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compositionComposition:TOPOTECAN-4MG
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Topoquis 4 mg Injection 4 ml contains topotecan which is used in the treatment of ovarian and small cell lung cancer. It is an anticancer medicine which works by binding to the cell's DNA, and stops it from naturally dividing and functioning, ultimately destroying it. This medicine can sometimes be used for treating other cancer conditions aswell. Common side effects inculde nausea, diarrhoea, vomiting, thrombocytopenia (a low platelet count), peripheral neuropathy and electrolyte disturbance.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

TOPOTECAN-4MG

Manufacturer/Marketer :

Fresenius Kabi India Pvt Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-28

Return Policy :

Not Returnable

About Topoquis 4 mg Injection 4 ml

Topoquis 4 mg Injection 4 ml is a prescription injection used to treat advanced cancer of the ovaries, small cell lung cancer, and cervical cancer. It is typically prescribed when other primary treatments have not worked or after the cancer has returned or spread to other parts of the body.

This medicine is given as a slow injection into a vein by a healthcare professional in a clinic or hospital setting. Because it is given in structured treatment cycles, keeping all your scheduled appointments is essential for the medicine to work effectively. Eating small, balanced meals and staying well-hydrated throughout your treatment cycles can help support your body and manage side effects.

Common side effects of this medicine include nausea, temporary hair loss, and extreme tiredness. You must consult your doctor immediately if you experience serious side effects, such as a high fever, severe shaking, unusual bruising, or persistent diarrhoea, which can indicate a drop in your blood cell counts.

Before starting this medicine, tell your doctor if you have kidney disease or a history of low blood cell counts. Do not receive this medicine if you are pregnant, planning to become pregnant, or breastfeeding, as it can cause serious harm to a developing baby.

This medicine can interact with other cancer treatments and live vaccines, which can severely weaken your immune system and increase your risk of infection. You should avoid alcohol and smoking during treatment, as they can worsen lung irritation and stomach upset. Always consult your doctor if you are elderly or have other chronic health conditions before starting your treatment cycles.

Uses of Topoquis 4 mg Injection 4 ml

Topoquis 4 mg Injection 4 ml is used to treat certain advanced cancers. The detailed uses of Topoquis 4 mg Injection 4 ml are as follows:

  • Ovarian Cancer: Treats advanced cancer of the ovaries when standard chemotherapy treatments have stopped working.
  • Small Cell Lung Cancer: Helps manage small cell lung cancer that has returned or worsened after initial chemotherapy cycles.
  • Cervical Cancer: Works in combination with other chemotherapy medicines to treat advanced, persistent, or recurrent cancer of the cervix when surgery or radiation are not options.

Key Benefits

Topoquis 4 mg Injection 4 ml provides important treatment benefits by helping control advanced cancers and supporting disease management. The key benefits of Topoquis 4 mg Injection 4 ml include:

  • Slows Cancer Progression: By targeting rapidly dividing cancer cells, Topoquis 4 mg Injection 4 ml helps slow the growth and spread of cancer and may help shrink existing tumours.
  • Second-Line Treatment Option: It provides an important treatment option for patients whose cancer has returned or has not responded adequately to first-line chemotherapy.
  • Symptom Management: By helping control the progression of cancer, Topoquis 4 mg Injection 4 ml may reduce cancer-related symptoms and improve overall comfort and daily physical function during treatment.
Side effects of Topoquis 4 mg Injection 4 ml
  • Talk to your doctor about medicines to manage neutropenia based on the underlying cause.
  • Avoid contact with people who are sick.
  • Wash your hands regularly with soap and water.
  • Avoid unpasteurized dairy products.
  • Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
  • Get sufficient sleep and manage stress which helps in improving white blood cell count.
  • Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
  • Try to prevent the factors that cause a decrease in the white blood cells that may lead to impaired immunity.
  • Managing a low platelet count (thrombocytopenia) caused by medication usage requires a multi-step approach. Here are some steps to help manage the condition:
  • Inform your doctor about your low platelet count and medication usage. They will assess the situation and guide the best course of action.
  • Your doctor may recommend adjusting or stopping the medication that is causing a low platelet count. This could involve switching to alternative medication or reducing the dosage.
  • Monitor your platelet count regularly through blood tests to track any changes. This will help the doctor determine the effectiveness of the treatment plan.
  • If an underlying condition, such as infection or inflammation, contributes to the low platelet count, your doctor will treat it.
  • In some cases, alternative treatments like platelet transfusions or medications that stimulate platelet production may be necessary.
  • Avoid risky activities and certain medications; eat a balanced diet with plenty of water to reduce bleeding risk and boost overall health.
  • If you experience severe bleeding or bruising, seek emergency medical attention immediately.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.

Directions for Use

  • Topoquis 4 mg Injection 4 ml is prescribed and administered based on your medical condition and treatment plan as determined by your doctor.
  • This injection is given only by qualified healthcare professionals experienced in administering cancer therapies.
  • It must not be self-administered, as it requires careful handling and monitoring during and after administration.
  • You will be closely monitored during treatment to ensure your safety and treatment effectiveness.

How Topoquis 4 mg Injection 4 ml Works

Topoquis 4 mg Injection 4 ml contains topotecan, which works by blocking an enzyme called topoisomerase I that cancer cells need to copy and repair their genetic material (DNA). By preventing this enzyme from functioning properly, Topoquis 4 mg Injection 4 ml stops cancer cells from repairing and replicating their DNA during cell division, causing DNA damage and eventually leading to cancer cell death. Because cancer cells multiply much faster than most normal cells, they are particularly sensitive to this action, helping slow or stop tumour growth.
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Alcohol

Unsafe

Avoid alcohol consumption while on treatment with Topoquis 4 mg Injection 4 ml.

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Pregnancy

Unsafe

Topoquis 4 mg Injection 4 ml should not be used during pregnancy because it can harm your fetus (newborn baby). Both women of childbearing potential and men must use an effective contraception method while taking Topoquis 4 mg Injection 4 ml and at least for six months later treatment. Your doctor will weigh the benefits and risks before prescribing this medicine.

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Breast Feeding

Unsafe

Topoquis 4 mg Injection 4 ml should not be used during breastfeeding as it passes into the breastmilk and may harm your baby. Hence, if you are breastfeeding, inform your doctor before receiving this medicine.

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Driving

Caution

Topoquis 4 mg Injection 4 ml may affect your reactions and your ability to drive. Note: Possible side effects of chemotherapy with Topoquis 4 mg Injection 4 ml may occur, such as nausea and vomiting. If you are affected by these side effects, do not drive and/or operate machines that require your alertness.

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Liver

Caution

If you have had a history or evidence of liver impairment, please inform your doctor before taking the Topoquis 4 mg Injection 4 ml. Your doctor may adjust the dose or prescribe a suitable alternative if necessary based on your condition.

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Kidney

Caution

If you have had a history or evidence of kidney diseases, please inform your doctor before taking the Topoquis 4 mg Injection 4 ml. Your doctor may adjust the dose or prescribe a suitable alternative if necessary based on your condition.

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Children

Unsafe

The safety and effectiveness of Topoquis 4 mg Injection 4 ml in pediatric patients have not been established. Please consult your doctor. Your doctor will weigh the benefits and any potential risks before prescribing this medicine.

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Heart

Consult your doctor

Inform your doctor if you have heart disease before using Topoquis 4 mg Injection 4 ml. Your doctor will prescribe only if the benefits outweigh the risks.

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Geriatrics

Consult your doctor

Please consult a doctor before administering Topoquis 4 mg Injection 4 ml to geriatric patients. Your doctor will prescribe Topoquis 4 mg Injection 4 ml if the benefits outweigh the risks.

What if I have taken an overdose of Topoquis 4 mg Injection 4 ml

Overdoses are extremely rare because your healthcare team carefully measures and prepares each dose. In the highly unlikely event of an accidental overdose, it can cause severe bone marrow suppression, leading to very low blood cell counts. Your doctor will monitor you closely in a hospital setting and provide supportive care as needed.

Diet & Lifestyle Advise

  • Practice infection prevention: Avoid crowds and stay away from people who are actively sick. Wash your hands frequently with soap and water to protect your weakened immune system.
  • Stay hydrated: Drink plenty of water, broth, or decaffeinated fluids throughout the day to help your kidneys clear the medicine and prevent dehydration from nausea or diarrhoea.
  • Eat small, frequent meals: If you suffer from nausea or loss of appetite, try eating five or six small, bland meals during the day instead of three large ones to maintain your energy.
  • Be gentle on your gums: Use a soft-bristled toothbrush to clean your teeth, and avoid using dental floss or undergoing dental procedures without checking with your oncologist first to prevent bleeding.
health query

Have a query?

How Soon It Starts Working

The time required for Topoquis 4 mg Injection 4 ml to start to work: The time required for Topoquis 4 mg Injection 4 ml to show its action is unknown. The time for which the effects of Topoquis 4 mg Injection 4 ml last: The duration of action for Topoquis 4 mg Injection 4 ml is unknown.

What if you forget to take Topoquis 4 mg Injection 4 ml

Because this medicine is given by a healthcare professional in a clinic, it is highly unlikely that you will miss a dose. However, if you miss a scheduled appointment for your injection, contact your doctor or clinic immediately to reschedule your treatment session.

Storage

.•Unopened vials are kept in a secure refrigerator between 2°C and 8°C (36°F to 46°F).

Drug Warnings

  • Monitor Your Temperature: Check your temperature daily and contact your healthcare provider immediately if it rises to 38°C (100.4°F) or higher, as this may be a sign of a serious infection.
  • Attend Blood Test Appointments: Keep all scheduled appointments for blood tests so your doctor can monitor your blood cell counts and adjust your treatment if necessary.
  • Report Injection Site Problems: Tell your nurse or doctor immediately if you experience burning, stinging, redness, pain, or swelling around the injection site during your infusion.
  • Use Effective Contraception: Use highly effective birth control during treatment and for the period recommended by your doctor after your final dose, as Topoquis 4 mg Injection 4 ml can cause serious harm to an unborn baby.
  • Avoid Live Vaccines: Do not receive live vaccines while undergoing treatment because your immune system may be weakened, increasing the risk of infection.

Drug-Drug Interactions

verifiedApollotooltip
  • Other chemotherapy medicines: Combining Topoquis 4 mg Injection 4 ml with other cancer drugs can severely increase the risk of low blood cell counts and bone marrow damage.
  • Immunosuppressants: Medicines that lower your immune system can significantly increase your risk of catching serious infections during treatment.
TopotecanEtanercept
Severe
TopotecanClozapine
Severe

Drug-Drug Interactions

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TopotecanEtanercept
Severe
How does the drug interact with Topoquis 4 mg Injection 4 ml:
When Etanercept is used with Topoquis 4 mg Injection 4 ml, the likelihood or severity of infection may increase.

How to manage the interaction:
Although there is a possible interaction between Topoquis 4 mg Injection 4 ml and Etanercept, you can take these medicines together if prescribed by a doctor. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
TopotecanClozapine
Severe
How does the drug interact with Topoquis 4 mg Injection 4 ml:
When Clozapine is taken with Topoquis 4 mg Injection 4 ml, the effect of Clozapine in the blood can go up.

How to manage the interaction:
Although there is a possible interaction between Topoquis 4 mg Injection 4 ml and Clozapine, you can take these medicines together if prescribed by your doctor. If you're having any of these symptoms - infection, fever, chills, diarrhea, sore throat, muscle aches, weight loss, pain or burning during urination - it's important to contact your doctor right away. They may be able to recommend other options that won't cause any problems with your current medications. Do not stop using any medications without a doctor's advice.
TopotecanInfliximab
Severe
How does the drug interact with Topoquis 4 mg Injection 4 ml:
Combining Infliximab with Topoquis 4 mg Injection 4 ml can increase the risk and severity of side effects.

How to manage the interaction:
Co-administration of Topoquis 4 mg Injection 4 ml with Infliximab can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience symptoms of fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in sputum, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
TopotecanThalidomide
Severe
How does the drug interact with Topoquis 4 mg Injection 4 ml:
Taking thalidomide together with Topoquis 4 mg Injection 4 ml may increase the risk of blood clots and other complications.

How to manage the interaction:
Although taking thalidomide and Topoquis 4 mg Injection 4 ml together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
TopotecanTofacitinib
Severe
How does the drug interact with Topoquis 4 mg Injection 4 ml:
Taking Tofacitinib with Topoquis 4 mg Injection 4 ml may increase the risk of infection.

How to manage the interaction:
Although there is a possible interaction between Tofacitinib and Topoquis 4 mg Injection 4 ml, you can take these medicines together if prescribed by your doctor. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without first consulting your doctor.
TopotecanCarboplatin
Severe
How does the drug interact with Topoquis 4 mg Injection 4 ml:
When carboplatin is used with Topoquis 4 mg Injection 4 ml, it may increase the risk of side effects.

How to manage the interaction:
Co-administration of carboplatin with clozapine can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience any unusual symptoms, consult the doctor. Do not discontinue any medications without consulting your doctor.
TopotecanBaricitinib
Severe
How does the drug interact with Topoquis 4 mg Injection 4 ml:
Coadministration of baricitinib and Topoquis 4 mg Injection 4 ml can increase the risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, baricitinib can be taken with Topoquis 4 mg Injection 4 ml if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • No clinically significant food interactions are known with Topoquis 4 mg Injection 4 ml when used as directed.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTINEOPLASTIC]

FAQs

Topoquis 4 mg Injection 4 ml belongs to a group of medicines called anti-cancer drugs used in the treatment of ovarian cancer and small cell lung cancer. It is also used to treat advanced cervical cancer if surgery or radiotherapy treatment is not possible.
Topoquis 4 mg Injection 4 ml contains 'Topotecan'. Topotecan works by breaching the cellular wall and binding to the cell’s DNA, preventing the cell from dividing and functioning normally, which eventually kills the cell.
If you are allergic to topotecan or any other ingredients in this medication, are breastfeeding, or have too low blood cell counts, you should not use Topoquis 4 mg Injection 4 ml.
Yes, Topoquis 4 mg Injection 4 ml can cause low neutrophils levels, a type of white blood cells that help fight infections. If your white blood cells become low, you can be at higher risk for infections. Tell your doctor if you develop a fever or have an infection.
Avoid taking Topoquis 4 mg Injection 4 ml if you are pregnant because Topoquis 4 mg Injection 4 ml can cause harmful effects on the unborn baby. Females should follow effective birth control methods during treatment and at least six months after the final dose of Topoquis 4 mg Injection 4 ml.
Topoquis 4 mg Injection 4 ml is given as a slow injection or infusion into a vein (intravenously) by a trained healthcare professional in a clinic or hospital setting. Talk to your doctor if you have questions about your treatment schedule.
Yes, temporary hair loss is a common side effect of this medicine. Your hair will typically begin to grow back after your treatment cycles are completed. Talk to your doctor if you need advice on hair care.
If you develop a fever of 38°C (100.4°F) or higher, call your healthcare provider or go to an emergency room immediately, as this can be a sign of a serious infection. Talk to your doctor to learn more about infection safety.
This medicine can lower the number of white blood cells, red blood cells, and platelets in your body. Regular blood tests help your doctor monitor these levels to ensure it is safe for you to continue treatment. Talk to your doctor.
No, you should avoid live vaccines during treatment because this medicine weakens your immune system, making live vaccines unsafe. Talk to your doctor or pharmacist about which vaccines are safe for you.
Tell the nurse or doctor immediately if you feel pain, burning, coldness, or swelling around your vein during the injection, as the medicine may be leaking outside the vein. Talk to your doctor.
The number of cycles depends on the type of cancer being treated, how well your body responds, and your blood test results. Your oncologist will determine the exact schedule. Talk to your doctor.

Disclaimer

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Country of origin

India

Manufacturer/Marketer address

Fresenius Kabi Ag , Else-Krã¶Ner-Straãÿe 1 , 61352 Bad Homburg , Germany
Other Info - TOP0558
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