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compositionComposition:SOFOSBUVIR-400MG+VELPATASVIR-100MG
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Prescription Medicine
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Velpanat Tablet is used to treat chronic hepatitis C virus (HCV) infection. It contains sofosbuvir and velpatasvir, which stop the hepatitis C virus from spreading in the body. In some cases, this medication may cause common side effects such as headache, dizziness, fatigue, diarrhoea, vomiting, rash, lack of energy, irritability, depression, and difficulty sleeping.

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Written By ,
Reviewed By Praneetha Akunuri , M.Pharmacy
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More about the Product

Composition :

SOFOSBUVIR-400MG+VELPATASVIR-100MG

Manufacturer/Marketer :

Natco Pharma Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Velpanat Tablet

Velpanat Tablet is a prescription medicine used to treat chronic hepatitis C, a long-term viral infection that causes inflammation of the liver. It works by targeting the virus directly, preventing it from multiplying and spreading throughout your body. This medicine is highly effective across all major genetic variations, or genotypes, of the hepatitis C virus.

To get the best results, you must take Velpanat Tablet consistently once every day at the same time, either with or without food. Maintaining a stable daily routine ensures that a constant level of the medicine remains in your system to fight the virus continuously. Additionally, adopting a liver-friendly lifestyle, such as eating nutrient-rich foods and avoiding alcohol, supports your liver's healing process during treatment.

While taking Velpanat Tablet , many people experience only mild side effects like headaches, mild nausea, or feeling unusually tired. However, you should contact your doctor immediately if you notice serious symptoms, such as an unusually slow heart rate, severe dizziness, or signs of an allergic reaction. Monitoring how you feel throughout your treatment is an important step in staying safe.

Before starting this medicine, you should tell your doctor if you have ever had hepatitis B, as this treatment can sometimes cause the hepatitis B virus to become active again. You should also discuss any history of severe kidney disease or other liver conditions. Do not take this if you are allergic to any of the ingredients in Velpanat Tablet or if you are taking certain medicines that can interfere with its action.

This medicine can interact with other substances, including certain acid reducers, heart medicines, and anti-seizure drugs, which can either reduce its effectiveness or cause dangerous side effects. It is also important for pregnant, breastfeeding, or elderly individuals to consult their healthcare provider before beginning treatment to ensure it is safe for their specific situation.

Uses of Velpanat Tablet

Your doctor may prescribe Velpanat Tablet to treat the following conditions:

  • Chronic Hepatitis C Infection: Velpanat Tablet is used to treat long-term hepatitis C infections across all major viral genotypes (types 1 through 6) by stopping the virus from multiplying.
  • Hepatitis C with Liver Scarring: Velpanat Tablet helps treat patients who have developed cirrhosis (liver scarring), helping to clear the virus and prevent further damage to the liver.

Key Benefits

Using Velpanat Tablet as prescribed helps eliminate the hepatitis C virus and protect your liver from long-term damage. Here are the key benefits you can expect:

  • Helps clear hepatitis C infection: Velpanat Tablet stops the hepatitis C virus from multiplying, allowing your liver to recover from ongoing inflammation and damage.
  • Protects long-term liver health: By eliminating the virus, Velpanat Tablet helps reduce the risk of serious complications such as liver cirrhosis, liver failure, and liver cancer.
  • Improves overall well-being: Successful treatment of hepatitis C may help reduce symptoms such as fatigue and physical discomfort, leading to improved energy levels and a better quality of life.
Side effects of Velpanat Tablet
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the 7 step-by-step strategies to manage the side effect of "inability to sleep" caused by medication usage:
  • Prepare for a restful night's sleep: Develop a calming pre-sleep routine, like reading or meditation, to help your body relax and prepare for sleep.
  • Create a sleep-conducive Environment: Make bedroom a sleep haven by ensuring it is quiet, dark and calm.
  • Follow a Sleep Schedule: Go to bed and get up at the same time every day to help regulate your body's internal clock and increase sleep quality.
  • Try relaxing techniques like deep breathing, mindfulness meditation and any others.
  • Limit stimulating activities before bedtime: Avoid stimulating activities before bedtime to improve sleep quality.
  • Monitor Progress: Keep track of your sleep patterns to identify areas for improvement.
  • Consult a doctor if needed: If these steps don't improve your sleep, consult a doctor for further guidance and therapy.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.

Directions for Use

  • Velpanat Tablet can be taken with or without food.
  • Follow your doctor’s instructions on the dosage and timing of this medication.
  • Swallow Velpanat Tablet as a whole with a glass of water.
  • Do not crush, break, or chew it.

How Velpanat Tablet Works

Velpanat Tablet contains sofosbuvir and velpatasvir, which work together to stop the hepatitis C virus (HCV) from multiplying. Each ingredient targets a different stage of the virus's life cycle, helping to eliminate the infection from the body. Sofosbuvir works by blocking the NS5B RNA polymerase, an enzyme that the hepatitis C virus needs to copy its genetic material. Without this enzyme, the virus cannot produce new copies of itself, preventing further viral replication. Velpatasvir works by inhibiting the NS5A protein, which plays an essential role in viral replication and the assembly of new virus particles. By blocking NS5A, velpatasvir prevents the virus from multiplying and spreading to healthy liver cells. Together, these two active ingredients interrupt the hepatitis C virus life cycle, allowing the body to clear the infection and helping protect the liver from further damage.
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Alcohol

Consult your doctor

The interaction of alcohol with Velpanat Tablet is unknown. If you have any concerns regarding this, please discuss them with your doctor.

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Pregnancy

Unsafe

Velpanat Tablet is often used with ribavirin, which can harm an unborn baby. To avoid this risk, it's crucial to prevent pregnancy during and after treatment. If you become pregnant while taking Velpanat Tablet or soon after, contact your doctor right away.

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Breast Feeding

Consult your doctor

It is unknown whether Velpanat Tablet is excreted in human milk. Therefore, if you are a breastfeeding mother, please inform your doctor before taking Velpanat Tablet .

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Driving

Caution

Velpanat Tablet may cause dizziness, tiredness, and reduced attention in some patients. Therefore, avoid driving or operating heavy machinery if you feel dizzy, tired, or reduced attention after taking Velpanat Tablet .

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Liver

Consult your doctor

Please inform your doctor if you have liver impairments or problems before taking Velpanat Tablet .

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Kidney

Caution

Please inform doctor if you have kidney impairments/problems or if you are on kidney dialysis before taking Velpanat Tablet .

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Children

Caution

Velpanat Tablet is usually used in children 6 years of age and older. If you have any concerns regarding the use of Velpanat Tablet in children, please consult a doctor.

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Heart

Caution

If you have an existing or a history of heart disease, inform your doctor before receiving Velpanat Tablet .

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Geriatrics

Caution

Velpanat Tablet should be used with caution in elderly patients. Please consult your doctor before use.

What if I have taken an overdose of Velpanat Tablet

In case of an accidental overdose, seek immediate medical attention right away. Do not wait for symptoms to develop before seeking help.

Diet & Lifestyle Advise

  • Avoid alcohol entirely: Alcohol directly damages liver cells and can interfere with your liver's ability to heal while you are fighting the hepatitis C virus.
  • Eat a balanced, liver-friendly diet: Focus on whole grains, fresh fruits, vegetables, lean proteins, and healthy fats while limiting foods high in sugar, salt, and saturated fats to minimize stress on your liver.
  • Stay hydrated: Drink plenty of water throughout the day to help your body process the medicine and stay healthy.
  • Avoid unprescribed supplements: Do not take herbal remedies, over-the-counter painkillers (like acetaminophen), or dietary supplements without consulting your doctor or pharmacist first, as some of these can put an extra strain on your liver.
  • Manage fatigue: Listen to your body and get plenty of rest, as fatigue is a common side effect of both the infection and the treatment.

Health Queries

I am suffering from liver cancer and hepatitis C. What medications or treatment options are recommended to manage these conditions?

Y. Lakshmi Thulasi

Y. Lakshmi Thulasi

Pharm-D (Post baccalaureate)

Managing both conditions involves a coordinated approach. For Hepatitis C, highly effective oral antiviral medications, such as sofosbuvir and velpatasvir, can cure the virus and protect your remaining liver function. For liver cancer, treatment depends on the stage and may include localized therapies like ablation, chemoembolization, surgical removal, or a liver transplant. If the cancer is advanced, systemic therapies like atezolizumab combined with bevacizumab, or targeted drugs like lenvatinib or sorafenib, are used. Your oncologist and hepatologist will collaborate to create a personalized, safe treatment plan tailored to your specific liver health. Stay hopeful, as modern treatments are very precise and manageable.

What medications are used to treat Hepatitis C, and is treatment necessary if the test is non-reactive?

Y. Lakshmi Thulasi

Y. Lakshmi Thulasi

Pharm-D (Post baccalaureate)

A non-reactive test result is excellent news?it means you do not currently have a Hepatitis C infection, so no treatment is necessary. If someone does test positive for the virus, highly effective oral medications called Direct-Acting Antivirals (DAAs) are used to cure the infection. Common generic combinations include sofosbuvir/velpatasvir or glecaprevir/pibrentasvir. These modern treatments are taken daily for 8 to 12 weeks, have very mild side effects, and have a cure rate of over 95%. Since your test is non-reactive, you are clear and do not require any therapy.

What medications are used to treat Hepatitis C, and is treatment necessary if the test is non-reactive?

Y. Lakshmi Thulasi

Y. Lakshmi Thulasi

Pharm-D (Post baccalaureate)

A non-reactive test result is excellent news?it means you do not currently have a Hepatitis C infection, so no treatment is necessary. If someone does test positive for the virus, highly effective oral medications called Direct-Acting Antivirals (DAAs) are used to cure the infection. Common generic combinations include sofosbuvir/velpatasvir or glecaprevir/pibrentasvir. These modern treatments are taken daily for 8 to 12 weeks, have very mild side effects, and have a cure rate of over 95%. Since your test is non-reactive, you are clear and do not require any therapy.

I am suffering from liver cancer and hepatitis C. What medications or treatment options are recommended to manage these conditions?

Y. Lakshmi Thulasi

Y. Lakshmi Thulasi

Pharm-D (Post baccalaureate)

Managing both conditions involves a coordinated approach. For Hepatitis C, highly effective oral antiviral medications, such as sofosbuvir and velpatasvir, can cure the virus and protect your remaining liver function. For liver cancer, treatment depends on the stage and may include localized therapies like ablation, chemoembolization, surgical removal, or a liver transplant. If the cancer is advanced, systemic therapies like atezolizumab combined with bevacizumab, or targeted drugs like lenvatinib or sorafenib, are used. Your oncologist and hepatologist will collaborate to create a personalized, safe treatment plan tailored to your specific liver health. Stay hopeful, as modern treatments are very precise and manageable.
health query

Have a query?

How Soon It Starts Working

The time required for Velpanat Tablet to start to work: The peak effect of Velpanat Tablet can be observed within a few minutes of administration. The time for which the effects of Velpanat Tablet last: The effect of Velpanat Tablet usually lasts up to 24 hours approximately.

What if you forget to take Velpanat Tablet

If you miss a dose of Velpanat Tablet and remember it within 18 hours of your usual time, take the missed dose as soon as possible. Then, take your next dose at your regularly scheduled time. If it has been more than 18 hours since your scheduled time, skip the missed dose entirely and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.

Storage

• Store Velpanat Tablet tablets at room temperature below 30°C (86°F) in their original container or packaging to protect them from moisture and light.

Drug Warnings

  • Complete the full course: Do not stop taking Velpanat Tablet early, even if you feel better, as stopping treatment prematurely may cause the hepatitis C virus to return and become resistant to treatment.
  • Get screened for hepatitis B: Before starting Velpanat Tablet , ensure your doctor has checked you for hepatitis B infection, as treatment may reactivate a dormant hepatitis B infection and lead to serious liver complications.
  • Separate antacids from your dose: If you take antacids, take them at least 4 hours before or 4 hours after taking Velpanat Tablet .
  • Take H2-receptor blockers correctly: If you use acid-reducing medicines such as ranitidine or famotidine, take them at the same time as Velpanat Tablet or 12 hours apart, as advised by your doctor.
  • Discuss proton pump inhibitors with your doctor: If you are taking proton pump inhibitors (PPIs) such as omeprazole, follow your doctor's instructions carefully, as these medicines must be taken with Velpanat Tablet under specific timing and food conditions.
  • Inform healthcare providers: Tell your doctor, dentist, or surgeon that you are taking Velpanat Tablet before undergoing any medical or dental procedure.

Drug-Drug Interactions

verifiedApollotooltip
  • Amiodarone: Taking this heart medicine with Velpanat Tablet can cause a dangerously slow heart rate, which can be life-threatening.
  • Acid reducers: Antacids, H2 blockers, and proton pump inhibitors can lower the absorption of Velpanat Tablet , reducing its ability to cure the virus.
  • Anti-seizure medicines: Drugs like carbamazepine, phenytoin, and phenobarbital can lower the amount of Velpanat Tablet in your blood, making the treatment less effective.
  • Tuberculosis medicines: Rifampin and rifabutin can significantly decrease the levels of Velpanat Tablet in your body, reducing its therapeutic effect.
  • Herbal supplements: St. John's Wort can lower the effectiveness of Velpanat Tablet and should not be used during treatment.
Sofosbuvir + VelpatasvirRifabutin
Severe
Sofosbuvir + VelpatasvirModafinil
Severe

Drug-Drug Interactions

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Sofosbuvir + VelpatasvirRifabutin
Severe
How does the drug interact with Velpanat Tablet:
Taking Rifabutin with Sofosbuvir and Velpatasvir may reduce the effects of Sofosbuvir and Velpatasvir.

How to manage the interaction:
Although taking Rifabutin with Sofosbuvir and Velpatasvir can possibly result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience any unusual symptoms contact a doctor immediately. Do not stop using any medications without talking to a doctor.
Sofosbuvir + VelpatasvirModafinil
Severe
How does the drug interact with Velpanat Tablet:
Taking Modafinil with Sofosbuvir and Velpatasvir may reduce the effects of Sofosbuvir and Velpatasvir.

How to manage the interaction:
Although taking Modafinil with Sofosbuvir and Velpatasvir can possibly result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience any unusual symptoms contact a doctor immediately. Do not stop using any medications without talking to a doctor.
Sofosbuvir + VelpatasvirOxcarbazepine
Severe
How does the drug interact with Velpanat Tablet:
Taking Oxcarbazepine with Sofosbuvir and Velpatasvir may reduce the effects of Sofosbuvir and Velpatasvir.

How to manage the interaction:
Although taking Oxcarbazepine with Sofosbuvir and Velpatasvir can possibly result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience any unusual symptoms contact a doctor immediately. Do not stop using any medications without talking to a doctor.
Sofosbuvir + VelpatasvirCarbamazepine
Severe
How does the drug interact with Velpanat Tablet:
Taking carbamazepine with Sofosbuvir and Velpatasvir may reduce the effects of Sofosbuvir and Velpatasvir.

How to manage the interaction:
Although taking carbamazepine with Sofosbuvir and Velpatasvir can possibly result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience any unusual symptoms contact a doctor immediately. Do not stop using any medications without talking to a doctor.
Sofosbuvir + VelpatasvirPhenobarbital
Severe
How does the drug interact with Velpanat Tablet:
Taking Phenobarbital with Sofosbuvir and Velpatasvir may reduce the effects of Sofosbuvir and Velpatasvir.

How to manage the interaction:
Although taking Phenobarbital with Sofosbuvir and Velpatasvir can possibly result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience any unusual symptoms contact a doctor immediately. Do not stop using any medications without talking to a doctor.
Sofosbuvir + VelpatasvirPhenytoin
Severe
How does the drug interact with Velpanat Tablet:
Taking Phenytoin with Sofosbuvir and Velpatasvir may reduce the effects of Sofosbuvir and Velpatasvir.

How to manage the interaction:
Although taking Phenytoin with Sofosbuvir and Velpatasvir can possibly result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience any unusual symptoms contact a doctor immediately. Do not stop using any medications without talking to a doctor.
Sofosbuvir + VelpatasvirTipranavir
Severe
How does the drug interact with Velpanat Tablet:
Taking Tipranavir with Sofosbuvir and Velpatasvir may reduce the effects of Sofosbuvir and Velpatasvir.

How to manage the interaction:
Although taking Tipranavir with Sofosbuvir and Velpatasvir can possibly result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience any unusual symptoms contact a doctor immediately. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Alcohol: While there are no direct chemical interactions with food, consuming alcohol during treatment can accelerate liver damage and hinder your recovery.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTIVIRALS]

FAQs

Velpanat Tablet is used to treat chronic hepatitis C virus (HCV) infection.
Velpanat Tablet contains sofosbuvir and velpatasvir, which work by stopping the hepatitis C virus from spreading in the body.
Velpanat Tablet contains sofosbuvir and velpatasvir. It is used in the treatment of chronic hepatitis C virus (HCV) infection.
Hepatitis C virus infection is contagious and spreads from one person to another through contact with an infected person’s blood. Therefore, it is recommended to avoid sharing personal items or needles containing an infected person’s blood.
No, Velpanat Tablet is not a protease inhibitor. It is an antiviral medication used to treat hepatitis C infection.
The common side effects of Velpanat Tablet may include headache, fatigue, diarrhoea, vomiting, spitting up the medicine, rash, lack of energy, irritability, depression, and sleep difficulties. These side effects are usually mild and temporary. If they persist or worsen, consult your doctor.
You should avoid alcohol entirely while taking Velpanat Tablet . Alcohol places extra stress on your liver, which is already inflamed from the virus, and can slow your liver's healing process. Talk to your doctor if you need support in avoiding alcohol during your treatment.
No, you can take Velpanat Tablet with or without food. The most important thing is consistency; try to take your tablet at the same time every day to maintain steady levels of the medicine in your body. Talk to your doctor or pharmacist if you have trouble maintaining a schedule.
If you vomit within 3 hours of taking Velpanat Tablet , you should take another tablet to ensure it is absorbed. If you vomit more than 3 hours after taking it, you do not need to take an extra dose; simply take your next dose at the regular time. Talk to your doctor or pharmacist if vomiting persists.
Yes, but you must separate the doses. Take antacids at least 4 hours before or 4 hours after taking Velpanat Tablet , as antacids can prevent your body from properly absorbing the medicine. Talk to your doctor or pharmacist before starting any new acid-reducing treatments.
The safety of Velpanat Tablet during pregnancy and breastfeeding is not fully known. You must inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding so they can evaluate the safest treatment option for you. Talk to your doctor for personalised medical advice.
Yes, Velpanat Tablet has a very high cure rate, typically clearing the virus in over 95% of patients. A cure is defined as having no detectable virus in your blood three months after completing the full treatment course. Talk to your doctor about your specific treatment expectations.
Yes, Velpanat Tablet can be taken by individuals with kidney disease, including those on dialysis, but it requires careful evaluation and monitoring by your healthcare team. Your doctor will determine if this is the right medicine for your specific condition. Talk to your doctor or pharmacist for more information.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

INDIA

Manufacturer/Marketer address

Natco House, Road No.2, Banjara Hills, Hyderabad-500 034, India
Other Info - VEL0186
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