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Twelup OD Tablet is used to treat peripheral neuropathy and Megaloblastic anemia caused by vitamin B12 deficiency. This medicine contains mecobalamin, which helps protect the nerves from damage and promotes blood cell production. Some common side effects include nausea, vomiting, diarrhoea, and headache.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

MECOBALAMIN-1500MCG

Manufacturer/Marketer :

Nexkem Pharmaceuticals Pvt Ltd

Consume Type :

Sublingual

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Twelup OD Tablet

Twelup OD Tablet is a specialised vitamin supplement in the form of a sublingual tablet, primarily used to treat vitamin B12 deficiency and nerve damage, also known as peripheral neuropathy. It plays a critical role in protecting your nerve cells and supporting the production of healthy red blood cells. By delivering the active form of the vitamin directly under the tongue, it ensures rapid absorption into your system.

For the best results, you should take Twelup OD Tablet consistently at the same time every day as directed by your doctor. This sublingual tablet can be taken with or without food, as it dissolves directly in your mouth, reducing reliance on stomach acid and intrinsic factor for absorption. Incorporating a balanced diet rich in eggs, dairy, poultry, fish, and B12-fortified foods can further support your nerve health and overall energy levels.

While taking Twelup OD Tablet , some people may experience mild side effects such as nausea, headaches, or a temporary upset stomach. These issues are usually temporary, but if you experience serious symptoms like difficulty breathing, chest tightness, or a severe skin rash, you must contact your doctor immediately. Always keep your healthcare provider informed of any unusual changes in your health.

Before starting this medicine, talk to your doctor if you have a history of optic nerve disease, low potassium levels, or kidney issues. Do not take this if you have a known allergy to any cobalamin-based vitamins or any ingredients listed in the product. Your doctor will help determine if this is the safest option for your specific condition.

Certain medicines, heavy alcohol consumption, and smoking can reduce the absorption of Twelup OD Tablet by interfering with how your body uses the vitamin. If you are pregnant, breastfeeding, or managing health conditions as an elderly individual, consult your doctor or pharmacist to ensure the correct dosage and safety before use.

Uses of Twelup OD Tablet

Twelup OD Tablet is used to treat vitamin B12 deficiency and related nerve and blood disorders. The detailed uses of Twelup OD Tablet are as follows:

  • Vitamin B12 deficiency: This medicine restores depleted vitamin levels in the body, helping to reverse fatigue and support normal cell function.
  • Peripheral neuropathy: It helps repair and maintain the protective covering around your nerves, which reduces symptoms like numbness, tingling, and burning pain in your hands and feet.
  • Megaloblastic anaemia: It helps in the healthy development and maturation of red blood cells, ensuring your body can carry oxygen efficiently and reducing overall weakness.

Key Benefits

Twelup OD Tablet provides important support for nerve health, energy levels, and overall well-being. The key benefits of Twelup OD Tablet include:

  • Nerve Health Support: Taking Twelup OD Tablet helps restore your physical well-being by directly targeting nerve discomfort and exhaustion. By supporting the health of your nervous system, it helps reduce the persistent tingling and burning sensations in your limbs, allowing you to move more comfortably and sleep better at night.
  • Improved Energy Levels: Another major benefit is the improvement in your daily energy levels. By assisting in the production of healthy red blood cells, it helps combat the constant fatigue and muscle weakness associated with vitamin deficiencies, making it easier to return to your normal daily activities.

Directions for Use

  • Twelup OD Tablet can be taken on an empty stomach for better absorption.
  • Follow your doctor’s instructions on the dosage and timing of this medication. It is often taken in the morning, at least 30 minutes before or two hours after a meal.
  • Place the tablet below the tongue and allow it to dissolve.
  • Do not break, chew, or crush it.
  • Do not handle the tablet with wet hands.

How Twelup OD Tablet Works

Twelup OD Tablet contains mecobalamin. Once placed under the tongue, Twelup OD Tablet dissolves and enters your bloodstream directly through the tiny blood vessels in your mouth. This sublingual route significantly reduces reliance on intrinsic factor-mediated gastric absorption, making it highly beneficial for individuals who have trouble absorbing vitamin B12 through their stomach. Inside the body, this active vitamin serves as an essential helper for key biological processes. It aids in the creation of myelin, which is the protective sheath that wraps around and insulates your nerves. By keeping the myelin sheath healthy, it helps restore proper nerve signal transmission and heals damaged nerves. Additionally, it works closely with your system to facilitate DNA synthesis and ensure red blood cells mature correctly, preventing blood-related deficiencies.
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Alcohol

Caution

Limit alcohol intake, as excessive alcohol consumption can interfere with B12 absorption.

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Pregnancy

Consult your doctor

Please visit your doctor. There are no competent and well-controlled pregnancy studies. Your doctor will only prescribe if the benefits outweigh the risks.

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Breast Feeding

Consult your doctor

Consult your doctor; there has been no significant research on the use of Twelup OD Tablet in breastfeeding/nursing mothers.

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Driving

Consult your doctor

It's unclear whether Twelup OD Tablet affects driving abilities, so don't drive or operate machinery if you're having trouble concentrating or reacting.

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Liver

Consult your doctor

Limited information is available on the use of Twelup OD Tablet in patients with liver disease. If you have a history of liver impairment, inform your doctor before receiving the Twelup OD Tablet . Your doctor will prescribe only if the benefits outweigh the risks.

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Kidney

Consult your doctor

Limited information is available on the use of Twelup OD Tablet in patients with kidney disease. If you have a history of kidney impairment, inform your doctor before receiving the Twelup OD Tablet . Your doctor will prescribe only if the benefits outweigh the risks.

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Children

Consult your doctor

There is limited information about the usage of Twelup OD Tablet in paediatric patients. Please seek medical advice. Only if the benefits greater than the risks, your doctor will prescribe Twelup OD Tablet .

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Heart

Caution

Twelup OD Tablet is generally safe for people with heart problems and may even support heart health by lowering homocysteine levels. Still, it's best to consult your doctor before starting any supplement, especially if you're on cardiac medications.

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Geriatrics

Safe if prescribed

Geriatric patients can safely take Twelup OD Tablet . However, it's best to consult your doctor to confirm the right dose and rule out any interactions with other medications.

What if I have taken an overdose of Twelup OD Tablet

If you accidentally take more than the prescribed dose, you may experience increased side effects such as severe nausea or headaches. In case of a suspected overdose, seek immediate medical attention.

Diet & Lifestyle Advise

  • Eat a balanced diet: Incorporate foods naturally rich in vitamin B12, such as poultry, fish, eggs, and dairy products. If you follow a strict vegetarian or vegan diet, talk to your doctor about fortified foods or long-term supplementation.
  • Limit alcohol consumption: Avoid or significantly reduce alcohol intake, as chronic alcohol use can damage your stomach lining and severely impair your body's ability to absorb active vitamins.
  • Protect your feet: If you are taking this for nerve damage (neuropathy), inspect your feet daily for cuts, blisters, or redness, and wear comfortable, protective footwear to prevent injuries you might not feel.
  • Manage blood sugar levels: If your nerve issues are related to diabetes, keep your blood sugar levels within your target range to prevent further nerve damage.
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How Soon It Starts Working

  • The time required for Twelup OD Tablet to start to work: Twelup OD Tablet ideally shows its action within 3 hours after administration.
  • The time for which the effects of Twelup OD Tablet last: The duration of action for Twelup OD Tablet is unknown.

What if you forget to take Twelup OD Tablet

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and return to your regular schedule. Do not take a double dose to make up for a missed one. Talk to your doctor or pharmacist if you frequently miss doses.

Storage

•Store Twelup OD Tablet sublingual tablets at room temperature, between 15°C and 30°C (59°F to 86°F).

Drug Warnings

  • Handle with dry hands: Ensure your hands are completely dry before taking the sublingual tablet out of its packaging to prevent it from dissolving prematurely.
  • Do not chew or swallow: Let the tablet sit completely under your tongue until it dissolves. Swallowing it whole like a regular tablet will reduce its absorption and effectiveness.
  • Inspect the package: Do not use the tablet if the blister pack or packaging is torn, punctured, or shows signs of tampering.
  • Avoid immediate rinsing: Wait at least 10 to 15 minutes after the tablet has completely dissolved before rinsing your mouth, drinking liquids, or brushing your teeth.
  • Inform your surgeon: If you have an upcoming surgery or dental procedure, tell your doctor you are taking this supplement, as it may interfere with certain laboratory tests.

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  • Proton pump inhibitors (e.g., omeprazole, pantoprazole): These acid-reducing stomach medicines can decrease gastric absorption of B12 when taken long-term. However, because sublingual Twelup OD Tablet substantially bypasses gastric acid-dependent absorption, this interaction is clinically far less relevant than with standard oral cyanocobalamin tablets.
  • Metformin: This common diabetes medicine can lower the intestinal absorption of vitamin B12 over time, increasing the risk of deficiency.
  • H2 blockers (e.g., famotidine): These medicines reduce stomach acid and can decrease oral vitamin absorption. (Note: Ranitidine has been withdrawn from most global markets due to safety concerns). Sublingual administration minimises this interaction risk compared to traditional oral pills.
  • Colchicine: This gout medicine can impair the gut's ability to absorb vitamin B12 effectively.

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  • Alcohol: Heavy or regular alcohol consumption can damage the lining of your digestive tract and reduce the absorption of active vitamins.

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Habit Forming

No

Therapeutic Class

[VITAMINS]

FAQs

Twelup OD Tablet belongs to the class of vitamins primarily used to treat peripheral neuropathies (nerve damage in the hands and feet) and megaloblastic anaemia (a blood disorder in which the red blood cells are abnormally larger than normal) caused by vitamin B12 deficiency.
Twelup OD Tablet addresses B12 insufficiency by replacing the body's low levels of vitamin B12. It further benefits in treating peripheral neuropathic pain by preventing nerve cell damage. It also involves cell proliferation, blood production, and protein synthesis.
If you miss a dose, take it as soon as you remember. However, if it is time for the next scheduled dose, skip the missed dose and follow your usual dosage.
Inform your doctor about all your medications, especially if you are taking chloramphenicol, colchicine, oral diabetes medicine (metformin), drugs that reduce stomach acid, such as cimetidine, lansoprazole, omeprazole, and antibiotics. These medications may interfere with Twelup OD Tablet , causing unpleasant side effects or making Twelup OD Tablet less effective.
Vitamin B12 sources include eggs, beef, liver, chicken, trout, salmon, tuna, clams, fortified breakfast cereal, low-fat milk, yoghurt, and cheese.
No, you should not swallow Twelup OD Tablet whole with water. This tablet is designed to be placed under your tongue to dissolve completely. Swallowing it whole bypasses the direct absorption pathway in your mouth and may make the medicine less effective. Talk to your doctor or pharmacist if you have trouble taking it.
Yes, Twelup OD Tablet is highly beneficial for vegetarians and vegans, as vitamin B12 is primarily found in animal products. However, you should check the inactive ingredients of your specific brand to ensure it fits your dietary choices. Talk to your doctor or pharmacist for guidance on suitable options.
Yes, Twelup OD Tablet is typically prescribed for daily use to maintain stable vitamin levels in your body. Your doctor will determine the exact duration of your treatment based on your condition. Talk to your doctor before making any changes to your schedule.

Disclaimer

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Country of origin

India

Manufacturer/Marketer address

Plot No. 288, 1st Floor, Industrial Area Phase 2, Panchkula, Haryana 134113
Other Info - TWE0012
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