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  1. Home
  2. Medicine

  3. Valren 450mg Tablet

Prescription drug
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Valren 450mg Tablet, Pack of 1 Tablet
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Extra 15% Off with Bank Offers

Composition :

VALGANCICLOVIR-450MG

Manufacturer/Marketer :

Myren Life Science India Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

About Valren 450mg Tablet

Valren 450mg Tablet is used to treat cytomegalovirus (CMV) infection of the retina of the eye in adult AIDS patients. Also, Valren 450mg Tablet is used to prevent CMV infection in patients who received an organ transplant from a donor infected with CMV.

Valren 450mg Tablet contains Valganciclovir, which is converted to ganciclovir in the body and inhibits viral multiplication.

In some cases, you may experience diarrhoea, loss of appetite, cough, headache, stomach pain, nausea, fever, tiredness, or sinusitis (sinus infection). Most of these side effects do not require medical attention. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Valren 450mg Tablet or any other medicines, please tell your doctor. Avoid taking Valren 450mg Tablet if you are pregnant, as it may cause birth defects. If you are breastfeeding, do not take Valren 450mg Tablet as it may be excreted in human milk and cause adverse effects in the baby. Women are recommended to use effective contraceptive measures while taking Valren 450mg Tablet and for 30 days after treatment with Valren 450mg Tablet.

Uses of Valren 450mg Tablet

Valren 450mg Tablet is used in the treatment of Cytomegalovirus (CMV) infection of the retina. The detailed uses of Valren 450mg Tablet are as follows:

  • CMV Retinitis: Valren 450mg Tablet treats viral eye infections in patients with AIDS.
  • CMV Prophylaxis: Valren 450mg Tablet prevents CMV disease in organ transplant recipients (kidney, heart, pancreas).

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Directions for Use

  • Valren 450mg Tablet can be taken with food to minimise stomach discomfort or as advised by your doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
  • Swallow Valren 450mg Tablet as a whole with a glass of water.
  • Do not chew, crush, or break it.

Medicinal Benefits

  • Valren 450mg Tablet contains Valganciclovir, an antiviral drug used to treat cytomegalovirus (CMV) infection of the retina of the eye in adult AIDS patients.
  • Valren 450mg Tablet is converted to ganciclovir in the body and inhibits viral replication.
  • Valren 450mg Tablet is used to prevent CMV infection in patients who received an organ transplant from a donor infected with CMV.

How Valren 450mg Tablet Works

Valren 450mg Tablet contains Valganciclovir, which works by getting converted to ganciclovir in the body and inhibits the multiplication of the virus. Thereby, it helps to control the infection.

Storage

• Store in a cool and dry place away from sunlight.• Keep Valren 450mg Tablet out of reach and sight of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Valren 450mg Tablet
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
Here are the steps to manage medication-triggered tremors or involuntary shaking:
  • Notify your doctor immediately if you experience tremors or involuntary shaking after taking medication or adjusting your medication regimen.
  • Your doctor may adjust your medication regimen or recommend alternative techniques like relaxation, meditation, or journaling to alleviate tremor symptoms.
  • Your doctor may direct you to practice stress-reducing techniques, such as deep breathing exercises, yoga, or journaling.
  • Regular physical activity, such as walking or jogging, can help reduce anxiety and alleviate tremor symptoms.
  • Your doctor may recommend lifestyle changes, such as avoiding caffeine, getting enough sleep, and staying hydrated, to help manage tremors.
  • Maintain regular follow-up appointments with your doctor to monitor tremor symptoms and adjust treatment plans as needed.
Here are the 7 step-by-step strategies to manage the side effect of "inability to sleep" caused by medication usage:
  • Prepare for a restful night's sleep: Develop a calming pre-sleep routine, like reading or meditation, to help your body relax and prepare for sleep.
  • Create a sleep-conducive Environment: Make bedroom a sleep haven by ensuring it is quiet, dark and calm.
  • Follow a Sleep Schedule: Go to bed and get up at the same time every day to help regulate your body's internal clock and increase sleep quality.
  • Try relaxing techniques like deep breathing, mindfulness meditation and any others.
  • Limit stimulating activities before bedtime: Avoid stimulating activities before bedtime to improve sleep quality.
  • Monitor Progress: Keep track of your sleep patterns to identify areas for improvement.
  • Consult a doctor if needed: If these steps don't improve your sleep, consult a doctor for further guidance and therapy.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Limit sugary drinks and foods to reduce yeast growth.
  • Avoid yeast-rich foods like beer, wine, and sourdough bread.
  • Include probiotic-rich foods like yogurt, kefir, kimchi, and sauerkraut.
  • Eat antifungal foods like garlic, onions, cinnamon, and coconut oil.
  • Focus on nutrient-rich foods high in vitamins C and E.
  • Use a warm saltwater rinse in your mouth several times daily.
  • Practice excellent oral hygiene through regular brushing, flossing, and denture cleaning.
  • Stay hydrated by drinking plenty of water.
  • To manage stress, try relaxation methods like deep breathing exercises, meditation, or yoga to help calm your mind and body.
  • Avoid smoking and tobacco to prevent immune function impairment.
  • Consult a doctor for proper diagnosis and treatment.

What if I have taken an overdose of Valren 450mg Tablet

Take Valren 450mg Tablet only as prescribed by the physician. Avoid exceeding the recommended dose as it could lead to an overdose. Symptoms of overdose may include upset stomach, vomiting, stomach pain, diarrhoea, uncontrolled shaking, seizures, decreased urination, bloody urine, signs of infection (sore throat, fever, chills, cough), excessive tiredness, pale skin, yellowing of skin or eyes, dizziness, fast heartbeat, weakness, and unusual bleeding or bruising. If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

  • If you are allergic to Valren 450mg Tablet or any other medicines, please tell your doctor.
  • If you have a low number of platelets, white blood cells or red blood cells and kidney problems, inform your doctor before taking Valren 450mg Tablet.
  • Avoid taking Valren 450mg Tablet if you are pregnant as it may cause birth defects.
  • If you are breastfeeding, do not take Valren 450mg Tablet as it may be excreted in human milk and cause adverse effects in the baby.
  • Women are recommended to use effective contraceptive measures while taking Valren 450mg Tablet and 30 days after treatment with Valren 450mg Tablet.
  • Men are advised to continue using contraceptive measures for 90 days after treatment with Valren 450mg Tablet.
  • Drive only if you are alert as Valren 450mg Tablet may cause dizziness, tiredness, drowsiness, shakiness or confusion.
  • If you are having blood dialysis or radiotherapy, please inform your doctor before taking Valren 450mg Tablet.

Drug-Drug Interactions

verifiedApollotooltip
ValganciclovirCidofovir
Critical
ValganciclovirInfliximab
Severe

Drug-Drug Interactions

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ValganciclovirCidofovir
Critical
How does the drug interact with Valren 450mg Tablet:
Taking cidofovir with Valren 450mg Tablet can increase the risk of kidney problems.

How to manage the interaction:
Taking Valren 450mg Tablet with Cidofovir is not recommended as it can possibly result in an interaction, but can be taken together if prescribed by a doctor. However, if you experience nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or loss, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.
ValganciclovirInfliximab
Severe
How does the drug interact with Valren 450mg Tablet:
The combined use of infliximumab and Valren 450mg Tablet can increase the risk of infections.

How to manage the interaction:
Co-administration of Valren 450mg Tablet with Infliximab can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
ValganciclovirZidovudine
Severe
How does the drug interact with Valren 450mg Tablet:
Combining Valren 450mg Tablet with Zidovudine can increase the risk of side effects.

How to manage the interaction:
Although taking Valren 450mg Tablet and Zidovudine together can cause an interaction, it can be taken if your doctor has suggested it. If you experience any complications or symptoms, make sure to contact your doctor right away. Do not stop using any medications without a doctor's advice.
ValganciclovirGolimumab
Severe
How does the drug interact with Valren 450mg Tablet:
The combined use of golimumab and Valren 450mg Tablet can increase the risk of infections.

How to manage the interaction:
Although taking Valren 450mg Tablet and Golimumab together can cause an interaction, it can be taken if your doctor has suggested it. If you notice any of the following symptoms - fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, pain or burning while peeing - contact your doctor right away. Do not stop using any medications without talking to your doctor.
ValganciclovirMaribavir
Severe
How does the drug interact with Valren 450mg Tablet:
When Valren 450mg Tablet is used with Maribavir, it may make Valren 450mg Tablet less effective in treating your condition

How to manage the interaction:
Although there is a possible interaction between Valren 450mg Tablet and Maribavir, you can take these medicines together if prescribed by your doctor. If you're having any unusual symptoms, contact a doctor right away. Do not stop using any medications without talking to your doctor.
ValganciclovirTenofovir alafenamide
Severe
How does the drug interact with Valren 450mg Tablet:
When Valren 450mg Tablet is taken with Tenofovir alafenamide it may increase the risk of kidney problems.

How to manage the interaction:
Although taking Tenofovir alafenamide and Valren 450mg Tablet together can cause an interaction, it can be taken if your doctor has suggested it. However, consult your doctor immediately if you experience symptoms such as nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not stop using any medications without talking to your doctor.
ValganciclovirAdalimumab
Severe
How does the drug interact with Valren 450mg Tablet:
The combined use of adalimumab and Valren 450mg Tablet can increase the risk of serious infections.

How to manage the interaction:
There may be a possibility of interaction between Valren 450mg Tablet and Adalimumab, but it can be taken if prescribed by a doctor. If you notice any of the following symptoms - fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, pain or burning while peeing - reach out to your doctor right away. Do not stop using any medications without talking to your doctor.
ValganciclovirCertolizumab
Severe
How does the drug interact with Valren 450mg Tablet:
Taking Valren 450mg Tablet and Certolizumab may increase the risk of serious infection.

How to manage the interaction:
Although there is a possible interaction between Valren 450mg Tablet and Certolizumab, you can take these medicines together if prescribed by your doctor. If you notice any of the following symptoms - fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, pain, or burning while urinating - contact your doctor right away. Do not discontinue any medications without consulting your doctor.
ValganciclovirDeferiprone
Severe
How does the drug interact with Valren 450mg Tablet:
Taking Valren 450mg Tablet and Deferiprone may increase the risk of severe infections.

How to manage the interaction:
There may be a possibility of interaction between Valren 450mg Tablet and Deferiprone, but it can be taken if prescribed by a doctor. If you're having any of these symptoms - like infection, fever, chills, diarrhea, sore throat, trouble breathing, losing weight, or pain while peeing - contact your doctor right away. Do not stop using any medications without a doctor's advice.
ValganciclovirCladribine
Severe
How does the drug interact with Valren 450mg Tablet:
The combined use of cladribine and Valren 450mg Tablet can increase the risk of infections.

How to manage the interaction:
Taking Cladribine with Valren 450mg Tablet together can possibly result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms - infection, fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, pain, or burning while urinating - contact your doctor right away. Do not discontinue any medications without consulting your doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat a healthy and balanced diet. Eat vitamin and nutrient-rich food such as dark-green, yellow, orange, and red vegetables and fruits as it helps to boost your immune system. Opt for lean protein and whole grains.
  • Avoid eating raw meat and eggs. Consume properly boiled and cooked meat, poultry or seafood.
  • Eat bland and low-fat foods and avoid spicy or oily foods if you experience nausea or vomiting.

Habit Forming

No

Therapeutic Class

ANTIVIRALS

Valren 450mg Tablet Substitute

Substitutes safety advice
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Alcohol

Consult your doctor

The interaction of alcohol with Valren 450mg Tablet is unknown. Please consult a doctor before consuming alcohol while using Valren 450mg Tablet.

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Pregnancy

Unsafe

Valren 450mg Tablet is not recommended for pregnant women as it may cause birth defects. Please consult a doctor if you are pregnant.

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Breast Feeding

Unsafe

Avoid breastfeeding while taking Valren 450mg Tablet as it may pass into breast milk. Therefore, please consult a doctor if you are breastfeeding.

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Driving

Unsafe

Valren 450mg Tablet may cause dizziness, tiredness, drowsiness, shakiness or confusion in some people. Therefore, avoid driving or operating heavy machinery if you experience any of these symptoms after taking Valren 450mg Tablet.

bannner image

Liver

Caution

Take Valren 450mg Tablet with caution, especially if you have a history of liver disease. The dose may be adjusted by your doctor as required.

bannner image

Kidney

Caution

Take Valren 450mg Tablet with caution, especially if you have a history of kidney disease. The dose may be adjusted by your doctor as required.

bannner image

Children

Consult your doctor

Valren 450mg Tablet should be used in children only if recommended by a doctor.

FAQs

Valren 450mg Tablet is used to treat cytomegalovirus (CMV) infection of the retina of the eye in adult AIDS patients. Also, it is used to prevent CMV infection in patients who received an organ transplant from a donor infected with CMV.

Valren 450mg Tablet contains Valganciclovir that works by getting converted to ganciclovir in the body and inhibits the multiplication of the virus. Thereby, it helps to control the infection.

Valren 450mg Tablet may be used to prevent cytomegalovirus infection in patients who received an organ transplant from a donor infected with CMV.

Valren 450mg Tablet may cause diarrhoea as a temporary side effect. However, if the condition persists or worsens, please consult a doctor.

Valren 450mg Tablet should be used with caution in patients with kidney problems and only in doses as prescribed by a doctor. However, regular blood tests are recommended while taking Valren 450mg Tablet to monitor kidney functioning.

You are not recommended to take Valren 450mg Tablet with tacrolimus (immunosuppressant) as it may increase the risk of kidney or nerve damage, cause side effects affecting bone marrow function leading to a low number of blood cells. Therefore, please consult a doctor before taking Valren 450mg Tablet with other medicines.

Valren 450mg Tablet is classed as a cytotoxic medicine and will therefore require special handling.

Common side effects of Valren 450mg Tablet may include diarrhoea, loss of appetite, cough, headache, stomach pain, nausea, fever, tiredness, or sinusitis (sinus infection). Most of the side effects of Valren 450mg Tablet do not require medical attention and resolve gradually over time. However, if the side effects persist or worsen, please consult your doctor.

Yes, it also has activity against the alpha herpesviruses. But it should be taken only if recommended by the healthcare professional.

Valren 450mg Tablet contains Valganciclovir as an active ingredient.

It is a viral infection of the retina (light-sensing cells) caused by cytomegalovirus. In serious cases, it may lead to blindness. CMV retinitis is more likely to affect people with a weakened immune system from HIV/AIDS. The symptoms include blurred vision, a blind spot in vision, floaters in the eye, loss of peripheral vision or flashes in the eye.

Valren 450mg Tablet is not recommended for pregnant women as it may cause birth defects. Please consult a doctor if you are pregnant or have any concerns.

If you are breastfeeding, do not take Valren 450mg Tablet as it may be excreted in human milk and cause adverse effects in the baby.

Valren 450mg Tablet may cause dizziness, tiredness, drowsiness, shakiness or confusion in some people. Therefore, avoid driving or operating heavy machinery if you experience these symptoms after taking Valren 450mg Tablet.

Manufacturer/Marketer address

50-51, 4Th Floor, B Block, Chandigarh City Center, Vip Road, Zirakpur-140603
Other Info - VA78989

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Author Details

Veda MaddalaDoctor badge

Written By

Veda Maddala

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Nov 5, 2025 | 1:38 PM IST

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Reference

  1. https://www.medicines.org.uk/emc/files/pil.8177.pdf
  2. https://www.medicines.org.uk/emc/files/pil.6508.pdf
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