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  3. Valkem 500 Oral Solution 100 ml

Valkem 500 Oral Solution 100 ml, Pack of 1 SOLUTION
Valkem 500 Oral Solution 100 ml, Pack of 1 SOLUTION
Valkem 500 Oral Solution 100 ml, Pack of 1 SOLUTION
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Written By Lakshmithulasi Yarragunta ,
Reviewed By Santoshini Reddy G , M Pharmacy

Valkem 500 Oral Solution is used to treat epilepsy/seizures/fits. Additionally, it is also used to treat manic episodes associated with bipolar disorder and prevent migraines. It contains Divalproex, which decreases the brain's excessive and abnormal nerve activity. Thereby helping in controlling seizures. It helps block nerve transmission across the brain and provides a calming effect. In some cases, it may cause side effects such as abdominal pain, back pain, constipation, diarrhoea, dizziness, nausea, increased appetite, and vomiting. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Composition :

DIVALPROEX-500MG

Manufacturer/Marketer :

Alkem Laboratories Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Valkem 500 Oral Solution

Valkem 500 Oral Solution is used to treat epilepsy/seizures/fits. Additionally, it is also used to treat manic episodes associated with bipolar disorder and prevent migraines. Epilepsy is a sudden rush of electricity in the brain.

Valkem 500 Oral Solution contains 'Divalproex', which decreases the brain's excessive and abnormal nerve activity. Thereby helping in controlling seizures. It also helps block nerve transmission across the brain and provides a calming effect. Thereby helping treat bipolar disorder.

In some cases, Valkem 500 Oral Solution may cause side effects, such as abdominal pain, back pain, constipation, diarrhoea, dizziness, nausea, increased appetite, and vomiting. Most of these side effects do not require medical attention and resolve gradually over time. However, consult your doctor if any of these side effects persist.

Do not take Valkem 500 Oral Solution if you are pregnant, as it could cause serious birth defects. Consult your doctor before taking Valkem 500 Oral Solution if you are breastfeeding. Keep your doctor informed about your health condition and medicines to rule out any potential interactions.

Uses of Valkem 500 Oral Solution

Valkem 500 Oral Solution is used in the treatment of epilepsy, bipolar disorder, and migraine. The detailed uses of Valkem 500 Oral Solution are as follows:

  • Seizure Management: Valkem 500 Oral Solution is primarily used to manage various types of seizures in individuals with epilepsy, helping to stabilise electrical activity in the brain.
  • Bipolar Disorder Treatment: Valkem 500 Oral Solution can be used in the treatment of bipolar disorder, aiding in mood stabilisation and reducing the frequency of mood swings.
  • Migraine Prevention: Valkem 500 Oral Solution may also be prescribed to prevent migraines, providing relief from recurrent headaches.
  • Insomnia Treatment: Valkem 500 Oral Solution can improve sleep quality by inducing sedation, offering relief for those suffering from insomnia or other sleep disturbances.

Directions for Use

  • Valkem 500 Oral Solution can be taken with or without food.
  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Measure the prescribed dose using a measuring cup and take it orally.
  • Do not use household spoons for measuring the dose. 
  • Shake well before each use. 
  • Make sure to close the cap properly to avoid contamination. Wash the measuring cup after each use to maintain cleanliness.

Medicinal Benefits

  • Valkem 500 Oral Solution is used to manage various types of seizures (fits), including: simple partial seizures, complex partial seizures, and complex absence seizures.
  • It works by decreasing excessive and abnormal electrical activity in the brain, helping prevent the onset and spread of seizures.
  • Valkem 500 Oral Solution is also effective in treating mood disorders, such as bipolar disorder, by increasing the level of GABA (gamma-aminobutyric acid), a calming chemical that reduces nerve transmission in the brain.
  • It is used as a preventive treatment for migraine headaches by reducing the transmission of nerve signals that cause pain.
  • Valkem 500 Oral Solution may be prescribed alone or in combination with other antiepileptic drugs, depending on the type and severity of the seizures.
  • By enhancing GABA activity, Valkem 500 Oral Solution produces a calming effect on the brain, which is beneficial in both seizure control and mood stabilisation.

How Valkem 500 Oral Solution Works

Valkem 500 Oral Solution contains 'Divalproex', which decreases the brain's excessive and abnormal nerve activity. Thereby helping in controlling seizures. It also helps block nerve transmission across the brain and provides a calming effect. Thereby helping treat bipolar disorder.

Storage

• Store in a cool and dry place away from sunlight.• Keep Valkem 500 Oral Solution out of reach and sight of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Valkem 500 Oral Solution 100 ml
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Eat a balanced diet containing enough proteins, fibre, healthy fats, vegetables and fruits.
  • Get quality sleep for about 7-9 hours.
  • Try to manage stress with meditation or yoga.
  • Drink enough water.
  • Exercise regularly as it helps regulate appetite.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.

What if I have taken an overdose of Valkem 500 Oral Solution

Do not take more than the prescribed dose of Valkem 500 Oral Solution as it may cause overdose resulting in heart block, excessive sleepiness and deep coma. If you suspect you have taken an overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

  • Do not take Valkem 500 Oral Solution if you are allergic to any of its contents, have/ had liver problems or urea cycle disorders.
  • Inform your doctor before taking Valkem 500 Oral Solution if you have pancreatitis, blood problems or multi-organ hypersensitivity.
  • Consult your doctor immediately if you experience suicidal tendencies while taking Valkem 500 Oral Solution .
  • Valkem 500 Oral Solution may cause thrombocytopenia (low blood platelets), hyperammonemia (high levels of ammonia in the blood), hypothermia (low body temperature) and liver problems.
  • Please do not stop taking Valkem 500 Oral Solution without consulting your doctor to avoid worsening of seizures.
  • Do not take Valkem 500 Oral Solution if you are pregnant, as it could cause serious birth defects.
  • If you are of childbearing age, use effective contraception while taking Valkem 500 Oral Solution .
  • Consult your doctor before taking Valkem 500 Oral Solution if you are breastfeeding.
  • Avoid driving or operating machinery, as Valkem 500 Oral Solution can cause dizziness and may affect thinking and motor skills.
  • Avoid consuming alcohol along with Valkem 500 Oral Solution as it could lead to increased dizziness.
  • Care should be taken while giving Valkem 500 Oral Solution to children below 2 years, as there is a higher risk of liver intoxication during the first six months of treatment.

Drug-Drug Interactions

verifiedApollotooltip
DivalproexGlycerol phenylbutyrate
Critical
DivalproexDoripenem
Severe

Drug-Drug Interactions

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DivalproexGlycerol phenylbutyrate
Critical
How does the drug interact with Valkem 500 Oral Solution 100 ml:
Coadministration of Glycerol phenylbutyrate and Valkem 500 Oral Solution 100 ml can increase ammonia levels in the blood.

How to manage the interaction:
Taking Glycerol phenylbutyrate and Valkem 500 Oral Solution 100 ml together is generally avoided as it can lead to an interaction, it can be taken when your doctor advises. If you experience any symptoms like sudden dizziness, headaches, vomiting, and visual disturbances, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
DivalproexDoripenem
Severe
How does the drug interact with Valkem 500 Oral Solution 100 ml:
Co-administration of Valkem 500 Oral Solution 100 ml and Doripenem can reduce the blood levels of Valkem 500 Oral Solution 100 ml sodium and increase the risk of developing seizures.

How to manage the interaction:
Co-administration of Valkem 500 Oral Solution 100 ml with Doripenem can possibly result in an interaction, it can be taken when your doctor has advised it. Do not stop using any medications without first talking to your doctor.
DivalproexSodium phenylbutyrate
Severe
How does the drug interact with Valkem 500 Oral Solution 100 ml:
Co-administration of Sodium phenylbutyrate and Valkem 500 Oral Solution 100 ml can increase ammonia levels in the blood and is generally not recommended for patients with urea cycle disorders.

How to manage the interaction:
Co-administration of Valkem 500 Oral Solution 100 ml with Sodium phenylbutyrate can possibly result in an interaction, but it can be taken if your doctor has advised it. Do not discontinue any medications without first consulting your doctor.
DivalproexSodium oxybate
Severe
How does the drug interact with Valkem 500 Oral Solution 100 ml:
Co-administration of Sodium oxybate and Valkem 500 Oral Solution 100 ml can increase the risk of developing side effects.

How to manage the interaction:
Co-administration of Sodium oxybate and Valkem 500 Oral Solution 100 ml can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like dizziness, sweating, palpitations, and shortness of breath, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
DivalproexKetoconazole
Severe
How does the drug interact with Valkem 500 Oral Solution 100 ml:
Coadministration of Ketoconazole and Valkem 500 Oral Solution 100 ml may increase the risk of liver damage.

How to manage the interaction:
Although taking Ketoconazole and Valkem 500 Oral Solution 100 ml together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you have any of the following symptoms: fever, chills, joint pain, fatigue, nausea, vomiting, stomach pain, dark urine, and yellowing of the skin or eyes, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
DivalproexEsketamine
Severe
How does the drug interact with Valkem 500 Oral Solution 100 ml:
Coadministration of Esketamine and Valkem 500 Oral Solution 100 ml can increase the side effects of esketamine.

How to manage the interaction:
Although taking Valkem 500 Oral Solution 100 ml and Esketamine together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience any symptoms like drowsiness and impaired motor coordination, consult the doctor immediately. Do not stop using any medications without talking to your doctor.
DivalproexMeropenem
Severe
How does the drug interact with Valkem 500 Oral Solution 100 ml:
Co-administration of Valkem 500 Oral Solution 100 ml and Meropenem can reduce the blood levels of Valkem 500 Oral Solution 100 ml sodium.

How to manage the interaction:
Co-administration of Valkem 500 Oral Solution 100 ml with Meropenem can possibly result in an interaction, but it can be taken if your doctor has advised it. Do not discontinue any medications without a doctor's advice.
DivalproexTeriflunomide
Severe
How does the drug interact with Valkem 500 Oral Solution 100 ml:
Co-administration of Valkem 500 Oral Solution 100 ml and teriflunomide can increase the risk of liver problems.

How to manage the interaction:
Co-administration of Valkem 500 Oral Solution 100 ml and teriflunomide can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like fever, chills, joint pain, unusual bleeding, weakness, nausea, vomiting, stomach pain, dark urine, pale stools, and yellowing of the skin or eyes, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
DivalproexBexarotene
Severe
How does the drug interact with Valkem 500 Oral Solution 100 ml:
Co-administration of Valkem 500 Oral Solution 100 ml and Bexarotene can increase the risk of pancreatitis (inflammation of the pancreas).

How to manage the interaction:
Co-administration of Valkem 500 Oral Solution 100 ml and Bexarotene can lead to an interaction, but it can be taken when advised by your doctor. However, if you experience any symptoms like nausea, vomiting, or stomach cramps, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
DivalproexErtapenem
Severe
How does the drug interact with Valkem 500 Oral Solution 100 ml:
Coadministration of Ertapenem with Valkem 500 Oral Solution 100 ml may reduce the blood levels of Valkem 500 Oral Solution 100 ml and increase the risk of developing seizures.

How to manage the interaction:
Although there is a possible interaction, ertapenem can be taken with Valkem 500 Oral Solution 100 ml if prescribed by the doctor. Consult the doctor if you experience loss of seizure control or changes in behaviour. Do not stop using any medications without talking to your doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • A ketogenic diet (low in carbohydrates and high in fats) is recommended for children with epilepsy. This diet helps in utilising fat instead of glucose for the generation of energy.
  • Atkins diet (high fat and controlled carbohydrates) is recommended for adolescents and adults.
  • Exercising regularly helps in maintaining weight and improving overall health.
  • Rest well, get plenty of sleep.
  • Avoid smoking and alcohol consumption.
  • Meditation and yoga can help lower stress, decrease pain sensitivity and improve coping skills.
  • Have a seizure response plan, and help those around you know what to do.
  • Prepare your living area; small changes may reduce the risk of physical injury during a seizure.
  • Understand what triggers seizures and try reducing or avoiding them.
  • Please pay attention to overall health, as it can help in reducing seizure activity.
  • Install an alarm or emergency device to get assistance during a seizure attack.

Habit Forming

No

Therapeutic Class

ANTICONVULSANT
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Alcohol

Unsafe

Avoid consumption of alcohol while taking Valkem 500 Oral Solution as it may cause increased dizziness.

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Pregnancy

Unsafe

Valkem 500 Oral Solution belongs to pregnancy category D. Avoid taking Valkem 500 Oral Solution if you are pregnant as it could lead to serious birth defects. Consult your doctor for further advice.

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Breast Feeding

Consult your doctor

Valkem 500 Oral Solution may pass into breastmilk. Consult your doctor before taking Valkem 500 Oral Solution if you are breastfeeding.

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Driving

Unsafe

Valkem 500 Oral Solution causes dizziness and may affect thinking and motor skills. Do not drive or operate machinery.

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Liver

Caution

Valkem 500 Oral Solution should not be used if you have liver problems or your family has a history of liver problems. Please consult your doctor if you have liver problems or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Consult your doctor

Valkem 500 Oral Solution can be given to children if prescribed by the doctor. The doctor will adjust the dose depending on the child's body weight. Care should be taken in children below two years, as they are at a higher risk of liver toxicity.

Have a query?

FAQs

Valkem 500 Oral Solution is used to treat epilepsy/seizures/fits. Additionally, it is also used to treat manic episodes associated with bipolar disorder and prevent migraines.

Valkem 500 Oral Solution decreases the excessive and abnormal nerve activity in the brain. This helps in controlling seizures.

Valkem 500 Oral Solution helps to treat manic episodes associated with bipolar disorder by increasing the amount of a chemical substance called GABA, which helps in blocking the nerve transmission across the brain and provides a calming effect.

Valkem 500 Oral Solution may interact with aspirin and cause abnormal side effects. So, it is recommended to take any medication along with Valkem 500 Oral Solution only after consulting a doctor.

Valkem 500 Oral Solution may improve the symptoms of depression. However, do not use it without consulting a doctor, as it may also cause mood disturbances and suicidal thoughts in some patients.

Do not discontinue Valkem 500 Oral Solution without consulting your doctor. To treat your condition effectually, continue taking Valkem 500 Oral Solution for as long as prescribed. Do not be reluctant to speak with your doctor if you feel any difficulty while taking Valkem 500 Oral Solution ; your doctor will gradually reduce the dose to avoid worsening seizures.

Before taking Valkem 500 Oral Solution , certain laboratory tests are recommended. These include a Complete Blood Count (CBC), liver function tests (LFTs), kidney function tests, blood urea nitrogen (BUN) and creatinine levels, and a pregnancy test for women of childbearing age. Additionally, blood glucose levels should be checked for patients with diabetes or at risk of developing diabetes. Platelet count and coagulation tests (PT/INR/APTT) are also recommended. Please note that this list may not be exhaustive, and additional tests or monitoring may be necessary based on individual circumstances.

Valkem 500 Oral Solution may cause thrombocytopenia (low levels of platelets). This might increase the risk of bleeding and bruising. Be cautious while using sharp objects. Consult your doctor if you notice unexplained bleeding or bruising. Regular monitoring of blood count is advised while taking Valkem 500 Oral Solution .

It's crucial to consult with your doctor before discontinuing Valkem 500 Oral Solution . Abruptly stopping this medication can lead to severe consequences, mainly if it's prescribed to treat conditions like epilepsy.

Valkem 500 Oral Solution can indeed make you sleepy. This is a common side effect of the medication. If you're experiencing excessive drowsiness, you must talk to your doctor.

Valkem 500 Oral Solution can be taken with or without food. However, it is recommended to take it with food to reduce stomach upset and improve absorption. Food can help buffer any potential stomach irritation and enhance the body's absorption of the medication.

Country of origin

India

Manufacturer/Marketer address

Alkem Laboratories Limited, Devashish Building, Alkem House, Senapati Bapat Road, Lower Parel, Mumbai - 400 013.
Other Info - VAL0426

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Author Details

Santoshini Reddy GDoctor badge

Reviewed By

Santoshini Reddy G

M Pharmacy

Last Updated

Jul 29, 2025 | 11:55 AM IST

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Reference

  1. https://meds.cvpharmacy.in/product/valance-250mg-5ml-solution/
  2. https://www.indiamart.com/proddetail/psyvox-syrup-divalproex-sodium-100-ml-pharma-franchise-pchpl-23905047012.html
  3. https://www.webmd.com/drugs/2/drug-1788/depakote-oral/details

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