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  3. Trexodat 10mg Tablet

Prescription drug
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Trexodat 10mg Tablet, Pack of 1 Tablet
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Extra 15% Off with Bank Offers
Written By Santoshini Reddy G , M Pharmacy
Reviewed By Veda Maddala , M Pharmacy

Trexodat 10mg Tablet is used to treat active rheumatoid arthritis, severe psoriasis, severe psoriatic arthritis, and cancer. It contains Methotrexate, which works by suppressing the overactive immune system. Besides this, it prevents and stops the growth of cancer cells, thereby helping treat cancer. In some cases, it may cause common side effects such as nausea, vomiting, diarrhoea, unusual fatigue, dizziness, headache, and loss of appetite. Before starting this medicine, inform your doctor if you are pregnant, breastfeeding, taking any other medicines or have pre-existing medical conditions.

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Composition :

METHOTREXATE-10MG

Manufacturer/Marketer :

Leeford Healthcare Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Trexodat 10mg Tablet

Trexodat 10mg Tablet is used to treat active rheumatoid arthritis, including polyarticular juvenile rheumatoid arthritis, severe psoriasis, and severe psoriatic arthritis.

It is also used alone or in combination with other medicines to treat breast cancer, lung cancer, head and neck cancer, mycosis fungoides (a type of blood cancer), and advanced-stage non-Hodgkin lymphomas (cancer that starts in the lymphatic system).

Trexodat 10mg Tablet contains 'Methotrexate', which works by interrupting the processes of the immune system that cause inflammation in the joint tissues. It reduces pain and inflammation and delays joint damage and disease progression over time.

Trexodat 10mg Tablet prevents and stops the growth of cancer cells, thereby helping treat cancer. It treats psoriasis by suppressing the overactive immune system that is responsible for causing psoriasis.

In some cases, Trexodat 10mg Tablet may cause side effects such as nausea, vomiting, diarrhoea, unusual fatigue, dizziness, headache, loss of appetite, and lowered resistance to infections. You are advised to talk to your doctor if you experience these side effects persistently.

Do not take Trexodat 10mg Tablet if you are pregnant or breastfeeding. Trexodat 10mg Tablet may cause dizziness and fatigue, so drive only if you are alert. Inform your doctor about your medications and health condition to rule out any unpleasant side effects/interactions.

Uses of Trexodat 10mg Tablet

Trexodat 10mg Tablet is used in the treatment of rheumatoid arthritis, psoriatic arthritis, psoriasis, and cancer. The detailed uses of Trexodat 10mg Tablet are as follows:

  • Treatment of Rheumatoid Arthritis: Trexodat 10mg Tablet is commonly prescribed to manage the symptoms of rheumatoid arthritis, reducing inflammation and pain in the joints.
  • Management of Psoriasis: Trexodat 10mg Tablet can be used to treat severe psoriasis, helping to clear the skin and reduce scaling.
  • Chemotherapy for Certain Cancers: Trexodat 10mg Tablet may be utilised in lower doses as part of a chemotherapy treatment regimen for specific types of cancers, such as osteosarcoma or certain leukaemias.
  • Autoimmune Disease Management: Trexodat 10mg Tablet is sometimes used to manage other autoimmune conditions, where it helps to suppress the immune system and reduce abnormal immune responses.

Have a query?

Directions for Use

  • Take Trexodat 10mg Tablet with food or as advised by your doctor.
  • It is advised to take Trexodat 10mg Tablet once a week; however, follow your doctor’s recommendation regarding the dosage and duration.
  • Swallow Trexodat 10mg Tablet as a whole with a glass of water.
  • Do not crush, break, or chew it.

Medicinal Benefits

  • Trexodat 10mg Tablet is used to treat rheumatoid arthritis and psoriatic arthritis. It reduces inflammation and pain in joints. It slows or prevents joint damage and disease progression.
  • It helps treat psoriasis by suppressing the overactive immune response that causes skin cell overgrowth. It reduces scaling, redness, and thickness of psoriatic plaques.
  • Trexodat 10mg Tablet is used in the management of breast cancer, lung cancer, head and neck cancer, mycosis fungoides (a type of blood cancer), and advanced-stage non-Hodgkin lymphomas.
  • It works by interfering with DNA synthesis, thereby stopping or slowing the growth of cancer cells.
  • It helps manage inflammation in the digestive tract.
  • Provides disease control by modulating the immune system.
  • Offers long-term relief from autoimmune and inflammatory conditions.
  • Improves treatment outcomes in certain cancers by preventing abnormal cell growth.

How Trexodat 10mg Tablet Works

Trexodat 10mg Tablet contains 'Methotrexate', which works by interrupting the processes of the immune system that cause inflammation in the joint tissues. It reduces pain and inflammation and delays joint damage and disease progression over time. Besides this, Trexodat 10mg Tablet prevents and stops the growth of cancer cells, thereby helping treat cancer. Trexodat 10mg Tablet treats psoriasis by suppressing the overactive immune system that is responsible for causing psoriasis.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Trexodat 10mg Tablet
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
  • Get sufficient sleep and manage stress which helps in improving white blood cell count.
  • Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
  • Try to prevent the factors that cause a decrease in white blood cells which may lead to impaired immunity.
Managing Medication-Triggered Erythema (Redness of the Skin or Skin redness): A Step-by-Step Guide:
  • Consult your doctor if you experience skin redness, itching, or irritation after taking medication.
  • Your doctor may adjust your treatment plan by changing your medication or providing guidance on managing your erythema symptoms.
  • Your doctor may recommend or prescribe certain medications to help alleviate symptoms.
  • Apply cool compresses or calamine lotion to the affected skin area to reduce redness and itching.
  • Stay hydrated by drinking plenty of water to help alleviate symptoms and keep your skin hydrated.
  • Monitor your skin condition closely and promptly report any changes, worsening symptoms, or concerns to your healthcare provider.
Here are the few steps for dealing with itching caused by drug use:
  • Report the itching to your doctor immediately; they may need to change your medication or dosage.
  • Use a cool, damp cloth on the itchy area to help soothe and calm the skin, reducing itching and inflammation.
  • Keep your skin hydrated and healthy with gentle, fragrance-free moisturizers.
  • Try not to scratch, as this can worsen the itching and irritate your skin.
  • If your doctor prescribes, you can take oral medications or apply topical creams or ointments to help relieve itching.
  • Track your itching symptoms and follow your doctor's guidance to adjust your treatment plan if needed. If the itching persists, consult your doctor for further advice.

What if I have taken an overdose of Trexodat 10mg Tablet

Do not take more than the prescribed dose of Trexodat 10mg Tablet as it may cause overdose leading to severe toxic reactions. The symptoms of overdose include unusual weakness, nausea, vomiting, easy bruising or bleeding, mouth sores, decreased urination, coughing up blood or vomit that looks like coffee grounds and black or bloody stools. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

  • Do not take Trexodat 10mg Tablet if you are allergic to any of its contents; if you have immunodeficiency conditions, bone marrow problems, low white blood cell count, low platelet count, serious anaemia, liver problems due to alcohol abuse, chronic liver disease; if you are pregnant or breastfeeding.
  • Talk to your doctor before taking Trexodat 10mg Tablet if you have/had liver or kidney problems, ulceration in the stomach or bowels, poor general condition, received any vaccinations or if you are due to have any vaccinations, diabetes, ascites (fluid in the stomach area), lung problems or fluid in the lungs.
  • Trexodat 10mg Tablet may cause dizziness and fatigue, so drive only if you are alert.
  • Take Trexodat 10mg Tablet exactly as directed by the doctor, as it may cause serious problems if not taken in the dose and duration prescribed by the doctor.
  • Stop taking Trexodat 10mg Tablet and consult your doctor immediately if you have mouth sores, diarrhoea, a fever, dehydration, cough, bleeding, shortness of breath, any signs of infection, or a skin rash.
  • Inform your doctor if you are taking any other medicines, including supplements and herbal products.

Drug-Drug Interactions

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MethotrexateEtretinate
Critical
MethotrexateBaricitinib
Severe

Drug-Drug Interactions

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MethotrexateEtretinate
Critical
How does the drug interact with Trexodat 10mg Tablet:
Co-administration of Etretinate with Trexodat 10mg Tablet may increase the risk or severity of liver problems.

How to manage the interaction:
Taking Etretinate with Trexodat 10mg Tablet is generally avoided as it can possibly result in an interaction, it can be taken if a doctor has advised it. Do not stop using any medications without talking to a doctor.
MethotrexateBaricitinib
Severe
How does the drug interact with Trexodat 10mg Tablet:
Co-administration of Baricitinib and Trexodat 10mg Tablet can increase the risk or severity of developing serious infections.

How to manage the interaction:
Although there is a possible interaction between Baricitinib and Trexodat 10mg Tablet, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin, and pain or burning during urination. Consult a doctor. Do not stop using any medications without consulting a doctor.
MethotrexateOxacillin
Severe
How does the drug interact with Trexodat 10mg Tablet:
Coadministration of Trexodat 10mg Tablet with oxacillin can increase the risk of developing serious infections.

How to manage the interaction:
Although there is a possible interaction between oxacillin and Trexodat 10mg Tablet, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin and pain or burning during urination. Consult your doctor. Do not stop using any medications without first consulting to your doctor.
MethotrexateKetorolac
Severe
How does the drug interact with Trexodat 10mg Tablet:
Coadministration of Trexodat 10mg Tablet with ketorolac can increase the blood levels and side effects of Trexodat 10mg Tablet.

How to manage the interaction:
Although there is a interaction between Trexodat 10mg Tablet and ketorolac, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as mouth sores or ulcers, nausea, vomiting, diarrhea, rash, appetite loss, joint pain or swelling, yellowing of the skin or eyes, dark urine, shortness of breath, a dry cough, pallor, dizziness or fainting, unusual bruising or bleeding, seizures, infection; as well as flu-like signs (fever, chills, body pains, sore throat, and weakening of the muscles), consult a doctor immediately. Do not stop using medications without a doctor's advice.
MethotrexateNaproxen
Severe
How does the drug interact with Trexodat 10mg Tablet:
Coadministration of Trexodat 10mg Tablet with Naproxen can increase the levels and side effects of Trexodat 10mg Tablet.

How to manage the interaction:
Taking Trexodat 10mg Tablet with Naproxen together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience any symptoms such as mouth ulcers or sores, vomiting, fever, chills, body aches, sore throat, muscle weakness, diarrhea, rash, loss of appetite, joint pain or swelling, yellow discoloration of skin and eyes, dark urine, breathing difficulty, dry cough, paleness, dizziness or fainting, unusual bruising or bleeding, seizures(fits), Consult a doctor. Do not stop using any medications without consulting a doctor.
MethotrexatePantoprazole
Severe
How does the drug interact with Trexodat 10mg Tablet:
Co-administration of Trexodat 10mg Tablet with pantoprazole can increase the levels and side effects of Trexodat 10mg Tablet.

How to manage the interaction:
Although there is a possible interaction between pantoprazole and Trexodat 10mg Tablet, you can take these medicines together if prescribed by a doctor. However, if you experience any symptoms such as nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, tiredness, weakness, or dizziness, consult a doctor. Do not stop using any medications without consulting a doctor.
MethotrexateEverolimus
Severe
How does the drug interact with Trexodat 10mg Tablet:
Coadministration of Everolimus with Trexodat 10mg Tablet can increase the risk or severity of kidney disorders.

How to manage the interaction:
Taking Everolimus with Trexodat 10mg Tablet together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not stop using any medications without talking to a doctor.
MethotrexateProcaine benzylpenicillin
Severe
How does the drug interact with Trexodat 10mg Tablet:
Coadministration of Trexodat 10mg Tablet with procaine benzyl penicillin can increase the levels and side effects of Trexodat 10mg Tablet.

How to manage the interaction:
Although there is a possible interaction between procaine benzyl penicillin and Trexodat 10mg Tablet, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as nausea, vomiting, mouth ulcers, paleness, fatigue, dizziness, fainting, unusual bleeding or bruising, fever, chills, sore throat, body aches, or other flu-like symptoms, consult your doctor. Do not stop using any medications without consulting to a doctor.
MethotrexateLansoprazole
Severe
How does the drug interact with Trexodat 10mg Tablet:
Co-administration of Trexodat 10mg Tablet with Lansoprazole can increase the blood levels and side effects of Trexodat 10mg Tablet.

How to manage the interaction:
Although there is a possible interaction between Trexodat 10mg Tablet and Lansoprazole, you can take these medicines together if prescribed by a doctor. However, if you notice any symptoms of headaches, irritation, confusion, decreased hunger, fatigue, heart palpitations, or diarrhea, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
MethotrexateTacrolimus
Severe
How does the drug interact with Trexodat 10mg Tablet:
Taking tacrolimus with Trexodat 10mg Tablet may increase the risk of kidney problems.

How to manage the interaction:
Although there is a possible interaction between tacrolimus and Trexodat 10mg Tablet, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, tiredness, weakness, dizziness. Consult your doctor. Do not stop using any medications without consulting to a doctor.

Drug-Food Interactions

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METHOTREXATE-10MGCaffeine containing foods/drinks
Moderate

Drug-Food Interactions

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METHOTREXATE-10MGCaffeine containing foods/drinks
Moderate
Common Foods to Avoid:
Cocoa, Coffee, Dark Chocolate, Energy Drinks With Caffeine, Green Tea, Kola Nut, Tea, Tiramisu

How to manage the interaction:
Caffeine may reduce the effectiveness of Trexodat 10mg Tablet. Avoid taking caffeine while taking Trexodat 10mg Tablet. This can increase the risk or severity of side effects.

Diet & Lifestyle Advise

Arthritis:

  • Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle exercises like 20-30minutes of walking or swimming would be helpful.
  • Performing yoga may also help in improving joint flexibility and pain management.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Get adequate sleep, as resting the muscles can help reduce inflammation and swelling.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Acupuncture, massage and physical therapy may also be helpful.
  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.
  • Avoid smoking and alcohol consumption.

Psoriasis:

  • Include foods such as cherries, berries, leafy vegetables, salmon, sardines, and fish rich in omega-3 fatty acids.
  • Consume antioxidant-rich spices and herbs like cumin, ginger, sage and thyme.
  • Avoid processed foods, refined sugars, and fatty foods.
  • Limit intake of food that might trigger allergies, such as dairy products, soy, eggs, and nuts.
  • Include fruits, vegetables, whole grains, healthy fats and fish in your diet.
  • Reducing stress and maintaining a good sleep cycle would be helpful.
  • Avoiding getting in contact with harsh soaps, detergents and rough fabrics.

Cancer:

  • Consume a healthy diet and exercise regularly to maintain a proper weight.
  • Avoid smoking and alcohol consumption.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, herbs, and spices in your diet.
  • Avoid fast food, fried food, processed meats, refined carbs, and added sugar.
  • Get optimal sleep; rest well.

Habit Forming

No

Therapeutic Class

IMMUNOSUPPRESSANTS

All Substitutes & Brand Comparisons

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Alcohol

Unsafe

You are recommended to avoid alcohol consumption while taking Trexodat 10mg Tablet.

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Pregnancy

Unsafe

Trexodat 10mg Tablet may cause serious birth defects. It is not recommended to take Trexodat 10mg Tablet while you are pregnant.

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Breast Feeding

Unsafe

Trexodat 10mg Tablet passes into breast milk. Avoid breastfeeding whilst on treatment with Trexodat 10mg Tablet.

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Driving

Caution

Trexodat 10mg Tablet may cause dizziness and tiredness; do not drive or operate heavy machinery if you experience these symptoms.

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Liver

Caution

Do not take Trexodat 10mg Tablet if you have chronic liver disease. Please consult your doctor if you have liver impairment before taking Trexodat 10mg Tablet.

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Kidney

Caution

Please consult your doctor if you have kidney impairment before taking Trexodat 10mg Tablet.

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Children

Caution

Trexodat 10mg Tablet should be used with caution in children and only if prescribed by the doctor.

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Heart

Trexodat 10mg Tablet can be used in heart patients if prescribed by the physician. Please consult your physician if you have any concerns.

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Geriatrics

Safe if prescribed

Trexodat 10mg Tablet can be safely used in elderly patients with proper monitoring and individualised care.

FAQs

Trexodat 10mg Tablet is used to treat active rheumatoid arthritis, including polyarticular juvenile rheumatoid arthritis, severe psoriasis, and severe psoriatic arthritis. It is also used alone or in combination with other medicines to treat breast cancer, lung cancer, head and neck cancer, mycosis fungoides (a type of blood cancer), and advanced-stage non-Hodgkin lymphomas (cancer that starts in the lymphatic system).

Trexodat 10mg Tablet acts as an immunosuppressant, which helps in reducing inflammation and preventing joint stiffness, thereby providing relief from rheumatoid arthritis.

Trexodat 10mg Tablet works by suppressing the overactive immune system that is responsible for causing psoriasis. Trexodat 10mg Tablet interferes with the synthesis of genetic material (DNA) and the growth of cells that multiply faster than usual, thereby helping in treating psoriasis and psoriatic arthritis.

Diarrhoea might be a side-effect of Trexodat 10mg Tablet. Stop taking Trexodat 10mg Tablet and consult your doctor if you have diarrhoea. Do not take anti-diarrheal medicine on your own.

Trexodat 10mg Tablet can affect egg and sperm production and could lead to birth defects. Women of child-bearing potential and men using Trexodat 10mg Tablet must use effective contraception while on treatment with Trexodat 10mg Tablet and for at least six months after stopping the treatment. Trexodat 10mg Tablet can lead to infertility. Therefore, male patients are advised to talk with their doctor regarding the possibility of sperm preservation before starting the treatment with Trexodat 10mg Tablet.

Country of origin

India
Other Info - TR44321

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Veda MaddalaDoctor badge

Reviewed By

Veda Maddala

M Pharmacy

Last Updated

Nov 18, 2025 | 7:32 AM IST

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Reference

  1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/011719s117lbl.pdfhttp://www.hpra.ie/img/uploaded/swedocuments/pil-2167015-11052016181932-635985875740562500.pdf
  2. https://www.cipla.com/sites/default/files/Methotrexate%202.5%20mg%20%E2%80%93%20Patient%20Card%20-%20Risk%20Minimisation%20Information%20for%20Patients.pdf
  3. https://www.stmarkshospital.nhs.uk/wp-content/uploads/2014/07/IBD_methotrexate_leaflet.pdf
  4. https://www.drugs.com/methotrexate.html
  5. https://medlineplus.gov/druginfo/meds/a682019.html
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