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Tripcobal Tablet is used to treat neuropathic pain. It contains Mecobalamin and Amitriptyline which work by lowering pain signals to the brain and rejuvenating & protecting the nerves. In some cases, this medicine may cause side effects such as nausea, vomiting, stomach pain, diarrhoea, and loss of appetite. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Dr. Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Manufacturer/Marketer :

Trimark Pharmaceuticals Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Tripcobal Tablet

Tripcobal Tablet is a combination prescription medicine used to relieve long-term nerve pain, also known as neuropathic pain. It is designed to target pain caused by damaged nerves while simultaneously supporting the health and recovery of your nervous system. By combining a nerve-calming agent with an active form of vitamin B12, this medicine helps manage discomfort and promotes nerve healing.

For the best results, you should take Tripcobal Tablet consistently every day, exactly as prescribed by your doctor. It is usually taken once daily at bedtime because it can cause drowsiness. You can take this medication with or without food, but taking it at the same time each day helps maintain a steady level of the medicine in your body. Making healthy lifestyle choices, such as eating a balanced diet and keeping your blood sugar stable, can also significantly improve your treatment outcomes.

While taking Tripcobal Tablet , some people may experience mild side effects like drowsiness, dry mouth, or constipation. These effects often decrease as your body adjusts to the medication, but you should contact your healthcare provider if they persist. If you experience severe side effects, such as an irregular heartbeat, extreme mood changes, or thoughts of harming yourself, seek medical attention immediately.

Do not take this if you have recently had a heart attack, have severe heart failure, or suffer from glaucoma or urinary retention. Before starting Tripcobal Tablet , tell your doctor if you have a history of liver damage, kidney disease, seizures, or thyroid problems. It is vital to discuss your full medical history so your doctor can ensure this treatment is safe for you.

This medicine can interact with alcohol and other drugs that cause drowsiness, such as sleeping pills or muscle relaxants, making you feel excessively sleepy or dizzy. It is important to consult your doctor if you are pregnant, planning to become pregnant, breastfeeding, or an older adult, as specific safety precautions or dose adjustments may be needed.

Uses of Tripcobal Tablet

Your doctor may prescribe Tripcobal Tablet to treat several conditions associated with nerve damage and discomfort, including:

  • Diabetic Neuropathy: Helps relieve the burning, tingling, or stabbing pain in the feet and hands caused by high blood sugar levels damaging the nerves.
  • Post-Herpetic Neuralgia: Relieves persistent nerve pain that can linger for months or years after an outbreak of shingles.
  • Peripheral Neuropathy: Manages generalised nerve pain in the extremities caused by physical injury, infections, or metabolic problems.

Key Benefits

Tripcobal Tablet offers significant relief by targeting the root causes of nerve discomfort. Here are the primary benefits you can expect from this treatment:

  • Effective Pain Relief: By calming overactive nerve signals, it reduces the constant burning, shooting, and throbbing sensations, allowing you to go about your day with less discomfort.
  • Nerve Regeneration: The vitamin component assists in rebuilding the protective covering of your nerves, which promotes natural healing and prevents further nerve deterioration.
  • Improved Sleep Quality: Because nerve pain often worsens at night, taking this medication at bedtime helps reduce nocturnal pain and has a relaxing effect that promotes deeper, uninterrupted sleep.
  • Better Daily Functioning: Easing chronic pain allows for improved mobility and easier movement, helping you return to your regular physical activities and improving your overall quality of life.
Side effects of Tripcobal Tablet
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Here are the steps to Dry Mouth (xerostomia) caused by medication:
  • Inform your doctor about dry mouth symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Drink plenty of water throughout the day to help keep your mouth moist and alleviate dry mouth symptoms.
  • Chew sugar-free gum or candies to increase saliva production and keep your mouth moisturized.
  • Use saliva substitutes, such as mouthwashes or sprays, only if your doctor advises them to help moisturize your mouth and alleviate dry mouth symptoms.
  • Avoid consuming smoking, alcohol, spicy or acidic foods, and other irritants that may aggravate dry mouth symptoms.
  • Schedule regular dental check-ups to keep track of your oral health and handle any dry mouth issues as they arise.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.

Directions for Use

  • Tripcobal Tablet can be taken with or without food as prescribed by your doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
  • Swallow Tripcobal Tablet as a whole with a glass of water.
  • Do not chew, crush, or break it.

How Tripcobal Tablet Works

Tripcobal Tablet works through the combined action of its two active ingredients, which target nerve pain from different angles. One active ingredient is amitriptyline, which acts on the central nervous system to block pain pathways. It increases the levels of specific chemical messengers in the brain and spinal cord, which stops pain signals from travelling from your damaged nerves to your brain. This helps lower your pain sensitivity. The second active ingredient is mecobalamin, an essential, highly bioavailable form of vitamin B12. It plays a critical role in producing myelin, which is the protective sheath that covers and insulates your nerve fibres. When nerves are damaged, this protective layer is worn away. By supporting myelin production, this ingredient helps repair and regenerate the damaged nerves, restoring normal nerve function over time.
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Alcohol

Unsafe

Avoid consumption of alcohol while taking Tripcobal Tablet as it may increase drowsiness and sleepiness.

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Pregnancy

Caution

Please consult your doctor if you have any concerns regarding this; your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

Consult your doctor before taking Tripcobal Tablet ; your doctor will decide whether Tripcobal Tablet can be taken by breastfeeding mothers or not.

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Driving

Unsafe

Tripcobal Tablet causes drowsiness, sleepiness, and blurred vision. Do not drive or operate machinery unless you are alert.

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Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Caution

Tripcobal Tablet should not be given to children as the safety and efficacy have not been established.

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Heart

Caution

Tripcobal Tablet should be taken with caution in patients with heart problems. Your doctor will prescribe only if the benefits outweigh the risks.

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Geriatrics

Caution

Tripcobal Tablet should be given with caution in elderly patients due to an increased risk of side effects. Please consult your doctor before using Tripcobal Tablet .

What if I have taken an overdose of Tripcobal Tablet

If you accidentally take too much of this medicine, seek immediate medical attention right away. An overdose can be dangerous and may cause symptoms such as severe drowsiness, rapid heart rate, confusion, hallucinations, or seizures.

Diet & Lifestyle Advise

  • Manage Your Blood Sugar: If you have diabetes, keeping your blood glucose levels within your target range is the most important step in preventing further nerve damage.
  • Protect Your Feet: Inspect your feet daily for cuts, blisters, or redness, as nerve damage can make it hard to feel minor injuries. Always wear comfortable, protective footwear.
  • Eat a Nutrient-Rich Diet: Focus on whole foods, including leafy green vegetables, lean proteins, and whole grains, which provide essential vitamins that support nerve health.
  • Stay Active: Engage in regular, low-impact exercise like walking, swimming, or stationary cycling. Physical activity improves blood circulation, which helps nourish damaged nerves.
  • Limit Alcohol and Avoid Smoking: Excessive alcohol intake can worsen nerve damage, and smoking restricts blood flow to your peripheral nerves, slowing down recovery.
health query

Have a query?

How Soon It Starts Working

The time required for Tripcobal Tablet to start to work: The time required for Tripcobal Tablet to show its action is unknown. The time for which the effects of Tripcobal Tablet last: The duration of action for Tripcobal Tablet is clinically unknown.

What if you forget to take Tripcobal Tablet

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one, as this increases the risk of side effects.

Storage

• Store Tripcobal Tablet tablets at room temperature, ideally between 15°C and 30°C (59°F to 86°F).

Drug Warnings

  • Do Not Stop Suddenly: Stopping this medicine abruptly can cause withdrawal symptoms like headache, nausea, and irritability. Your doctor will guide you in gradually decreasing the dose.
  • Avoid Driving Initially: Because this medication can make you feel sleepy or dizzy, do not drive, operate heavy machinery, or perform risky activities until you know how it affects you.
  • Stand Up Slowly: This medicine can cause your blood pressure to drop when you stand up, making you feel dizzy. Rise slowly from sitting or lying positions to prevent falls.
  • Monitor Your Mood: Pay close attention to any sudden changes in your mental state, such as worsening anxiety, depression, or unusual thoughts. Report these to your doctor immediately.
  • Stay Hydrated: To combat dry mouth, try sipping water frequently, chewing sugar-free gum, or sucking on sugar-free hard candies.

Drug-Drug Interactions

verifiedApollotooltip

Inform your doctor if you are taking any of the following medicines, as they may interact.

  • MAO Inhibitors (MAOIs): Do not take this if you are using, or have recently used, monoamine oxidase inhibitors (medicines for depression). Combining them can cause dangerously high blood pressure and severe, life-threatening reactions.
  • Central Nervous System Depressants: Taking this with sleeping pills, anxiety medications, muscle relaxants, or strong pain relievers can cause extreme drowsiness and slowed breathing.
  • Anticholinergic Drugs: Medicines for bladder control or irritable bowel syndrome can worsen side effects like dry mouth, blurred vision, and difficulty urinating when combined with this treatment.

Drug-Drug Interactions

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How does the drug interact with Tripcobal Tablet:
Taking Furazolidone with Amitriptyline and Mecobalamin can increase the risk of serotonin syndrome(increased serotonin hormone).

How to manage the interaction:
Taking Amitriptyline and Mecobalamin with Furazolidone is not recommended as it may lead to an interaction, it can be taken if prescribed by the doctor. However, if you experience sudden dizziness, fits, increased heart rate, blurred vision, pain in the muscles, consult the doctor. It is advised to maintain a gap of 14 days between both the medications. Do not stop using any medications without a doctor's advice.
How does the drug interact with Tripcobal Tablet:
Taking Amitriptyline and Mecobalamin with Ziprasidone may increase the risk of irregular heartbeat.

How to manage the interaction:
Taking Amitriptyline and Mecobalamin with Ziprasidone is not recommended as it may lead to an interaction, it can be taken if prescribed by the doctor. If you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not stop any medications without a doctor's advice.
How does the drug interact with Tripcobal Tablet:
Coadministration of Amitriptyline and Mecobalamin with Cisapride may increase the risk of irregular heartbeat.

How to manage the interaction:
Taking Amitriptyline and Mecobalamin with Cisapride is not recommended as it may lead to an interaction, it can be taken if prescribed by the doctor. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not stop any medications without a doctor's advice.
Critical
How does the drug interact with Tripcobal Tablet:
Taking Amitriptyline and Mecobalamin with Halofantrine may increase the risk of irregular heartbeat.

How to manage the interaction:
Taking Amitriptyline and Mecobalamin with Halofantrine is not recommended as it may lead to an interaction, it can be taken if prescribed by the doctor. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not stop any medications without a doctor's advice.
How does the drug interact with Tripcobal Tablet:
Using Amitriptyline and Mecobalamin together with Safinamide can increase the risk of serotonin syndrome (A condition resulting from the accumulation of high levels of serotonin in the body).

How to manage the interaction:
Taking Amitriptyline and Mecobalamin with Safinamide is not recommended as it may lead to an interaction, it can be taken if prescribed by the doctor. However, if you experience sudden dizziness, fits, increased heart rate, blurred vision, pain in the muscles, consult the doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Tripcobal Tablet:
The combination of Amitriptyline and Mecobalamin with Potassium chloride may cause stomach and upper intestinal discomfort. (Only applicable to an oral preparation)

How to manage the interaction:
Co-administration of Amitriptyline and Mecobalamin with Potassium chloride is not recommended, they can be taken if prescribed by a doctor. If you experience severe stomach pain, bloating, vomiting (in particular with blood), black stools, consult a doctor immediately. Do not discontinue any medications without talking to a doctor.
How does the drug interact with Tripcobal Tablet:
Taking Amitriptyline and Mecobalamin with Bepridil may increase the risk of irregular heartbeat.

How to manage the interaction:
Although taking Amitriptyline and Mecobalamin with Bepridil is not recommended, it can be used if prescribed by a doctor. If you have sudden dizziness, lightheadedness, fainting, or fast or rapid heartbeats, consult the doctor. Do not discontinue any medication without consulting a doctor.
How does the drug interact with Tripcobal Tablet:
Taking Linezolid with Amitriptyline and Mecobalamin can increase the risk of serotonin syndrome (increased serotonin hormone).

How to manage the interaction:
Taking Amitriptyline and Mecobalamin with Linezolid is not recommended, it can be taken if prescribed by the doctor. However, if you experience sudden dizziness, fits, increased heart rate, blurred vision, pain in the muscles, consult the doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Tripcobal Tablet:
Taking Tranylcypromine with Amitriptyline and Mecobalamin can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Although using Tranylcypromine with Mecobalamin and Amitriptyline together is not recommended as it can possibly result in an interaction, it can be taken if prescribed by a doctor. However, if you experience sudden dizziness, fits, increased heart rate, blurred vision, pain in the muscles, consult the doctor. It is advised to maintain a 14 days of gap between both the medications. Do not stop using any medications without a doctor's advice.
How does the drug interact with Tripcobal Tablet:
Taking Methylene blue with Amitriptyline and Mecobalamin can increase the risk of serotonin syndrome (increased serotonin hormone).

How to manage the interaction:
Taking Amitriptyline and Mecobalamin with Methylene blue is not recommended, it can be taken if prescribed by the doctor. However, if you experience sudden dizziness, fits, increased heart rate, blurred vision, pain in the muscles, consult the doctor. It is advised to maintain a gap of at least 2 weeks between both the medications. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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  • Alcohol: Drinking alcohol while taking this medicine can significantly increase extreme sedation, impaired coordination, and slowed respiration.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTICONVULSANT]

FAQs

Tripcobal Tablet is used to treat neuropathic pain.
Tripcobal Tablet is a combination of two drugs: Amitriptyline (antiepileptic) and Methylcobalamin (vitamin B12). Amitriptyline improves nerve signal conduction of damaged nerves. Methylcobalamin is a form of Vitamin B12 that helps in the regeneration of damaged nerves and helps produce the myelin sheath (outer protecting layer of nerves). Thus, Tripcobal Tablet promotes the healing of damaged nerves and improves nerve conduction in diabetes or traumatic conditions.
Tripcobal Tablet is used to treat neuropathic pain due to diabetic neuropathy. Diabetic neuropathy is a condition in which nerve damage occurs due to high blood glucose levels. It mostly damages the nerves in the legs and feet.
Do not discontinue Tripcobal Tablet without consulting your doctor as it could lead to withdrawal symptoms. To treat your condition effectually, continue taking Tripcobal Tablet for as long as prescribed. Do not be reluctant to speak with your doctor if you feel any difficulty while taking Tripcobal Tablet ; your doctor will reduce the dose gradually.
Tripcobal Tablet is used to treat neuropathic pain due to diabetic neuropathy. Diabetic neuropathy is a condition in which nerve damage occurs due to high blood glucose levels. It mostly damages the nerves in the legs and feet.
Do not discontinue Tripcobal Tablet without consulting your doctor as it could lead to withdrawal symptoms. To treat your condition effectually, continue taking Tripcobal Tablet for as long as prescribed. Do not be reluctant to speak with your doctor if you feel any difficulty while taking Tripcobal Tablet ; your doctor will reduce the dose gradually.
It is strongly advised to avoid alcohol while taking this medicine. Alcohol increases the sedating effects of the medication, which can lead to extreme drowsiness, severe dizziness, impaired coordination, and an increased risk of liver damage. Talk to your doctor if you have questions about alcohol use.
This medicine frequently causes drowsiness and sleepiness as a side effect. Taking your dose at bedtime helps you sleep better, reduces nighttime nerve pain, and minimises daytime drowsiness. Talk to your doctor if the timing of your dose is causing any issues.
Yes, some patients may experience an increase in appetite or water retention, which can lead to weight gain. Managing your diet, staying physically active, and monitoring your weight can help. Talk to your doctor or pharmacist if you are concerned about weight changes.
It is strongly advised to avoid alcohol while taking this medicine. Alcohol increases the sedating effects of the medication, which can lead to extreme drowsiness, severe dizziness, impaired coordination, and an increased risk of liver damage. Talk to your doctor if you have questions about alcohol use.

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Country of origin

INDIA

Manufacturer/Marketer address

Plot No: 260, H.No:1-257/260, 2nd Floor, Srinivasa Nagar, A.S.Rao Nagar, Kapra, Hyderabad-500062, Telangana, India.
Other Info - TRI1408
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