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  3. XL-90 Plus Cough Syrup 100 ml

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XL-90 Plus Cough Syrup 100 ml, Pack of 1
XL-90 Plus Cough Syrup 100 ml, Pack of 1
XL-90 Plus Cough Syrup 100 ml, Pack of 1
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

XL-90 Plus Cough Syrup is a combination medicine which belongs to the class of expectorants. It is used in the treatment of dry cough. This medicine works by preventing nerve signals from the brain's cough centre from reaching the muscles that cause coughing and thus reduce cough. You may experience common side effects like headache, dizziness, numbness, drowsiness, or nausea.

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Synonym :

CHLORPHENIRAMINE+DEXTROMETHORPHAN+PHENYLEPHRINE

Composition :

CHLORPHENIRAMINE MALEATE-2MG + DEXTROMETHORPHAN HYDROBROMIDE-10MG + PHENYLEPHRINE HYDROCHLORIDE-5MG

Manufacturer/Marketer :

Dwd Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About XL-90 Plus Cough Syrup

XL-90 Plus Cough Syrup is used to treat dry cough. Coughing (dry or productive) is the body's way of clearing irritants (like allergens, mucus, or smoke) from airways and preventing infection. A dry cough is tickly and doesn't produce any viscous or thick mucus, while a chesty cough (wet cough) means mucus or sputum is created to help clear the airways.

XL-90 Plus Cough Syrup is a combination of three drugs: Chlorpheniramine, Phenylephrine, and Dextromethorphan. Chlorpheniramine works by blocking the action of histamine. Phenylephrine helps in shrinking the blood vessels located in the nasal passage. Dextromethorphan works by blocking the transmission of nerve signals from the cough centre in the brain to the muscles that produce a cough.

Some people may experience dry mouth, throat, or nose, as well as drowsiness, blurred vision, constipation, dizziness, restlessness, or excitation. Most of these side effects do not require medical attention and typically resolve on their own over time. However, if the side effects persist or worsen, please consult your doctor.

If you are pregnant or breastfeeding, it is advised to inform your doctor before using XL-90 Plus Cough Syrup . Avoid using XL-90 Plus Cough Syrup if you have taken monoamine oxidase inhibitors in the past 14 days. If you have glaucoma, urinary problems, an enlarged prostate, phenylketonuria (a congenital disability that causes accumulation of the amino acid phenylalanine in the body), a cough with mucus or a cough caused by asthma or smoking, inform your doctor before taking it.

Uses of XL-90 Plus Cough Syrup

XL-90 Plus Cough Syrup is used to treat dry cough. The detailed uses of XL-90 Plus Cough Syrup are as follows:

  • Relief from Cough: XL-90 Plus Cough Syrup helps to relieve persistent and dry coughs caused by respiratory conditions like colds and allergies.
  • Treatment of Allergic Conditions: XL-90 Plus Cough Syrup helps to alleviate symptoms of allergies and respiratory infections, including runny nose and throat irritation, providing relief for patients.
  • Decongestant: XL-90 Plus Cough Syrup works as a decongestant as it contains phenylephrine, which narrows blood vessels in the nasal passages, reducing swelling and relieving congestion.

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Directions for Use

  • XL-90 Plus Cough Syrup can be taken with or without food, as advised by your doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Shake the bottle well before each use. Take the prescribed dose by mouth using the measuring cup/dosing syringe/dropper provided with the pack.
  • Avoid using regular household spoons, as they may not accurately measure the dose.

Medicinal Benefits

  • XL-90 Plus Cough Syrup contains Chlorpheniramine maleate, Phenylephrine, and Dextromethorphan, used to treat dry cough. 
  • Chlorpheniramine maleate helps provide relief from allergy symptoms, including sneezing, a runny nose, watery eyes, itching, swelling, congestion, and stiffness.
  • Phenylephrine helps in shrinking the blood vessels located in the nasal passage, thereby reducing the stuffy nose. 
  • Dextromethorphan works by blocking the transmission of nerve signals from the cough centre in the brain to the muscles that produce cough.
  • Thus, XL-90 Plus Cough Syrup helps to relieve overall cough, cold and allergic symptoms.

How XL-90 Plus Cough Syrup Works

XL-90 Plus Cough Syrup is a combination of three drugs, namely: Chlorpheniramine maleate (antihistamine), Phenylephrine (decongestant), and Dextromethorphan (cough suppressant). Chlorpheniramine maleate works by blocking the action of histamine, a substance responsible for causing allergic reactions. Phenylephrine helps in shrinking the blood vessels located in the nasal passage, thereby reducing the stuffy nose. Dextromethorphan works by blocking the transmission of nerve signals from the cough centre in the brain to the muscles that produce cough. Collectively, it helps to provide relief from a dry cough.

Storage

• Store in a cool and dry place away from sunlight.• Keep XL-90 Plus Cough Syrup out of reach and sight of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of XL-90 Plus Cough Syrup 100 ml
  • Get enough sleep. Maintain a regular sleep cycle.
  • Eat a healthy diet and exercise regularly.
  • Manage stress with yoga or meditation.
  • Limit alcohol and caffeine.
  • Avoid driving or operating machinery unless you are alert.
  • Avoid driving or operating machinery or activities that require high focus until you know how the medication affects you.
  • Maintain a fixed sleeping schedule, create a relaxing bedtime routine and ensure your sleeping space is comfortable to maximize your sleep quality.
  • Limit alcohol and caffeine as these may worsen drowsiness and disturb sleep patterns.
  • Drink plenty of water as it helps with alertness and keeps you hydrated and for overall well-being.
  • Moderate physical activity can improve energy levels, but avoid intense workouts right before bedtime.
  • Try to get 7-9 hours of sleep per night.
  • Maintain a fixed sleeping schedule, create a relaxing bedtime routine and ensure your sleeping space is cool, quiet and dark to maximize your sleep quality.
  • Get plenty of sunlight in the morning.
  • Do moderate-intensity exercises most days of the week and avoid strenuous exercise close to bedtime.
  • Limit processed foods and sugary drinks.
  • Avoid caffeine late in the day and drink in moderation in the morning.
  • Take short nap (20 to 30 minutes) mid-afternoon if required.
Here are the steps to Dry Mouth (xerostomia) caused by medication:
  • Inform your doctor about dry mouth symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Drink plenty of water throughout the day to help keep your mouth moist and alleviate dry mouth symptoms.
  • Chew sugar-free gum or candies to increase saliva production and keep your mouth moisturized.
  • Use saliva substitutes, such as mouthwashes or sprays, only if your doctor advises them to help moisturize your mouth and alleviate dry mouth symptoms.
  • Avoid consuming smoking, alcohol, spicy or acidic foods, and other irritants that may aggravate dry mouth symptoms.
  • Schedule regular dental check-ups to keep track of your oral health and handle any dry mouth issues as they arise.

What if I have taken an overdose of XL-90 Plus Cough Syrup

Avoid exceeding the recommended dose as it might cause an overdose. Seek medical attention if you experience any unusual symptoms.

Drug Warnings

  • If you are allergic to XL-90 Plus Cough Syrup or any other medicines, please tell your doctor.
  • If you are pregnant or breastfeeding, it is advised to inform your doctor before using it.
  • XL-90 Plus Cough Syrup is not recommended for children below 12 years of age.
  • If you are about to undergo any medical tests or surgery, please inform your doctor that you are taking this medicine.
  • Avoid taking XL-90 Plus Cough Syrup if you have taken medicines such as linezolid, phenelzine, selegiline, rasagiline, isocarboxazid, tranylcypromine and methylene blue injection in the past 14 days.
  • If you have glaucoma, urinary problems, an enlarged prostate, phenylketonuria (a birth defect that causes the accumulation of the amino acid, phenylalanine in the body), cough with mucus or cough caused by asthma, smoking, chronic bronchitis or emphysema (a lung condition causing shortness of breath), inform your doctor before taking XL-90 Plus Cough Syrup .

Drug-Drug Interactions

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DextromethorphanSelegiline
Critical
DextromethorphanTranylcypromine
Critical

Drug-Drug Interactions

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DextromethorphanSelegiline
Critical
How does the drug interact with XL-90 Plus Cough Syrup 100 ml:
Co-administration of XL-90 Plus Cough Syrup 100 ml and Selegiline may increase the risk of serotonin syndrome (a condition in which a chemical called serotonin builds up in your body).

How to manage the interaction:
Co-administration of Selegiline with XL-90 Plus Cough Syrup 100 ml can possibly result in an interaction, but it can be taken if a doctor has advised it. If you notice any of these symptoms - confusion, hallucination, fits, increased heart rate, fever, excessive sweating, shivering, shaking, blurred vision, muscle spasm, stiffness, incoordination, stomach cramps, nausea, vomiting, or diarrhea - make sure to contact a doctor right away. Do not stop using any medications without talking to a doctor.
DextromethorphanTranylcypromine
Critical
How does the drug interact with XL-90 Plus Cough Syrup 100 ml:
Taking Tranylcypromine with XL-90 Plus Cough Syrup 100 ml can increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
Taking XL-90 Plus Cough Syrup 100 ml with Tranylcypromine is not recommended, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fit blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting a doctor.
DextromethorphanProcarbazine
Critical
How does the drug interact with XL-90 Plus Cough Syrup 100 ml:
Co-administration of XL-90 Plus Cough Syrup 100 ml and Procarbazine may increase the risk of serotonin syndrome (a condition in which a chemical called serotonin builds up in your body).

How to manage the interaction:
Co-administration of Procarbazine with XL-90 Plus Cough Syrup 100 ml can possibly result in an interaction, but it can be taken if a doctor has advised it. If you notice any of these symptoms - confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering, shaking, blurred vision, muscle spasm, stiffness, incoordination, stomach cramps, nausea, vomiting, or diarrhea - make sure to contact a doctor right away. Do not stop using any medications without talking to a doctor.
DextromethorphanPhenelzine
Critical
How does the drug interact with XL-90 Plus Cough Syrup 100 ml:
Co-administration of Phenelzine and XL-90 Plus Cough Syrup 100 ml can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin builds up in your body).

How to manage the interaction:
Co-administration of Phenelzine and XL-90 Plus Cough Syrup 100 ml can lead to an interaction. However, if you experience any symptoms like confusion, hallucination, seizure, changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle stiffness, tremors, stomach cramps, nausea, vomiting, and diarrhea, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
DextromethorphanPargyline
Critical
How does the drug interact with XL-90 Plus Cough Syrup 100 ml:
Co-administration of Pargyline and XL-90 Plus Cough Syrup 100 ml can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin builds up in your body).

How to manage the interaction:
Co-administration of XL-90 Plus Cough Syrup 100 ml and Pargyline can lead to an interaction. However, if you experience any symptoms like confusion, hallucination, seizure, changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle stiffness, tremors, stomach cramps, nausea, vomiting, and diarrhea, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
DextromethorphanRasagiline
Critical
How does the drug interact with XL-90 Plus Cough Syrup 100 ml:
Taking Rasagiline with XL-90 Plus Cough Syrup 100 ml can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking XL-90 Plus Cough Syrup 100 ml with Rasagiline is not recommended as it can possibly result in an interaction, it can be taken if a doctor has advised it. If you notice any of these symptoms like confusion, hallucination, fits, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, shaking, incoordination, stomach cramps, nausea, vomiting, and diarrhea, consult a doctor. Do not discontinue any medications without consulting a doctor.
DextromethorphanIsocarboxazid
Critical
How does the drug interact with XL-90 Plus Cough Syrup 100 ml:
Co-administration of Isocarboxazid with XL-90 Plus Cough Syrup 100 ml can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin builds up in your body).

How to manage the interaction:
Taking XL-90 Plus Cough Syrup 100 ml and Isocarboxazid can lead to an interaction. However, if you experience any symptoms like confusion, hallucination, seizure, changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle stiffness, tremors, stomach cramps, nausea, vomiting, and diarrhea, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
PhenylephrineSevoflurane
Critical
How does the drug interact with XL-90 Plus Cough Syrup 100 ml:
Co-administration of XL-90 Plus Cough Syrup 100 ml with Sevoflurane can increase the levels of XL-90 Plus Cough Syrup 100 ml and lead to side effects.

How to manage the interaction:
Taking XL-90 Plus Cough Syrup 100 ml with Sevoflurane is not recommended, it can be taken if prescribed by the doctor. Do not discontinue the medications without consulting a doctor.
PhenylephrinePropofol
Critical
How does the drug interact with XL-90 Plus Cough Syrup 100 ml:
Taking XL-90 Plus Cough Syrup 100 ml with Propofol may lead to increased levels of XL-90 Plus Cough Syrup 100 ml leading to side effects like high blood pressure.

How to manage the interaction:
Taking XL-90 Plus Cough Syrup 100 ml with Propofol is not recommended, but it can be taken if prescribed by the doctor. Do not discontinue the medications without consulting a doctor.
PhenylephrineFurazolidone
Critical
How does the drug interact with XL-90 Plus Cough Syrup 100 ml:
Taking Furazolidone with XL-90 Plus Cough Syrup 100 ml can cause an increase in high blood pressure.

How to manage the interaction:
Taking Furazolidone with XL-90 Plus Cough Syrup 100 ml is not recommended, it can be taken if prescribed by the doctor. However, if you experience sudden and severe headache, blurred vision, confusion, seizures, chest pain, nausea or vomiting, sweating, lightheadedness, fainting, sudden numbness or weakness (especially on one side of the body), speech difficulties, fever, consult the doctor immediately. It is advised to use XL-90 Plus Cough Syrup 100 ml only after 14 days of stopping Furazolidone.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Avoid dairy products such as milk, as they may increase mucus production. Also, avoid processed or refined foods. 
  • Drink plenty of fluids to avoid a dry throat. It also helps loosen mucus.
  • Avoid citrus fruits as they may worsen the cough.
  • Eat fruits rich in water content, such as pears, watermelon, peaches and pineapples.

Habit Forming

No

Therapeutic Class

COUGH AND COLD PREPARATIONS

XL-90 Plus Cough Syrup Substitute

Substitutes safety advice
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Alcohol

Caution

Avoid consumption of alcohol with XL-90 Plus Cough Syrup as it may increase drowsiness. Please consult a doctor before consuming alcohol with XL-90 Plus Cough Syrup .

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Pregnancy

Caution

The safety of XL-90 Plus Cough Syrup in pregnant women is unknown. Consult your doctor if you have any concerns; your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

It is unknown whether XL-90 Plus Cough Syrup is excreted in human milk. Consult your doctor if you have any concerns; your doctor will decide if XL-90 Plus Cough Syrup can be taken by breastfeeding mothers or not.

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Driving

Caution

XL-90 Plus Cough Syrup may cause dizziness or drowsiness in some people. Therefore, drive only if you are alert after taking XL-90 Plus Cough Syrup .

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Liver

Caution

Take XL-90 Plus Cough Syrup with caution, especially if you have a history of liver diseases/conditions. The dose may be adjusted by your doctor as required.

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Kidney

Caution

Take XL-90 Plus Cough Syrup with caution, especially if you have a history of kidney diseases/conditions. The dose may be adjusted by your doctor as required.

bannner image

Children

Caution

XL-90 Plus Cough Syrup is not recommended for children below 12 years of age. However, please consult a doctor if you have any concerns.

FAQs

XL-90 Plus Cough Syrup is used to treat dry cough. It helps relieve cough, cold, and allergic symptoms.

XL-90 Plus Cough Syrup contains Chlorpheniramine maleate, Phenylephrine, and Dextromethorphan hydrobromide. Chlorpheniramine maleate works by blocking the action of histamine, a substance responsible for causing allergic reactions. Phenylephrine helps in shrinking the blood vessels located in the nasal passage, thereby reducing the stuffy nose. Dextromethorphan hydrobromide works by blocking the transmission of nerve signals from the cough centre in the brain to the muscles that produce cough.

Consult your doctor before taking XL-90 Plus Cough Syrup if you need to undergo surgery as it may lead to excessive drowsiness and sleepiness when given along with anaesthesia. Your doctor may advise you to stop taking XL-90 Plus Cough Syrup 72 hours prior to the surgery.

It is not recommended to take XL-90 Plus Cough Syrup along with any anti-depressant medication, especially MAO inhibitors (linezolid, phenelzine, selegiline, rasagiline, isocarboxazid, tranylcypromine), as it may lead to unpleasant side-effects or drug interaction. Also, XL-90 Plus Cough Syrup should be taken at least 14 days after the last dose of anti-depressants.

Take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take the scheduled dose. Do not take extra medicine to make up for the missed dose.

XL-90 Plus Cough Syrup may rarely worsen the symptoms of glaucoma. Therefore, XL-90 Plus Cough Syrup should be used with caution and only when prescribed by a doctor in patients with glaucoma.

No, XL-90 Plus Cough Syrup does not contain steroids. It is a combination of three active ingredients phenylephrine, chlorpheniramine maleate, and dextromethorphan hydrobromide.

Yes, XL-90 Plus Cough Syrup can make you feel drowsy as a side effect. It contains dextromethorphan and chlorpheniramine, both of which can cause drowsiness. It's important to be cautious when performing activities that require alertness, such as driving or operating machinery, until you know how the medication affects you.

No, taking XL-90 Plus Cough Syrup in more than the recommended dose will not make it more effective. Instead, it can increase the risk of side effects. It's important to follow the dosage instructions provided by your doctor to ensure safe and effective use of the medication.

It is generally not recommended to breastfeed while taking XL-90 Plus Cough Syrup . XL-90 Plus Cough Syrup contains chlorpheniramine, an antihistamine, which can pass into the breast milk and may harm the baby. Therefore, inform your doctor that you are breastfeeding if you are advised to take this medicine.

Shake the bottle well before use. Take the prescribed dose by mouth using the measuring cup/dosing syringe/dropper provided by the pack. Follow your doctor’s instructions regarding dosage and duration.

Yes XL-90 Plus Cough Syrup causes some side effects such as dry mouth, throat or nose, drowsiness, dizziness, blurred vision, headache, constipation, restlessness or excitation, and loss of appetite. If any of these side effects persist or worsen, please consult your doctor.

Yes, inform your doctor if your child has conditions like glaucoma, urinary retention, phenylketonuria (a birth defect that causes accumulation of amino acid, phenylalanine in the body), cough with mucus or cough caused by asthma, and chronic bronchitis or emphysema (a lung condition causing shortness of breath).

No, XL-90 Plus Cough Syrup interacts with other medications, including, MOIs (monoamine oxidase inhibitors), antidepressants, sedatives or tranquillizers, and alcohol. Therefore, you should inform your doctor about all the medicines, supplements, and herbal products they are currently taking before starting XL-90 Plus Cough Syrup .

Store XL-90 Plus Cough Syrup at room temperature in a cool and dry place away from sunlight. Do not freeze. Keep it out of reach of children.

Country of origin

India

Manufacturer/Marketer address

Dalamal House, 4Th Floor, J. B. Road, Nariman Point, Mumbai, 400 021
Other Info - XL90003

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Sep 16, 2025 | 1:02 PM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.drugs.com/mtm/chlorpheniramine-dextromethorphan-and-phenylephrine.html#:~:text=Chlorpheniramine%20is%20an%20antihistamine.,common%20cold%2C%20or%20the%20flu.
  2. https://www.drugs.com/mtm/chlorpheniramine-and-dextromethorphan.html
  3. https://www.nhs.uk/medicines/chlorphenamine-including-piriton/
  4. https://www.medicines.org.uk/emc/files/pil.11927.pdf

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