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Ulinafic Injection is used to treat severe sepsis (a condition triggered by an extreme immune system response to infections) and acute pancreatitis (inflammation of the pancreas). It contains Ulinastatin, an active ingredient belonging to the protease inhibitor class of drugs. It works by inhibiting serine proteases, which help prevent organ dysfunction.

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Written By Dr. Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Manufacturer/Marketer :

Gufic Bioscience Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Ulinafic Injection

Ulinafic Injection is a medicine used in some countries to help manage acute pancreatitis, which is sudden inflammation of the pancreas. It is also used in some settings for severe inflammatory conditions, including sepsis. Approved uses can vary by country, so your doctor will decide whether this medicine is appropriate for your condition.

During severe inflammation, enzymes and other substances released in the body can contribute to tissue damage. This medicine helps reduce the activity of several of these enzymes and may help control excessive inflammation and protect tissues from further damage.

Ulinafic Injection is given directly into a vein by a trained healthcare professional, usually in a hospital or clinical setting. The dose, frequency, and length of treatment depend on your condition and response to treatment. Because it is given into a vein, food does not affect how the medicine is absorbed.

Some people may experience mild side effects, such as redness or discomfort at the injection site, nausea, or a skin rash. Serious allergic reactions can occur rarely. Consult your doctor right away if you develop difficulty breathing, severe dizziness, or swelling of the face, lips, tongue, or throat.

Before receiving this medicine, tell your doctor if you have had an allergic reaction to ulinastatin or any of its ingredients, or if you have liver or kidney problems. Tell your doctor about all medicines you take, including prescription medicines, over-the-counter medicines, vitamins, and herbal products. Also tell your doctor if you are pregnant, planning a pregnancy, breastfeeding, or are an older adult.

Uses of Ulinafic Injection

Your doctor may prescribe Ulinafic Injection to help manage the following conditions:

  • Acute pancreatitis: Ulinafic Injection may help control inflammation and limit tissue damage caused by excessive enzyme activity during sudden inflammation of the pancreas.
  • Sepsis and severe inflammation: In countries where this use is approved or part of clinical practice, this medicine may be used alongside other treatments to help control an excessive inflammatory response.

Key Benefits

Ulinafic Injection may provide supportive benefits by helping control excessive enzyme activity and inflammation during serious illness.

  • Helps control inflammation: It reduces the activity of enzymes involved in inflammatory tissue damage.
  • Helps protect tissues: By limiting excessive enzyme activity, this medicine may help reduce further damage to tissues during severe inflammation.
  • Supports treatment of acute pancreatitis: It may be used alongside fluids, pain relief, nutritional support, and other treatments to help manage acute pancreatitis.
  • Provides supportive treatment in severe inflammation: In some settings, it may be added to standard treatment for severe inflammatory conditions when considered appropriate by the doctor.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication to ensure safety and optimal results.
  • Ulinafic Injection is administered by a trained healthcare professional.
  • Do not self-administer.

How Ulinafic Injection Works

Ulinafic Injection contains ulinastatin, a naturally occurring type of protein known as a protease inhibitor. Proteases are enzymes that break down proteins. During acute pancreatitis and severe inflammation, excessive activity of these enzymes can contribute to inflammation and tissue damage. Ulinastatin inhibits a broad range of serine proteases (protein-breaking enzymes), including trypsin, elastase, chymotrypsin, plasmin, and other related enzymes. It can also inhibit certain lysosomal enzymes (enzymes released from structures inside cells that can contribute to tissue damage during severe inflammation). By reducing excessive enzyme activity, ulinastatin may help limit tissue injury and control the inflammatory response.
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Alcohol

Unsafe

Avoid alcohol consumption during the treatment as it can increase the adverse effects and worsen the condition.

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Pregnancy

Caution

Limited data is available on the effect of Ulinafic Injection in pregnancy. Hence, if you are pregnant or planning pregnancy, inform your doctor before receiving Ulinafic Injection. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Breast Feeding

Caution

Limited data is available on the effect of Ulinafic Injection on breastfeeding. Hence, if you are a nursing mother, inform your doctor before receiving Ulinafic Injection. You should not breastfeed while on treatment with Ulinafic Injection.

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Driving

Caution

Ulinafic Injection will be administered in the hospital setting. Hence, avoid driving.

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Liver

Consult your doctor

If you have a pre-existing or a history of liver disease, inform your doctor before receiving Ulinafic Injection. A dose adjustment of this medicine or a suitable alternative may be advised based on your condition.

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Kidney

Consult your doctor

If you have a pre-existing or a history of kidney disease, inform your doctor before receiving Ulinafic Injection. A dose adjustment of this medicine or a suitable alternative may be advised based on your condition.

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Children

Unsafe

Ulinafic Injection is not recommended for use in children as the safety and efficacy are not established.

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Heart

Consult your doctor

Please consult your doctor if you have any heart problems before taking Ulinafic Injection.

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Geriatrics

Consult your doctor

Limited information available about the use of Ulinafic Injection in geriatric patients. Please consult your physician.

What if I have taken an overdose of Ulinafic Injection

An overdose is unlikely because this medicine is given by trained healthcare professionals. If too much medicine is given, your healthcare team will monitor you closely and provide appropriate treatment if needed.

Diet & Lifestyle Advise

  • Follow your doctor's nutrition advice: During acute pancreatitis, your healthcare team will decide when and what you should eat based on the severity of your illness and how well you tolerate food.
  • Choose lower-fat foods when advised: Once you are eating normally, your doctor or dietitian may recommend limiting high-fat foods depending on the cause and severity of pancreatitis.
  • Avoid alcohol: Alcohol can contribute to pancreatitis and may increase the risk of further pancreatic problems. Follow your doctor's advice about avoiding alcohol.
  • Stay hydrated: Drink fluids as recommended by your healthcare team, particularly while recovering from an acute illness.
  • Avoid smoking: Smoking is associated with pancreatic disease and can increase the risk of further pancreatic problems.
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How Soon It Starts Working

The time required for Ulinafic Injection to start to work: The time required for Ulinafic Injection to show its action is not clinically established. The time for which the effects of Ulinafic Injection last: The duration of action for Ulinafic Injection is not clinically established.

What if you forget to take Ulinafic Injection

Ulinafic Injection is usually given by healthcare professionals according to a planned treatment schedule. If an infusion is delayed or missed, your healthcare team will decide when the next dose should be given. Do not try to make up for a missed dose yourself.

Storage

• Keep vials at room temperature below 25°C (77°F). Do not freeze the medicine.

Drug Warnings

  • Report allergy symptoms immediately: Tell your healthcare team if you develop difficulty breathing, swelling, severe dizziness, itching, or a widespread rash during or after treatment.
  • Tell your doctor about previous allergies: Inform your doctor about any previous serious reactions to medicines before treatment begins.
  • Report infusion-site problems: Tell your nurse if you develop pain, burning, redness, or swelling around the IV site.
  • Share your complete medicine list: Tell your healthcare team about all prescription medicines, over-the-counter medicines, vitamins, supplements, and herbal products you use.
  • Follow your treatment plan: Ulinastatin is supportive treatment and does not replace other treatment needed for pancreatitis, sepsis, or the underlying cause of severe inflammation.
  • Discuss pregnancy and breastfeeding: Tell our doctor if you are pregnant, planning a pregnancy, or breastfeeding so the benefits and possible risks can be considered.

Drug-Drug Interactions

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  • Other intravenous medicines: Compatibility can depend on the medicine and the way the infusion is prepared. Healthcare professionals will follow product-specific instructions when administering ulinastatin with other intravenous treatments.
  • Other treatments for severe illness: People receiving ulinastatin may also need antibiotics, fluids, pain medicines, or other treatments. Your healthcare team will manage these medicines together and monitor your response.
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

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  • Food: No clinically important interaction with food is expected because Ulinafic Injection is given directly into a vein. Meals do not affect the absorption of intravenous ulinastatin. Follow the nutrition plan recommended for your underlying condition.
     
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[GASTROINTESTINAL AGENTS]

FAQs

Ulinafic Injection contains Ulinastatin, which works by inhibiting serine proteases, including trypsin, chymotrypsin, kallikrein, plasmin, thrombin, factors IXa, Xa, XIa, and XlIa. This helps prevent organ dysfunction.
Ulinafic Injection can be used safely when prescribed and administered by a healthcare professional at the appropriate dose and duration. However, like any medicine, it can cause side effects or allergic reactions. Your doctor will consider your condition and medical history before treatment.
Ulinafic Injection causes side effects such as nausea, skin rash stomach upset, diarrhoea, itching, vomiting, pain at site of injection, and headache. Most of these are temporary and do not require any medical attention, as they will gradually reduce over time. Please, contact a doctor if these persist for longer durations.
Ulinafic Injection contains ulinastatin and is used in some countries as supportive treatment for acute pancreatitis and certain severe inflammatory conditions, including severe sepsis. Its approved uses vary by country, and your doctor will decide whether it is appropriate for you.
This medicine is given directly into a vein by a trained healthcare professional. It is usually administered in a hospital or clinical setting where your condition can be monitored.
During acute pancreatitis, excessive enzyme activity and inflammation can damage pancreatic and surrounding tissues. Ulinastatin inhibits several protein-breaking enzymes and may help reduce this damage and control inflammation.
No. Ulinastatin inhibits a broader range of enzymes involved in inflammation and tissue damage. These include several serine proteases, such as trypsin, elastase, chymotrypsin, and plasmin, as well as certain lysosomal enzymes.
This medicine is generally given by trained healthcare professionals in a clinical setting. Your healthcare team will determine where and how treatment should be administered.
No. Ulinastatin may be used as supportive treatment where appropriate. Acute pancreatitis usually requires other care, which may include fluids, pain relief, nutritional support, treatment of the underlying cause, and close monitoring.
Alcohol can cause or worsen pancreatitis in some people. Follow your doctor's advice about avoiding alcohol, particularly if alcohol contributed to your illness.
Safety information during pregnancy and breastfeeding is limited. Tell your doctor if you are pregnant, planning a pregnancy, or breastfeeding so they can decide whether treatment is appropriate.
The treatment duration depends on your condition, its severity, and how you respond. Ulinastatin is generally used for acute illness rather than as routine long-term treatment, and your doctor will decide when it should be stopped.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

INDIA

Manufacturer/Marketer address

Shantisadan, Mirzapur Road, Ahmedabad -380001
Other Info - ULI0013
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