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  3. TRILOSACAR TABLET

TRILOSACAR TABLET, Pack of 10 TABLETS
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Written By Lakshmithulasi Yarragunta ,
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
TRILOSACAR TABLET is used to treat high blood pressure, heart failure, and oedema (a buildup of fluid in the body). It works by increasing the amount of urine passed out from the kidneys and relaxing and widening the blood vessels, making the heart more efficient at pumping blood throughout the body. In some cases, this medicine may cause side effects such as sleepiness, headache, flushing, tiredness, and nausea. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Composition :

AMLODIPINE-5MG + CHLORTHALIDONE-12.5MG + LOSARTAN-50MG

Manufacturer/Marketer :

Zydus Cadila

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About TRILOSACAR TABLET

TRILOSACAR TABLET is used to treat high blood pressure, heart failure, and oedema (a buildup of fluid in the body). Hypertension or high blood pressure is a lifelong or chronic condition in which the force exerted by the blood against the blood vessel (artery wall) increases. The higher this blood pressure, the harder the heart has to pump. Oedema may occur in high blood pressure where fluids of the body get trapped in the tissues of the hands, arms, feet, ankles and legs, leading to swelling.

TRILOSACAR TABLET contains Chlorothiazide, Losartan and Amlodipine. Chlorothiazide is a diuretic that works by increasing the amount of urine passed out from the kidneys. It effectively reduces excess fluid levels in the body and treats Edema (swelling) associated with heart, liver, kidney or lung disease. Amlodipine is a calcium channel blocker, and Losartan is an angiotensin receptor antagonist. Both work by relaxing and widening the blood vessels. This, in turn, reduces the heart's workload and makes the heart more efficient at pumping blood throughout the body. So, it helps to lower high blood pressure, reducing the chances of heart attack or stroke.

Take TRILOSACAR TABLET as prescribed by your doctor. Depending on your medical conditions, you are advised to take TRILOSACAR TABLET for as long as your doctor has prescribed it for you. You may experience glucose intolerance (low or high level of glucose), ankle swelling, sleepiness, headache (sense of heat in the face, ears, neck, and trunk), flushing, tiredness, nausea, decreased potassium level in the blood, Increased blood uric acid and altered blood lipid level. Most of these side effects of TRILOSACAR TABLET do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Try not to stop taking this medicine of your own. Tell your doctor about this, as it may cause a rise in blood pressure and increase the risk of heart complications like stroke and heart disease. Inform your doctor if you are suffering from kidney, liver, heart disease, or diabetes. Taking TRILOSACAR TABLET during pregnancy may cause side effects like jaundice (yellowing of the skin or eyes), unexplained bleeding, low blood sugar or an electrolyte imbalance in the newborn baby. Do not use the TRILOSACAR TABLET if you cannot urinate, have low blood pressure (hypotension), and have a cardiogenic shock (sudden stopping blood flow to the heart). Reducing the amount of table salt (sodium chloride) in your food often relieves the body's swelling.

Uses of TRILOSACAR TABLET

Treatment of Hypertension (high blood pressure), Oedema (swelling due to fluid retention)

Directions for Use

• Take TRILOSACAR TABLET with or without food as advised by your doctor.• Follow your doctor's instructions on the dosage and timing of this medication.• Swallow TRILOSACAR TABLET as a whole with a glass of water.• Do not chew, crush or break it.

Medicinal Benefits

TRILOSACAR TABLET is a combination drug used to treat hypertension. When you take TRILOSACAR TABLET, your body's blood vessels will be relaxed, and it will help lower the raised blood pressure. It also widens the blood vessels (lining of arteries wall) and improves blood flow. It helps in losing out excess fluids from the body by increasing the production of urine. This reduces the heart's workload and makes the heart more efficient at pumping blood throughout the body. Thus, it helps to lower high blood pressure, reducing the chances of heart attack or stroke. TRILOSACAR TABLET also helps decrease fluid buildup, which reduces inflammation or swelling. In addition, this relieves Oedema and enables you to carry out your daily activities more efficiently.

How TRILOSACAR TABLET Works

TRILOSACAR TABLET contains Chlorothiazide, Losartan and Amlodipine. Chlorothiazide is a diuretic that works by increasing the amount of urine passed out from the kidneys. It effectively reduces excess fluid levels in the body and treats Edema (swelling) associated with heart, liver, kidney or lung disease. Amlodipine is a calcium channel blocker, and Losartan is an angiotensin receptor antagonist. Both work by relaxing and widening the blood vessels. This, in turn, reduces the heart's workload and makes the heart more efficient at pumping blood throughout the body. So, it helps to lower high blood pressure, reducing the chances of heart attack or stroke.

Storage

• Store in a cool and dry place away from sunlight.• Keep TRILOSACAR TABLET out of the sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

What if I have taken an overdose of TRILOSACAR TABLET

Take TRILOSACAR TABLET only as prescribed by the physician. Do not exceed the recommended dose, as it might cause an overdose. If you suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

TRILOSACAR TABLET should not be given to the people allergic to TRILOSACAR TABLET, have low blood pressure (less than 90 mm of Hg), have had a heart attack, kidney disease, liver disease, gout (high uric acid), high cholesterol (hyperlipidemia), pregnant women or planning to get pregnant and breastfeeding women. Besides this, it is contraindicated in people with cardiogenic shock (sudden stopping of blood flow to the heart) and aortic stenosis (heart valve problem). TRILOSACAR TABLET can pass into breast milk, but its effect on the baby is unknown. So, it is better to tell your doctor if you take TRILOSACAR TABLET and breastfeeding. Tell your doctor if you are on low sodium (table salt) diet. Cases of electrolyte imbalance have been observed (like low levels of sodium, potassium, or magnesium in your blood). So your doctor might advise monitoring blood pressure, kidney function tests and electrolytes.

Drug-Drug Interactions

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AmlodipineDantrolene
Critical
chlorthalidoneCisapride
Critical

Drug-Drug Interactions

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AmlodipineDantrolene
Critical
How does the drug interact with Trilosacar Tablet:
Using Trilosacar Tablet together with dantrolene may increase the risk of hyperkalemia (high blood potassium).

How to manage the interaction:
Taking Trilosacar Tablet with Dantrolene can cause an interaction, consult a doctor before taking it. You should seek medical attention if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, a weak pulse, or a slow or irregular heartbeat. Do not stop using any medications without talking to a doctor.
chlorthalidoneCisapride
Critical
How does the drug interact with Trilosacar Tablet:
Co-administration of Trilosacar Tablet and cisapride may increase the risk or severity of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Trilosacar Tablet with Cisapride is not recommended, please consult your doctor before taking it. Do not discontinue the medication without consulting a doctor.
AmlodipineMitotane
Severe
How does the drug interact with Trilosacar Tablet:
Using Trilosacar Tablet and mitotane together may drastically lower Trilosacar Tablet blood levels, which makes the medicine less effective.

How to manage the interaction:
Although co-administration of Trilosacar Tablet with mitotane can result in an interaction, it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
AmlodipineLemborexant
Severe
How does the drug interact with Trilosacar Tablet:
Coadministration of lemborexant and Trilosacar Tablet may increase the blood levels of lemborexant.

How to manage the interaction:
Although co-administration of Trilosacar Tablet with Lemborexant can result in an interaction, it can be taken if a doctor has advised it. However, consult your doctor if you experience abnormal sleep patterns, worsening of depression, changes in heartbeat, or headache. Do not discontinue any medications without consulting a doctor.
AmlodipineCeritinib
Severe
How does the drug interact with Trilosacar Tablet:
Coadministration of Ceritinib together with Trilosacar Tablet can slow heart rate and increase the risk of an irregular heart rhythm.

How to manage the interaction:
Although there is an interaction between Trilosacar Tablet with Ceritinib, it can be taken if a doctor has advised it. However, if you have sudden dizziness, lightheadedness, fainting, or an irregular heartbeat, consult the doctor. Do not discontinue any medications without consulting a doctor.
AmlodipineEnzalutamide
Severe
How does the drug interact with Trilosacar Tablet:
Using a combination of Trilosacar Tablet and enzalutamide may drastically lower Trilosacar Tablet blood levels, making the medicine less effective.

How to manage the interaction:
Taking Trilosacar Tablet with enzalutamide can result in an interaction, it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
AmlodipineNitisinone
Severe
How does the drug interact with Trilosacar Tablet:
Coadministration of Trilosacar Tablet and Nitisinone may increase the blood levels and effects of Nitisinone.

How to manage the interaction:
Taking Nitisinone with Trilosacar Tablet together can result in an interaction, but it can be taken if a doctor has advised it. If you notice any of these symptoms or if you feel unwell after taking your medication, it's important to contact a doctor right away. Do not stop using any medications without a doctor's advice.
AmlodipineItraconazole
Severe
How does the drug interact with Trilosacar Tablet:
Coadministration of Trilosacar Tablet with itraconazole may significantly raise the blood levels and effects of Trilosacar Tablet.

How to manage the interaction:
Trilosacar Tablet and itraconazole may interact, but if prescribed by a doctor, they can be used together. Consult a doctor if you develop chest discomfort, trouble breathing, dizziness or fainting, swelling of the hands, ankles, or feet, or any other of these symptoms. Without consulting a doctor, never stop taking any medication.
AmlodipineRifapentine
Severe
How does the drug interact with Trilosacar Tablet:
Coadministration of Trilosacar Tablet and Rifapentine may significantly reduce the blood levels of Trilosacar Tablet, which may make the medication less effective.

How to manage the interaction:
There may be a possibility of interaction between Trilosacar Tablet and Rifapentine, but it can be taken if prescribed by a doctor. If you have any symptoms, make sure to call a doctor right away. Do not stop using any medications without talking to a doctor.
AmlodipinePrimidone
Severe
How does the drug interact with Trilosacar Tablet:
Using Trilosacar Tablet and primidone together may lower Trilosacar Tablet blood levels, which makes the medicine less effective.

How to manage the interaction:
Although co-administration of Trilosacar Tablet with primidone can result in an interaction, it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Consume antioxidant-rich food. Blueberries, cherries, tomatoes, squash, and bell peppers are high in antioxidants.

  • Eat natural diuretic foods. Asparagus, beets, green beans, grapes, onion, leafy greens, pineapple, leeks, pumpkin, and garlic are all-natural diuretic foods.

  • Use healthy cooking oils like soybean, olive, canola, and coconut oil.

  • You should avoid refined foods such as white bread, spaghetti, sugar, and red meat.

  • Reduce or eliminate Trans fatty acids, which are found in commercially baked items such as cookies, cakes, crackers, French fries, onion rings, doughnuts, and processed foods.

  • Avoid the consumption of too much salt or salty food.

  • Keep your weight under control with a BMI of 19.5-24.9.

  • Regular physical activity or exercise like walking improves your blood flow.

  • When possible, elevate your legs or the swollen area on a chair or pillows.

  • Avoid standing or sitting for extended periods of time.

  • Avoid chronic stress, as it can raise your blood pressure.

  • Spend time with your loved ones to cope with stress and practice mindfulness techniques.

  • Quitting smoking and alcohol consumption is the best strategy to lower the risk of many health complications.

Habit Forming

No

Therapeutic Class

ANTI- HYPERTENSIVES

TRILOSACAR TABLET Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Caution

You are recommended not to consume alcohol along with TRILOSACAR TABLET to avoid unpleasant side-effects.

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Pregnancy

Caution

TRILOSACAR TABLET is not recommended during pregnancy unless your doctor considers it essential. Your doctor will weigh the benefits and any potential risks before prescribing it to you.

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Breast Feeding

Caution

TRILOSACAR TABLET should not be used when breastfeeding unless clearly necessary. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

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Driving

Unsafe

It is not recommended to drive after taking TRILOSACAR TABLET as it may occasionally cause drowsiness.

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Liver

Caution

TRILOSACAR TABLET to be taken with caution, especially if you have a history of liver diseases/conditions. Your doctor may adjust your dose depending upon your current kidney conditions.

bannner image

Kidney

Caution

TRILOSACAR TABLET to be taken with caution, especially if you have a history of kidney diseases/conditions. Your doctor may adjust your dose depending upon your current kidney conditions.

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Children

Caution

TRILOSACAR TABLET to be taken with caution, especially if you are children below the age of 12. Your doctor may adjust your dose depending upon your age.

Have a query?

FAQs

TRILOSACAR TABLET belongs to a group of medicines known as anti-hypertensives, primarily used to treat high blood pressure, heart failure, and oedema (a buildup of fluid in the body).

TRILOSACAR TABLET contains Chlorothiazide, Losartan and Amlodipine. Chlorothiazide works by increasing the amount of urine passed out from the kidneys. It effectively reduces excess fluid levels in the body and treats Oedema (swelling) associated with heart, liver, kidney or lung disease. Amlodipine and Losartan work by relaxing and widening the blood vessels. This, in turn, reduces the heart's workload and makes the heart more efficient at pumping blood throughout the body.

Also known as 'dropsy' or 'hydropsy,' it is a condition of fluid retention in the body characterized by swelling of the body's tissue, including ankles, feet and legs. It is usually caused by standing or sitting in the same position for too long, eating too much salty food and being overweight. Edema mainly affects the lymphatic system (including the circulatory and immune systems) and organs like the tonsils, spleen and thymus, maintaining fluid balance and fights infections. If it does not subside, please consult your doctor immediately.

TRILOSACAR TABLET can be safely taken as long as your doctor has prescribed it to you. Conditions such as high blood pressure are life-long conditions, and one should not abruptly discontinue it without discussing it with a doctor.

It's unlikely that TRILOSACAR TABLET affects fertility in men or women. However, some water pills like hydrochlorothiazide may lead to erectile dysfunction. There's not enough evidence to say for certain. For the best advice, consult your doctor.

No, you are advised to inform your doctor and monitor your blood pressure for at least two weeks before stopping the medicine. Depending upon your current blood pressure readings, there is a possibility your doctor may lower your medicine dosage and not recommend discontinuing it.

If you stop taking TRILOSACAR TABLET, your blood pressure may increase, and your condition may worsen. Consult your doctor before stopping or changing your treatment plan to ensure your blood pressure remains controlled.

The optimal time to take TRILOSACAR TABLET is typically in the morning, as it helps to maintain blood pressure control throughout the day. However, it is essential to follow your doctor's specific instructions regarding the best time to take your medication.

If you forgot a dose of TRILOSACAR TABLET, take it as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose of TRILOSACAR TABLET to compensate for the missed dose.

When taking TRILOSACAR TABLET, exercising caution and monitoring your health is crucial. Inform your doctor about any pre-existing kidney or liver disease, low blood pressure (hypotension), diabetes, or heart conditions to ensure safe treatment. Monitor serum electrolytes periodically. Regularly check your blood pressure and kidney function, and be aware of low blood pressure, such as dizziness or fainting. Additionally, report any unusual symptoms, like swelling or difficulty breathing, and limit your intake of salt, potassium-rich foods, and certain medications. By being proactive and following these guidelines, you can minimize potential risks and maximize the benefits of your treatment.

Avoid consumption of alcohol while taking TRILOSACAR TABLET as it might make you feel dizzier and drowsier. Additionally, combining alcohol with this medication may reduce its effectiveness in controlling your blood pressure.

Taking more than the prescribed dose of TRILOSACAR TABLET leads to an overdose. Symptoms of overdose include nausea, weakness, dizziness and disturbances of electrolyte balance. If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

TRILOSACAR TABLET is a long-term hypertension medication typically taken once daily. It is essential to take this medication daily as directed by your doctor for as long as prescribed to maintain control over your blood pressure and reduce the risk of complications. Consistency is key to effectively managing hypertension.

The common side effects of TRILOSACAR TABLET are glucose intolerance (low or high level of glucose), ankle swelling, sleepiness, headache (sense of heat in the face, ears, neck, and trunk), flushing, tiredness, nausea, decreased potassium level in the blood, Increased blood uric acid and altered blood lipid level. Please consult your doctor if any of these side effects persist or worsen.

Country of origin

India

Manufacturer/Marketer address

Zydus Tower, Satellite Cross Roads,Ahmedabad – 380015 Gujarat, India
Other Info - TRI0797

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Author Details

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 6:29 PM IST

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Reference

  1. https://www.drugs.com/mtm/chlorthalidone.html
  2. https://www.drugs.com/amlodipine.html
  3. https://medlineplus.gov/druginfo/meds/a695008.html

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