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compositionComposition:MIDODRINE-2.5MG
prescription
Prescription Medicine
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XIDORIN 2.5MG TAB is used to treat orthostatic hypotension (sudden lowering in blood pressure on standing). It contains midodrine, which works by tightening the blood vessels, thereby increasing blood pressure. In some cases, this medicine may cause side effects such as headache, nausea, heartburn, and pain during urination. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

MIDODRINE-2.5MG

Manufacturer/Marketer :

Sigmund Promedica

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About XIDORIN 2.5MG TAB

XIDORIN 2.5MG TAB is a prescription medication used to treat severe low blood pressure that causes dizziness or lightheadedness when you stand up. This medical condition, known as symptomatic orthostatic hypotension, occurs when your body cannot maintain normal blood pressure during position changes. By helping to raise your standing blood pressure, this medication relieves these symptoms and helps you perform daily activities more comfortably.

You should take XIDORIN 2.5MG TAB consistently during your daytime hours when you are upright and active. Because of how this medication affects your blood pressure, you must never take it right before bedtime or before lying down for long periods. It can be taken with or without food. Combining this treatment with lifestyle adjustments, such as wearing compression stockings and staying well-hydrated, can help you get the best results.

While taking XIDORIN 2.5MG TAB, you may experience mild and temporary side effects like goosebumps, shivering, or an itchy scalp. However, you must monitor your health closely and contact your doctor immediately if you experience signs of high blood pressure while lying down, such as a severe headache, blurred vision, or pounding in your ears. Your doctor will help you manage these symptoms safely.

Do not take this if you have severe heart disease, acute kidney disease, urinary retention, or persistent high blood pressure while lying down. Before starting this medication, it is vital to tell your doctor if you have diabetes, thyroid issues, or a history of kidney or liver problems. Your doctor will evaluate your health history to ensure this medication is safe for you.

This medication can interact with other prescription medicines, especially those used to treat high blood pressure, thyroid disorders, or heart rate problems. You should avoid drinking alcohol while taking this medicine, as it can cause sudden drops in blood pressure and worsen dizziness. If you are pregnant, breastfeeding, or are an older adult, talk to your doctor or pharmacist to discuss the risks and benefits before starting treatment.

Uses of XIDORIN 2.5MG TAB

XIDORIN 2.5MG TAB is used to treat severe low blood pressure that causes dizziness or lightheadedness when you stand up. The detailed uses of XIDORIN 2.5MG TAB are as follows:

  • Orthostatic hypotension: XIDORIN 2.5MG TAB helps raise low blood pressure that occurs when standing up from a sitting or lying position, reducing symptoms like dizziness, lightheadedness, and fainting.

Key Benefits

XIDORIN 2.5MG TAB helps manage symptoms of low blood pressure on standing by improving blood pressure stability and reducing dizziness. With regular use, it helps improve physical stability, supports everyday activities, and enhances overall quality of life.

  • Reduces Dizziness on Standing: By helping stabilise blood pressure when you stand up, this medicine reduces dizziness and light-headedness, making it easier to change positions comfortably.
  • Lowers the Risk of Fainting: This medicine helps reduce the likelihood of fainting episodes, improving safety and confidence during daily activities.
  • Supports Independence and Mobility: By improving standing tolerance and physical stability, this medicine helps you perform routine tasks and move around with greater comfort and confidence.

Directions for Use

  • XIDORIN 2.5MG TAB can be taken with meals.
  • It is usually taken 2-3 times daily during the daytime, with each dose taken 3 hours apart, or as prescribed by your doctor.
  • Swallow XIDORIN 2.5MG TAB as a whole with a glass of water.
  • Do not crush, chew, or break it.

How XIDORIN 2.5MG TAB Works

XIDORIN 2.5MG TAB contains midodrine, which works by targeting specific proteins on your blood vessels called alpha-1 receptors. When these receptors are activated, they cause the blood vessels (both arteries and veins) to constrict or narrow. This narrowing increases pressure within your circulatory system, preventing blood from pooling in your legs and lower body when you stand. As a result, more blood flows back to your heart and brain, keeping your blood pressure stable when you change positions.
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Alcohol

Unsafe

Consuming alcohol along with XIDORIN 2.5MG TAB is not advisable as it may cause unpleasant side effects.

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Pregnancy

Consult your doctor

Please consult the doctor. There are no adequate and well-controlled studies on pregnant women.

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Breast Feeding

Consult your doctor

Consult your doctor, and there is no substantial research yet on the use of XIDORIN 2.5MG TAB in breastfeeding/nursing mothers.

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Driving

Unsafe

If you feel dizzy or lightheaded while taking XIDORIN 2.5MG TAB, avoid driving or using machines.

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Liver

Consult your doctor

Limited information is available on the use of XIDORIN 2.5MG TAB in patients with liver disease. Please consult your doctor.

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Kidney

Consult your doctor

Limited information is available on the use of XIDORIN 2.5MG TAB in patients with Kidney disease. Please consult your doctor.

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Children

Unsafe

XIDORIN 2.5MG TAB is not recommended for children below 18 years of age.

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Heart

Unsafe

XIDORIN 2.5MG TAB is contraindicated in patients with heart conditions. Please seek medical advice before using this medicine.

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Geriatrics

Caution

XIDORIN 2.5MG TAB should be given to elderly patients only if prescribed by a doctor. If you have any concerns about using XIDORIN 2.5MG TAB in geriatrics, please consult your doctor.

What if I have taken an overdose of XIDORIN 2.5MG TAB

If you take more than your prescribed dose, seek immediate emergency medical attention. Symptoms of an overdose may include severe high blood pressure, a very slow heart rate, intense goosebumps, and difficulty urinating.

Diet & Lifestyle Advise

  • Drink plenty of fluids, such as water or electrolyte-rich drinks, throughout the day to help maintain your blood volume.
  • Increase your dietary salt intake, but only if explicitly recommended and guided by your doctor.
  • Wear medical-grade compression stockings to help prevent blood from pooling in your legs.
  • Elevate the head of your bed by 10 to 15 degrees using bed risers to help prevent high blood pressure while you sleep.
  • Get out of bed or stand up from a chair very slowly, pausing for a moment before moving to prevent sudden dizziness.
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How Soon It Starts Working

  • The time required for XIDORIN 2.5MG TAB to start to work: The time required for XIDORIN 2.5MG TAB to show its action is unknown.
  • The time for which the effects of XIDORIN 2.5MG TAB last: XIDORIN 2.5MG TAB effect lasts for 24 hours.

What if you forget to take XIDORIN 2.5MG TAB

If you miss a dose, take it as soon as you remember, provided you will be upright and active for several hours. If it is within 4 hours of your bedtime or if you plan to lie down, skip the missed dose and resume your regular schedule the next day. Do not take a double dose to make up for a missed one.

Storage

•Store XIDORIN 2.5MG TAB tablets at a controlled room temperature between 20°C to 25°C (68°F to 77°F). •Keep the medication in its original container, tightly closed, and stored in a dry place away from direct light and moisture.

Drug Warnings

  • Never take a dose of XIDORIN 2.5MG TAB if you plan to lie down, rest, or nap shortly afterwards.
  • Always take your final dose of the day at least 4 hours before bedtime to avoid dangerously high blood pressure while sleeping.
  • Check your blood pressure regularly both while standing up and while lying down, and keep a log for your doctor.
  • Stop taking the medication and contact your doctor immediately if your resting heart rate drops below 60 beats per minute or if you feel your heart pounding.
  • Avoid strenuous physical exercise in hot environments, as this can worsen low blood pressure.

Drug-Drug Interactions

verifiedApollotooltip
  • Beta-blockers or digitalis: Taking these together with XIDORIN 2.5MG TAB may cause your heart rate to slow down to an unsafe level.
  • Other blood pressure-raising medications: Decongestants, thyroid hormones, or certain antidepressants may cause dangerously high blood pressure when combined with this medication.
  • Steroids: May increase blood pressure further and lead to excessive fluid retention.
MidodrineDihydroergotamine
Critical
MidodrineDoxapram
Severe

Drug-Drug Interactions

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MidodrineDihydroergotamine
Critical
How does the drug interact with Xidorin 2.5mg Tab,:
Coadministration of Dihydroergotamine with Xidorin 2.5mg Tab, can increase the risk or severity of high blood pressure.

How to manage the interaction:
Taking Dihydroergotamine with Xidorin 2.5mg Tab, together is generally avoided as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you notice any of these symptoms like headaches, abdominal pain, nausea, vomiting, numbness or tingling, muscle pain or weakness, blue or purple discolouration of fingers or toes, pale or cold skin, chest pain or tightness, severe or throbbing headache, irregular heartbeat, shortness of breath, blurred vision, eye redness, confusion, or slurred speech, consult a doctor right away. Do not discontinue any medications without consulting a doctor.
MidodrineDoxapram
Severe
How does the drug interact with Xidorin 2.5mg Tab,:
Coadministration of Xidorin 2.5mg Tab, with doxapram can increase effect of Doxapram.

How to manage the interaction:
Taking Doxapram with Xidorin 2.5mg Tab, together can result in an interaction, but it can be taken if a doctor has advised it. Do not stop using any medications without talking to a doctor.
MidodrineMethysergide
Severe
How does the drug interact with Xidorin 2.5mg Tab,:
Using methysergide maleate together with Xidorin 2.5mg Tab, may cause significant increases in blood pressure.

How to manage the interaction:
Co-administration of Xidorin 2.5mg Tab, with Methysergide can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience abdominal pain, nausea, vomiting, numbness or tingling, muscle pain or weakness, blue or purple discolouration of fingers or toes, pale or cold skin, chest pain or tightness, severe or throbbing headache, irregular heartbeat, shortness of breath, blurred vision, confusion, and/or slurred speech, contact a doctor immediately. Do not discontinue any medications without first consulting a doctor.
MidodrineLinezolid
Severe
How does the drug interact with Xidorin 2.5mg Tab,:
Taking Xidorin 2.5mg Tab, along with linezolid could increase the risk or severity of high blood pressure.

How to manage the interaction:
Although taking linezolid with Xidorin 2.5mg Tab, together can result in an interaction, they can be taken if a doctor has prescribed it. However, if you experience abdominal pain, nausea, vomiting, numbness or tingling, muscle pain or weakness, blue or purple discoloration of fingers or toes, pale or cold skin, chest pain or tightness, severe or throbbing headache, irregular heartbeat, shortness of breath, blurred vision, confusion, and/or slurred speech, contact a doctor immediately. Do not discontinue any medication without consulting a doctor.
MidodrineErgotamine
Severe
How does the drug interact with Xidorin 2.5mg Tab,:
Using ergotamine together with Xidorin 2.5mg Tab, can increase the risk or severity of high blood pressure.

How to manage the interaction:
There may be a possibility of interaction between Xidorin 2.5mg Tab, and Ergotamine, but it can be taken if prescribed by a doctor. If you're having any of these symptoms like abdominal pain, nausea, vomiting, numbness or tingling, muscle pain or weakness, blue or purple discolouration of fingers or toes, pale or cold skin, chest pain or tightness, severe or throbbing headache, irregular heartbeat, shortness of breath, blurred vision, confusion, and/or slurred speech, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
MidodrineIobenguane (131i)
Severe
How does the drug interact with Xidorin 2.5mg Tab,:
Coadministration of Xidorin 2.5mg Tab, with Iobenguane can cause a decrease in the absorption of Iobenguane resulting in a low treatment outcomes.

How to manage the interaction:
Co-administration of Xidorin 2.5mg Tab, with Iobenguane (131i) can possibly result in an interaction, but it can be taken if your doctor has advised it. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip

No clinically significant food interactions are known with XIDORIN 2.5MG TAB when used as directed. 

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Therapeutic Class

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FAQs

XIDORIN 2.5MG TAB is used to treat idiopathic postural hypotension or hypotension (low blood pressure)
XIDORIN 2.5MG TAB contains the active ingredient midodrine hydrochloride, which acts on the blood vessels via the sympathetic nervous system to correct imbalances of blood distribution. This should help relieve the symptoms you might suffer, such as dizziness, fainting, blurred vision, and weakness when sitting or standing up.
Do not stop taking XIDORIN 2.5MG TAB on your own. Depending on your medical condition, you are advised to take XIDORIN 2.5MG TAB for as long as your doctor has prescribed it for you. Do not hesitate to speak with your doctor if you experience difficulty while taking XIDORIN 2.5MG TAB.
XIDORIN 2.5MG TAB is contraindicated in patients with severe organic heart disease, congestive heart failure, thyrotoxicosis, phaeochromocytoma, acute renal disease, severe renal insufficiency, urinary retention, narrow-angle glaucoma, hyperthyroidism, known hypersensitivity to any component of the product. And also, Patients with a history of CVA should be monitored closely.
XIDORIN 2.5MG TAB is metabolised to desglymidodrine, an active metabolite that activates alpha-1-adrenergic receptors on arterioles and venules, causing smooth muscle contraction and blood pressure increase. Midodrine may cause a drop in heart rate due to the vagal reflex.
The side effects of XIDORIN 2.5MG TAB include nausea, vomiting, indigestion, supine hypertension (high blood pressure while lying down), and dysuria (painful or uncomfortable urination). If these side effects persist or worsen, please consult your doctor.
Yes, XIDORIN 2.5MG TAB may cause high blood pressure when you are lying flat on your back (supine hypertension). XIDORIN 2.5MG TAB should only be used by people whose low blood pressure affects their daily activities and in people who could not be treated successfully with other therapies.
You are advised not to lie down immediately after taking XIDORIN 2.5MG TAB due to the risk of supine hypertension (high blood pressure when you are lying flat on your back). Therefore, it is recommended to take the final dose of the day at least 4 hours before bedtime. By elevating the head, you can reduce the risk of supine hypertension during the night.
XIDORIN 2.5MG TAB may take about 1 hour to show its effects. Though the effect lasts for about 2-3 hours, the action lasts for a short time only.
Take XIDORIN 2.5MG TAB exactly as advised by your doctor. It is taken orally with or without food. Swallow it as a whole with a glass of water. Do not break, crush or chew it.
XIDORIN 2.5MG TAB is not recommended for patients who are allergic to any of its components, who have unusually slow heart rate, severe heart disease, high blood pressure, conditions causing tightening of the arteries, urinary retention (when the bladder cannot empty properly), overactive thyroid, enlarged prostate gland, pheochromocytoma (tumour of the adrenal medulla), acute or severe kidney disease, poor vision as a result of diabetes and narrow-angle glaucoma (elevated pressure in the eye).
Before starting XIDORIN 2.5MG TAB, you may need to get your liver and kidney function tests done and check your blood pressure. After starting the treatment, keep a constant track of your heart rate and blood pressure, especially after lying down.
Symptoms of supine hypertension include shortness of breath, chest pain, palpitations (abnormalities of heartbeat), blurred vision, and headache. If you develop these symptoms, consult your doctor immediately. The doctor may lower the dose of XIDORIN 2.5MG TAB or discontinue treatment if the symptoms persists.
You should be cautious while using XIDORIN 2.5MG TAB and metoprolol together as it can decrease your heart rate significantly. If you experience dizziness, fainting and slow pulse, inform your doctor as the dose of these medicines may need to be adjusted. However, please consult your doctor before using other medicines with XIDORIN 2.5MG TAB.
No, you must not take this medication before bedtime. Taking it within 4 hours of lying down can cause dangerously high blood pressure. Talk to your doctor or pharmacist if you need help scheduling your doses.
You should avoid alcohol while taking this medicine. Alcohol can cause your blood vessels to widen, which may cause your blood pressure to drop suddenly and make your dizziness worse. Talk to your doctor for personalised advice.
Yes, you can take this medication with or without food. However, taking it the same way each day helps keep the level of medicine in your body consistent. Talk to your doctor or pharmacist if you experience stomach upset.
The safety of this medication during pregnancy is not fully established. It should only be used if the benefits outweigh the risks to the unborn baby. Talk to your doctor if you are pregnant or planning to become pregnant.

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Reference

  1. National Health Service (NHS). Midodrine Information Leaflet - NHS Medicines Reference Guide. London, UK: NHS; 2025. [Accessed on 02 Jun. 2026]Check here
  2. Electronic Medicines Compendium (EMC). Product Summary of Product Characteristics (SmPC). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  3. Electronic Medicines Compendium (EMC). Pil.12496 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  4. Drugs.com Clinical Review Team. Midodrine Drug Interactions Reference. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  5. Midodrine hydrochloride [Product Information]. 2023. [Accessed on 05 Mar. 2025]Check here
  6. Midodrine Hydrochloride [Product Information]. 2024. [Accessed on 05 Mar. 2025]Check here
  7. Midodrine 2.5 Tablets - Patient Information Leaflet (PIL) - (emc) [Internet]. Medicines.org.uk. 2025 [Accessed on 13 June 2025]Check here

Country of origin

India

Manufacturer/Marketer address

Karl Marx Rd, Moghalrajpuram, Sitharamapuram, Vijayawada, Andhra Pradesh 520002
Other Info - XID0002
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