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compositionComposition:ESTRAMUSTINE-140MG
prescription
Prescription Medicine
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Xtrant Capsule is used to treat prostate cancer. It contains Estramustine, an antimicrotubule agent that works by blocking DNA replication (genetic material) in cancer cells. Hence, this stops the further growth and multiplication of the cancer cells. Common side effects of Xtrant Capsule may include nausea, dizziness, heartburn, headache, diarrhoea, muscle weakness, joint pain, hot flushes, nausea, vomiting, thirst, flatulence, edema, and GI bleeding.

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Written By Dr. Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

ESTRAMUSTINE-140MG

Manufacturer/Marketer :

Natco Pharma Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Xtrant Capsule

Xtrant Capsule is a prescription medication used to treat advanced, progressive, or metastatic prostate cancer. It is typically prescribed when other hormone therapies are no longer working. The primary medical purpose of this medicine is to help slow down or halt the growth of cancer cells in the prostate gland.

To get the best results, you must take Xtrant Capsule consistently at the same times every day as directed by your healthcare provider. This medication should be taken on an empty stomach, either one hour before or two hours after a meal. Making certain dietary changes, such as eating a low-salt diet, can help manage the fluid retention that often occurs with this treatment.

While taking Xtrant Capsule , you may experience some common side effects like mild nausea or breast tenderness. However, you should contact your doctor immediately if you experience serious symptoms like sudden shortness of breath, severe leg pain, or chest tightness. These can be signs of more serious complications that require urgent medical attention.

Do not take this if you have active blood clots, severe heart problems, or a known allergy to similar medications. Before starting your treatment, tell your doctor if you have a history of liver damage, kidney disease, high blood pressure, or diabetes, as these conditions require extra monitoring.

This medicine can interact with calcium-rich foods like milk and yogurt, as well as calcium supplements, making the medication much less effective. It is also important to tell your doctor if you are taking blood thinners. Since this medication is specifically for prostate cancer, it is not used in women, but pregnant women should avoid handling the capsules entirely due to the risk of birth defects.

Uses of Xtrant Capsule

Xtrant Capsule helps treat advanced prostate cancer by slowing or stopping the growth of cancer cells. Your doctor may prescribe it for the following condition:

  • Advanced Prostate Cancer: Xtrant Capsule helps by slowing down or stopping the growth of cancer cells in patients whose prostate cancer has spread to other parts of the body and has not responded to standard hormone therapies.

Key Benefits

Using Xtrant Capsule as prescribed helps control advanced prostate cancer and relieve symptoms caused by the disease. Here are the key benefits you can expect:

  • Helps control cancer growth: Xtrant Capsule helps slow the growth and spread of advanced prostate cancer, supporting better disease management.
  • Relieves cancer-related symptoms: By slowing tumour growth, it may help reduce pain and discomfort associated with bone metastases and other cancer-related symptoms.
  • Improves urinary comfort: Xtrant Capsule may help relieve urinary symptoms caused by an enlarged prostate tumour, making day-to-day activities more comfortable.
  • Enhances quality of life: Better control of the disease and its symptoms can help improve daily comfort, mobility, and overall wellbeing.

Directions for Use

  • Xtrant Capsule should be taken on an empty stomach, at least two hours before or after a meal.
  • Xtrant Capsule is usually taken 3-4 times in a day; however, follow your doctor’s advice regarding the dosage and duration.
  • Swallow the whole medicine with a glass of water.
  • Do not split, chew, or crush it.

How Xtrant Capsule Works

Xtrant Capsule contains estramustine; it works using a dual-action mechanism. It combines a hormone (estrogen) with a chemotherapy agent. The estrogen part helps the medicine target prostate tissue specifically, as these cancer cells have receptors that attract estrogen. Once the medicine enters the cancer cells, the Xtrant Capsule component disrupts the normal function of microtubules, which are essential structures needed for cell division. By preventing cancer cells from dividing and multiplying, it slows or stops tumour growth. This antimitotic action, together with the estrogen component, helps control the progression of advanced prostate cancer.
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Alcohol

Consult your doctor

Interaction of Xtrant Capsule with alcohol is unknown. It is advisable to consult your doctor if you have concerns.

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Pregnancy

Not applicable

Not intended for women. Xtrant Capsule has the potential to harm a fetus. If there is a chance that your partner will become pregnant while you are on estramustine, you should utilize effective birth control.

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Breast Feeding

Not applicable

Not intended for women.

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Driving

Unsafe

Xtrant Capsule may decrease alertness or make you feel sleepy and dizzy. So, do not drive or operate heavy machinery after taking Xtrant Capsule until your vision improves.

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Liver

Caution

Xtrant Capsule should be used with caution, especially if you have a history of liver diseases/conditions. Your doctor may adjust the dose based on your condition.

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Kidney

Caution

Xtrant Capsule should be used with caution, especially if you have a history of kidney diseases/conditions. This medicine causes fluid retention and edema which can be worsened by kidney impairment. Your doctor may adjust the dose based on your condition.

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Children

Not applicable

Intended for use in adult men.

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Heart

Caution

If you have a history of heart disease, please inform the doctor before receiving Xtrant Capsule .

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Geriatrics

Caution

Xtrant Capsule should be used with caution in elderly patients. Please consult your doctor before use.

What if I have taken an overdose of Xtrant Capsule

If you take more than the prescribed dose of Xtrant Capsule , seek emergency medical attention immediately. Do not wait for symptoms to appear.

Diet & Lifestyle Advise

  • Avoid Dairy and Calcium: Do not eat or drink milk, cheese, yogurt, or calcium-fortified foods within two hours of taking your medicine, as they prevent your body from absorbing the drug.
  • Reduce Salt Intake: Eat a low-sodium diet to help prevent or manage fluid retention and ankle swelling during your treatment.
  • Stay Gently Active: Engage in regular, gentle physical activity like short walks to help maintain your strength and lower the risk of blood clots. Always check with your doctor before starting any exercise routine.
  • Stay Hydrated: Drink plenty of water throughout the day to support your kidney function and help manage mild side effects like diarrhea or dry skin.
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How Soon It Starts Working

The time required for Xtrant Capsule to start to work: The exact onset time of Xtrant Capsule has not been clinically established. The time for which the effects of Xtrant Capsule last: The duration of Xtrant Capsule ’s effect is clinically not established.

What if you forget to take Xtrant Capsule

If you miss a dose, take it as soon as you remember. However, if your next scheduled dose is only a few hours away, skip the missed dose and return to your normal schedule. Do not take two doses at the same time to make up for a missed one.

Storage

•Store Xtrant Capsule capsules in a refrigerator between 2°C and 8°C. Do not freeze the medicine.

Drug Warnings

  • Do Not Smoke: Avoid smoking completely while taking this medication, as it significantly increases your risk of developing dangerous blood clots, heart attacks, or strokes.
  • Safe Handling: Pregnant women or women who may become pregnant should not handle these capsules, as the active ingredients can be absorbed through the skin and cause harm to an unborn baby. Wear gloves if someone else must handle your medication.
  • Monitor Your Blood Pressure: Check your blood pressure regularly at home, as this medicine can cause your blood pressure to rise.
  • Keep Up with Blood Tests: Attend all scheduled medical appointments for blood tests so your doctor can monitor your liver function, kidney health, and blood counts.

Drug-Drug Interactions

verifiedApollotooltip
  • Blood Thinners: May alter the effectiveness of medications like warfarin, requiring closer monitoring of your blood clotting times.
  • Live vaccines: Medicines that affect the immune system, including some cancer treatments, may increase the risk of infection or reduce the effectiveness of live vaccines. Tell your doctor before receiving any vaccination during treatment. 
EstramustineExemestane
Severe
EstramustineLetrozole
Severe

Drug-Drug Interactions

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EstramustineExemestane
Severe
How does the drug interact with Xtrant Capsule:
Co-administration of Exemestane with Xtrant Capsule may interfere with exemestane's activity and make it less effective in treating the condition.

How to manage the interaction:
There may be a possibility of interaction between Exemestane and Xtrant Capsule, but it can be taken if prescribed by a doctor. Do not stop using any medications without talking to a doctor.
EstramustineLetrozole
Severe
How does the drug interact with Xtrant Capsule:
when taken together letrozole's function could be blocked by Xtrant Capsule, which would reduce its ability to effectively treat your illness.

How to manage the interaction:
Although taking Letrozole and Xtrant Capsule together can possibly result in an interaction, it can be taken if your doctor has prescribed it. Do not discontinue any medications without a doctor's advice.
EstramustineTranexamic acid
Severe
How does the drug interact with Xtrant Capsule:
Co-administration of Xtrant Capsule with Tranexamic acid can increase the risk of blood clots.

How to manage the interaction:
Taking Xtrant Capsule with Tranexamic acid possibly lead to an interaction, however, it can be taken only if a doctor has advised it. If you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, and numbness or weakness on one side of the body contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Calcium-Rich Foods: Dairy products (milk, yogurt, cheese) and calcium-fortified juices severely decrease the absorption of this medicine, making it less effective.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTINEOPLASTIC]

FAQs

Xtrant Capsule is used to treat metastatic prostate cancer.
Xtrant Capsule contains Estramustine, which belongs to the class of antimicrotubule agents. It works by blocking the replication of DNA (genetic material) in the cancer cells. Hence, this stops the further growth and multiplication of the cancer cells.
No, do not stop taking Xtrant Capsule without consulting your doctor. It is recommended to take this medicine for the entire prescribed duration, even when symptoms improve or resolve.
Xtrant Capsule is an antineoplastic medicine that contains the active ingredient Estramustine, which is used in the treatment of prostate cancer in men.
The common side effects of Xtrant Capsule include nausea, dizziness, heartburn, headache, diarrhea, muscle weakness, joint pain, hot flushes, vomiting, thirst, flatulence, edema, and stomach bleeding. These side effects do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.
No, you must not take Xtrant Capsule with milk or any other dairy products. Calcium binds to the medication and prevents your body from absorbing it properly. Take it with water on an empty stomach.
The active ingredients in Xtrant Capsule are temperature-sensitive. Storing the capsules between 2°C and 8°C ensures the medicine remains stable and effective. Talk to your pharmacist if you have questions about storage.
If you vomit shortly after taking your capsule, do not take an extra dose to make up for it. Wait until your next scheduled dose time and take your normal amount. Talk to your doctor if vomiting continues.
If your wife is pregnant, nursing, or planning to become pregnant, she must not handle this medication. The drug can be absorbed through the skin and cause birth defects. If someone else must handle the capsules, they should wear protective gloves.
Yes, breast tenderness and enlargement (gynecomastia) are common side effects because the medicine contains an estrogen component. Talk to your doctor if this becomes painful or concerning.
No, you should not smoke. Smoking greatly increases the risk of serious cardiovascular side effects, including blood clots, heart attacks, and strokes, while on this therapy. Talk to your doctor about smoking cessation support.
Yes, it is highly recommended to check your blood pressure regularly. This medication can cause fluid retention and high blood pressure. Keep a log of your readings and share them with your doctor.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. DrugBank Online. Db01196 Clinical & Chemical Summary. Edmonton, AB: DrugBank; 2026. [Accessed on 02 Jun. 2026]Check here
  2. Mayo Clinic Staff. Drg 20063721 Inhalation and Dosage Monograph. Rochester, MN: Mayo Foundation for Medical Education; 2025. [Accessed on 02 Jun. 2026]Check here
  3. MedlinePlus. A608046 Patient Information Monograph. Bethesda, MD: U.S. National Library of Medicine (NLM); 2025. [Accessed on 02 Jun. 2026]Check here
  4. National Center for Biotechnology Information (NCBI). Estramustine Scientific Research Publication. Bethesda, MD: NLM; 2025. [Accessed on 02 Jun. 2026]Check here
  5. U.S. Food and Drug Administration (FDA). 018045S023Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  6. Central Drugs Standard Control Organisation (CDSCO). [Accessed on 27 Mar. 2019]Check here

Country of origin

INDIA

Manufacturer/Marketer address

Natco House, Road No.2, Banjara Hills, Hyderabad-500 034, India
Other Info - XTR0012
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