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compositionComposition:VORICONAZOLE-200MG
prescription
Prescription Medicine
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₹2390 with coupons & bank offers*

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VONAZ INJECTION is used to treat a broad range of fungal infections. It contains 'Voriconazole' that kills or prevents fungus by inhibiting an enzyme in fungi responsible for its normal fat metabolism, thereby interfering with the fungal cell membrane formation. As a result, fungal cells get killed, or their growth is minimised. Common side effects of VONAZ INJECTION are injection site reactions, peripheral oedema, headache, diarrhoea, vomiting, abdominal pain, chest pain, nausea, fever, anxiety, insomnia, confusion, weakness, tingling sensation, sleepiness, dizziness, irregular heartbeats, low blood pressure, stomach upset, constipation, rashes, itchiness, red skin, back pain and chills.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Santoshini Reddy G , M Pharmacy
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More about the Product

Composition :

VORICONAZOLE-200MG

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About VONAZ INJECTION

VONAZ INJECTION is a prescription medicine used to treat serious, invasive fungal infections that can affect different parts of the body. This parenteral medicine is typically prescribed for deep tissues or blood infections when immediate and direct treatment is required. It helps stop the spread of dangerous fungi in patients with weakened immune systems.

Because this medicine is given as an injection into a vein, it is usually scheduled at regular times throughout the day to keep a steady amount in your blood. Consistency is vital for completely clearing the infection, so you should receive every scheduled dose. No food restrictions apply to this injectable form, but staying well-hydrated can support your kidneys during treatment.

While receiving this medicine, you may experience mild, temporary side effects such as vision changes or slight nausea. However, you must contact your doctor immediately if you experience signs of liver damage, severe skin rashes, or an irregular heartbeat.

Talk to your doctor before starting this medicine if you have a history of liver disease, kidney problems, or heart rhythm issues. Do not receive this medicine if you are taking certain other drugs that can cause dangerous interactions, or if you have had an allergic reaction to similar antifungal treatments.

This medicine can interact with alcohol, which can increase the risk of liver damage, and with many common prescription medicines. If you are pregnant, planning to become pregnant, breastfeeding, or are an older adult, consult your doctor to discuss the risks and benefits.

Uses of VONAZ INJECTION

VONAZ INJECTION is used in the treatment of serious, invasive fungal infections. The detailed uses of VONAZ INJECTION are as follows:

  • Invasive aspergillosis: This medicine helps by targeting and treating this serious fungal infection that usually starts in the lungs and can spread to other organs.
  • Candidemia and deep Candida infections: It helps treat Candida infections affecting the blood, skin, abdomen, kidneys, and wounds.
  • Oesophageal candidiasis: It helps treat severe fungal infections of the oesophagus when an injection is preferred over oral medicine.
  • Serious fungal infections caused by rare moulds: It helps fight severe infections caused by specific rare moulds like Scedosporium and Fusarium when other treatments may not work.
     

Key Benefits

VONAZ INJECTION helps treat serious fungal infections by stopping the growth of fungi and preventing the infection from spreading. The following are the benefits of this medication:

  • Begins working quickly when injected directly into the bloodstream to stop fungi from multiplying, helping you start recovering faster.
  • Relieves symptoms such as fever, breathing difficulties, and other signs of severe fungal infection as the infection improves.
  • Provides effective treatment for people with weakened immune systems who are at high risk of invasive fungal infections.
Side effects of Vonaz Injection
  • Your doctor may recommend regular liver function tests (LFT) to monitor liver enzyme levels.
  • To support your liver, eat a healthy diet with lots of fruits, vegetables, lean proteins, and healthy fats.
  • Avoid eating processed meats, sugary foods, and unhealthy fats.
  • Limit your alcohol consumption, since too much can worsen liver function and contribute to high levels of Alkaline Phosphatase (ALP).
  • Stay active with regular exercise, drink plenty of water, and try to avoid harmful chemicals that can damage your liver.
  • Quit smoking to lower the risk of elevated ALP levels.
  • Increased creatinine levels must be corrected immediately with the help of a doctor.
  • Reduce strenuous activities that can lead to muscle breakdown and production of creatinine.
  • Sleep for 7-8 hours per night to assist your body in repairing and rebuilding tissue.
  • Manage your blood pressure by implementing changes in lifestyle like losing weight, reducing stress and exercising regularly.
  • Avoid smoking and drinking alcohol.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Eat more potassium-rich foods, like bananas, leafy greens, sweet potatoes, avocados, and nuts/seeds.
  • Choose potassium-fortified foods such as orange juice and sports beverages.
  • Limit potassium-depleting foods like caffeine, processed foods, and sugary drinks.
  • Exercise regularly, like walking or yoga, to help maintain potassium balance.
  • Inform your doctor if hypokalemia doesn't improve or worsen despite treatment.

Directions for Use

  • Your doctor will determine the dosage and frequency depending on your condition.
  • VONAZ INJECTION will be administered by a healthcare professional.
  • Do not self-administer.

How VONAZ INJECTION Works

VONAZ INJECTION belongs to a class of medicines known as triazole antifungals. It works by blocking a specific enzyme (lanosterol 14-alpha-demethylase) that fungi need to produce ergosterol, an essential component of the fungal cell membrane. Without enough ergosterol, the cell membrane becomes unstable and leaky, causing essential cellular contents to escape. This disrupts fungal growth and may kill the fungus, allowing your body's natural defences to clear the remaining infection.
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Alcohol

Consult your doctor

It is not known if alcohol affects VONAZ INJECTION. Please consult your doctor.

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Pregnancy

Consult your doctor

VONAZ INJECTION is generally not recommended in pregnancy. Your doctor may prescribe this medicine if the benefit to the mother outweighs the potential risk to the fetus.

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Breast Feeding

Consult your doctor

If you are breastfeeding, please inform your doctor. It is not known if VONAZ INJECTION passes into breastmilk. Your doctor may advise you to stop breastfeeding before starting the treatment with VONAZ INJECTION.

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Driving

Unsafe

VONAZ INJECTION may affect your ability to drive or operate machinery; thus, avoid driving or using machinery.

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Liver

Consult your doctor

Inform your doctor if you have liver problems before receiving VONAZ INJECTION.

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Kidney

Consult your doctor

Inform your doctor if you have kidney problems before receiving VONAZ INJECTION.

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Children

Consult your doctor

Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Heart

Caution

VONAZ INJECTION may disrupt heart rhythm, so patients with heart conditions must consult their doctor before use. Careful monitoring is crucial to avoid serious cardiac side effects.

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Geriatrics

Caution

Geriatric patients may receive VONAZ INJECTION, but only with close medical supervision. Older adults are more prone to side effects like visual disturbances, liver issues, and heart rhythm changes, so dosage and monitoring must be carefully tailored.

What if I have taken an overdose of VONAZ INJECTION

If you receive too much of this medicine, you may experience severe vision changes, rapid heartbeat, or extreme nausea. Seek immediate emergency medical care or contact a poison control centre if you suspect an overdose.

Diet & Lifestyle Advise

  • Limit sun exposure: This medicine makes your skin highly sensitive to sunlight. Wear protective clothing, a wide-brimmed hat, and a high-SPF sunscreen whenever you go outdoors.
  • Avoid night driving: Temporary vision changes can occur, especially in low light. Avoid driving or operating machinery in the dark or under poor lighting conditions.
  • Avoid alcohol: Drinking alcohol while receiving this medication puts extra stress on your liver and increases the risk of liver damage.
  • Stay hydrated: Drinking plenty of water helps your body process the medication efficiently and protects your kidneys.
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How Soon It Starts Working

  • The time required for VONAZ INJECTION to start to work: VONAZ INJECTION effect is observed within 1 to 2 hours of administration.
  • The time for which the effects of VONAZ INJECTION last: VONAZ INJECTION effect lasts approximately for 6 hours.

What if you forget to take VONAZ INJECTION

Because you will likely receive this medicine in a clinical setting, missed doses are highly uncommon. If you miss an appointment or suspect you missed a scheduled dose, contact your healthcare provider right away to get back on schedule.

Storage

• Store the dry, unused powder vials of VONAZ INJECTION at room temperature, ideally between 15°C to 30°C (59°F to 86°F).
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Keep Refrigerated. Do not freeze.Prepaid payment required.

Drug Warnings

  • Check the medicine before use: Your healthcare provider should inspect the solution before giving the injection. It should not be used if it is cloudy, has changed colour, or contains visible particles.
  • Report injection site reactions: Tell your doctor or nurse immediately if you notice pain, burning, swelling, or redness where the injection is given.
  • Attend regular blood tests: Keep all follow-up appointments for blood tests, as your doctor will need to monitor your liver function and kidney health regularly.
  • Avoid pregnancy during treatment: Do not become pregnant while receiving this medicine. Use effective birth control and discuss suitable contraceptive options with your doctor.
  • Protect your skin from sunlight: Contact your doctor immediately if you develop a skin rash or sunburn-like reaction, even after brief exposure to sunlight.

Drug-Drug Interactions

verifiedApollotooltip
  • Medicines used to treat tuberculosis (e.g., rifampin): These medicines may greatly reduce the effectiveness of VONAZ INJECTION, leading to treatment failure.
  • Medicines used to treat seizures (e.g., carbamazepine, phenobarbital): Taking these medicines alongside VONAZ INJECTION may reduce its effectiveness or increase the risk of side effects by affecting how it is processed in the body.
  • Medicines used to treat HIV infection (e.g., ritonavir): Combining these medicines may alter the levels of either medicine in the body and may require closer monitoring or dose adjustments.
  • Medicines used to treat abnormal heart rhythms or high cholesterol (e.g., quinidine, simvastatin): Combining these medicines may increase the risk of serious side effects because their levels can become dangerously high.
     
VoriconazoleRifampicin
Critical
VoriconazoleIvabradine
Critical

Drug-Drug Interactions

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VoriconazoleRifampicin
Critical
How does the drug interact with Vonaz Injection:
Taking Vonaz Injection with Rifampicin can increase blood level of Vonaz Injection.

How to manage the interaction:
Although there is an interaction between Vonaz Injection with Rifampicin, it can be taken if prescribed by a doctor. However, if you experience any unusual symptoms contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
VoriconazoleIvabradine
Critical
How does the drug interact with Vonaz Injection:
Using ivabradine together with Vonaz Injection may significantly increase the blood levels and effects of ivabradine.

How to manage the interaction:
Taking Ivabradine with Vonaz Injection together is generally avoided as it can result in an interaction, it can be taken if a doctor has advised it. However, contact a doctor immediately if you experience dizziness, shortness of breath, rapid heartbeat. Do not discontinue any medications without consulting a doctor.
VoriconazoleEfavirenz
Critical
How does the drug interact with Vonaz Injection:
Coadministration of Vonaz Injection with Efavirenz can alter the blood levels and effects of both medications.

How to manage the interaction:
Taking Vonaz Injection with Efavirenz can be taken if a doctor has advised it. Contact a doctor if you experience vomiting, dizziness, difficulty concentrating. Do not discontinue any medications without consulting a doctor.
VoriconazoleRitonavir
Critical
How does the drug interact with Vonaz Injection:
When Vonaz Injection is taken with Ritonavir, the amount of Vonaz Injection in the blood may decrease.

How to manage the interaction:
Taking Vonaz Injection with Ritonavir is not recommended as it can result in an interaction, it can be taken if your doctor has advised it. However, if you notice any unusual symptoms contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
VoriconazoleTicagrelor
Critical
How does the drug interact with Vonaz Injection:
Using Ticagrelor together with Vonaz Injection can significantly increase the blood levels of Ticagrelor.

How to manage the interaction:
Taking Ticagrelor with Vonaz Injection is not recommended, but it can be taken together if prescribed by a doctor. However, consult a doctor if you experience vomiting, headache, dizziness, or weakness. Do not discontinue any medications without consulting a doctor.
VoriconazoleConivaptan
Critical
How does the drug interact with Vonaz Injection:
Using Conivaptan together with Vonaz Injection may significantly increase the blood levels and effects of conivaptan.

How to manage the interaction:
Taking Vonaz Injection with Conivaptan is not recommended, please consult your doctor before taking it. Call a doctor if you experience difficulty swallowing, trouble speaking, trouble controlling body movements. Do not stop using any medications without talking to a doctor.
VoriconazoleErgotamine
Critical
How does the drug interact with Vonaz Injection:
The serum concentration of Ergometrine can be increased when it is combined with Vonaz Injection.

How to manage the interaction:
Taking Ergotamine with Vonaz Injection is not recommended, please consult your doctor before taking it.
VoriconazoleRanolazine
Critical
How does the drug interact with Vonaz Injection:
Co-administration of Ranolazine together with Vonaz Injection may significantly increase the blood levels and effects of Ranolazine.

How to manage the interaction:
Taking Ranolazine with Vonaz Injection together can result in an interaction, but it can be taken if a doctor has advised it. Consult a doctor if you experience dizziness, or fast or pounding heartbeats. Do not discontinue any medications without consulting a doctor.
VoriconazolePrimidone
Critical
How does the drug interact with Vonaz Injection:
Taking Vonaz Injection together with primidone may reduce the blood levels of Vonaz Injection, which may make the medication less effective.

How to manage the interaction:
Although there is an interaction between Vonaz Injection and Primidone, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms contact a doctor immediately. Do not stop using any medications without talking to a doctor.
VoriconazoleTolvaptan
Critical
How does the drug interact with Vonaz Injection:
Co-administration of Tolvaptan together with Vonaz Injection may significantly increase the blood levels and effects of Tolvaptan.

How to manage the interaction:
There may be a possibility of interaction between Tolvaptan and Vonaz Injection, but it can be taken if prescribed by a doctor. If you experience difficulty swallowing, trouble speaking, muscle weakness call a doctor right away. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
  • No clinically significant food interactions are known with VONAZ INJECTION.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIFUNGALS]

FAQs

VONAZ INJECTION is used to treat fungal infections.
VONAZ INJECTION contains Voriconazole that kills or prevents fungus by inhibiting an enzyme in fungi responsible for its normal fat metabolism, thereby interfering with the fungal cell membrane formation. As a result, fungal cells get killed, or their growth is minimized.
VONAZ INJECTION can also prevent fungal infections in people undergoing bone marrow transplants.
VONAZ INJECTION may not be suitable in patients with known hypersensitivity to any of the components present in VONAZ INJECTION; or with a hereditary intolerance for galactose, Lapp lactase deficiency, or glucose-galactose malabsorption.
You can take VONAZ INJECTION with contraceptive pills. However, some studies show a chance of an increase in the body's hormonal levels when you take VONAZ INJECTION with a combined pill. Seek your doctor's advice if any side effects occur.
Yes, fungal infection is a contagious skin condition that spreads from one person to another through direct skin-to-skin contact or by contact with contaminated soil or surfaces and infected animals. Therefore, it is recommended to avoid close direct contact until the infection is clear and avoid sharing things with the infected person, as it can also spread the infection.
VONAZ INJECTION can use women of childbearing potential; however, they must always use effective contraception during treatment.
This medicine can cause temporary vision changes, such as blurred vision or sensitivity to light, especially in the dark. It is safest to avoid driving or operating machinery, particularly at night, until you know how this medicine affects you. Talk to your doctor if you experience persistent vision changes.
This medicine is generally not recommended during pregnancy because it can cause harm to an unborn baby. Women who can become pregnant should use effective birth control while receiving this treatment. Talk to your doctor to discuss safe alternatives and family planning.
Regular blood tests are necessary to monitor your liver and kidney function, as well as the levels of electrolytes in your blood. This helps your healthcare provider ensure the medication is working safely without causing damage to your vital organs. Talk to your doctor about your test results.
No, you should avoid drinking alcohol during your treatment. Both alcohol and this medicine are processed by your liver, and combining them can significantly increase your risk of experiencing serious liver damage. Talk to your doctor if you have questions about alcohol use.
This medicine makes your skin highly sensitive to sunlight, which can lead to severe sunburns or skin reactions. Avoid direct sunlight, wear protective clothing, and apply high-SPF sunscreen daily. If you notice any unusual skin reactions, talk to your doctor immediately.
Because this medicine is given as an intravenous infusion, it is typically administered by a trained healthcare professional in a hospital or clinic. In some cases, home health nurses may administer it at home after detailed training. Talk to your doctor to find out which setting is best for you.
A rapid, pounding, or irregular heartbeat is a serious potential side effect of this medicine. If you notice any sudden changes in your heart rate, feel dizzy, or faint, seek medical attention immediately. Talk to your doctor if you have a pre-existing heart condition before starting treatment.

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Country of origin

INDIA
Other Info - VON0004
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