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compositionComposition:BISOPROLOL-5MG+HYDROCHLOROTHIAZIDE-12.5MG
prescriptionPrescription Medicine
Zabesta Xlo Tablet 10's

Zabesta Xlo Tablet is used in the treatment of high blood pressure. It effectively lowers elevated blood pressure and supports better heart function. By maintaining normal blood pressure, this combination helps reduce the risk of heart attack, stroke, heart failure, and kidney complications associated with long-term hypertension.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

BISOPROLOL-5MG+HYDROCHLOROTHIAZIDE-12.5MG

Manufacturer/Marketer :

USV Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Zabesta Xlo Tablet

Zabesta Xlo Tablet is primarily used to treat high blood pressure. High blood pressure is a condition in which the force of the blood against the artery walls is too high, leading to hypertension.

Zabesta Xlo Tablet contains bisoprolol and hydrochlorothiazide. It relaxes the blood vessels and removes extra water/fluid from the body. Thereby, it helps treat high blood pressure.

Take Zabesta Xlo Tablet as prescribed by your doctor. Zabesta Xlo Tablet may cause side effects such as dizziness, weakness, diarrhoea, nausea, headache, and indigestion. Most of these side effects of Zabesta Xlo Tablet do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Before starting Zabesta Xlo Tablet , please inform your doctor if you have any allergies, heart disease, asthma, diabetes, thyroid, glaucoma, kidney/liver disease, gout or if you cannot pass urine. Notify your doctor if you are pregnant or breastfeeding.

Uses of Zabesta Xlo Tablet

Zabesta Xlo Tablet is used in the treatment of high blood pressure (hypertension). The detailed uses of Zabesta Xlo Tablet are as follows:

  • Management of Hypertension: Zabesta Xlo Tablet helps to lower high blood pressure by relaxing the blood vessels, reducing heart rate, and increasing urine production.

Have a query?

Directions for Use

  • Zabesta Xlo Tablet can be taken with or without food as advised by your doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
  • Swallow Zabesta Xlo Tablet as a whole with a glass of water.
  • Do not chew, crush, or break it.

Key Benefits

  • Reduces blood pressure effectively, particularly in cases of moderate to severe hypertension.
  • Offers more effective and durable blood pressure management than single-drug therapy.
  • Removes excess fluid and salts from the body, helping maintain healthy blood pressure levels.
  • Lowers the risk of serious complications such as heart attack and stroke.
  • Provides cardiovascular protection by reducing strain on the heart and blood vessels.
  • Helps patients with chronic high blood pressure avoid kidney damage.

How Zabesta Xlo Tablet Works

Zabesta Xlo Tablet contains bisoprolol (beta-blocker) and hydrochlorothiazide (diuretic). • Bisoprolol relaxes the blood vessels by blocking the action of certain natural substances in the body. It helps slow down the heart rate, making it easier to pump blood around the body. • Hydrochlorothiazide lowers blood pressure by removing extra water/fluid and certain electrolyte overload from the body.

Storage

Store in a cool and dry place away from sunlight
Side effects of Zabesta Xlo Tablet
  • Exercising regularly helps lower the risk of heart problems.
  • Maintain a healthy diet, including vegetables and fruits.
  • Rest well; get enough sleep.
  • Manage stress with yoga and meditation.
  • Limit alcohol and smoking.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Chest pain may last for a while and needs immediate medical attention as it is a significant health issue to be attended to.
  • Take rest and refrain from doing physical activity for a while, and restart after a few days.
  • Try applying an ice pack to the strained area for at least 20 minutes thrice a day. Ice pack thus helps reduce inflammation.
  • Sit upright and maintain proper posture if there is persistent chest pain. • Use extra pillows to elevate your position and prop your chest up while sleeping.
  • Wear compression garments like stockings, sleeves, or gloves to apply pressure and help stop fluid from building up, especially after the swelling goes down.
  • Move around and do exercises to help the fluid circulate, especially in swollen limbs. Ask your doctor for specific exercises.
  • Raise the swollen area above your heart level several times a day, even while sleeping, to help reduce swelling.
  • Gently massage the swollen area with firm but not painful pressure.
  • Keep the swollen area clean and moisturized to prevent injury and infection.
  • Reduce salt intake to help prevent fluid from building up and worsening the swelling, as advised by a doctor.
  • If the swelling does not get better after a few days of home treatment or worsens, consult your doctor right away.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.

What if I have taken an overdose of Zabesta Xlo Tablet

Do not take more than the prescribed dose of Zabesta Xlo Tablet as it may cause an overdose. The symptoms of overdose include a very slow heartbeat, fainting, severe weakness, trouble breathing or severe dizziness. If you suspect you have taken an overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

  • Do not take Zabesta Xlo Tablet if you are allergic to any of its components.
  • Inform your doctor if you have heart problems, asthma, diabetes, thyroid problems, glaucoma, gout, kidney/liver problems or if you are unable to urinate.
  • Please do not abruptly discontinue Zabesta Xlo Tablet , as this worsens the condition.
  • Zabesta Xlo Tablet is not recommended for children younger than 18 years of age.

Drug-Drug Interactions

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HydrochlorothiazideCisapride
Critical
HydrochlorothiazideDofetilide
Critical

Drug-Drug Interactions

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HydrochlorothiazideCisapride
Critical
How does the drug interact with Zabesta Xlo Tablet:
Taking Cisapride and Zabesta Xlo Tablet can increase the risk of an irregular heart rhythm which can be severe. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Combining Cisapride and Zabesta Xlo Tablet together is generally avoided as it can possibly result in an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like dizziness, lightheadedness, fainting, or fast or pounding heartbeats, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
HydrochlorothiazideDofetilide
Critical
How does the drug interact with Zabesta Xlo Tablet:
Taking Dofetilide and Zabesta Xlo Tablet can increase the risk of an irregular heart rhythm which can be severe. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Combining Dofetilide and Zabesta Xlo Tablet together is not recommended as it can possibly result in an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
BisoprololGlimepiride
Severe
How does the drug interact with Zabesta Xlo Tablet:
Concomitant use of Zabesta Xlo Tablet with glimepiride may increase the risk, severity, and/or duration of hypoglycemia (low blood sugar). It may also mask some of the symptoms of hypoglycemia such as palpitation, tremor, and rapid heartbeat, making it more difficult to recognize an oncoming episode.

How to manage the interaction:
Although there may be an interaction, Zabesta Xlo Tablet can be taken with glimepiride if prescribed by the doctor. Consult the prescriber if you develop symptoms of low blood sugar like shakiness, dizziness, sweating, nausea, hunger, weakness, or lightheadedness.
BisoprololAminophylline
Severe
How does the drug interact with Zabesta Xlo Tablet:
Co-administration of Aminophylline with Zabesta Xlo Tablet could reduce the metabolism of Aminophylline which increased the levels and enhance the effects of Aminophylline.

How to manage the interaction:
Taking aminophylline and Zabesta Xlo Tablet together can result in an interaction; it can be taken if a doctor has advised it. However, if you experience nausea, vomiting, insomnia, tremors, restlessness, uneven heartbeats, or difficulty breathing, Contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
BisoprololFingolimod
Severe
How does the drug interact with Zabesta Xlo Tablet:
Co-administration of Zabesta Xlo Tablet with Fingolimod may cause excessive slowing of the heart rate that can lead to serious cardiac complications.

How to manage the interaction:
Although there may be an interaction, Zabesta Xlo Tablet can be taken with Fingolimod if prescribed by the doctor. Consult the prescriber if you develop dizziness, fainting, lightheadedness, shortness of breath, chest pain, or heart palpitations during treatment. Do not discontinue the medication without consulting a doctor.
BisoprololPotassium gluconate
Severe
How does the drug interact with Zabesta Xlo Tablet:
Co-administration of Potassium gluconate may increase the hyperkalemic (high potassium levels in the blood) activities of Zabesta Xlo Tablet.

How to manage the interaction:
Although there may be an interaction, Potassium gluconate can be taken with Zabesta Xlo Tablet if prescribed by the doctor. Consult the prescriber if you develop symptoms of hyperkalemia (high potassium) such as muscle weakness, numbness, shortness of breath, nausea, or vomiting. Do not discontinue the medication without consulting a doctor.
BisoprololLofexidine
Severe
How does the drug interact with Zabesta Xlo Tablet:
Co-administration of Zabesta Xlo Tablet with Lofexidine may have effects in lowering blood pressure.

How to manage the interaction:
Although there may be an interaction, Zabesta Xlo Tablet can be taken with Lofexidine if prescribed by the doctor. Consult the prescriber if you develop headache, dizziness, lightheadedness, fainting, and/or changes in pulse or heart rate. Do not discontinue the medication without consulting a doctor.
BisoprololTheophylline
Severe
How does the drug interact with Zabesta Xlo Tablet:
Co-administration of Zabesta Xlo Tablet with Theophylline may cause Zabesta Xlo Tablet to be less effective and increase the effects of Theophylline.

How to manage the interaction:
Although there may be an interaction, Zabesta Xlo Tablet can be taken with Theophylline if prescribed by the doctor. Consult the prescriber if you experience nausea, vomiting, insomnia, shaking hands and legs, restlessness, uneven heartbeats, or difficulty breathing. Do not discontinue the medication without consulting a doctor.
BisoprololCarvedilol
Severe
How does the drug interact with Zabesta Xlo Tablet:
Taking Zabesta Xlo Tablet with Carvedilol can increase the risk of low blood pressure and high potassium levels.

How to manage the interaction:
Although there is an interaction, Zabesta Xlo Tablet can be taken with carvedilol if prescribed by the doctor. However, consult your doctor if you experience any lightheadedness, excessive sweating, or shortness of breath. Do not discontinue the medication without consulting a doctor.
BisoprololDolasetron
Severe
How does the drug interact with Zabesta Xlo Tablet:
Co-administration of Zabesta Xlo Tablet with Dolasetron may increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Although there may be an interaction, Zabesta Xlo Tablet can be taken with Dolasetron if prescribed by the doctor. Consult the prescriber if you experience sudden dizziness, fainting, lightheadedness, or irregular heartbeat. Do not discontinue the medication without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

Healthy eating habits:

  • Reduce your intake of packaged, processed, and fried foods, as they are high in salt.
  • Avoid refined carbs and sweets to support cardiovascular health.

Weight management

  • Increase your intake of fruits, vegetables, healthy grains, and lean proteins while maintaining a calorie-restricted, balanced diet.
  • Most days of the week, partake in regular physical activities like yoga, swimming, cycling, or brisk walking.

Lifestyle changes

  • Avoid alcohol, tobacco, and smoking since they raise your risk of cardiovascular disease.
  • Maintain a consistent sleep pattern and make sure you get enough sleep.

Stress Management:

  • Avoid chronic stress, as it can increase blood pressure levels.
  • Spend quality time with loved ones to promote emotional well-being.
  • Practice mindfulness techniques to help manage daily stress.

Habit Forming

No

Therapeutic Class

[ANTI- HYPERTENSIVES]

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Alcohol

Unsafe

You are recommended not to consume alcohol along with Zabesta Xlo Tablet to avoid unpleasant side effects.

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Pregnancy

Consult your doctor

It is not known whether this Zabesta Xlo Tablet will harm an unborn baby. Inform your doctor if you are pregnant or plan to become pregnant.

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Breast Feeding

Unsafe

Zabesta Xlo Tablet can pass into breast milk and may harm newborn babies. You should not breast-feed while using this Zabesta Xlo Tablet .

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Driving

Caution

It is not recommended to drive after taking Zabesta Xlo Tablet as it may occasionally cause drowsiness or fatigue.

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Liver

Caution

Zabesta Xlo Tablet to be taken with caution, especially if you have a history of liver diseases. Your doctor may adjust your dose depending on your current liver conditions.

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Kidney

Caution

Zabesta Xlo Tablet to be taken with caution, especially if you have a history of Kidney diseases. Your doctor may adjust your dose depending on your current kidney conditions.

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Children

Unsafe

Zabesta Xlo Tablet is not recommended for children below 18 years.

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Heart

Safe if prescribed

Zabesta Xlo Tablet is safe for use in heart patients if recommended by the physician.

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Geriatrics

Caution

Zabesta Xlo Tablet should be used under caution in geriatric patients. Please consult your physician.

FAQs

Zabesta Xlo Tablet is used to treat high blood pressure.

It is advised to continue your medicine even after your blood pressure is under control or becomes normal, as blood pressure can shoot up at any time. If you have any discomfort, please consult your doctor immediately.

Zabesta Xlo Tablet is a combination medication containing Hydrochlorothiazide, a diuretic that helps remove excess fluid and lower blood pressure, and bisoprolol, a beta-blocker that slows the heart rate and reduces blood pressure by blocking certain stress hormones. Together, they help manage hypertension and improve heart function.

Your doctor may probably tell you to stop taking Zabesta Xlo Tablet as it lowers blood pressure (hypotension) when combined with general anaesthesia before surgery. So, please inform your doctor before surgery if you are taking Zabesta Xlo Tablet .

Avoid drinking alcohol it may cause dizziness. Avoid standing suddenly from a lying or sitting position, or you may feel dizzy. Get up slowly and stabilise yourself to avoid a fall.

No, Zabesta Xlo Tablet and Metoprolol are not the same. Zabesta Xlo Tablet contains bisoprolol, a beta-blocker combined with a diuretic, whereas Metoprolol is a beta-blocker used alone. Although both medications are beta-blockers, they have different effects. Always consult your doctor before making any changes to your medication.

The common side effects of Zabesta Xlo Tablet include weakness or fatigue, dizziness, nausea, diarrhoea, indigestion, headache, and cough. Most of these side effects do not require medical attention and gradually resolve over time. However, consult a doctor if any of these symptoms persist or worsen.

Yes, Zabesta Xlo Tablet can increase urination due to its diuretic component, Hydrochlorothiazide, which helps remove excess fluid from the body and lower blood pressure. However, if you experience any significant concerns, such as excessive frequency of urination, urgent need to urinate, or painful urination, consult your doctor promptly for guidance and assessment.

It is not known whether Zabesta Xlo Tablet will harm an unborn baby. Therefore, consult a doctor if you are pregnant or plan to become pregnant before taking Zabesta Xlo Tablet .

Yes, Zabesta Xlo Tablet can cause photosensitivity reactions by making your skin more sensitive to sunlight, sunlamps, and tanning beds. This can result in severe sunburn, blisters, or swelling. Use sunscreen, wear protective clothing, and avoid prolonged sun exposure to minimise the risk.

Yes, Zabesta Xlo Tablet may impair your ability to drive. It can cause side effects such as dizziness, fatigue, or drowsiness, which can reduce your alertness. If you experience these symptoms, avoid driving or operating heavy machinery until you know how the medication affects you.

Country of origin

India

Manufacturer/Marketer address

Arvind Vithal Gandhi Chowk, BSD Marg, Station Road, Govandi East, Mumbai - 400 088. , India.
Other Info - ZAB0003

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Author Details

Veda MaddalaDoctor badge

Written By

Veda Maddala

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Feb 12, 2026 | 1:24 PM IST

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