenly, or breathing problem, consult a doctor. Do not stop using any medications without talking to a doctor.
AmbrisentanLeflunomide
Severe
How does the drug interact with Zambri 10mg Tablet:
Taking leflunomide and Zambri 10mg Tablet can lead to or increase the risk or severity of developing liver problems.

How to manage the interaction:
Although there is an interaction between leflunomide and Zambri 10mg Tablet, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, and/or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
AmbrisentanMipomersen
Severe
How does the drug interact with Zambri 10mg Tablet:
Taking Zambri 10mg Tablet with Mipomersen can increase the risk or severity of liver problems.

How to manage the interaction:
Taking Zambri 10mg Tablet with Mipomersen together is generally avoided as it can result in an interaction, it can be taken if your doctor has advised it. However, if you notice any symptoms of fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
AmbrisentanLomitapide
Severe
How does the drug interact with Zambri 10mg Tablet:
Taking Zambri 10mg Tablet with Lomitapide can lead to or increase the risk or severity of developing liver problems.

How to manage the interaction:
Although there is a possible interaction, Zambri 10mg Tablet can be taken with Lomitapide if prescribed by the doctor. Consult the prescriber if you experience symptoms such as fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark urine, pale stools, and/or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
AmbrisentanTeriflunomide
Severe
How does the drug interact with Zambri 10mg Tablet:
When Zambri 10mg Tablet and Teriflunomide are taken together, the risk or severity of developing liver injury increases.

How to manage the interaction:
Although taking Zambri 10mg Tablet and Teriflunomide together can cause an interaction, it can be taken if your doctor has suggested it. If you have any of these symptoms - fever, chills, joint pain, swelling, bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, liver damage, or bleeding - make sure to contact a doctor right away. Do not stop using any medications without a doctor's advice.
AmbrisentanTizanidine
Severe
How does the drug interact with Zambri 10mg Tablet:
Coadministration of Tizanidine with Zambri 10mg Tablet may increase the risk or severity of developing low blood pressure.

How to manage the interaction:
Although there is a possible interaction between Zambri 10mg Tablet and Tizanidine, you can take these medicines together if your doctor advises. If you notice any symptoms like headache, dizziness, shortness of breath, chest pain, or sweating, contact a doctor immediately. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Reduce sodium intake in your diet to maintain your blood pressure.
  • Eat natural and healthy foods by cutting down on high-sodium processed foods.
  • Lose those extra pounds, since being obese can be a risk factor for hypertension.
  • Exercise regularly to maintain good heart health.
  • Avoid smoking and alcohol intake.
  • Chronic stress may also cause high blood pressure. Therefore, avoid stress triggers and make time for yourself to relax and do activities that you enjoy.
  • Try to include heart-healthy omega-3 fatty acids in your daily diet. You can also use low-fat cooking oil like olive oil, soybean oil, canola oil and coconut oil to lower your elevated blood pressure.
  • Limit sodium chloride intake (table salt) in your daily diet to 2300 mg per day or less than 1500 mg is ideal for most adults.

Habit Forming

No

Therapeutic Class

ANTI- HYPERTENSIVES

Zambri 10mg Tablet Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Caution

It is advised to limit alcohol intake, since alcohol consumption may increase the risk of low blood pressure and cause adverse effects, such as dizziness, fainting, light-headedness or headache.

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Pregnancy

Unsafe

Zambri 10mg Tablet is not recommended and unsafe in pregnancy. It can affect and harm the developing baby. You are advised to get a pregnancy test done before starting Zambri 10mg Tablet. You should get a negative pregnancy test for sure before using Zambri 10mg Tablet. Also, please use reliable forms of birth control if you are undergoing treatment with Zambri 10mg Tablet to avoid pregnancy.

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Breast Feeding

Caution

It is not known if Zambri 10mg Tablet is excreted into the breast milk. Please consult your doctor for more information before taking Zambri 10mg Tablet if you are a nursing mother.

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Driving

Caution

Zambri 10mg Tablet may cause side effects like dizziness and weakness, affecting your ability to concentrate and drive. Hence, it is recommended not to drive or operate machinery until you are mentally alert.

bannner image

Liver

Caution

Let your doctor know if you have any history of liver disease before taking Zambri 10mg Tablet. Zambri 10mg Tablet may cause an increase in liver enzymes. If you are using Zambri 10mg Tablet and experience any nausea, vomiting, loss of appetite, dark-coloured urine and yellowing of the skin, please see your doctor immediately.

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Kidney

Caution

Zambri 10mg Tablet should be used with caution in cases of renal impairment. It is recommended to seek a doctor's advice before starting Zambri 10mg Tablet if you have any kidney problems.

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Children

Unsafe

Safety and effectiveness of Zambri 10mg Tablet have not been established in patients below 18 years of age.

Have a query?

FAQs

Zambri 10mg Tablet is used to treat Pulmonary arterial hypertension.

Zambri 10mg Tablet consists of Ambrisentan. It is an anti-hypertensive medicine that lowers blood pressure by widening the pulmonary arteries and making the heart pump blood efficiently.

Yes, Zambri 10mg Tablet can make you feel dizzy. Dizziness usually occurs when you suddenly stand up from a lying or sitting position. Try rising slowly when you change your posture to relieve dizziness. If the side effect persists longer, please seek medical help.

Do not stop using Zambri 10mg Tablet even if you feel better. It should be strictly used as advised by your doctor to avoid the recurrence of symptoms and worsening of the disease.

Zambri 10mg Tablet should be used with caution in cases of any allergic reactions, heart failure, liver, kidney diseases, lung conditions (pulmonary fibrosis), anaemia, oedema (fluid retention) and hypotension (low blood pressure).

Store Zambri 10mg Tablet away from direct sunlight and at a temperature not exceeding 30°C. Keep this medicine out of the sight and reach of children.

Zambri 10mg Tablet may rarely cause liver problems. Your doctor will monitor your liver function while you're taking Zambri 10mg Tablet. If you experience symptoms like yellowing skin, dark urine, or abdominal pain, seek medical attention. Discuss any concerns with your doctor.

Take Zambri 10mg Tablet exactly as your doctor tells you to. Typically, it's one tablet once a day. Swallow the tablet whole with water, and take it at the same time each day. Don't crush, chew, or break it.

Don't stop taking Zambri 10mg Tablet without talking to your doctor first. Stopping suddenly can worsen your condition and increase the risk of heart problems. Your doctor will advise you on how to safely stop taking Zambri 10mg Tablet if needed. Follow their instructions carefully.

Zambri 10mg Tablet is used to treat high blood pressure in the lungs, but have risks and limitations. They can cause serious side effects and may not be suitable for everyone, including pregnant women and those with certain medical conditions. Always follow your doctor's instructions and ask questions if needed.

Zambri 10mg Tablet can be effective in treating certain conditions, but in some cases, it can cause serious side effects. Watch out for severe swelling, difficulty breathing or swallowing, and sudden weight gain. Additionally, be aware of extreme tiredness, yellowing of the skin or eyes, dark urine, and severe itching. If you experience any of these symptoms, call your doctor right away or seek emergency medical help. Don't delay; these side effects can be serious and require prompt attention. Discussing the potential risks and benefits with your doctor before starting treatment is essential.

You have been prescribed Zambri 10mg Tablet to treat pulmonary arterial hypertension (PAH), which is high blood pressure in the lungs.

Avoid exceeding the recommended dose, as it could lead to an overdose. Symptoms of overdose may include sweating, confusion, blurred vision, dizziness, light-headedness when getting up suddenly from a sitting/lying position, or faintness. If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Common side effects of Zambri 10mg Tablet may include headache, dizziness, palpitations, breathlessness, runny nose, feeling sick, diarrhoea, and fatigue. These side effects are not familiar to everyone and vary individually. If you notice any side effects that are not manageable, please consult your doctor.

No, you should not take Zambri 10mg Tablet on your own without consulting a doctor. This medication is prescribed for specific medical conditions and requires a doctor's supervision to ensure safe and effective use.

Safety and effectiveness of Zambri 10mg Tablet have not been established in patients below 18 years of age.

Other Info - ZA23270

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Author Details

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 22, 2025 | 11:06 AM IST

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Reference

  1. https://www.medicines.org.uk/emc/files/pil.11697.pdf
  2. https://www.webmd.com/drugs/2/drug-148530/ambrisentan-oral/details
  3. https://www.drugs.com/dosage/ambrisentan.html
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