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Valrate Syrup is used to treat epilepsy and helps control different types of seizures or fits. It reduces the frequency and severity of seizure episodes and supports long-term seizure management, improving overall quality of life. Additionally, Valrate Syrup is used in the treatment of bipolar disorder, where it helps stabilise mood, reduce episodes of mania, and control mood swings.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Manufacturer/Marketer :

3C Pharmaceuticals Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

NPPA :

Regulated

About Valrate Syrup

Valrate Syrup is an oral liquid medicine prescribed primarily to control and prevent various types of seizures in children. It helps stabilise the electrical activity in the brain, reducing the frequency and severity of fits. This syrup is a key part of long-term management for paediatric epilepsy.

For the medicine to work effectively, your child must take it consistently at the same times every day as directed by their doctor. It can be taken with or after food to help prevent an upset stomach, which is a common initial side effect. Maintaining a regular sleep schedule and avoiding known seizure triggers can significantly support the benefits of this treatment.

While many children tolerate this medicine well, some may experience temporary side effects like sleepiness, mild nausea, or changes in appetite. If you notice any serious signs such as unusual bruising, yellowing of the skin or eyes, or severe stomach pain with vomiting, you must contact your child's doctor immediately.

Before starting this treatment, tell your doctor if your child has a history of liver problems, kidney disease, or a family history of metabolic disorders. This medicine should not be given to children who have active liver disease or certain rare genetic conditions affecting liver function.

It can interact with other medicines, such as certain antibiotics or other anti-seizure drugs, which may change how well it works or increase the risk of side effects. Although this is a pediatric formulation, it is important to know that this medicine can cause harm during pregnancy, so teenage patients or caregivers of childbearing age should discuss appropriate precautions with their doctor.

Uses of Valrate Syrup

Valrate Syrup is used to control and prevent various types of seizures in children. The detailed uses of Valrate Syrup are as follows:

  • Epilepsy and seizures: Valrate Syrup helps control various types of seizures, including absence seizures, generalised tonic-clonic seizures, and partial seizures, by calming overactive nerve signals in the brain.
  • Manic episodes: In older children or teenagers, it may be used under specialist supervision to manage phases of extreme excitement or overactivity associated with bipolar disorder.

Key Benefits

Valrate Syrup helps control seizures in children by stabilising abnormal electrical activity in the brain. With regular use as prescribed, it helps reduce the frequency of seizures, supports healthy growth and development, and provides an easy-to-administer treatment option for young children.

  • Reduces Seizure Frequency: By helping stabilise brain activity, this medicine helps reduce the number of seizures, allowing your child to participate more comfortably in daily activities.
  • Supports Healthy Growth and Development: Better seizure control helps minimise disruptions to learning, sleep, play, and social interactions, supporting your child's physical, cognitive, and emotional development.
  • Easy for Children to Take: The syrup formulation is suitable for infants and young children who cannot swallow tablets, ensuring accurate dosing and making treatment more convenient for caregivers.

Directions for Use

  • Valrate Syrup can be administered with or without food as directed by the doctor.
  • Follow your doctor’s instructions on the dosage and timing of this medication to ensure safety.
  • Administer the prescribed dose to the child using the measuring cup/dosing syringe.
  • Shake well before use.

How Valrate Syrup Works

Valrate Syrup contains sodium valproate, which works by regulating natural chemicals in the brain that carry signals between nerve cells. When a seizure occurs, there is a sudden, abnormal burst of electrical activity. This medicine helps increase the levels of a calming chemical messenger called GABA (gamma-aminobutyric acid). By boosting GABA, the medicine dampens excessive and rapid nerve signalling. This stabilises the electrical pathways in the brain, making it much harder for a seizure to start or spread.
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Alcohol

Not applicable

It is intended for Children.

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Pregnancy

Not applicable

It is intended for Children.

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Breast Feeding

Not applicable

It is intended for Children.

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Driving

Not applicable

It is intended for Children.

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Liver

Consult your doctor

Inform your doctor if your child has liver problems. Your doctor will prescribe only if the benefits outweigh the risks.

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Kidney

Consult your doctor

Inform your doctor if your child has kidney problems. Your doctor will prescribe only if the benefits outweigh the risks.

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Children

Safe if prescribed

Valrate Syrup can be given safely to children. Give this medicine to your child in the doses as prescribed by the doctor.

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Heart

Caution

Valrate Syrup is generally safe for children, but caution is needed if they have heart problems. Always consult a paediatrician before use to ensure it’s appropriate for your child’s condition and medications.

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Geriatrics

Not applicable

Valrate Syrup is specifically for children's use and is not meant for geriatric patients.

What if I have taken an overdose of Valrate Syrup

If your child takes more than their prescribed dose, seek emergency medical care immediately. Look out for signs like extreme sleepiness, shallow breathing, or confusion.

Diet & Lifestyle Advise

  • Maintain a strict sleep schedule: Sleep deprivation is a common trigger for seizures. Ensure your child gets a consistent, age-appropriate amount of sleep every night.
  • Offer meals with the medicine: Giving the syrup with healthy, non-acidic foods or milk can ease digestive side effects like nausea or stomach ache.
  • Keep a seizure diary: Track when seizures occur, what your child was doing beforehand, and when they took their medicine. This helps the doctor monitor how well the treatment is working.
  • Avoid sudden dietary shifts: Do not start specialised diets (like a ketogenic diet) unless specifically recommended and monitored by your child's medical team.
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How Soon It Starts Working

  • The time required for Valrate Syrup to start to work: Valrate Syrup ideally shows its action within 1 hour after administration.
  • The time for which the effects of Valrate Syrup last: The effect of Valrate Syrup lasts for 8 to 12 hours.

What if you forget to take Valrate Syrup

If you forget to give a dose, give it as soon as you remember. However, if it is nearly time for the next scheduled dose, skip the missed one and continue with the regular schedule. Do not give a double dose to make up for a missed one.

Storage

•Store Valrate Syrup syrup at controlled room temperature, ideally between 15°C and 25°C.•Keep the bottle tightly closed in its original packaging to protect the liquid from direct sunlight and moisture.

Drug Warnings

  • Inspect the liquid before use: Ensure the syrup is clear and free of unusual particles or cloudiness before giving it to your child.
  • Use the correct measuring device: Always use the syringe or cup that comes with the package to ensure precise dosing; a normal teaspoon is not accurate.
  • Never stop treatment abruptly: Suddenly stopping this medicine can trigger severe, continuous seizures that can be dangerous.
  • Watch for early warning signs: Monitor your child closely for severe abdominal pain, persistent vomiting, or extreme lethargy, especially during the first six months of starting the treatment.
  • Schedule regular blood tests: Your doctor will need to perform periodic blood tests to check your child's liver function and monitor medicine levels in the body.

Drug-Drug Interactions

verifiedApollotooltip
  • Other Epilepsy Medicines: Medicines used to treat seizures, such as phenobarbital, phenytoin, or carbamazepine, may interact with Valrate Syrup , increasing the risk of drowsiness or altering how well either medicine works. Your doctor may monitor your child's treatment and adjust the dose if necessary.
  • Certain Antibiotics: Antibiotics such as erythromycin may affect how your child's body processes Valrate Syrup , increasing the risk of side effects. Inform your doctor if your child is taking any antibiotics.
  • Blood Thinners: Valrate Syrup may interact with blood-thinning medicines, affecting how they work and potentially increasing the risk of bleeding. Your doctor may recommend closer monitoring if these medicines are used together.
Sodium ValproateSodium phenylbutyrate
Critical

Drug-Drug Interactions

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Sodium ValproateSodium phenylbutyrate
Critical
How does the drug interact with Valrate Syrup 100 ml:
Combining Sodium phenylbutyrate and Valrate Syrup 100 ml can increase ammonia levels in the blood.

How to manage the interaction:
Taking Sodium phenylbutyrate with Valrate Syrup 100 ml is not recommended, but it can be taken if prescribed by a doctor. If you experience any symptoms like sudden dizziness, lightheadedness, fainting, headache, shortness of breath, nausea, vomiting, chest pain or tightness, rapid heartbeat, or memory loss, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Valrate Syrup 100 ml:
Co-administration of Ketamine and Valrate Syrup 100 ml can increase side effects and cause respiratory depression.

How to manage the interaction:
Co-administration of Ketamine and Valrate Syrup 100 ml can lead to an interaction, but it can be taken if your doctor advises. However, consult your doctor immediately if you experience any symptoms like dizziness, drowsiness, confusion, difficulty concentrating, excessive sedation, impaired thinking, judgment, and motor coordination. Avoid driving or operating hazardous machinery until you know how these medications affect you. Do not discontinue any medications without consulting the doctor.
How does the drug interact with Valrate Syrup 100 ml:
Co-administration of Leflunomide and Valrate Syrup 100 ml can increase the risk of causing liver problems.

How to manage the interaction:
Co-administration of Leflunomide and Valrate Syrup 100 ml can lead to an interaction, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Valrate Syrup 100 ml:
Co-administration of Meropenam and Valrate Syrup 100 ml together can reduce the effect of Valrate Syrup 100 ml.

How to manage the interaction:
Co-administration of Meropenam and Valrate Syrup 100 ml can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any unusual symptoms, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Valrate Syrup 100 ml:
Using buprenorphine together with Valrate Syrup 100 ml may increase the risk of severe side effects, including respiratory problems and loss of consciousness.

How to manage the interaction:
Although the administration of buprenorphine alongside Valrate Syrup 100 ml can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Severe
How does the drug interact with Valrate Syrup 100 ml:
Co-administration of Vorinostat with Valrate Syrup 100 ml can increase the risk of unusual bleeding.

How to manage the interaction:
Co-administration of Vorinostat and Valrate Syrup 100 ml can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness, consult your doctor immediately. Do not discontinue any medications without consulting your doctor.
How does the drug interact with Valrate Syrup 100 ml:
The combined use of Ertapenem and Valrate Syrup 100 ml can reduce the blood levels of valproic acid.

How to manage the interaction:
Co-administration of Ertapenem and Valrate Syrup 100 ml can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like loss of seizure control or changes in behavior, consult your doctor immediately. Do not discontinue any medications without consulting the doctor.
How does the drug interact with Valrate Syrup 100 ml:
Co-administration of Teriflunomide and Valrate Syrup 100 ml can increase the risk of causing liver problems.

How to manage the interaction:
Co-administration of Teriflunomide and Valrate Syrup 100 ml can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, light-colored stools, and yellowing of the skin or eyes. Avoid alcohol while taking these medications, and consult your doctor immediately. Do not discontinue any medications without consulting your doctor.
How does the drug interact with Valrate Syrup 100 ml:
Co-administration of Valrate Syrup 100 ml with doripenem can reduce the blood levels of valproic acid.

How to manage the interaction:
Co-administration of Doripenam and Valrate Syrup 100 ml can lead to an interaction, it can be taken if advised by your doctor. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, involuntary muscle movements, or memory loss, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Valrate Syrup 100 ml:
Co-administration of Lithium with Valrate Syrup 100 ml can increase the risk irregular heart rhythm.

How to manage the interaction:
Co-administration of Lithium and Valrate Syrup 100 ml can lead to an interaction, but it can be taken if advised by your doctor. However, consult your doctor immediately if you experience any symptoms like dizziness, drowsiness, confusion, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, and difficulty concentrating. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Food: There are no major food interactions with Valrate Syrup . However, giving the syrup with food may help reduce stomach irritation and improve your child's comfort during treatment.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTICONVULSANT]

FAQs

Valrate Syrup is used to treat epilepsy/seizures/fits and bipolar disorder.
Valrate Syrup decreases the excessive and abnormal nerve activity in the brain. It balances the brain's chemical messenger and prevents overactivity of the brain, thereby controlling seizure episodes.
Valrate Syrup helps to treat manic episodes associated with bipolar disorder by increasing the amount of a chemical substance called GABA; this helps block nerve transmission across the brain and provides a calming effect.
Do not discontinue Valrate Syrup without consulting your doctor. To treat your child's condition effectively, continue using Valrate Syrup for as long as prescribed. Do not be reluctant to speak with your doctor if your child experiences difficulty while taking Valrate Syrup ; your doctor will gradually reduce the dose to avoid worsening seizures.
Valrate Syrup may change the results of liver enzymes, urine, and blood tests. Inform the person doing the tests that your child is using Valrate Syrup .
Yes, you can mix the syrup with a small amount of water, milk, or fruit juice if your child dislikes the taste, but ensure they drink the entire mixture immediately. Talk to your doctor or pharmacist for specific advice.
If your child vomits within 15 minutes of taking the medicine, talk to your doctor or pharmacist to ask if you should give another dose. Do not give a second dose without professional advice.
Yes, mild sleepiness or drowsiness is a common side effect, especially when starting the medicine or after gradually increasing the dose. Talk to your doctor if the sleepiness is severe or does not improve.
Generally, paracetamol is safe to use for occasional pain or fever, but you should avoid aspirin as it can interact with this medicine. Always talk to your doctor or pharmacist before introducing any new over-the-counter medicines.
Some children may experience mild mood shifts, hyperactivity, or irritability. However, if you notice severe mood changes, depression, or unusual behaviours, talk to your doctor immediately.
Give the missed dose as soon as you remember, unless it is close to the next scheduled dose. Never double the dose to make up for a missed one, and talk to your doctor or pharmacist if you miss multiple doses.

Disclaimer

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Country of origin

India

Manufacturer/Marketer address

142 AB, Kandivli Industrial Estate, Kandivli (West), Mumbai - 400 067, Maharashtra.
Other Info - VAL0117
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