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compositionComposition:PREDNISOLONE-20MG
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Prescription Medicine
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Wysolone DT 20 Tablet is used to treat various medical conditions, including allergies, endocrine problems, rheumatic disorders, collagen diseases, dermatological diseases, ophthalmic diseases, respiratory diseases, hematologic diseases, neoplastic diseases, gastrointestinal diseases, hepatic diseases, and nervous system conditions. It contains Prednisolone, which reduces redness and swelling and changes the way the immune system works. In some cases, you may experience side effects such as fluid retention, alteration in glucose tolerance, elevation in blood pressure, behavioural and mood changes, increased appetite and weight gain. Before starting this medicine, inform the doctor if you are pregnant, breastfeeding, taking other medicines or have pre-existing medical conditions.

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Written By ,
Reviewed By Santoshini Reddy G , M Pharmacy
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More about the Product

Composition :

PREDNISOLONE-20MG

Manufacturer/Marketer :

Pfizer Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

NPPA :

Regulated

About Wysolone DT 20 Tablet

Wysolone DT 20 Tablet is a prescription steroid medicine used to treat a wide variety of inflammatory and allergic conditions. It helps manage severe issues such as asthma flare-ups, intense allergic reactions, skin disorders, and arthritis by reducing swelling and calming an overactive immune system. This medicine is designed as a disintegrating tablet that dissolves quickly in your mouth.

Your doctor will guide you on how often to take Wysolone DT 20 Tablet , and it is highly important to take it consistently at the same time each day, usually in the morning. Taking this medicine with food or a glass of milk can help prevent stomach irritation. To support your body during treatment, your doctor may suggest some diet and lifestyle adjustments, such as reducing your daily salt intake and eating more potassium-rich foods.

While Wysolone DT 20 Tablet is highly effective, it can cause common side effects such as an increased appetite, trouble sleeping, or mild mood shifts. If you experience severe side effects, such as changes in your vision, signs of an infection, or severe stomach pain, you must contact your doctor right away.

Do not take this if you have a widespread fungal infection or an untreated serious infection. Before you start taking this medicine, talk to your doctor if you have a history of diabetes, high blood pressure, stomach ulcers, or bone thinning (osteoporosis).

Some medicines, alcohol, and smoking can interact with Wysolone DT 20 Tablet , which can increase your risk of stomach bleeding or reduce how well your treatment works. If you are pregnant, breastfeeding, or an older adult, talk to your doctor or pharmacist to make sure this medicine is safe for your specific situation.

Uses of Wysolone DT 20 Tablet

Wysolone DT 20 Tablet is used in the treatment of various conditions. The detailed uses of Wysolone DT 20 Tablet are as follows:

  • Severe allergic reactions: Helps quickly reduce swelling, redness, and severe itching during acute allergic flare-ups.
  • Asthma and breathing disorders: Calms inflammation in the airways, making it easier for you to breathe during severe respiratory flares.
  • Arthritis and joint inflammation: Relieves painful swelling, heat, and stiffness in your joints to improve your mobility.
  • Severe skin conditions: Eases intense inflammation and skin shedding caused by conditions like eczema or severe psoriasis.
  • Inflammatory bowel diseases: Lowers painful swelling in your digestive tract during active flare-ups of conditions like Crohn's disease or ulcerative colitis.

Key Benefits

  • Helps reduce inflammation: This medicine calms excessive inflammatory and immune responses, helping relieve swelling, discomfort, and other related symptoms.
  • Improves daily comfort: By reducing inflammation and irritation, it can make everyday activities more comfortable during a flare-up.
  • No water required: The disintegrating tablet dissolves quickly on the tongue, which can be convenient for people who have difficulty swallowing regular tablets or do not have water available.
  • Rapid symptom relief: By reducing the body's inflammatory response, it may help relieve uncomfortable symptoms such as breathing difficulty, skin rashes, or allergic flare-ups.
Side effects of Wysolone DT 20 Tablet
  • Avoid diet rich in salt and carbohydrates
  • Drink plenty of water and stay hydrated.
  • Exercise regularly and maintain a healthy lifestyle.
  • Take potassium rich foods like potatoes, spinach, tomatoes, sea food and dairy products.
  • Take beverages containing caffeine like coffee and tea.
  • Consult your doctor if you experience severe symptoms like high blood sugar, increased thirst, urination, or blurred vision to check if your medication is the cause.
  • Your doctor may adjust your medications to reduce the risk of impaired blood sugar regulation.
  • Eat a balanced diet rich in whole foods like fruits, vegetables, whole grains, and lean proteins.
  • Protein and healthy fats, such as avocado, almonds, and seeds, can help manage blood sugar levels.
  • Limit added sugars from sugary drinks, baked goods, and candy.
  • To maintain your blood sugar levels within a healthy range, check them frequently.
  • Eat a balanced diet containing enough proteins, fibre, healthy fats, vegetables and fruits.
  • Get quality sleep for about 7-9 hours.
  • Try to manage stress with meditation or yoga.
  • Drink enough water.
  • Exercise regularly as it helps regulate appetite.
  • Exercising regularly helps lower the risk of heart problems.
  • Maintain a healthy diet, including vegetables and fruits.
  • Rest well; get enough sleep.
  • Manage stress with yoga and meditation.
  • Limit alcohol and smoking.

Directions for Use

  • Wysolone DT 20 Tablet can be taken with food or milk to prevent gastric irritation.
  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Disperse the tablet in the prescribed amount of water and consume the mixture orally.
  • Do not crush, break, or chew it.

How Wysolone DT 20 Tablet Works

Wysolone DT 20 Tablet is a corticosteroid that works by reducing excessive inflammation and calming an overactive immune response. After the medicine is absorbed, it acts inside cells to reduce the production of substances that cause swelling, redness, and pain. This helps calm inflamed tissues and relieve symptoms caused by allergic or inflammatory conditions.
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Alcohol

Caution

You are recommended not to consume alcohol along with Wysolone DT 20 Tablet to avoid unpleasant side-effects like excessive dizziness.

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Pregnancy

Caution

Please consult the doctor if you are pregnant. Your doctor will weigh the benefits and any potential risks before prescribing it to you.

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Breast Feeding

Caution

Wysolone DT 20 Tablet should be used during breastfeeding only after a careful assessment of the benefit-risk ratio to the mother and infant. Consult your doctor if you are breastfeeding.

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Driving

Caution

Wysolone DT 20 Tablet may cause dizziness and visual disturbances. Drive only if you are alert.

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Liver

Consult your doctor

Please consult the doctor if you have liver impairment or any concerns regarding this.

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Kidney

Caution

Wysolone DT 20 Tablet to be taken with caution, especially if you have a history of Kidney diseases/conditions. The dose may have to be adjusted by your doctor.

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Children

Caution

Please consult the doctor if you have any concerns regarding the usage of Wysolone DT 20 Tablet in children. The doctor may adjust the dose based on the child's condition.

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Heart

Caution

Please inform your doctor before taking Wysolone DT 20 Tablet if you have heart problems, as there is limited information available on its safety in such conditions.

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Geriatrics

Caution

Wysolone DT 20 Tablet can be taken by geriatric patients, but with caution and medical supervision.

What if I have taken an overdose of Wysolone DT 20 Tablet

If you take too much of this medicine, seek immediate medical attention or contact a poison control center. While a single accidental extra dose is unlikely to cause severe harm, a large overdose can be dangerous and requires professional medical evaluation.

Diet & Lifestyle Advise

  • Limit your salt intake: This medicine can cause your body to retain extra sodium and water, which can lead to swelling and higher blood pressure. Avoid adding extra salt to your meals and limit highly processed foods.
  • Eat potassium-rich foods: Treatment can cause your body to lose potassium. Focus on incorporating natural sources of potassium into your daily meals, such as bananas, spinach, avocados, sweet potatoes, and white beans.
  • Protect your bone health: Steroid medications can weaken your bones over time. Support your bones by consuming enough calcium and vitamin D through dairy products, leafy green vegetables, or daily supplements if recommended by your doctor.
  • Monitor your blood sugar: Since this medicine can raise blood glucose levels, keep a close watch on your sugar levels, especially if you have diabetes or prediabetes. Talk to your doctor if you notice persistent high readings.

Health Queries

Why are my painful, burning mouth patches returning just two weeks after completing a 7-day course of Wysolone DT 20 mg that had almost completely cleared them, and what should my next steps be?

Vikas Singh

Vikas Singh

M Pharmacy

I am so sorry you are experiencing this painful return. Wysolone (prednisolone) is a powerful steroid that reduces inflammation quickly. However, a short 7-day course sometimes only temporarily suppresses the symptoms. When stopped, the inflammation can rebound, causing the patches to return. Please be reassured that this is a common reaction. Your best next step is to consult your doctor or a dentist. They can evaluate the exact cause of these patches and may recommend a safer, localized treatment like a steroid gel, or a longer, gradually tapered dose of oral medication to help you heal completely.

Is it safe or harmful for my father to get the COVID-19 vaccine immediately while taking 20mg of Wysolone daily for his kidney condition, instead of waiting a month as his doctor recommended?

G.santoshini Reddy

G.santoshini Reddy

M Pharmacy (Pharmaceutics)

It is safest and most effective to follow his doctor?s advice to wait. Wysolone (prednisolone) is a steroid that can temporarily lower his immune system's strength. If he gets the COVID-19 vaccine right now, his body may not build a strong defense, making the vaccine much less effective. Waiting the recommended month allows his body to better respond to the vaccine for maximum protection. Please continue to consult his doctor before scheduling the shot to ensure his kidney condition remains stable and he gets the best possible protection.

I have had polymyositis since 2010. My doctor recently increased my daily dosage to 20 mg of Wysolone and two tablets of Mofilet because of new upper limb weakness, suspecting a relapse. How can I confirm if this is a true relapse of polymyositis or just temporary weakness?

Vikas Singh

Vikas Singh

M Pharmacy

To confirm whether this is a true polymyositis relapse or temporary weakness, your doctor will typically recommend the following investigations: Blood Tests: Measuring muscle enzymes like Creatine Kinase (CK) and aldolase. Elevated levels usually indicate active muscle inflammation. Muscle MRI: An MRI of your upper limbs can detect active muscle inflammation (oedema) and help distinguish a relapse from other causes. Electromyography (EMG): This measures electrical activity in the muscles to check for active myopathy It is also crucial to differentiate a relapse from steroid-induced muscle weakness (a side effect of Wysolone), which typically presents with normal CK levels. Please consult your rheumatologist to schedule these diagnostic tests.

I have been dealing with eosinophilia and want a long-term solution. Is there any way to control it permanently?

Vikas Singh

Vikas Singh

M Pharmacy

Eosinophilia usually results from an underlying cause, such as allergy, infection, or irritation, so long-term control depends on identifying and managing that cause rather than on a single permanent cure. Avoid common triggers like dust, smoke, and animal allergens, keep your surroundings clean, and follow a healthy routine to reduce flare-ups. Your doctor may advise treatment based on the cause, such as allergy control or treatment for any infection present. Regular follow-up and tests are important to keep it under control and prevent it from coming back.
health query

Have a query?

How Soon It Starts Working

The time required for Wysolone DT 20 Tablet to start to work: The time required for Wysolone DT 20 Tablet to show its action is not clinically established. The time for which the effects of Wysolone DT 20 Tablet last: The duration of action for Wysolone DT 20 Tablet is not clinically established.

What if you forget to take Wysolone DT 20 Tablet

If you miss a dose of Wysolone DT 20 Tablet , take it as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose and resume your regular schedule. Do not take two doses at the same time to make up for a missed one. Talk to your doctor or pharmacist if you are unsure of what to do.

Storage

• Store Wysolone DT 20 Tablet disintegrating tablets at room temperature, ideally between 20°C to 25°C (68°F to 77°F).

Drug Warnings

  • Always ensure your hands are completely dry before touching the disintegrating tablet to prevent it from melting in your hand.
  • Gently peel the foil backing away from the blister pack instead of pushing the tablet through, which can easily crush or damage the medicine.
  • Do not stop taking this medicine suddenly if you have been on it for more than a couple of weeks. Your doctor will help you by gradually lowering your dose to prevent fatigue, dizziness, and other withdrawal symptoms.
  • Avoid close contact with anyone who has an active contagious illness, such as chickenpox, shingles, or measles, as this medicine lowers your body's ability to fight off infections.
  • Inform all your healthcare professionals, including your dentist and surgeons, that you are taking this steroid medicine before undergoing any medical procedures or receiving any vaccinations.

Drug-Drug Interactions

verifiedApollotooltip
  • Pain relievers (NSAIDs): Taking medicines like ibuprofen or naproxen with Wysolone DT 20 Tablet can significantly increase your risk of stomach irritation, ulcers, and bleeding.
  • Blood thinners: Combining this medicine with blood thinners like warfarin can alter their effects and increase your risk of bleeding.
  • Diabetes medications: This medicine can raise your blood sugar, which may reduce the effectiveness of insulin or oral diabetes drugs.
  • Live vaccines: Receiving a live vaccine while your immune system is suppressed by this medicine can increase the risk of vaccine-related infections or reduce the vaccine's effectiveness.
PrednisoloneIohexol
Critical
PrednisoloneBCG vaccine
Critical

Drug-Drug Interactions

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PrednisoloneIohexol
Critical
How does the drug interact with Wysolone DT 20 Tablet:
Co-administration of Iohexol and Wysolone DT 20 Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Wysolone DT 20 Tablet with Iohexol is not generally advised as they can lead to an interaction, they can be taken if prescribed by the doctor. Do not discontinue the medications without consulting a doctor.
PrednisoloneBCG vaccine
Critical
How does the drug interact with Wysolone DT 20 Tablet:
When BCG vaccine is used with Wysolone DT 20 Tablet, its effectiveness may be reduced.

How to manage the interaction:
Taking Wysolone DT 20 Tablet with BCG vaccine is not generally advised, but they can be taken if prescribed by the doctor. Do not discontinue any medications without a doctor's advice.
PrednisoloneMifepristone
Critical
How does the drug interact with Wysolone DT 20 Tablet:
When Mifepristone is taken with Wysolone DT 20 Tablet, the effects of Wysolone DT 20 Tablet might be considerably reduced, which may be less effective in treating your condition.

How to manage the interaction:
Taking Wysolone DT 20 Tablet with Mifepristone is not recommended, they can be taken together if advised by a doctor. Do not discontinue the medication without consulting a doctor.
PrednisoloneDesmopressin
Critical
How does the drug interact with Wysolone DT 20 Tablet:
Co-administration of Wysolone DT 20 Tablet and Desmopressin may increase the risk of hyponatremia (low levels of sodium in the blood).

How to manage the interaction:
Taking Wysolone DT 20 Tablet with Desmopressin is not generally advised as they lead to an interaction, they can be taken together if advised by a doctor. However, if you experience loss of appetite, headache, nausea, vomiting, lethargy (very tired), irritability, difficulty concentrating, weakness, unsteadiness, memory impairment, confusion, muscle spasm, decreased urination, and/or sudden weight gain, contact a doctor immediately. Do not discontinue the medication without consulting a doctor.
PrednisoloneCladribine
Severe
How does the drug interact with Wysolone DT 20 Tablet:
Co-administration of Cladribine with Wysolone DT 20 Tablet may increase the risk of serious infections.

How to manage the interaction:
Although taking Cladribine with Wysolone DT 20 Tablet together can result in an interaction, it can be taken if your doctor has prescribed it. However, consult a doctor immediately if you experience fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in the coughing fluid, weight loss, red or irritated skin, body sores, or discomfort or burning while urinating. Do not stop using any medications without a doctor's advice.
PrednisoloneEnoxacin
Severe
How does the drug interact with Wysolone DT 20 Tablet:
Co-administration of Enoxacin with Prednislome may cause tendinitis (inflammation of a tissue that attaches muscle to bone) and tendon rupture, and the risk may be increased when combined with Wysolone DT 20 Tablet.

How to manage the interaction:
Although there is an interaction, Wysolone DT 20 Tablet can be taken with Enoxacin if prescribed by the doctor. However, if you experience pain, inflammation, or swelling of a tendon area such as the back of the ankle, biceps, shoulder, hand, or thumb, stop taking enoxacin and consult your doctor. Additionally, you need to avoid exercising or using the impacted area until a doctor issues further instructions. Do not stop using any medications without a doctor's advice.
PrednisoloneDeferasirox
Severe
How does the drug interact with Wysolone DT 20 Tablet:
Co-administration of Deferasirox with Wysolone DT 20 Tablet can increase the risk of gastrointestinal ulcers and bleeding.

How to manage the interaction:
Although taking Deferasirox with Wysolone DT 20 Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience stomach pain, bloating, dizziness, lightheadedness, loss of appetite, nausea, vomiting (especially with fresh or dried blood that looks like coffee grounds), and red or black, tarry stools, you should consult a doctor immediately. Do not stop using any medications without a doctor's advice.
PrednisoloneBempedoic acid
Severe
How does the drug interact with Wysolone DT 20 Tablet:
Co-administration of Bempedoic acid and Wysolone DT 20 Tablet can increase the risk of tissue injury near muscles and joints.

How to manage the interaction:
Although there is an interaction, Bempedoic acid can be taken with Wysolone DT 20 Tablet if prescribed by the doctor. However, if you experience pain, swelling, or inflammation of a tendon area such as the back of the ankle, shoulder, or biceps, stop taking bempedoic acid and consult a doctor. Exercise and using the impacted area should both be avoided. Do not discontinue any medications without a doctor's advice.
PrednisoloneGolimumab
Severe
How does the drug interact with Wysolone DT 20 Tablet:
Co-administration of Golimumab with Wysolone DT 20 Tablet could increase the risk of severe infections.

How to manage the interaction:
Although taking Golimumab with Wysolone DT 20 Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. However, consult a doctor immediately if you experience fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in the coughing fluid, weight loss, red or irritated skin, body sores, or discomfort or burning when urinating. Do not stop using any medications without a doctor's advice.
PrednisoloneGrepafloxacin
Severe
How does the drug interact with Wysolone DT 20 Tablet:
Co-administration of Grepafloxacin may cause tendinitis (inflammation of a tissue that attaches muscle to bone) and tendon rupture, and the risk may be increased when combined with Wysolone DT 20 Tablet.

How to manage the interaction:
Although there is an interaction, Wysolone DT 20 Tablet can be taken with Grepafloxacin if prescribed by the doctor. However, if you experience pain, inflammation, or swelling of a tendon area such as the back of the ankle, biceps, shoulder, hand, or thumb, stop taking grepafloxacin and consult a doctor. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
  • Grapefruit juice: Drinking grapefruit juice can increase the levels of this medicine in your body, which may raise your risk of experiencing side effects.
  • Alcohol: Consuming alcohol while taking this medicine can increase stomach irritation and elevate your risk of developing stomach ulcers.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[CORTICOSTEROIDS]

FAQs

Wysolone DT 20 Tablet is used to treat various medical conditions such as endocrine disorders, rheumatic disorders, collagen diseases, allergy, dermatological diseases, ophthalmic diseases, respiratory diseases, hematologic diseases, neoplastic diseases, gastrointestinal diseases, edematous states, hepatic diseases, nervous system conditions and in the prevention of organ rejection.
Wysolone DT 20 Tablet contains Prednisolone, which works by reducing redness and swelling. It also suppresses the immune system, which may aid in autoimmune disorders such as rheumatoid arthritis, where the immune system incorrectly attacks its own tissues.
Your symptoms may improve before the problem is completely cured. However, completing the full course of treatment is recommended, even if you feel better.
Receiving live or live-attenuated vaccines is not recommended in patients taking immunosuppressive doses of corticosteroids.
Yes, Wysolone DT 20 Tablet is known to cause an upset stomach. So, take Wysolone DT 20 Tablet with a meal to avoid an upset stomach.
No, it is a prescribed drug given by a physician to prevent specific medical conditions. Taking it on your own can cause unwanted side effects.
The medicine begins to dissolve and absorb into your bloodstream quickly, often bringing noticeable relief to severe inflammation or allergic symptoms within a few hours. However, it may take a few days of consistent use to achieve the full therapeutic effect. Talk to your doctor if your symptoms do not begin to improve.
No, you do not need water. This disintegrating tablet is specially formulated to melt rapidly on your tongue so you can swallow it easily. You may drink a glass of water afterward if you prefer, but it is not required. Talk to your pharmacist if you have questions about handling the tablet.
Yes, difficulty sleeping is a common side effect of steroid medicines because they can act as a mild stimulant. Taking your dose early in the morning rather than late in the evening can help reduce this effect. Talk to your doctor if sleep issues continue to affect you.
Yes, this medicine can raise your blood sugar level by changing how your body processes carbohydrates. If you have diabetes, you will need to monitor your blood glucose levels more frequently while taking this medicine. Talk to your doctor about how to adjust your diabetes management plan if needed.
Taking common pain relievers like ibuprofen or naproxen alongside this medicine significantly increases your risk of developing stomach ulcers and internal bleeding. If you need pain relief, ask your healthcare provider for safer alternatives. Talk to your doctor or pharmacist before taking any new medication.

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While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Drugs.com Clinical Review Team. Prednisolone Odt Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  2. U.S. Food and Drug Administration (FDA). 021959Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  3. Prednisolone 1mg Tablets - Summary of Product Characteristics (SmPC) - (emc) [Internet]. Medicines.org.uk. 2021 [Accessed on 2 December 2021]Check here
  4. Prednisolone 1mg Tablets - Patient Information Leaflet (PIL) - (emc) [Internet]. Medicines.org.uk. 2021 [Accessed on 2 December 2021]Check here
  5. Prednisolone [Internet]. Ncbi.nlm.nih.gov. 2021 [Accessed on 2 December 2021]Check here
  6. Prednisolone [Internet]. nhs.uk. 2021 [Accessed on 11 January 2022]Check here
  7. Yana Puckett, Preeti Patel, Abdullah A. Bokhari. Prednisone. National Library of Medicine. [Revised on April 26, 2025] [Accessed on 18th March 2026]Check here

Country of origin

India

Manufacturer/Marketer address

The Capital, 1802, 18th Floor , Plot No. C-70, ?G? Block , Bandra Kurla Complex, Bandra East , Mumbai ? 400051.
Other Info - WYS0002
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