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compositionComposition:ASPIRIN-75MG+TICAGRELOR-90MG
prescription
Prescription Medicine
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Twigrel Combikit Tablet is used to prevent heart attack and stroke. It works by preventing platelets from adhering together and reducing the formation of harmful blood clots. This decreases the likelihood of having a heart attack or stroke. In some cases, this medicine may cause side effects like mild indigestion, nausea, headache, dizziness, and joint pain.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Santoshini Reddy G , M Pharmacy
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More about the Product

Composition :

ASPIRIN-75MG+TICAGRELOR-90MG

Manufacturer/Marketer :

Med Manor Organics Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Twigrel Combikit Tablet

Twigrel Combikit Tablet is a combination prescription medicine used to reduce the risk of serious cardiovascular events, such as heart attacks and strokes, in patients with a history of heart disease or acute coronary syndrome. Its primary medical purpose is to prevent blood cells from sticking together and forming harmful clots in your blood vessels, keeping your blood flowing smoothly. This medicine helps protect patients who have recently suffered a heart attack or had a stent placed in their heart arteries.

To ensure continuous protection, you must take Twigrel Combikit Tablet daily and consistently, exactly as your doctor prescribes. This oral tablet can be taken with or without food, but taking it at the same time every day helps maintain a steady level of the medicine in your body. Along with taking this medicine, incorporating heart-healthy lifestyle changes—such as eating a low-salt diet, maintaining a healthy weight, and performing light physical activity—can significantly improve your long-term health outcomes.

Like all medicines, Twigrel Combikit Tablet can cause side effects, with easy bruising and mild bleeding being the most common. You should consult your doctor immediately if you experience severe or uncontrolled bleeding, blood in your urine or stools, or sudden shortness of breath. Because this medicine slows down your body's ability to form clots, even minor cuts may take longer than usual to stop bleeding.

Talk to your doctor before starting this medicine if you have a history of asthma, gout, stomach ulcers, or liver damage. Do not take this if you are currently experiencing any active internal bleeding, such as a bleeding stomach ulcer, or if you have previously had bleeding in your brain.

This medicine can interact with other substances, especially blood thinners, certain pain relievers like ibuprofen, and alcohol, which can significantly raise your risk of stomach bleeding. Specific groups, including pregnant women, breastfeeding mothers, and elderly individuals, must consult their healthcare provider before using Twigrel Combikit Tablet to weigh the benefits against potential risks.

Uses of Twigrel Combikit Tablet

Twigrel Combikit Tablet is used to reduce the risk of serious cardiovascular events, such as heart attacks and strokes, in patients with a history of heart disease or acute coronary syndrome. The detailed uses are as follows:

  • Acute Coronary Syndrome (ACS): Twigrel Combikit Tablet helps keep blood flowing smoothly through the heart's arteries, reducing the risk of a new heart attack or unstable chest pain in high-risk patients.
  • Prevention of Blood Clots after Stent Placement: Twigrel Combikit Tablet prevents blood cells from clumping together and forming clots inside newly placed heart stents, ensuring the blood vessel remains open.
  • Prevention of Stroke: Twigrel Combikit Tablet reduces the risk of blood clots travelling to the brain, helping prevent ischemic strokes in patients with a history of cardiovascular events.

Key Benefits

This medicine brings several key health benefits:

  • Reduces the risk of heart attack and stroke: The primary benefit of Twigrel Combikit Tablet is its ability to provide dual protection against life-threatening cardiovascular events. It significantly lowers the chances of experiencing another heart attack or stroke, giving you peace of mind during your recovery.
  • Keeps stents open: For patients who have undergone stent procedures, this medicine ensures that the stent remains open and functional. Preventing clot formation on the stent surface reduces the need for emergency repeat procedures and supports a safer, more stable recovery period.
Side effects of Twigrel Combikit Tablet
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.
Managing Medication-Triggered Epistaxis (Nosebleed): A Step-by-Step Guide:
  • If you experience nosebleeds or unusual bleeding after taking medication, seek medical attention right away and schedule an appointment to discuss your symptoms with your doctor.
  • Your doctor may adjust your treatment plan by changing the dosage, switching to a different medication, or stopping the medication.
  • If your doctor advises, take steps to manage bleeding and promote healing, such as applying pressure, using saline nasal sprays, or applying a cold compress, using humidifiers, avoiding blowing or picking your nose, and applying petroleum jelly to the nostrils.
  • Schedule follow-up appointments with your doctor to monitor progress, adjust treatment plans, and prevent future episodes.
  • Increased creatinine levels must be corrected immediately with the help of a doctor.
  • Reduce strenuous activities that can lead to muscle breakdown and production of creatinine.
  • Sleep for 7-8 hours per night to assist your body in repairing and rebuilding tissue.
  • Manage your blood pressure by implementing changes in lifestyle like losing weight, reducing stress and exercising regularly.
  • Avoid smoking and drinking alcohol.
Managing back pain as a side effect of medication requires a combination of self-care techniques, lifestyle modifications, and medical interventions. Here are the steps:
  • Talk to your doctor about your back pain and potential medication substitutes or dose changes.
  • Try yoga or Pilates and other mild stretching exercises to increase flexibility and strengthen your back muscles.
  • To lessen the tension on your back, sit and stand upright and maintain proper posture.
  • To alleviate discomfort and minimize inflammation, apply heat or cold packs to the afflicted area.
  • Under your doctor's supervision, think about taking over-the-counter painkillers like acetaminophen or ibuprofen.
  • Make ergonomic adjustments to your workspace and daily activities to reduce strain on your back.
  • To handle tension that could make back pain worse, try stress-reduction methods like deep breathing or meditation.
  • Use pillows and a supportive mattress to keep your spine in the right posture as you sleep.
  • Back discomfort can worsen by bending, twisting, and heavy lifting.
  • Speak with a physical therapist to create a customized training regimen to increase back strength and flexibility.

Directions for Use

  • Twigrel Combikit Tablet can be taken with or without food, as advised by your doctor.
  • Your doctor will decide the dosage and timing of this medication based on your medical condition.
  • Swallow the whole Twigrel Combikit Tablet with a glass of water.
  • Do not crush, chew, or break it.

How Twigrel Combikit Tablet Works

Twigrel Combikit Tablet contains two active medicines, aspirin and ticagrelor, which work together as a dual antiplatelet therapy to prevent dangerous blood clots from forming in your arteries. Aspirin works by blocking a specific enzyme in your body that normally triggers platelets (the cells that cause blood to clot) to stick together at the site of a blood vessel injury. By blocking this initial chemical pathway, it reduces the body's natural clot-forming response. Ticagrelor works on a completely different target on the surface of the platelets. It blocks a specific chemical receptor, preventing the platelets from receiving the signals that cause them to clump together. By targeting two separate pathways at the same time, the combination provides a much stronger defence against blood clots than either medicine could offer on its own.
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Alcohol

Caution

Avoid consumption of alcohol as it may increase dizziness.

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Pregnancy

Caution

It is not advised to use Twigrel Combikit Tablet when pregnant. Please consult a doctor, your doctor may prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

Twigrel Combikit Tablet should be used in nursing mothers only if clinically needed, and the benefits outweigh the risks. Please consult the doctor.

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Driving

Caution

Twigrel Combikit Tablet may cause drowsiness and dizziness, so drive or operate machinery only if you are alert.

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Liver

Caution

Caution should be exercised while using Twigrel Combikit Tablet in patients suffering from liver impairment. Please consult a doctor. Your doctor will prescribe only if the benefits outweigh the risks.

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Kidney

Caution

Caution should be exercised while using Twigrel Combikit Tablet in patients suffering from kidney impairment. Please consult a doctor. Your doctor will prescribe only if the benefits outweigh the risks.

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Children

Caution

The safety and efficacy of Twigrel Combikit Tablet in children have not been demonstrated. For further information, please contact your doctor.

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Heart

Caution

Please inform your doctor if you have a history of heart disease before taking Twigrel Combikit Tablet . Your doctor will prescribe it only if the benefits outweigh the risks.

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Geriatrics

Caution

Twigrel Combikit Tablet should be given with caution in elderly patients due to an increased risk of side effects. Please consult your doctor before using Twigrel Combikit Tablet .

What if I have taken an overdose of Twigrel Combikit Tablet

If you suspect an overdose, seek emergency medical care immediately. An overdose of this medication can lead to severe, life-threatening bleeding. Show the medicine packaging to the emergency healthcare providers.

Diet & Lifestyle Advise

  • Follow a heart-healthy diet: Eat a heart-healthy diet low in saturated fats, cholesterol, and sodium, and rich in fibre, vegetables, and whole grains to support your blood vessels.
  • Limit alcohol: Limit or avoid alcohol consumption, as alcohol can irritate your stomach lining and greatly increase your risk of internal stomach bleeding when combined with this medicine.
  • Avoid activities with a high risk of injury: Avoid contact sports or activities with a high risk of falls and injuries, as minor bumps can lead to severe bruising or internal bleeding.
  • Reduce the risk of cuts: Use a soft-bristled toothbrush and shave with an electric razor rather than a manual blade to minimise the risk of cuts and bleeding.
  • Quit smoking: If you smoke, seek help to quit. Smoking damages your blood vessels, speeds up arterial clogging, and directly counteracts the protective benefits of Twigrel Combikit Tablet .
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How Soon It Starts Working

The time required for Twigrel Combikit Tablet to start to work: Twigrel Combikit Tablet shows its action within 1 hour of administration. The time for which the effects of Twigrel Combikit Tablet last: Twigrel Combikit Tablet effect lasts for 12 hours.

What if you forget to take Twigrel Combikit Tablet

If you miss a dose, skip the missed dose and take your next dose at its regular, scheduled time. Do not take a double dose to make up for the one you missed.

Storage

• Store Twigrel Combikit Tablet at room temperature, ideally between 20°C and 25°C (68°F to 77°F).

Drug Warnings

  • Inform your healthcare providers: Tell any doctor, surgeon, or dentist you visit that you are taking Twigrel Combikit Tablet before scheduling any medical or dental procedures, as you may need to stop taking it temporarily to prevent excess bleeding.
  • Do not stop treatment on your own: Do not stop taking Twigrel Combikit Tablet on your own, even if you experience minor bleeding or bruising, as stopping this medicine abruptly can trigger a sudden heart attack or stroke.
  • Monitor for unusual bruising: Regularly check your skin for unusual, dark bruises or tiny purple-red spots, and notify your healthcare provider if you notice any unexplained markings.
  • Carry a medical alert: Carry a medical alert card in your wallet or wear a medical alert bracelet stating that you take Twigrel Combikit Tablet (dual antiplatelet therapy) in case of an emergency.
  • Check before taking new medicines: Always consult your doctor or pharmacist before taking any new over-the-counter drugs, especially cold remedies, pain relievers, or herbal supplements.

Drug-Drug Interactions

verifiedApollotooltip

Inform your doctor if you are taking any of the following medicines, as they may interact.

  • Other Blood Thinners: Taking this medicine with warfarin, heparin, or other oral blood thinners can severely increase your risk of major bleeding.
  • Pain Relievers (NSAIDs): Medicines like ibuprofen, naproxen, or high-dose aspirin can irritate the stomach and increase the risk of stomach ulcers and bleeding.
  • Certain Anti-seizure and Anti-fungal Medicines: Drugs such as ketoconazole or phenytoin can alter how your body processes this medicine, either increasing the risk of bleeding or making the treatment less effective.
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

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  • Grapefruit and Grapefruit Juice: Avoid regularly consuming grapefruit products, as they can interfere with how your body breaks down this medication and affect its performance.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[PLATELET AGGREGATION INHIBITOR]

FAQs

Twigrel Combikit Tablet is used to prevent heart attack and stroke.
Twigrel Combikit Tablet prevents platelets from aggregating, thereby minimising the formation of dangerous blood clots. This lowers the chances of having a heart attack or stroke.
Twigrel Combikit Tablet may increase the risk of bleeding. Exercise caution when performing daily tasks such as shaving, cutting fingernails, or using sharp instruments. Inform your doctor if you are due to undergo any surgical procedure.
Yes, you can get vaccinated while on Twigrel Combikit Tablet . However, it would be better to tell your doctor or nurse that you're taking an antiplatelet medication.
Avoid consuming grapefruit or grapefruit juice while taking Twigrel Combikit Tablet since it may increase the effectiveness of Twigrel Combikit Tablet . This elevates the chances of bleeding more easily.
You are recommended to avoid alcohol, grapefruit juice, and medications like apixaban or other anticoagulants while taking Twigrel Combikit Tablet , as they increase bleeding risk. If you still have any concerns, discuss with your doctor.
Use of Twigrel Combikit Tablet during menstruation may increase the risk of heavier or prolonged bleeding due to its blood-thinning effects. Therefore, please take your doctor’s advice before taking Twigrel Combikit Tablet .
Brilinta 90 contains only ticagrelor, while Twigrel Combikit Tablet is a combination of two components as aspirin and ticagrelor used to prevent blood clots.
Your doctor decides the best time to take Twigrel Combikit Tablet . Take it with or without food as advised. Follow your doctor's instructions regarding the timing and dosage for effective results.
Twigrel Combikit Tablet causes side effects such as mild indigestion, pain and swelling in the joints, headache, dizziness, nausea, diarrhoea, constipation, and mild rash. However, please consult a doctor if these persist for longer durations.
No. You should never stop taking Twigrel Combikit Tablet without your doctor's direct guidance. Stopping this medicine early, especially after a heart attack or stent placement, greatly increases your risk of developing a dangerous blood clot that could cause another heart attack. Talk to your doctor if you have concerns.
Many common pain relievers like ibuprofen or naproxen can increase your risk of stomach bleeding when combined with Twigrel Combikit Tablet . Acetaminophen is generally considered a safer option for mild pain, but you should always talk to your doctor or pharmacist before taking any new pain medication.
Shortness of breath is a known side effect of one of the active ingredients in Twigrel Combikit Tablet . It is usually mild and often improves over time. However, because shortness of breath can also be a sign of a heart issue, you should talk to your doctor to ensure it is not a symptom of a more serious condition.
It is highly recommended to avoid or strictly limit alcohol while taking this medicine. Alcohol irritates your stomach lining and increases the risk of internal bleeding, which is a potential complication of Twigrel Combikit Tablet . Talk to your doctor about your alcohol intake.
Because Twigrel Combikit Tablet prevents blood clotting, even minor cuts will bleed longer than usual. Apply firm, continuous pressure with a clean cloth for at least 10 to 15 minutes. If the bleeding does not stop after this time, or if the cut is deep or near your eye, seek immediate medical help.
Twigrel Combikit Tablet is generally not recommended during pregnancy, particularly in the third trimester, as it can harm the unborn baby and cause bleeding complications during delivery. If you are pregnant, planning to become pregnant, or breastfeeding, talk to your doctor immediately about safer alternatives.
Yes, you may need to stop taking Twigrel Combikit Tablet temporarily before dental extractions or surgeries to prevent excessive bleeding. However, you must never make this decision on your own. Always consult both your dentist and your cardiologist before pausing your medication.
Yes, this medicine can cause uric acid levels to rise in some patients, which can trigger a gout flare-up. If you experience sudden, severe pain, swelling, or redness in your joints—especially your big toe—talk to your doctor right away.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Electronic Medicines Compendium (EMC). Product Summary of Product Characteristics (SmPC). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  2. National Health Service (NHS). Ticagrelor - NHS Medicines Reference Guide. London, UK: NHS; 2025. [Accessed on 02 Jun. 2026]Check here
  3. National Health Service (NHS). About Low Dose Aspirin - NHS Medicines Reference Guide. London, UK: NHS; 2025. [Accessed on 02 Jun. 2026]Check here
  4. Drugs.com Clinical Review Team. Aspirin,Aspirin Low Strength Drug Interactions Reference. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  5. Drugs.com Clinical Review Team. Ticagrelor Drug Interactions Reference. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  6. National Health Services National Health Services. [Accessed on 09 Jul. 2021]Check here
  7. Dexcel Pharma Ltd. Aspirin 75mg Gastro-resistant Tablets. Electronic Medicines Compendium (EMC). [Revised in May 2021] [Accessed on 28th February 2023].Check here

Country of origin

India

Manufacturer/Marketer address

16-11-477/45, Dilsukh Nagar, Hyderabad-500036, Telangana, India.
Other Info - TWI0106
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