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compositionComposition:DOCARAVIMAB-300IU+MIROMAVIMAB-300IU
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Prescription Medicine
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Twinrab 600Iu/1Ml Inj is used to prevent rabies post-exposure. It contains Docaravimab and Miromavimab, which bind to and neutralize the rabies virus, providing immediate passive immunity to individuals exposed to it. Twinrab 600Iu/1Ml Inj may cause side effects such as injection site reactions like pain, redness, swelling, and low-grade fever. Before starting Twinrab 600Iu/1Ml Inj, inform your doctor if you are allergic to any of its ingredients, taking other medicines, or have any pre-existing medical conditions.

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Written By ,
Reviewed By Dr. Lakshmithulasi Yarragunta , PharmD (PB)
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More about the Product

Composition :

DOCARAVIMAB-300IU+MIROMAVIMAB-300IU

Manufacturer/Marketer :

Cadila Healthcare Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Twinrab 600Iu/1Ml Inj

Twinrab 600Iu/1Ml Inj is a specialised medicine injected to prevent rabies after a person has been scratched or bitten by a potentially rabid animal. This emergency treatment is injected as soon as possible after exposure. It is designed to work immediately to neutralise the virus at the wound site before it can reach the nervous system.

This preventative treatment is injected as a single, one-time dose. Thoroughly washing the wound with soap and water immediately after the bite is a critical step that must be done alongside receiving this injection. No long-term dietary changes are needed, but resting and keeping the injection area clean will help your body heal.

While the injection is generally well-tolerated, some people may experience mild soreness, swelling, or redness at the injection site. Serious side effects are rare, but you must contact a doctor immediately if you notice signs of a severe allergic reaction, such as trouble breathing, hives, or swelling of the face and throat.

Do not take this if you have had a severe allergic reaction to similar antibody treatments in the past. Talk to your doctor before receiving this injection if you have a bleeding disorder, as muscle injections can cause bruising or bleeding.

Tell your healthcare provider about all medicines you take, as immune-suppressing drugs can affect how your body builds protection. If you are pregnant, breastfeeding, or caring for an elderly patient, discuss this with your doctor, though rabies prevention remains an absolute medical priority.

Uses of Twinrab 600Iu/1Ml Inj

Your doctor may administer Twinrab 600Iu/1Ml Inj as part of rabies treatment for the following condition:

  • Rabies post-exposure prophylaxis: Twinrab 600Iu/1Ml Inj helps by immediately neutralizing the rabies virus at the bite or scratch site, preventing the virus from spreading to the nervous system while the rabies vaccine builds up your body's active immunity.
     

Key Benefits

Using Twinrab 600Iu/1Ml Inj as prescribed provides immediate protection against rabies following a suspected exposure. Here are the key benefits you can expect:

  • Provides immediate protection: Twinrab 600Iu/1Ml Inj contains ready-made antibodies that help neutralise the rabies virus at the exposure site, offering immediate protection while your body develops its own immunity from the rabies vaccine.
  • Helps prevent the spread of the virus: By acting directly at the bite or scratch site, Twinrab 600Iu/1Ml Inj reduces the risk of the rabies virus entering the nerves and spreading to the brain and spinal cord.
  • Complements rabies vaccination: Twinrab 600Iu/1Ml Inj works alongside the rabies vaccine by providing passive immunity during the first few days, ensuring continuous protection until the vaccine produces a long-lasting immune response.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication.
  • Twinrab 600Iu/1Ml Inj is administered by the doctor or healthcare professional.
  • Do not self-administer.

How Twinrab 600Iu/1Ml Inj Works

Twinrab 600Iu/1Ml Inj contains docaravimab and miromavimab, two monoclonal antibodies that work together to provide immediate protection against the rabies virus after a suspected exposure. Docaravimab is a monoclonal antibody that binds to a specific site on the rabies virus glycoprotein, preventing the virus from attaching to and entering human cells. Miromavimab is another monoclonal antibody that binds to a different site on the same rabies virus glycoprotein. By targeting a separate region, it provides additional viral neutralisation and reduces the likelihood of the virus escaping treatment. Together, these two monoclonal antibodies rapidly neutralise the rabies virus at the exposure site, helping prevent it from entering the nervous system while the rabies vaccine stimulates the body's long-term immune response.
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Alcohol

Consult your doctor

There is no evidence that alcohol affects the medication's effectiveness. Please consult your doctor about the safety of consuming alcohol with Twinrab 600Iu/1Ml Inj.

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Pregnancy

Consult your doctor

Before receiving Twinrab 600Iu/1Ml Inj, consult your doctor, as limited information is available for the use of Twinrab 600Iu/1Ml Inj in pregnant women.

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Breast Feeding

Consult your doctor

Please consult your doctor if you are a breastfeeding mother, as limited information is available for the use of Twinrab 600Iu/1Ml Inj in breastfeeding mothers.

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Driving

Consult your doctor

It is unclear whether Twinrab 600Iu/1Ml Inj affects your ability to drive. Refrain from driving if you suspect any difficulty.

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Liver

Consult your doctor

There is limited information available on the use of Twinrab 600Iu/1Ml Inj in individuals with liver problems. You are recommended to consult a doctor for further guidance.

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Kidney

Consult your doctor

There is limited information available on the use of Twinrab 600Iu/1Ml Inj in individuals with kidney problems. You are recommended to consult a doctor for further guidance.

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Children

Consult your doctor

Please consult your doctor before administering Twinrab 600Iu/1Ml Inj to your child, as there is limited information available.

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Heart

Consult your doctor

Please inform your doctor if you have any pre-existing heart problems before using Twinrab 600Iu/1Ml Inj. Your doctor will prescribe Twinrab 600Iu/1Ml Inj if the benefits outweigh the risk.

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Geriatrics

Consult your doctor

Please consult your doctor before giving Twinrab 600Iu/1Ml Inj to elderly people. Your doctor will prescribe Twinrab 600Iu/1Ml Inj if the benefits outweigh the risk.

What if I have taken an overdose of Twinrab 600Iu/1Ml Inj

This medicine is prepared and administered under strict medical supervision in a clinical environment, making an overdose extremely rare. If you suspect an error has occurred or experience unusual symptoms after your injection, tell your healthcare provider immediately.

Diet & Lifestyle Advise

  • Wash the wound immediately: Before receiving any injections, wash the bite or scratch thoroughly with plenty of soap and running water for at least 15 minutes to physically flush out the virus.
  • Stay hydrated and rest: Your body needs energy to build a strong immune response alongside the rabies vaccine. Drink plenty of water and get extra sleep in the days following your injections.
  • Avoid alcohol: Refrain from drinking alcohol during your rabies treatment schedule, as alcohol can temporarily suppress your immune system and make it harder to monitor for vaccine side effects.
  • Protect the injection site: Keep the injection area clean and dry. Avoid rubbing or massaging the injection sites to prevent irritation and allow the tissue to heal.
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How Soon It Starts Working

The time required for Twinrab 600Iu/1Ml Inj to start to work: The time required for Twinrab 600Iu/1Ml Inj to show its action is unknown. The time for which the effects of Twinrab 600Iu/1Ml Inj last: The duration of action for Twinrab 600Iu/1Ml Inj is unknown.

What if you forget to take Twinrab 600Iu/1Ml Inj

Because Twinrab 600Iu/1Ml Inj is given as a single, one-time emergency dose by a healthcare professional immediately after exposure, it is highly unlikely that you will miss a dose. However, if there has been any delay in receiving this treatment after an animal bite, contact a doctor or visit an emergency room immediately to get injected as soon as possible.

Storage

•Store Twinrab 600Iu/1Ml Inj in a refrigerator at 2°C to 8°C (36°F to 46°F). Do not freeze the medicine. Do not use it if it has been frozen.
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Keep Refrigerated. Do not freeze.Prepaid payment required.

Drug Warnings

  • Inspect before administration: Ensure the injection solution is clear to slightly cloudy and free of visible particles before it is administered.
  • Separate administration: Make sure Twinrab 600Iu/1Ml Inj and the rabies vaccine are administered using separate syringes and at different injection sites.
  • Seek prompt treatment: Get treated as soon as possible after an animal bite, scratch, or saliva exposure, as rabies post-exposure treatment is most effective when started immediately.
  • Report all exposure sites: Tell your doctor about every bite, scratch, or area of broken skin so the medicine can be administered to all potential exposure sites.
  • Complete the vaccine schedule: Do not miss any follow-up appointments for your rabies vaccine series, as Twinrab 600Iu/1Ml Inj provides temporary protection while the vaccine helps develop long-term immunity.

verifiedApollotooltip
  • Rabies vaccine: Must not be mixed in the same syringe or injected into the same muscle site as Twinrab 600Iu/1Ml Inj, as the antibodies can neutralise the vaccine before it can trigger your immune system.
  • Immunosuppressive medicines: Drugs like chemotherapy, radiation, or high-dose corticosteroids may weaken your body's immune response to the rabies vaccine given alongside Twinrab 600Iu/1Ml Inj.

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verifiedApollotooltip
  • No clinically significant food interactions are known with Twinrab 600Iu/1Ml Inj when used as directed.

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[MONOCLONAL ANTIBODIES]

FAQs

Twinrab 600Iu/1Ml Inj is used in post-exposure rabies prophylaxis (prevention).
Twinrab 600Iu/1Ml Inj contains Docaravimab and miromavimab as its active components. It works by binding to the rabies virus and neutralizing it, providing immediate passive immunity to individuals exposed to the virus.
Twinrab 600Iu/1Ml Inj causes side effects such as injection site reactions like pain, redness, swelling, and low-grade fever. Therefore, contact a doctor if these side effects persist or worsen.
Twinrab 600Iu/1Ml Inj is stored in temperatures between 2°C and 8°C. Protect from light. Do not freeze. Keep out of reach of children.
No, Twinrab 600Iu/1Ml Inj is strictly a preventative treatment meant to be used immediately after exposure. Once clinical symptoms of rabies appear, the infection is almost always fatal, and preventative antibody treatments are no longer effective. Talk to your doctor immediately if you have been exposed.
Yes, because rabies is a fatal disease, the life-saving benefits of receiving Twinrab 600Iu/1Ml Inj far outweigh any theoretical risks during pregnancy. If you are pregnant or breastfeeding, you should still receive this treatment immediately after exposure. Talk to your doctor to discuss any questions.
You should receive Twinrab 600Iu/1Ml Inj as soon as possible after a suspected exposure, ideally within the first 24 to 72 hours. Delaying treatment decreases its effectiveness, so seek emergency medical care immediately. Talk to your doctor if you have concerns about the timing.
Yes, whenever physically possible, the doctor will inject as much of the dose as possible directly into and around your bite or scratch wounds. This helps neutralise the rabies virus right where it entered your body. Talk to your doctor about how your specific wounds will be treated.
If you have completed a full pre-exposure or post-exposure rabies vaccine series in the past, you generally do not need to receive Twinrab 600Iu/1Ml Inj. Your body already has memory cells to fight the virus, and you will only need booster doses of the vaccine. Talk to your doctor to confirm your vaccination history.
Twinrab 600Iu/1Ml Inj provides passive immunity by delivering pre-made antibodies that fight the virus immediately, while the rabies vaccine stimulates your own immune system to make its own antibodies over several weeks. They are used together to give you both immediate and long-term protection. Talk to your doctor for more details.
It is highly recommended to avoid alcohol while receiving treatment for rabies exposure. Alcohol can weaken your immune system and mimic or mask side effects of the treatment, making it harder for doctors to evaluate your recovery. Talk to your doctor for specific advice.
Yes, children can safely receive Twinrab 600Iu/1Ml Inj. The dosage is carefully calculated based on the child's body weight to ensure safe and effective protection against the rabies virus. Talk to your doctor if you have any questions about your child's treatment plan.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Faq Twinrab. [Accessed on 02 Jun. 2026]Check here
  2. Zydus Life Zydus Life. [Accessed on 19 Sep. 2023]Check here
  3. Ministry of Health and Family Welfare. National Formulary of India (NFI) 2021. 6th ed. New Delhi, India: IPC; 2021. Clinical Drug Monographs: Twinrab 600Iu Injection

Country of origin

India

Manufacturer/Marketer address

Sarkhej-Dholka Road, Bhat, Ahmedabad-382 210, INDIA.
Other Info - TWI0103

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