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compositionComposition:CABAZITAXEL-60MG
prescription
Prescription Medicine
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It is used to treat advanced prostate cancer or metastatic prostate cancer. It contains Cabazitaxel, a microtubule receptor blocker (inhibitor). Cabazitaxel shrinks tumours by attacking rapidly dividing cells, including cancer cells, so they can no longer grow and divide. Sometimes, Z-Texel Injection may cause side effects such as being sick (vomiting), neutropenia (lower-than-normal levels of neutrophils), low blood cell count, diarrhoea, vomiting, constipation, asthenia (abnormal weakness), pyrexia (fever), dyspnea (shortness of breath), altered taste, cough, pain in the joint, and alopecia (hair loss).

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

CABAZITAXEL-60MG

Manufacturer/Marketer :

BDR Pharmaceuticals Internationals Pvt Ltd

Consume Type :

Parenteral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Z-Texel Injection

Z-Texel Injection is a prescription chemotherapy medication used to treat patients with advanced prostate cancer. Specifically, it is prescribed for cancer that has spread to other parts of the body and is no longer responding to standard hormone therapies. This medicine is typically given to patients who have already received other chemotherapy treatments.

Because Z-Texel Injection is given as an intravenous infusion, it is injected by a healthcare professional in a clinic or hospital setting, usually once every few weeks. Maintaining a consistent treatment schedule is vital for managing the progression of the disease. While undergoing treatment, adopting gentle lifestyle adjustments, such as eating smaller meals and drinking plenty of fluids, can significantly support your overall physical strength.

While taking Z-Texel Injection, you may experience common side effects like tiredness, nausea, and mild diarrhea. It is critical to monitor your health closely and contact your doctor immediately if you develop serious symptoms, such as a high fever, severe stomach pain, or difficulty breathing, as these require urgent medical care.

Do not take this if you have severe liver damage or dangerously low white blood cell counts. Before starting treatment, you must discuss your complete medical history with your doctor, especially if you have a history of lung issues, kidney problems, or severe allergic reactions to other chemotherapy medicines.

This medication can interact with other drugs, including certain antibiotics, antifungals, or seizure medicines, which may affect how the treatment works or increase side effects. It is highly recommended to avoid alcohol, as it can put extra strain on your liver, and to consult your healthcare provider. This medicine can cause harm to an unborn baby. Men receiving Z-Texel Injection should use effective contraception during treatment and for the period recommended by their doctor after treatment ends. If you plan to have children in the future, discuss fertility 

Uses of Z-Texel Injection

Z-Texel Injection is used to treat advanced prostate cancer. Your doctor may prescribe it for the following condition:

  • Advanced Prostate Cancer: Z-Texel Injection helps slow the growth and spread of cancer cells in patients with metastatic castration-resistant prostate cancer (prostate cancer that has spread to other parts of the body and is no longer responding to hormone-lowering treatments) whose disease has worsened after receiving other chemotherapy treatments.

Key Benefits

Using Z-Texel Injection as prescribed helps slow the progression of advanced prostate cancer and manage symptoms. Here are the key benefits you can expect:

  • Slows cancer progression: Helps slow the growth and spread of cancer cells, supporting better disease control.
  • Helps relieve cancer-related symptoms: By limiting tumour growth, it may help reduce pain and discomfort caused by tumours, improving daily comfort and quality of life.
  • Provides a treatment option after chemotherapy: Offers an effective treatment for metastatic castration-resistant prostate cancer when previous chemotherapy is no longer effective, helping extend survival and support ongoing disease management.
Side effects of Z-Texel Injection
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
  • Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
  • Get sufficient sleep and manage stress which helps in improving white blood cell count.
  • Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
  • Try to prevent the factors that cause a decrease in the white blood cells that may lead to impaired immunity.
  • Talk to your doctor about medicines to manage neutropenia based on the underlying cause.
  • Avoid contact with people who are sick.
  • Wash your hands regularly with soap and water.
  • Avoid unpasteurized dairy products.
  • Managing a low platelet count (thrombocytopenia) caused by medication usage requires a multi-step approach. Here are some steps to help manage the condition:
  • Inform your doctor about your low platelet count and medication usage. They will assess the situation and guide the best course of action.
  • Your doctor may recommend adjusting or stopping the medication that is causing a low platelet count. This could involve switching to alternative medication or reducing the dosage.
  • Monitor your platelet count regularly through blood tests to track any changes. This will help the doctor determine the effectiveness of the treatment plan.
  • If an underlying condition, such as infection or inflammation, contributes to the low platelet count, your doctor will treat it.
  • In some cases, alternative treatments like platelet transfusions or medications that stimulate platelet production may be necessary.
  • Avoid risky activities and certain medications; eat a balanced diet with plenty of water to reduce bleeding risk and boost overall health.
  • If you experience severe bleeding or bruising, seek emergency medical attention immediately.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication.
  • Z-Texel Injection will be administered by a doctor or nurse in a healthcare facility.
  • Do not self-administer.

How Z-Texel Injection Works

Z-Texel Injection contains cabazitaxel, a chemotherapy medicine that targets microtubules, which act like the internal scaffolding and transport system inside cells. These structures are essential for cells to divide and multiply. Z-Texel Injection binds to these microtubules and prevents them from breaking down, locking them in place. This stops cancer cells from dividing and multiplying. As a result, the cancer cells eventually die, helping to slow the growth and spread of metastatic castration-resistant prostate cancer.
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Alcohol

Unsafe

Avoid alcohol consumption while on treatment with Z-Texel Injection.

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Pregnancy

Unsafe

-

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Breast Feeding

Unsafe

-

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Driving

Caution

Z-Texel Injection may affect your reactions and your ability to drive. Do not drive and/or operate machines that require your alertness.

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Liver

Caution

The safety of Z-Texel Injection has not been evaluated in patients with liver impairment. Inform your doctor before receiving the Z-Texel Injection if you have had a Liver impairment/disorder history. Your doctor will prescribe only if the benefits outweigh the risks.

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Kidney

Caution

Kidney failure may occur with Z-Texel Injection because of severe infection, loss of too much body fluid (dehydration), and other factors, and may result in death. Your doctor will examine you for this condition and, if necessary, treat you.

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Children

Unsafe

The safety and effectiveness of Z-Texel Injection in pediatric patients have not been established.

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Heart

Caution

Exercise caution before using Z-Texel Injection in case of heart problems. Please consult your doctor if you have any concerns.

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Geriatrics

Caution

Z-Texel Injection should be used with caution in elderly patients, as it may increase the risk of dizziness and other side effects.

What if I have taken an overdose of Z-Texel Injection

Since a trained healthcare professional administers this medication, an overdose is highly unlikely. However, if you suspect an error or experience severe side effects immediately after an infusion, notify the clinic staff or seek emergency medical care right away.

Diet & Lifestyle Advise

  • Stay well-hydrated: Drink plenty of water and clear broths, especially on the days surrounding your treatment, to help protect your kidneys and prevent dehydration from diarrhea or vomiting.
  • Eat frequent, small meals: If you experience nausea or a loss of appetite, eating small portions five to six times a day instead of three large meals can help maintain your nutrition.
  • Practice strict infection prevention: Wash your hands frequently with soap and water, avoid close contact with people who are sick, and avoid large crowds, as your body's ability to fight infections will be lower during treatment.
  • Gentle skin care: Use mild, fragrance-free soaps and moisturizers to protect your skin, which can become dry or sensitive during chemotherapy.
health query

Have a query?

How Soon It Starts Working

The time required for Z-Texel Injection to start to work: Z-Texel Injection ideally shows its action within 1 hour after administration. The time for which the effects of Z-Texel Injection last: The duration of action for Z-Texel Injection is unknown.

What if you forget to take Z-Texel Injection

Because this medication is injected by a healthcare provider at a clinic, missing a dose means missing an appointment. Contact your clinic immediately to reschedule your infusion and keep your treatment on track.

Storage

•Z-Texel Injection is stored by healthcare professionals in a secure pharmacy at 20°C–25°C (68°F–77°F).• Keep the medicine in its original packaging to protect it from light. Do not freeze.

Drug Warnings

  • Check before treatment: Ensure your healthcare provider inspects the solution before the infusion. It should be clear and free of visible particles.
  • Monitor for infection: Check your temperature daily and seek immediate medical attention if you develop a fever, as low white blood cell counts can increase the risk of serious infections.
  • Attend blood test appointments: Keep all scheduled blood test appointments so your doctor can monitor your liver function and blood cell counts before each infusion.
  • Take care when standing up: Rise slowly from a sitting or lying position, as Z-Texel Injection may cause dizziness or light-headedness.
  • Avoid live vaccines: Do not receive live vaccines during treatment with Z-Texel Injection unless your doctor advises it.
  • Discuss fertility before treatment: Z-Texel Injection may affect male fertility. If you plan to have children in the future, ask your doctor whether sperm banking is appropriate before starting treatment. 

Drug-Drug Interactions

verifiedApollotooltip
  • Strong liver enzyme blockers: Medicines such as ketoconazole, clarithromycin, or ritonavir can increase the levels of Z-Texel Injection in your blood, which may raise your risk of severe side effects.
  • Strong liver enzyme speeders: Medicines such as rifampicin, carbamazepine, or phenytoin can lower the levels of Z-Texel Injection in your body, making the treatment less effective.
CabazitaxelInfliximab
Severe
CabazitaxelBaricitinib
Severe

Drug-Drug Interactions

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CabazitaxelInfliximab
Severe
How does the drug interact with Z-Texel Injection:
When Z-Texel Injection is taken with Infliximab, it can increase the risk or severity of developing serious infections.

How to manage the interaction:
Co-administration of Z-Texel Injection with Infliximab can result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms like fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, pain, or burning during urination contact a doctor right away. Do not discontinue any medications without consulting a doctor.
CabazitaxelBaricitinib
Severe
How does the drug interact with Z-Texel Injection:
Coadministration of baricitinib and abatacept can raise the risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, baricitinib can be taken with abatacept if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscular aches, shortness of breath, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not discontinue any medication without consulting a doctor.
CabazitaxelLeflunomide
Severe
How does the drug interact with Z-Texel Injection:
The use of leflunomide together with Z-Texel Injection may raise the risk of severe infections.

How to manage the interaction:
Taking Z-Texel Injection with Leflunomide together can possibly result in an interaction, but it can be taken if your doctor has advised it. If you notice any symptoms like infection, sore throat, diarrhea, muscle pain, weight loss, fever, or difficulty breathing, contact your doctor immediately. If you experience any discomfort or burning while urinating, let your doctor know. Do not stop using any medications without talking to your doctor.
CabazitaxelClozapine
Severe
How does the drug interact with Z-Texel Injection:
Co-administering clozapine with Z-Texel Injection may increase the risk of neutropenia.

How to manage the interaction:
Although taking Z-Texel Injection and Clozapine together can cause an interaction, it can be taken if your doctor has suggested it. If you notice any of these symptoms - such as a severe infection, fever, chills, diarrhea, sore throat, muscle pain, difficulty breathing, weight loss, or pain while urinating - contact a doctor right away. Do not discontinue any medications without consulting a doctor.
CabazitaxelTofacitinib
Severe
How does the drug interact with Z-Texel Injection:
Using tofacitinib together with Z-Texel Injection may increase the risk of serious infections.

How to manage the interaction:
Taking Z-Texel Injection with Tofacitinib together can possibly result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without consulting your doctor.
CabazitaxelEtanercept
Severe
How does the drug interact with Z-Texel Injection:
When Etanercept is used with Z-Texel Injection, the likelihood or severity of infection may increase.

How to manage the interaction:
Although there is a possible interaction between Z-Texel Injection and Etanercept, you can take these medicines together if prescribed by a doctor. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
  • Grapefruit and grapefruit juice: Avoid consuming grapefruit products, as they can interfere with how your liver processes this medicine, leading to potentially dangerous levels of the drug in your system.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTINEOPLASTIC]

FAQs

Z-Texel Injection is used to treat Prostate cancer.
Z-Texel Injection contains Cabazitaxel, a microtubule receptor blocker (inhibitor). Cabazitaxel shrinks tumours by attacking rapidly dividing cells, including cancer cells, so they can no longer grow and divide.
Based on the medical condition, Z-Texel Injection may be given alone or with other medicines used to treat Prostate cancer.
Z-Texel Injection is only for use in men. Women should not take this medication, especially if they are or may become pregnant or are breast-feeding.
You may not be able to get your partner pregnant after treatment with this drug. If you plan to have a baby, consult your doctor before beginning treatment. You might be able to store sperm before starting treatment.
Cabazitaxel, a prostate cancer medication, is used to treat prostate cancer.
No, it is unsafe to father a child while taking Z-Texel Injection. It is recommended for sexually active men to use condoms while on treatment and for at least four months after their last dose of Z-Texel Injection.
Z-Texel Injection can cause a significant decrease in the number of blood cells and platelets. Your doctor may suggest laboratory tests before and during the treatment. Tell your healthcare provider if you develop a fever or have signs of bruising or bleeding.
It is not a vesicant. Z-Texel Injection is a chemotherapeutic drug, used in the treatment of prostate cancer.
The common side effects of Z-Texel Injection may include being sick (vomiting), neutropenia (lower-than-normal levels of neutrophils), low blood cell count, diarrhoea, vomiting, constipation, asthenia (abnormal weakness), pyrexia (fever), dyspnea (shortness of breath), altered taste, cough, pain in the joint, and alopecia (hair loss). Most of these side effects may gradually resolve over time. However, if the side effects persist or worsen, consult your doctor immediately.
Z-Texel Injection is given as an intravenous (IV) infusion, which is a slow drip into a vein, administered by a healthcare professional in a clinic or hospital. Talk to your doctor for details about your specific treatment schedule.
Your doctor will prescribe a steroid medication, such as prednisone, to be taken daily during your treatment. This helps reduce the risk of allergic reactions and controls inflammation. Talk to your doctor if you have questions about your daily medications.
If your blood tests show that your white blood cell count is dangerously low, your doctor will likely delay your next infusion until your blood levels recover. Talk to your doctor about your regular blood test results.
Some patients experience extreme tiredness, dizziness, or weakness after receiving this medication. It is highly recommended to have someone drive you to and from your appointments. Talk to your doctor about how this medicine may affect your daily activities.
You should avoid or strictly limit alcohol during treatment, as both alcohol and this medicine can strain your liver and worsen side effects like dizziness and nausea. Talk to your doctor or pharmacist for personalised advice.
This medicine can sometimes affect kidney function, especially if you become dehydrated from diarrhea or vomiting. Your doctor will monitor your kidney health through regular blood tests. Talk to your doctor if you notice a decrease in urination.
It is generally safe to receive inactive vaccines like the standard flu shot, but you must avoid live vaccines during treatment. Always consult your doctor before getting any vaccine while on this medicine.
Yes. Because Z-Texel Injection can significantly lower white blood cell counts, your doctor may prescribe a medicine called granulocyte colony-stimulating factor (G-CSF) to help reduce the risk of serious infections. Your doctor will decide whether you need this based on your age, blood counts, and overall health.

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Country of origin

India
Other Info - ZT23535
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