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  3. Vegfxta 400 mg Infusion 16 ml

Vegfxta 400 mg Infusion 16 ml, Pack of 1 INJECTION
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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Santoshini Reddy G , M Pharmacy
Vegfxta 400 mg Infusion is an anti-cancer medicine used in the treatment of metastatic breast cancer, non-small cell lung cancer, kidney cancer, cervical cancer, epithelial ovarian, fallopian tube, or primary peritoneal cancer, cancer of colon and rectum. This medicine works on vascular endothelial growth factor and causes blood vessels to grow within tumours which provide oxygen and nutrients to the tumour. Common side effects include loss of appetite, constipation, fever, nosebleeds, change in speech, and taste.
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Composition :

BEVACIZUMAB-400MG

Manufacturer/Marketer :

Fresenius Kabi India Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Vegfxta 400 mg Infusion

Vegfxta 400 mg Infusion is a monoclonal antibody used to treat metastatic breast cancer, non-small cell lung cancer, kidney cancer, cervical cancer, epithelial ovarian, fallopian tube, or primary peritoneal cancer, cancer of colon and rectum. Cancer is a condition where cells in a specific part of the body grow and reproduce uncontrollably. Cancer can start in one region of the body and spread to other parts. This is referred to as metastasis.

Vegfxta 400 mg Infusion contains 'Bevacizumab' that works against vascular endothelial growth factor (VEGF) which is found on the lining of lymph and blood vessels. VEGF causes blood vessels to grow within tumours which provide oxygen and nutrients to the tumour. Inhibition of vascular endothelial growth factor limits the flow of oxygen and nutrients to the tumour, causing it to shrink or cease developing. Thus, it helps treat cancers.

Vegfxta 400 mg Infusion will be administered by a healthcare professional; do not self-administer. Based on your medical condition, your doctor will decide the dose and duration. In some cases, Vegfxta 400 mg Infusion may cause loss of appetite, constipation, fever, nosebleeds, change in speech, and taste. The majority of these side effects do not require medical treatment and fade away with time. However, consult your doctor if the side effects persist or worsen

Avoid taking Vegfxta 400 mg Infusion if you are pregnant. Use effective contraception during the treatment and for 6months after the last dose. Vegfxta 400 mg Infusion may cause sleepiness and fainting, so avoid driving while on treatment with Vegfxta 400 mg Infusion. Do not breastfeed during the treatment and for 6months after the last dose of Vegfxta 400 mg Infusion. Keep your doctor informed about your health condition and all the medicines you take to rule out any side effects.

Uses of Vegfxta 400 mg Infusion

Vegfxta 400 mg Infusion is used in the treatment of Metastatic breast cancer, non-small cell lung cancer, kidney cancer, cervical cancer, epithelial ovarian, fallopian tube, or primary peritoneal cancer, cancer of colon and rectum. The detailed uses of Vegfxta 400 mg Infusion are as follows:<br/>• Colorectal Cancer: Vegfxta 400 mg Infusion is used in combination with chemotherapy for metastatic cases.<br/>• Non-Small Cell Lung Cancer (NSCLC): Vegfxta 400 mg Infusion helps slow tumor growth and spread when combined with carboplatin and paclitaxel.<br/>• Ovarian, Cervical, and Peritoneal Cancer: Vegfxta 400 mg Infusion is often used post-surgery or with chemotherapy to improve outcomes.<br/>• Renal Cell Carcinoma (Kidney Cancer): Vegfxta 400 mg Infusion enhances treatment efficacy when paired with other agents.<br/>• Glioblastoma (Brain Tumor): Vegfxta 400 mg Infusion is approved for recurrent cases to reduce tumor vascularization.<br/>• Hepatocellular Carcinoma (Liver Cancer): Vegfxta 400 mg Infusion is used in combination with other drugs for advanced stages.<br/>

Directions for Use

• Follow your doctor's instructions regarding doses and timing of Vegfxta 400 mg Infusion for optimal results.• Vegfxta 400 mg Infusion will be administered by a healthcare professional in a medical setting.• Kindly do not self-administer.

Medicinal Benefits

Vegfxta 400 mg Infusion contains Bevacizumab, a monoclonal antibody used to treat metastatic breast cancer, non-small cell lung cancer, kidney cancer, cervical cancer, epithelial ovarian, fallopian tube, or primary peritoneal cancer, cancer of colon and rectum. Vegfxta 400 mg Infusion works against a protein called vascular endothelial growth factor (VEGF). Vascular endothelial growth factor (VEGF) inhibition limits the flow of oxygen and nutrients to the tumour cells, causing them to shrink or cease developing. Thus, it helps treat cancer.

How Vegfxta 400 mg Infusion Works

Vegfxta 400 mg Infusion contains 'Bevacizumab' that works against vascular endothelial growth factor (VEGF) which is found on the lining of lymph and blood vessels. VEGF causes blood vessels to grow within tumours which provide oxygen and nutrients to the tumour. Inhibition of vascular endothelial growth factor limits the flow of oxygen and nutrients to the tumour, causing it to shrink or cease developing. Thus, it helps treat cancers.

Storage

Keep Vegfxta 400 mg Infusion out of the sight and reach of children.
Side effects of Vegfxta 400 mg Infusion 16 ml
Managing Medication-Triggered Epistaxis (Nosebleed): A Step-by-Step Guide:
  • If you experience nosebleeds or unusual bleeding after taking medication, seek medical attention right away and schedule an appointment to discuss your symptoms with your doctor.
  • Your doctor may adjust your treatment plan by changing the dosage, switching to a different medication, or stopping the medication.
  • If your doctor advises, take steps to manage bleeding and promote healing, such as applying pressure, using saline nasal sprays, or applying a cold compress, using humidifiers, avoiding blowing or picking your nose, and applying petroleum jelly to the nostrils.
  • Schedule follow-up appointments with your doctor to monitor progress, adjust treatment plans, and prevent future episodes.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Managing Medication-Triggered Rhinitis (Stuffy Nose): A Step-by-Step Guide
  • Consult your doctor if you experience nasal congestion, runny nose, or sinus pressure after taking medication.
  • Your doctor may adjust your treatment plan by changing your medication, adding new medications, or providing guidance on managing your rhinitis symptoms.
  • If advised by your doctor, use nasal decongestants or saline nasal sprays to help relieve nasal congestion.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Stay hydrated by drinking plenty of water and other fluids to help thin out mucus and soothe your nasal passages.
  • Increased protein levels indicate the body is dehydrated and when blood plasma is concentrated.
  • Consume water and stay hydrated. Talk to your doctor and take an oral rehydrating salt (ORS).
  • Sleep for 7-8 hours per night to assist your body in repairing and rebuilding hydration.
  • Manage your blood pressure by implementing changes in lifestyle like losing weight, reducing stress and exercising regularly.
  • Regularly brush and floss your teeth.
  • Rinse your mouth with water and baking soda a solution to neutralize acid in the mouth. This makes your food taste as it should.
  • Drink plenty of water or non-caffeinated drinks to prevent dry mouth which may lead to altered taste.
  • Try ginger, peppermint, fruit or green teas, lemonade, ginger ale or fruit juice to help mask unpleasant tastes.
  • Try sucking on sugar-free ice pops or ice cubes to prevent dry mouth.
  • Apply moisturizer immediately after showering or bathing.
  • Use a moisturizer containing lanolin, petroleum jelly, glycerine, hyaluronic acid or jojoba oil.
  • Do not use hot water for bathing. Instead use warm water and limit showers and bath to 5 to 10 minutes.
  • Apply a sunscreen with SPF-30 or higher.
  • Avoid harsh soaps, detergents and perfumes.
  • Do not scratch or rub the skin.
  • Drink adequate water to prevent dehydration.
  • Wear pants, full sleeves and a wide-brimmed hat while going out in the sun.
  • Apply warm compresses to the affected eye to help loosen blockages.
  • Gently massage the eyelids to promote tear drainage.
  • Avoid rubbing the eyes, as this can exacerbate the condition.
  • Use artificial tears to help lubricate the eyes.
  • Keep the eyes clean and free of irritants.
  • Avoid exposure to wind, dust, and other environmental irritants.
  • Consider using humidifiers to add moisture to the air and reduce tear evaporation.

What if I have taken an overdose of Vegfxta 400 mg Infusion

An overdose of Vegfxta 400 mg Infusion does not have a recommended course of action or counteragent. Because infusion reactions can be quite severe, treatment for hypersensitivity reactions must be started as soon as possible. Your doctor may take necessary action if an overdose is suspected.

Drug Warnings

Vegfxta 400 mg Infusion should only be taken under medical supervision. While taking Vegfxta 400 mg Infusion, the doctor will monitor your condition on a regular basis. If you have a history of allergic reactions to Vegfxta 400 mg Infusion or other medications, inform your doctor before taking it. Avoid taking Vegfxta 400 mg Infusion if you are pregnant. Use effective contraception during the treatment and for 6months after the last dose. Vegfxta 400 mg Infusion may cause sleepiness and fainting, so avoid driving while on treatment with Vegfxta 400 mg Infusion. Inform your doctor if you have/had high blood pressure, heart attack, stroke, bleeding problems, stomach/intestinal bleeding, perforation; if you had surgery in the past 28days/are due to have surgery. Do not breastfeed during the treatment and for 6months after the last dose of Vegfxta 400 mg Infusion. While taking Vegfxta 400 mg Infusion, please do not get any immunizations or vaccinations unless your doctor has approved it. Vegfxta 400 mg Infusion may increase the risk of bleeding, so be cautious and consult your doctor if you notice any bleeding or bruising.

Drug-Drug Interactions

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BevacizumabThalidomide
Severe
BevacizumabIdarubicin
Severe

Drug-Drug Interactions

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BevacizumabThalidomide
Severe
How does the drug interact with Vegfxta 400 mg Infusion 16 ml:
Taking thalidomide together with Vegfxta 400 mg Infusion 16 ml may increase the risk of blood clots.

How to manage the interaction:
Although taking thalidomide and Vegfxta 400 mg Infusion 16 ml together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
BevacizumabIdarubicin
Severe
How does the drug interact with Vegfxta 400 mg Infusion 16 ml:
Taking Vegfxta 400 mg Infusion 16 ml with Idarubicin can increase the risk of heart problems.

How to manage the interaction:
There may be a possibility of interaction between Vegfxta 400 mg Infusion 16 ml and Idarubicin, but it can be taken if prescribed by a doctor. Do not stop using any medications without a doctor's advice.
BevacizumabClozapine
Severe
How does the drug interact with Vegfxta 400 mg Infusion 16 ml:
Taking Vegfxta 400 mg Infusion 16 ml and clozapine may increase the risk of infection.

How to manage the interaction:
Although taking Vegfxta 400 mg Infusion 16 ml and Clozapine together can cause an interaction, it can be taken if your doctor has suggested it. If you notice fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, losing weight, or feeling pain, make sure to contact a doctor right away. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Meditating, reading novels, taking a nice bubble bath, or listening to calming music can all help you relax.
  • Yoga can also aid in the improvement of both physical and mental health.
  • Maintain a healthy weight by engaging in low-strain workouts on a regular basis and consuming nutritious foods.
  • To maintain a healthy weight, eat a portion of nutritious food and exercise on a regular basis.
  • Leafy greens, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs should all be part of your daily diet.
  • Rest well and get a good night's sleep.
  • Avoid smoking and consuming alcoholic beverages.
  • Fast food, fried foods, processed meats, refined carbohydrates, and added sugars should be avoided.

Habit Forming

No

Therapeutic Class

MONOCLONAL ANTIBODIES

Vegfxta 400 mg Infusion Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

You are recommended to avoid alcohol consumption while taking Vegfxta 400 mg Infusion. It could lead to unpleasant side effects.

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Pregnancy

Unsafe

Vegfxta 400 mg Infusion should not be used during pregnancy because it causes harm to the fetus. Women of childbearing potential must use an effective contraception method while taking Vegfxta 400 mg Infusion and at least six months after the last dose. Please consult your doctor about any concerns regarding this.

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Breast Feeding

Unsafe

Avoid breastfeeding during treatment and for 6months after the last dose. This is due to the possibility of the medication being passed on to the infant through breast milk.

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Driving

Caution

Caution should be exercised when driving or operating machinery because in some cases, Vegfxta 400 mg Infusion may cause sleepiness and fainting.

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Liver

Caution

If you have/had a history of any liver-related diseases, please inform the doctor before taking Vegfxta 400 mg Infusion. Your doctor will weigh the benefits and potential risks before prescribing Vegfxta 400 mg Infusion.

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Kidney

Caution

If you have/had a history of any kidney-related diseases, please inform the doctor before taking Vegfxta 400 mg Infusion. Your doctor will weigh the benefits and potential risks before prescribing Vegfxta 400 mg Infusion.

bannner image

Children

Unsafe

Vegfxta 400 mg Infusion is not recommended for children below 18years as the safety and effectiveness have not been established.

Have a query?

FAQs

Vegfxta 400 mg Infusion is a monoclonal antibody used to treat metastatic breast cancer, non-small cell lung cancer, kidney cancer, cervical cancer, epithelial ovarian, fallopian tube, or primary peritoneal cancer, cancer of colon and rectum.

Vegfxta 400 mg Infusion works against a protein called vascular endothelial growth factor (VEGF). Inhibition of vascular endothelial growth factor (VEGF) limits the flow of oxygen and nutrients to the tumour cells, causing them to shrink or cease developing. Thereby, Vegfxta 400 mg Infusion helps treat cancer.

Vegfxta 400 mg Infusion may reduce the number of red blood cells leading to anaemia. Its symptoms include pale skin, lack of energy, feeling breathless, feeling dizzy and lightheadedness.

Chemotherapy remains necessary. Vegfxta 400 mg Infusion is given along with chemotherapy for treating cancer.

Vegfxta 400 mg Infusion may increase the risk of bleeding and problems with wound healing. If you have had major surgery in the past 28days or if the wound hasn&amp;#039;t healed, you should not take Vegfxta 400 mg Infusion. Talk to your doctor for more information.

Cancer can affect anyone, though the risk increases with age. Individual risk is determined by factors such as smoking and drinking habits, lifestyle choices such as what you eat and exercise; a family history of cancer, and factors in your workplace and environment.

Vegfxta 400 mg Infusion may increase the incidence of hypertension. Therefore, consult your doctor before taking Vegfxta 400 mg Infusion if you have high blood pressure.

Vegfxta 400 mg Infusion is given intravenously (into a vein) infusion by a healthcare professional. Vegfxta 400 mg Infusion should never be given as an intravenous push or bolus. Do not self-administer.

The duration of treatment with Vegfxta 400 mg Infusion depends on your condition and response to the treatment. Your doctor will decide the length of time, based on its effectiveness and your tolerance. Regular monitoring will guide ongoing treatment.

Chemotherapy targets and destroys rapidly dividing cells, including cancer cells, to stop their growth and spread. While, Vegfxta 400 mg Infusion works by inhibiting the formation of new blood vessels that supply oxygen and nutrients to tumors. Cutting off this blood supply helps shrink the tumor or prevent it from growing further.

A person taking Vegfxta 400 mg Infusion may still require chemotherapy. Vegfxta 400 mg Infusion is often used in combination with chemotherapy to treat certain cancers, as it helps prevent tumor growth by blocking blood vessel formation and improves the effectiveness of chemotherapy.

Vegfxta 400 mg Infusion causes side effects such as constipation, loss of appetite, fever, nose bleeds, change in speech, voice changes/hoarseness, and loss of body weight. Most of these side effects do not require any medical requirements as they will gradually reduce over time. Contact a doctor if these side effects persist for longer durations.

Country of origin

India

Manufacturer/Marketer address

Fresenius Kabi Ag , Else-Krã¶Ner-Straãÿe 1 , 61352 Bad Homburg , Germany
Other Info - VEG0194

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Santoshini Reddy GDoctor badge

Reviewed By

Santoshini Reddy G

M Pharmacy

Last Updated

Jul 18, 2025 | 6:55 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.ema.europa.eu/en/documents/product-information/avastin-epar-product-information_en.pdf
  2. https://www.avastin.com/hcp.html
  3. https://www.macmillan.org.uk/cancer-information-and-support/treatments-and-drugs/bevacizumab
  4. https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/125085s332lbl.pdf
  5. https://www.drugs.com/drug-interactions/bevacizumab.html
  6. https://www.medicines.org.uk/emc/files/pil.3885.pdf

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