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compositionComposition:VALPROIC ACID-500MG
prescription
Prescription Medicine
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Valance Oral Solution is used to treat seizures and manage manic episodes in bipolar disorder. It also helps prevent migraine attacks. It supports better brain stability and reduces symptom frequency. This helps improve daily functioning and overall quality of life.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

VALPROIC ACID-500MG

Manufacturer/Marketer :

Abbott India Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Valance Oral Solution

Valance Oral Solution is an oral prescription medication used to control various types of seizures in people with epilepsy. It is also prescribed to treat the manic phase of bipolar disorder and to prevent migraine headaches from occurring. This medicine works by calming overactive nerve activity in the brain to help stabilise your mood and prevent abnormal brain signals.

To get the best results, you must take Valance Oral Solution consistently every day at the same time as directed by your doctor. You can take this medicine with or without food, but taking it with meals can help prevent an upset stomach. Incorporating a regular sleep schedule, managing stress levels, and avoiding known seizure or migraine triggers can also support the effectiveness of your treatment.

While taking Valance Oral Solution , you may experience some common side effects such as mild sleepiness, nausea, or temporary hair thinning. However, you must seek medical help immediately if you notice serious symptoms like severe abdominal pain, dark urine, yellowing of your skin or eyes, or unusual mood changes.

Before starting this medication, tell your doctor if you have a history of liver problems, kidney disease, or pancreatic disorders. Do not take this if you have a family history of severe liver damage or genetic mitochondrial disorders. Pregnant women, or those planning to become pregnant, should not take this medicine for migraine prevention, and should only use it for epilepsy or bipolar disorder if no other treatments are suitable, due to a high risk of birth defects.

Valance Oral Solution can interact with alcohol, which can worsen drowsiness, and with other medicines like aspirin or certain antidepressants by changing how your body processes them. If you are pregnant, breastfeeding, or an older adult, consult your doctor or pharmacist to discuss the risks and benefits before starting this medicine.

Uses of Valance Oral Solution

Valance Oral Solution is used for the treatment of epilepsy (seizures), bipolar disorder, and migraine. The detailed uses of Valance Oral Solution are as follows:

  • Epilepsy and Seizure Control: Valance Oral Solution helps prevent and control various types of seizures, including absence seizures, complex partial seizures, and generalised tonic-clonic seizures, by reducing abnormal electrical activity in the brain.
  • Bipolar Disorder (Manic Episodes): Valance Oral Solution helps stabilise mood swings and manage manic episodes, which are periods of overly high, excited, or irritable mood.
  • Migraine Prevention: Valance Oral Solution reduces the frequency and severity of migraine headaches when taken daily as a preventive treatment.

Key Benefits

Valance Oral Solution helps manage seizures, stabilise mood in bipolar disorder, and prevent migraine headaches, helping you lead a more active and balanced life.

The following are the benefits of Valance Oral Solution :

  • Helps reduce the frequency and severity of seizures.
  • Improves mood stability in people with bipolar disorder.
  • Reduces the occurrence of migraine headaches.
  • Supports better concentration and emotional well-being.
  • Promotes greater confidence in carrying out everyday activities.
  • Provides long-term control of symptoms with regular treatment.
Side effects of Valance Oral Solution 500 ml
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Eat a balanced diet containing enough proteins, fibre, healthy fats, vegetables and fruits.
  • Get quality sleep for about 7-9 hours.
  • Try to manage stress with meditation or yoga.
  • Drink enough water.
  • Exercise regularly as it helps regulate appetite.

Directions for Use

  • Swallow the tablets or capsules whole with a full glass of water. Do not crush, chew, or break it.
  • Take this medicine with food if it causes an upset stomach.
  • Never change your dose or stop taking this medication suddenly without talking to your doctor first. Stopping abruptly can cause your seizures to return or worsen.
  • Always follow your doctor's exact instructions regarding your dosing schedule.

How Valance Oral Solution Works

Valance Oral Solution contains valproic acid, which works by stabilising electrical activity in the brain. In conditions like epilepsy, bipolar disorder, and migraines, brain cells can become overactive and send rapid, uncontrolled signals. To help restore balance, Valance Oral Solution increases the levels of a natural calming chemical in the brain called gamma-aminobutyric acid (GABA), which helps slow excessive nerve activity. It also reduces abnormal electrical signalling by blocking certain sodium channels and T-type calcium channels in nerve cells. Together, these actions help keep nerve signals stable, thereby preventing seizures, managing mood shifts, and reducing processes that can trigger migraines.
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Alcohol

Unsafe

Do not consume alcohol while taking Valance Oral Solution as alcohol can worsen the side effects of the Valance Oral Solution , including sleepiness and dizziness.

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Pregnancy

Unsafe

Valance Oral Solution is a Category D pregnancy drug. It is not recommended for use during pregnancy as it may cause an increase in the risk of a cleft lip, which is a congenital disability in the unborn baby. If you are a female able to have a baby, you must use an effective method of birth control (contraception) without interruption during your entire treatment with Valance Oral Solution .

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Breast Feeding

Caution

Valance Oral Solution passes into breast milk and may harm your infant. Please consult a doctor if you are breastfeeding before taking Valance Oral Solution . Breastfed infants are at risk for valproic acid-induced hepatotoxicity, so infants should be monitored for jaundice and other signs of liver damage during maternal therapy.

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Driving

Unsafe

Valance Oral Solution may cause dizziness, drowsiness, or fatigue in some individuals. Therefore, avoid driving if you feel drowsy, dizzy or tired after taking Valance Oral Solution .

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Liver

Caution

Inform your doctor before taking the Valance Oral Solution if you have a history of liver diseases. Extreme caution is recommended in patients with impaired liver function. Your doctor will weigh the benefits and potential risks before prescribing Valance Oral Solution .

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please inform your doctor if you have kidney impairment.

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Children

Caution

Use is not recommended for children under 10 years old. Your doctor will decide the dose based on your child's condition if they are more than ten years old.

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Heart

Caution

Valance Oral Solution can be used cautiously in patients with heart disease if prescribed by a physician.

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Geriatrics

Caution

Valance Oral Solution can be given to elderly patients with extreme caution if prescribed by a physician.

What if I have taken an overdose of Valance Oral Solution

If you suspect an overdose, seek immediate emergency medical attention or call your local poison control centre. Symptoms of an overdose may include severe drowsiness, shallow breathing, or loss of consciousness.

Diet & Lifestyle Advise

  • Avoid alcohol: Do not drink alcohol while taking this medicine, as it can increase drowsiness, dizziness, and the risk of liver problems.
  • Maintain a healthy diet: Eat a balanced diet and check your weight regularly, as this medicine may increase your appetite and lead to weight gain.
  • Stay well hydrated: Drink plenty of water throughout the day to support kidney function and your overall health.
  • Care for your hair and skin: Use gentle hair care products and moisturising skin creams if you notice temporary hair thinning or dry skin while taking this medicine.
  • Keep a symptom diary: Record your seizures, mood changes, or migraine episodes to help your doctor monitor your progress and adjust your treatment if needed.
health query

Have a query?

How Soon It Starts Working

  • The time required for Valance Oral Solution to start to work: Valance Oral Solution ideally shows its action within 1 to 4 hours after administration.
  • The time for which the effects of Valance Oral Solution last: The effect of Valance Oral Solution lasts for 13 to 19 hours.

What if you forget to take Valance Oral Solution

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.

Storage

• Store in a cool and dry place away from sunlight.• Keep Valance Oral Solution out of the sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • Attend regular blood tests: Get the blood tests your doctor recommends to check your liver, pancreas, and the amount of medicine in your body. This helps ensure the medicine is working safely.
  • Use effective birth control: If you can become pregnant, use reliable birth control while taking this medicine. Valance Oral Solution can seriously harm an unborn baby.
  • Watch for mood changes: Contact your doctor right away if you notice unusual changes in your mood, behaviour, or thoughts, including feelings of depression or thoughts of self-harm.
  • Tell healthcare providers about this medicine: Inform your doctor, dentist, or surgeon that you are taking this medicine before any procedure. It can affect how your blood clots.
  • Be careful with activities requiring alertness: Do not drive, operate heavy machinery, or do other dangerous activities until you know how this medicine affects you. It may cause drowsiness or reduce alertness.

Drug-Drug Interactions

verifiedApollotooltip
  • Anti-seizure medicines (e.g., phenytoin, carbamazepine): Taking these medicines alongside Valance Oral Solution may affect how either medicine works and may increase the risk of side effects or reduce seizure control.
  • Blood thinners (e.g., warfarin): Taking these medicines with Valance Oral Solution may increase the risk of bleeding and may require closer monitoring.
  • Certain antibiotics (e.g., meropenem, imipenem): These antibiotics may greatly reduce the amount of Valance Oral Solution in the body, increasing the risk of breakthrough seizures.
DivalproexGlycerol phenylbutyrate
Critical
DivalproexLamotrigine
Severe

Drug-Drug Interactions

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DivalproexGlycerol phenylbutyrate
Critical
How does the drug interact with Valance Oral Solution 500 ml:
Coadministration of Glycerol phenylbutyrate and Valance Oral Solution 500 ml can increase ammonia levels in the blood.

How to manage the interaction:
Taking Glycerol phenylbutyrate and Valance Oral Solution 500 ml together is generally avoided as it can lead to an interaction, it can be taken when your doctor advises. If you experience any symptoms like sudden dizziness, headaches, vomiting, and visual disturbances, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
DivalproexLamotrigine
Severe
How does the drug interact with Valance Oral Solution 500 ml:
Coadministration of Valance Oral Solution 500 ml and Lamotrigine can increase the risk and severity of side effects.

How to manage the interaction:
Although there is a possible interaction between Valance Oral Solution 500 ml and Lamotrigine, you can take these medicines together if prescribed by your doctor. However, contact your doctor if you experience restlessness, rash, or muscle weakness. Do not stop using any medications without a doctor's advice.
DivalproexLeflunomide
Severe
How does the drug interact with Valance Oral Solution 500 ml:
Co-administration of Valance Oral Solution 500 ml and leflunomide can increase the risk of liver problems.

How to manage the interaction:
Although there is an interaction between Valance Oral Solution 500 ml and leflunomide, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, and/or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
DivalproexVorinostat
Severe
How does the drug interact with Valance Oral Solution 500 ml:
Coadministration of Valance Oral Solution 500 ml and Vorinostat can increase the risk of bleeding.

How to manage the interaction:
Although there is a possible interaction between Valance Oral Solution 500 ml and Vorinostat, you can take these medicines together if prescribed by your doctor. If you experience any symptoms like unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness, consult the doctor immediately. Do not discontinue any medications without consulting your doctor.
DivalproexErtapenem
Severe
How does the drug interact with Valance Oral Solution 500 ml:
Coadministration of Ertapenem with Valance Oral Solution 500 ml may reduce the blood levels of Valance Oral Solution 500 ml and increase the risk of developing seizures.

How to manage the interaction:
Although there is a possible interaction, ertapenem can be taken with Valance Oral Solution 500 ml if prescribed by the doctor. Consult the doctor if you experience loss of seizure control or changes in behaviour. Do not stop using any medications without talking to your doctor.
DivalproexMeropenem
Severe
How does the drug interact with Valance Oral Solution 500 ml:
Co-administration of Valance Oral Solution 500 ml and Meropenem can reduce the blood levels of Valance Oral Solution 500 ml sodium.

How to manage the interaction:
Co-administration of Valance Oral Solution 500 ml with Meropenem can possibly result in an interaction, but it can be taken if your doctor has advised it. Do not discontinue any medications without a doctor's advice.
DivalproexSodium oxybate
Severe
How does the drug interact with Valance Oral Solution 500 ml:
Co-administration of Sodium oxybate and Valance Oral Solution 500 ml can increase the risk of developing side effects.

How to manage the interaction:
Co-administration of Sodium oxybate and Valance Oral Solution 500 ml can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like dizziness, sweating, palpitations, and shortness of breath, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
DivalproexDoripenem
Severe
How does the drug interact with Valance Oral Solution 500 ml:
Co-administration of Valance Oral Solution 500 ml and Doripenem can reduce the blood levels of Valance Oral Solution 500 ml sodium and increase the risk of developing seizures.

How to manage the interaction:
Co-administration of Valance Oral Solution 500 ml with Doripenem can possibly result in an interaction, it can be taken when your doctor has advised it. Do not stop using any medications without first talking to your doctor.
DivalproexTeriflunomide
Severe
How does the drug interact with Valance Oral Solution 500 ml:
Co-administration of Valance Oral Solution 500 ml and teriflunomide can increase the risk of liver problems.

How to manage the interaction:
Co-administration of Valance Oral Solution 500 ml and teriflunomide can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like fever, chills, joint pain, unusual bleeding, weakness, nausea, vomiting, stomach pain, dark urine, pale stools, and yellowing of the skin or eyes, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
DivalproexBuprenorphine
Severe
How does the drug interact with Valance Oral Solution 500 ml:
Co-administration of buprenorphine with Valance Oral Solution 500 ml may increase the risk of developing side effects.

How to manage the interaction:
Co-administration of Buprenorphine with Valance Oral Solution 500 ml can result in an interaction, it can be taken when a doctor has advised it. However, if you experience shortness of breath, irregular heart rhythms, nausea, vomiting, and diarrhea contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Carbonated beverages (e.g., soda, sparkling water): Consuming these drinks while taking Valance Oral Solution may increase the risk of irritation to the mouth and throat.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTICONVULSANT]

FAQs

Valance Oral Solution is used to treat epilepsy/seizures/fits. In addition, it also helps treat manic episodes associated with bipolar disorder and prevent migraine symptoms (like a headache).
Valance Oral Solution decreases the excessive and abnormal nerve activity in the brain. Thereby helping in controlling seizures.
Valance Oral Solution helps to treat manic episodes associated with bipolar disorder by increasing the amount of a chemical substance called GABA; this helps block nerve transmission across the brain and provides a calming effect.
Valance Oral Solution limits the transmission of nerve pain, thereby preventing migraine headaches. Migraines are a neurological condition characterised by intense headaches.
Valance Oral Solution may cause weight gain due to an increase in appetite. Maintain a healthy weight by following a healthy diet and exercising regularly.
Use an effective method of contraception during the treatment with Valance Oral Solution . Avoid getting pregnant while taking Valance Oral Solution as it could lead to serious birth defects. Do not stop taking Valance Oral Solution and consult your doctor immediately if you become pregnant.
Valance Oral Solution may cause weight gain due to an increase in appetite. Maintain a healthy weight by following a healthy diet and exercising regularly.
Valance Oral Solution may cause common side effects such as nausea, vomiting, headache, sleepiness, tremor, weakness, dizziness, stomach pain, and weight gain. If these side effects persist or worsen, please consult your doctor.
Valance Oral Solution contains Valproic acid as its active ingredient.
Take Valance Oral Solution with food to avoid stomach upset or as advised by your doctor.
You are recommended to avoid alcohol consumption while taking Valance Oral Solution as it may worsen the side effects of the Valance Oral Solution , including sleepiness and dizziness.
No, Valance Oral Solution does not cause addiction. However, Valance Oral Solution should be used as per the dose and duration prescribed by your doctor. Do not self-medicate.
Valance Oral Solution does not cure epilepsy; it only helps prevent seizures. However, you must take Valance Oral Solution for as long as your doctor advises. If you face any difficulty while taking Valance Oral Solution , consult your doctor.
If you stop taking Valance Oral Solution suddenly, it may increase the risk of recurrence of seizures. Therefore, it should be stopped gradually. If you feel the need to discontinue Valance Oral Solution , please consult your physician.
Some birth control pills (oestrogen-containing birth control pills) may lower the levels of Valance Oral Solution in blood. Thus, inform your doctor if you are using birth control pills and discuss with your doctor about a suitable method of contraception.
Valance Oral Solution is safe for long-term use in many patients when prescribed by a physician. In rare cases, prolonged use of Valance Oral Solution may weaken bones, thereby increasing the risk of fractures (osteopenia and osteoporosis). Get regular checkups for bone health if you have been taking Valance Oral Solution for a long time.
Valance Oral Solution may cause hair thinning, hair colour changes and even hair loss. If you have any concerns about this, please ask your doctor whether it is possible to reduce the dose of Valance Oral Solution . Your hair may regrow after either lowering your dose or changing medication.
Your doctor will order regular blood tests to check the levels of Valance Oral Solution in your body and to monitor how well your liver and blood cells are working. This ensures the medicine is working safely and effectively. Talk to your doctor if you have questions about your tests.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Drugs.com Clinical Review Team. Valproic Acid Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  2. Electronic Medicines Compendium (EMC). Pil.6102 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  3. U.S. Food and Drug Administration (FDA). 018081S065 018082S048Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  4. National Health Service (NHS). Valproic Acid - NHS Medicines Reference Guide. London, UK: NHS; 2025. [Accessed on 02 Jun. 2026]Check here
  5. Valporic acid. 1978. [Accessed on 19 Mar 2019]Check here
  6. Valproic acid. 2026. [Accessed on 21 Apr. 2026]Check here
  7. Sodium valproate: medicine to treat epilepsy and bipolar disorder [Internet]. nhs.uk. 2025 [Accessed on 10 Mar 2025]Check here

Country of origin

India

Manufacturer/Marketer address

16th Floor, Godrej BKC, Plot – C, “G” Block, Bandra-Kurla Complex, Bandra (East), Mumbai – 400 051, India
Other Info - VAL0271

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