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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy

TRIPOX 12.500MG TABLET is used to treat moderate to severe depression associated with moderate to severe anxiety. It contains Amitriptyline and Chlordiazepoxide, which works by affecting certain chemical messengers in the brain that communicate between brain cells, thereby regulating mood and treating depression. Also, it helps suppress the excessive and abnormal activity of the nerve cells in the brain. In some cases, you may experience common side effects such as dizziness, drowsiness, dry mouth, constipation, blurred vision and bloating. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Manufacturer/Marketer :

Aarti Healthcare Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About TRIPOX 12.500MG TABLET

TRIPOX 12.500MG TABLET is used to treat moderate to severe depression associated with moderate to severe anxiety. Depression is a mood disorder characterised by sadness, unhappiness, anger, hopelessness or loss. Anxiety is a mental health disorder characterised by feelings of anxiety, worry or fear that are strong enough to interfere with one’s daily activities. Anxiety and depression can occur at the same time.

TRIPOX 12.500MG TABLET is a combination of two drugs: Amitriptyline (tricyclic anti-depressant) and Chlordiazepoxide (benzodiazepine anxiolytic). Amitriptyline works by affecting certain chemical messengers in the brain that communicate between brain cells, thereby regulating mood and treating depression. Chlordiazepoxide works by increasing the action of a chemical messenger called GABA. This helps suppress the excessive and abnormal activity of the nerve cells in the brain. 

You are advised to take TRIPOX 12.500MG TABLET only for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side effects such as dizziness, drowsiness, dry mouth, constipation, blurred vision and bloating. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Consult your doctor immediately if you have suicidal thoughts, such as killing or harming yourself. Do not take TRIPOX 12.500MG TABLET if you are pregnant, as it may cause birth defects. Consult your doctor before taking TRIPOX 12.500MG TABLET if you are breastfeeding. Avoid driving or operating machinery as TRIPOX 12.500MG TABLET causes sleepiness and dizziness and might impair thinking and motor skills. Avoid consuming alcohol along with TRIPOX 12.500MG TABLET as it could lead to increased drowsiness and dizziness. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Uses of TRIPOX 12.500MG TABLET

TRIPOX 12.500MG TABLET is used in the treatment of depression associated with anxiety. The detailed uses of TRIPOX 12.500MG TABLET are as follows:

  • Managing Anxiety Disorders: TRIPOX 12.500MG TABLET is often prescribed to alleviate symptoms of anxiety, offering relief from excessive worry and nervousness.
  • Treating Depression: TRIPOX 12.500MG TABLET plays a role in treatment plans for depression, helping to improve mood and emotional well-being.
  • Sleep Aid: With its sedative properties, TRIPOX 12.500MG TABLET may assist in managing insomnia and other sleep-related concerns.
  • Neuropathic Pain Relief: TRIPOX 12.500MG TABLET is effective in alleviating chronic pain caused by nerve damage, improving the quality of life for affected individuals.
  • ADHD Management: As part of a comprehensive treatment approach, TRIPOX 12.500MG TABLET can help enhance focus and concentration in patients with attention deficit hyperactivity disorder.

Directions for Use

• Take TRIPOX 12.500MG TABLET with or without food or as advised by a doctor. • Follow your doctor's instructions on the dosage and timing of this medication, to ensure the safety. • Swallow the medicine as a whole with glass of water. • Do not crush, break, or chew it.

Medicinal Benefits

TRIPOX 12.500MG TABLET is a combination of two drugs: Amitriptyline and Chlordiazepoxide. TRIPOX 12.500MG TABLET is used to treat moderate to severe depression and anxiety. Amitriptyline is a tricyclic anti-depressant that affects certain chemical messengers (serotonin and/or norepinephrine) in the brain, which communicate between brain cells, thereby regulating mood and treating depression. Chlordiazepoxide is a benzodiazepine anxiolytic that works by increasing the action of a chemical messenger called GABA. This helps suppress the excessive and abnormal activity of the nerve cells in the brain. TRIPOX 12.500MG TABLET has a calming effect on various functions of the brain. Thereby, TRIPOX 12.500MG TABLET helps in treating anxiety and depression.

How TRIPOX 12.500MG TABLET Works

TRIPOX 12.500MG TABLET is a combination of two drugs: Amitriptyline (tricyclic anti-depressant) and Chlordiazepoxide (benzodiazepine anxiolytic). Amitriptyline works by affecting certain chemical messengers in the brain that communicate between brain cells, thereby regulating mood and treating depression. Chlordiazepoxide works by increasing the action of a chemical messenger called GABA. This helps suppress the excessive and abnormal activity of the nerve cells in the brain.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

What if I have taken an overdose of TRIPOX 12.500MG TABLET

Do not take more than the prescribed dose of TRIPOX 12.500MG TABLET as it may cause overdose. The symptoms of overdose include difficulty sleeping, disorientation, dizziness, blurred vision, confusion, faintness, or lightheadedness when getting up suddenly from a lying or sitting position, headache, loss of consciousness, fast/slow/irregular heartbeat, hallucinations, mood or other mental changes, seeing/hearing/feeling things that are not there, nightmares, seizures (fits), sweating, trouble breathing, unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness, or unusual excitement, nervousness, restlessness, or irritability. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

Do not take TRIPOX 12.500MG TABLET if you are allergic to any of its contents, if you recently had a heart attack or heart problems, are taking monoamine oxidase inhibitors (MAOI). Do not take opioids with TRIPOX 12.500MG TABLET as it may result in increased sedation, depression, coma and death. TRIPOX 12.500MG TABLET should not be taken for longer durations as it may cause physical dependence. Inform your doctor before taking TRIPOX 12.500MG TABLET if you have bipolar disorder, eye problems, urination problems, seizures, thyroid problems, kidney or liver problems or if you are due to have any surgery. Consult your doctor immediately if you have suicidal thoughts, such as killing or harming yourself. Talk to your doctor before taking TRIPOX 12.500MG TABLET if you have a history of drug abuse, addiction or alcohol abuse as TRIPOX 12.500MG TABLET may cause dependence. Do not take TRIPOX 12.500MG TABLET if you are pregnant, as it may cause birth defects. Consult your doctor before taking TRIPOX 12.500MG TABLET if you are breastfeeding. Avoid driving or operating machinery as TRIPOX 12.500MG TABLET causes sleepiness, dizziness and might impair thinking and motor skills. Avoid consuming alcohol along with TRIPOX 12.500MG TABLET as it could lead to increased drowsiness and dizziness. TRIPOX 12.500MG TABLET should not be given to children as safety and effectiveness have not been established.

Drug-Drug Interactions

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ChlordiazepoxideSodium oxybate
Critical

Drug-Drug Interactions

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ChlordiazepoxideSodium oxybate
Critical
How does the drug interact with Tripox 12.500mg Tablet:
Taking Tripox 12.500mg Tablet with Sodium oxybate increases the risk of breathing difficulty or low blood pressure.

How to manage the interaction:
Taking Tripox 12.500mg Tablet with Sodium oxybate is generally avoided as it can lead to an interaction, it can be taken if prescribed by a doctor. However, if you experience dizziness, shortness of breath, excessive sweating, or blurred vision, contact your doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Tripox 12.500mg Tablet:
Combining Tripox 12.500mg Tablet and Dronedarone may increase the risk of irregular heartbeat.

How to manage the interaction:
Although combining Tripox 12.500mg Tablet with Dronedarone may result in an interaction, it can be used if a doctor recommends it. If you have any heart problems or electrolyte imbalances, you may be susceptible. If you have sudden dizziness, lightheadedness, fainting, or fast or rapid heartbeats during therapy, get emergency medical help. Do not discontinue any medication without consulting a doctor.
How does the drug interact with Tripox 12.500mg Tablet:
Coadministration of Tripox 12.500mg Tablet and Cisapride may increase the risk of irregular heartbeat.

How to manage the interaction:
Although combining Tripox 12.500mg Tablet with Cisapride may result in an interaction, it can be used if a doctor recommends it. If you have any heart problems or electrolyte imbalances, you may be susceptible. If you have sudden dizziness, lightheadedness, fainting, or fast or rapid heartbeats during therapy, get emergency medical help. Do not discontinue any medication without consulting a doctor.
How does the drug interact with Tripox 12.500mg Tablet:
Combining Furazolidone with Tripox 12.500mg Tablet can increase the risk of serotonin syndrome(increased serotonin hormone).

How to manage the interaction:
Although using Furazolidone and Tripox 12.500mg Tablet together may cause an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have symptoms such as confusion, hallucination, fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Inform a doctor if you have recently taken Tripox 12.500mg Tablet. Do not discontinue any medications without consulting a doctor.
AmitriptylinePhenelzine
Critical
How does the drug interact with Tripox 12.500mg Tablet:
Using Tripox 12.500mg Tablet together with Phenelzine can increase the risk of serotonin syndrome (A condition resulting from the accumulation of high levels of serotonin in the body. Serotonin is especially a mood stabilizer).

How to manage the interaction:
Although using Phenelzine and Tripox 12.500mg Tablet together may cause an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have symptoms such as confusion, hallucination, fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Inform a doctor if you have recently taken Tripox 12.500mg Tablet. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Tripox 12.500mg Tablet:
Co-administration of Tripox 12.500mg Tablet together with Selegiline can increase the risk of serotonin syndrome (A condition resulting from the accumulation of high levels of serotonin in the body. Serotonin is a mood stabilizer).

How to manage the interaction:
Although using Selegiline and Tripox 12.500mg Tablet together may cause an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have symptoms such as confusion, hallucination, fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Inform a doctor if you have recently taken Tripox 12.500mg Tablet. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Tripox 12.500mg Tablet:
Combining Tripox 12.500mg Tablet and Sparfloxacin may increase the risk of irregular heartbeat.

How to manage the interaction:
Although combining Tripox 12.500mg Tablet with Sparfloxacin may result in an interaction, it can be used if a doctor recommends it. If you have any heart problems or electrolyte imbalances, you may be susceptible. If you have sudden dizziness, lightheadedness, fainting, or fast or rapid heartbeats during therapy, get emergency medical help. Do not discontinue any medication without consulting a doctor. Note: Sparfloxacin is no longer available in the market. Grepafloxacin should not be combined with any other medications.
How does the drug interact with Tripox 12.500mg Tablet:
Taking Tranylcypromine with Tripox 12.500mg Tablet can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Although using Tranylcypromine and Tripox 12.500mg Tablet together is not recommended as it can possibly result in an interaction, it can be taken if prescribed by a doctor. However, consult a doctor if you have symptoms such as confusion, hallucination, fits, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting a doctor.
AmitriptylineMesoridazine
Critical
How does the drug interact with Tripox 12.500mg Tablet:
Coadministration of Tripox 12.500mg Tablet and Mesoridazine may increase the risk of irregular heartbeat.

How to manage the interaction:
Although combining Tripox 12.500mg Tablet with Mesoridazine may result in an interaction, it can be used if a doctor recommends it. If you have any heart problems or electrolyte imbalances, you may be susceptible. If you have sudden dizziness, lightheadedness, fainting, or fast or rapid heartbeats during therapy, get emergency medical help. Do not discontinue any medication without consulting a doctor.
How does the drug interact with Tripox 12.500mg Tablet:
The combination of Tripox 12.500mg Tablet and Potassium chloride may cause stomach and upper intestinal discomfort. (Only applicable to an oral preparation)

How to manage the interaction:
Although co-administration of Tripox 12.500mg Tablet and Potassium chloride is not recommended as it can possibly lead to an interaction, they can be taken if prescribed by a doctor. If you experience severe stomach pain, bloating, sudden dizziness or lightheadedness, nausea, vomiting (in particular with blood), decreased hunger, and black stools while taking these medications, consult a doctor immediately. Do not discontinue any medications without talking to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Maintain a healthy diet and exercise regularly as it helps in improving overall health and boosts self-esteem.

  • Regularly attend therapy sessions.

  • Perform meditation and yoga. This helps in relieving stress and provides relaxation.

  • Follow a regular sleep pattern to improve the amount and quality of sleep you get.

  • Include foods rich in omega-fatty acids such as fish, nuts, fresh fruits, vegetables and olive oils.

  • Neurotransmitters are made up of amino acids. Amino acid-rich foods such as meat, dairy products and certain fruits and vegetables help in the proper maintenance of neurotransmitters.

  • Complex carbohydrates help in stimulating serotonin (a feel-good neurotransmitter). These include whole grains, legumes, spinach, broccoli, oranges and pears.

  • Exercising helps in the production of the body’s natural anti-depressants. It also helps in relieving stress, improving mood, boosting self-esteem and providing restful sleep.

  • Avoid smoking and alcohol consumption.

  • Learn about your condition, understand the risk factors and follow the doctor’s treatment plan.

Habit Forming

Yes

Therapeutic Class

PSYCHOTHERAPEUTICS
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Alcohol

Unsafe

Avoid consumption of alcohol while taking TRIPOX 12.500MG TABLET as it may cause increased sleepiness and dizziness.

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Pregnancy

Unsafe

Avoid taking TRIPOX 12.500MG TABLET if you are pregnant unless prescribed by a doctor as it may cause birth defects.

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Breast Feeding

Caution

Consult your doctor before taking TRIPOX 12.500MG TABLET; your doctor will decide whether TRIPOX 12.500MG TABLET can be taken by breastfeeding mothers or not.

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Driving

Unsafe

TRIPOX 12.500MG TABLET may cause sleepiness, dizziness and might impair thinking and motor skills. Do not drive or operate machinery if you experience these symptoms.

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Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Unsafe

TRIPOX 12.500MG TABLET should not be given to children as safety and effectiveness have not been established.

Have a query?

FAQs

TRIPOX 12.500MG TABLET is used to treat moderate to severe depression associated with moderate to severe anxiety.

TRIPOX 12.500MG TABLET contains Amitriptyline and Chlordiazepoxide. Amitriptyline works by affecting certain chemical messengers (serotonin and/or norepinephrine) in the brain, which communicate between brain cells, thereby regulating mood and treating depression. Chlordiazepoxide works by increasing the action of a chemical messenger called GABA. This helps suppress the excessive and abnormal activity of the nerve cells in the brain.

TRIPOX 12.500MG TABLET may cause weight gain due to increased appetite. Eat a healthy diet and exercise regularly to maintain a healthy weight.

Do not discontinue TRIPOX 12.500MG TABLET without consulting your doctor, as it could cause withdrawal symptoms. To treat your condition effectually, continue taking TRIPOX 12.500MG TABLET for as long as prescribed. Do not be reluctant to speak with your doctor if you feel any difficulty while taking TRIPOX 12.500MG TABLET.

Dry mouth could be a side-effect of TRIPOX 12.500MG TABLET. Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly, and chewing sugar-free gum/candy might stimulate saliva and prevent drying of the mouth.

Constipation might occur as a side-effect of TRIPOX 12.500MG TABLET. Drink plenty of fluids and eat fibre-rich food if you experience constipation. Consult your doctor if you experience severe constipation.

TRIPOX 12.500MG TABLET may cause side effects like dizziness and tiredness in some people. Consult the doctor if the condition persists or if you experience severe dizziness or tiredness.

Painkillers should be taken with TRIPOX 12.500MG TABLET only if advised by the doctor. However, opioid-based analgesics should not be taken with TRIPOX 12.500MG TABLET as it may cause drowsiness and breathing problems. Always check with the doctor before taking painkillers or other medicines along with TRIPOX 12.500MG TABLET.

TRIPOX 12.500MG TABLET may cause suicidal thoughts/behaviour; therefore, monitor the person taking TRIPOX 12.500MG TABLET for any changes in mood/behaviour and report to the doctor if you notice any unusual behaviour.

Eat a healthy diet and exercise regularly to manage weight gain associated with the use of TRIPOX 12.500MG TABLET. Talk to the doctor if the increase in weight bothers you.

Store TRIPOX 12.500MG TABLET at room temperature, protected from light and moisture. Keep it out of sight and reach of children.

Yes, TRIPOX 12.500MG TABLET may cause sleepiness. Do not drive or operate machinery unless you know how the medicine affects you.

TRIPOX 12.500MG TABLET may cause sexual problems like decreased sexual desire, inability to reach an orgasm and erectile dysfunction in men. Discuss with the doctor if you experience sexual problems during treatment with TRIPOX 12.500MG TABLET.

No, do not drink alcohol while taking TRIPOX 12.500MG TABLET. Consuming alcohol along with TRIPOX 12.500MG TABLET could lead to increased drowsiness & dizziness and very serious side effects.

TRIPOX 12.500MG TABLET may change the colour of urine to green or blue. It is generally harmless and resolves once the medicine is stopped. However, consult the doctor if you have any concerns regarding this.

TRIPOX 12.500MG TABLET may start working within a week. However, it might take around 4 weeks to notice the full benefits of TRIPOX 12.500MG TABLET. Continue taking TRIPOX 12.500MG TABLET for the prescribed duration to treat your condition effectively.

The active ingredients of TRIPOX 12.500MG TABLET are Amitriptyline (tricyclic anti-depressant) and Chlordiazepoxide (benzodiazepine anxiolytic). It is used to treat moderate to severe depression associated with moderate to severe anxiety.

TRIPOX 12.500MG TABLET can be taken with or without food as advised by the doctor. Swallow TRIPOX 12.500MG TABLET as a whole with a glass of water; do not chew or crush it.

Yes, TRIPOX 12.500MG TABLET is safe if taken in the dose and duration prescribed by the doctor. It should not be taken for longer durations as it may cause physical dependence.

Though TRIPOX 12.500MG TABLET may help you sleep better by improving your mood, it should not be used for sleep-related issues. Talk to the doctor if you have sleep-related problems.

TRIPOX 12.500MG TABLET may not be beneficial for heart health as it may cause QT prolongation (a condition that affects heart rhythm) in some people. Before starting treatment with TRIPOX 12.500MG TABLET discuss you’re your doctor if you have heart rhythm problems.

Side effects of TRIPOX 12.500MG TABLET include dizziness, drowsiness, dry mouth, constipation, blurred vision and bloating. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Country of origin

India

Manufacturer/Marketer address

109-D, Road No. 29, Mahendra Indl. Estate, Sion - East, Mumbai Mh 400022 India
Other Info - TRI0357

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