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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Tonact Plus Tablet is used to treat high cholesterol. It contains atorvastatin and nicotinic acid which works by reducing the bad cholesterol, triglycerides and increasing the levels of good cholesterol. In some cases, this medicine may cause side effects such as constipation, nausea, stomach pain, weakness, muscle pain, headache, dizziness, and itching. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Manufacturer/Marketer :

Lupin Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Tonact Plus Tablet

Tonact Plus Tablet belongs to a class of medications called antilipemic (cholesterol-lowering agent). Tonact Plus Tablet is used to treat raised cholesterol levels in our body. Tonact Plus Tablet helps lower the level of low-density lipoprotein (LDL) or bad cholesterol in the blood and increases high-density lipoprotein (HDL) or good cholesterol. Dyslipidaemia is the deposition of unhealthy levels of fats (lipid) in the blood. In this condition, there is always a high level of low-density lipoprotein (LDL or bad cholesterol), triglycerides (TG), and a low level of high-density lipoprotein (HDL or good cholesterol). Tonact Plus Tablet is an extended-release formulation that releases slowly for a longer duration of time.

Tonact Plus Tablet contains two medicines, namely atorvastatin and nicotinic acid (vitamin B3). Atorvastatin is a lipid-lowering medication that blocks the enzyme required to make cholesterol in the body. It reduces the bad cholesterol (also known as low-density lipoproteins or LDL), triglycerides (TG) and increases the levels of good cholesterol (also known as high-density lipoproteins or HDL). On the other hand, Tonact Plus Tablet contains nicotinic acid, which is a form of vitamin B that further increases good cholesterol levels (HDL).

Take Tonact Plus Tablet as prescribed by your doctor. You are advised to take Tonact Plus Tablet for as long as your doctor has prescribed it for you, depending on your medical conditions. You may experience constipation, nausea, stomach pain, weakness, muscle pain, headache, dizziness, itching, flushing of the skin, the increased glucose level in the blood. Most of these side effects of Tonact Plus Tablet do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Do not take Tonact Plus Tablet if you are allergic to Tonact Plus Tablet , or any other ingredients present in it. Tonact Plus Tablet should not be taken in conditions like liver disease or kidney disease. Tonact Plus Tablet should not be prescribed to children less than 10 years of age. Immediately inform your doctor before taking Tonact Plus Tablet if you are pregnant or planning to get pregnant, breastfeeding. Tonact Plus Tablet has negligible influence on the ability to drive and use machines. Do not drink too much while taking this medicine.

Uses of Tonact Plus Tablet

Treatment of High cholesterol.

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Directions for Use

• Take Tonact Plus Tablet with or without food as advised by your doctor.• Follow your doctor's instructions on the dosage and timing of this medication.• Swallow it as a whole with a glass of water.• Do not crush, chew or break it.

Medicinal Benefits

Tonact Plus Tablet taken with dietary measures helps treat high cholesterol, especially for heart patients when initial dietary measures fail to lower cholesterol. It helps lower the bad cholesterol (LDL) and increases the level of good cholesterol (HDL) in the state of dyslipidemia or hyperlipidemia. Tonact Plus Tablet is considered more effective compared to other cholesterol-lowering medicines. Tonact Plus Tablet also lowers the amount of fat or cholesterol deposition (plaque) in the heart's arteries, thereby reducing the chance of having a heart attack or stroke in the future. Tonact Plus Tablet contains nicotinic acid, which is a form of vitamin B that further increases good cholesterol levels (HDL). 

How Tonact Plus Tablet Works

Tonact Plus Tablet contains two medicines, namely atorvastatin and nicotinic acid (vitamin B3). Atorvastatin is a lipid-lowering medication that blocks the enzyme required to make cholesterol in the body. It reduces the bad cholesterol (also known as low-density lipoproteins or LDL), triglycerides (TG) and increases the levels of good cholesterol (also known as high-density lipoproteins or HDL). On the other hand, Tonact Plus Tablet contains nicotinic acid, which is a form of vitamin B that further increases good cholesterol levels (HDL).

Storage

• Store in a cool and dry place away from sunlight.• Keep this medicine out of the sight and reach of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

What if I have taken an overdose of Tonact Plus Tablet

Do not exceed the recommended dose, as it might cause an overdose. If you suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Tonact Plus Tablet may cause a breakdown of skeletal muscle tissue, leading to kidney failure. This condition usually occurs in the elderly, people with kidney disease, and poorly controlled hypothyroidism (underactive thyroid). Tonact Plus Tablet should not be prescribed to children less than 10 years of age. You should contact a doctor before if you have had an allergic reaction to Tonact Plus Tablet , have a liver problem (jaundice, liver cirrhosis), or kidney problems, pregnant or planning to get pregnant, breastfeeding, have severe lung disease, have a previous heart attack or stroke caused by bleeding in the brain, have hypothyroidism, drink more than 2 servings of alcohol per day and have a muscle disorder (fibromyalgia) and damaged muscle tissue (rhabdomyolysis).

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Tonact Plus Tablet:
Taking Tonact Plus Tablet with Posaconazole can increase the blood levels of Tonact Plus Tablet. This can increase the risk of side effects.

How to manage the interaction:
Although there is an interaction between posaconazole with Tonact Plus Tablet, they can be taken together if advised by your doctor. However, contact the doctor if you experience unexplained muscle pain, weakness, fever, chills, joint pain or swelling, unusual bleeding, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark coloured urine, or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Tonact Plus Tablet:
Combining atorvastatin with Tonact Plus Tablet may raise the risk of rhabdomyolysis, (an uncommon illness that leads to the destruction of skeletal muscle tissue). If you are elderly or have preexisting kidney disease, you may be at higher risk. This interaction is only relevant if you are taking large doses of Tonact Plus Tablet to treat high cholesterol. It does not apply if you are taking Tonact Plus Tablet in nutritional supplement amounts.

How to manage the interaction:
Taking atorvastatin and Tonact Plus Tablet together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you happen to experience, unexplained muscle pain, tenderness, weakness, fever, dark coloured urine, light coloured stools, you are advised to seek immediate medical attention. Do not discontinue any medications without consulting a doctor.
AtorvastatinNelfinavir
Severe
How does the drug interact with Tonact Plus Tablet:
Taking Tonact Plus Tablet with nelfinavir may considerably raise Tonact Plus Tablet levels in the blood. This can raise the chance of side effects (liver injury and rhabdomyolysis - an uncommon but serious illness that causes the breakdown of skeletal muscle tissue. Rhabdomyolysis occasionally results in kidney injury).

How to manage the interaction:
Although taking Tonact Plus Tablet and cyclosporine together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience muscle pain, tenderness, or weakness especially accompanied by fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, light colored stools, and/or yellowing of the skin or eyes, you should consult the doctor. Do not stop using any medications without talking to a doctor.
How does the drug interact with Tonact Plus Tablet:
Combining Tonact Plus Tablet with darunavir may profoundly enhance Tonact Plus Tablet levels in the blood. This can raise the chance of side effects (liver injury and rhabdomyolysis, an uncommon but serious illness that causes the breakdown of skeletal muscle tissue. Rhabdomyolysis occasionally results in kidney injury).

How to manage the interaction:
Taking Tonact Plus Tablet with darunavir can result in an interaction, it can be taken if a doctor has advised it. However, if you experience muscle pain, tenderness, or weakness, accompanied by fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, light colored stools, and/or yellowing of the skin or eyes, you should consult the doctor. Do not stop using any medications without talking to a doctor.
How does the drug interact with Tonact Plus Tablet:
Taking Tonact Plus Tablet with indinavir may considerably raise Tonact Plus Tablet levels in the blood.

How to manage the interaction:
Taking Tonact Plus Tablet and indinavir together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience muscle pain, tenderness, or weakness especially accompanied by fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, light colored stools, and/or yellowing of the skin or eyes, you should consult the doctor. Do not stop using any medications without talking to a doctor.
AtorvastatinConivaptan
Severe
How does the drug interact with Tonact Plus Tablet:
Using conivaptan together with Tonact Plus Tablet may significantly increase the blood levels of Tonact Plus Tablet.

How to manage the interaction:
Taking Tonact Plus Tablet with Conivaptan together can result in an interaction, but it can be taken if a doctor has advised it. You should also seek immediate medical attention if you develop fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, and/or yellowing of the skin or eyes. Do not stop using any medications without a doctor's advice.
AtorvastatinTroleandomycin
Severe
How does the drug interact with Tonact Plus Tablet:
Using Tonact Plus Tablet together with troleandomycin may significantly increase the blood levels of Tonact Plus Tablet.

How to manage the interaction:
Taking Tonact Plus Tablet with Troleandomycin together can result in an interaction, but it can be taken if a doctor has advised it. You should seek immediate medical attention if you develop fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, and/or yellowing of the skin or eyes. Do not stop using any medications without a doctor's advice.
How does the drug interact with Tonact Plus Tablet:
Using Tonact Plus Tablet together with danazol may significantly increase the blood levels of Tonact Plus Tablet.

How to manage the interaction:
Concomitant administration of Tonact Plus Tablet along with danazol can result in an interaction, it can be taken if a doctor has advised it. However, if you experience muscle pain, tenderness, or weakness, accompanied by fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, light colored stools, and/or yellowing of the skin or eyes, you should consult the doctor. Do not stop taking any medication without doctor's advice.
AtorvastatinLetermovir
Severe
How does the drug interact with Tonact Plus Tablet:
The combination of Tonact Plus Tablet and letermovir may substantially elevate the blood levels of Tonact Plus Tablet. This can raise the chance of side effects (liver injury and rhabdomyolysis, an uncommon but serious illness that causes the breakdown of skeletal muscle tissue. Rhabdomyolysis occasionally results in kidney injury).

How to manage the interaction:
Taking Tonact Plus Tablet with letermovir can result in an interaction, it can be taken if a doctor has advised it. However, if you experience muscle pain, tenderness, or weakness especially accompanied by fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, light colored stools, and/or yellowing of the skin or eyes, you should consult the doctor. Do not stop using any medications without talking to a doctor.
How does the drug interact with Tonact Plus Tablet:
Combining Tonact Plus Tablet with atazanavir may drastically elevate Tonact Plus Tablet levels in the blood. This can raise the chance of side effects (liver damage and rhabdomyolysis - an uncommon but serious illness that causes the breakdown of skeletal muscle tissue. Rhabdomyolysis occasionally results in kidney injury).

How to manage the interaction:
Taking Tonact Plus Tablet with atazanavir can result in an interaction, it can be taken if a doctor has advised it. However, if you experience muscle pain, tenderness, or weakness, accompanied by fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, light colored stools, and/or yellowing of the skin or eyes, you should consult the doctor. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Try aromatherapy, yoga, meditation to help relax your body and mind.
  • Try to do breathing exercises to get more oxygen.
  • Eat a healthy diet rich in soluble fiber like beans, legumes, whole grain, flax, apples, and citrus fruits.
  • Try to replace most of your saturated fats with unsaturated fats that can reduce total cholesterol and LDL cholesterol in a short span of time. Foods like avocados, olive oil, fatty fish, and nuts contain many heart-healthy unsaturated fats, so it’s beneficial to eat them regularly.
  • Try to adopt a Mediterranean-style diet rich in olive oil, fruits, vegetables, nuts, whole grains, fish, and low in red meat and most dairy.
  • Try to give priority to more fruits and veggies in your daily meal as these contain antioxidants that help to lower LDL
  • Minimize the intake of added sugar. The American Heart Association (ADA) recommends, one should not eat more than 100 calories (25 grams) of added sugar for women and children and no more than 150 calories (37.5 grams) for men every day.
  • American Heart Association recommends sodium chloride intake (table salt) should not exceed more than 2,300 mg per day as part of a healthy eating pattern.
  • As a precautionary measure, do not consume alcohol and quit smoking.

Habit Forming

No

Therapeutic Class

ANTILIPEMICS
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Alcohol

Unsafe

Do not drink too much while taking this medicine. Drinking a lot of alcohol, you may be more likely to get muscle and liver side effects.

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Pregnancy

Unsafe

Tonact Plus Tablet is not recommended during pregnancy. Contact your doctor before taking Tonact Plus Tablet .

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Breast Feeding

Unsafe

Breastfeeding is not recommended. Contact your doctor before taking Tonact Plus Tablet .

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Driving

Unsafe

Tonact Plus Tablet has negligible influence on the ability to drive and use machines.

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Liver

Caution

Tonact Plus Tablet to be taken with caution, especially if you have a history of Liver diseases/conditions. The dose may have to be adjusted by your doctor.

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Kidney

Caution

Tonact Plus Tablet to be taken with caution, especially if you have a history of Kidney diseases/conditions. The dose may have to be adjusted by your doctor.

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Children

Unsafe

Tonact Plus Tablet is not indicated in the treatment of patients below the age of 10 years.

FAQs

Tonact Plus Tablet is used to treat raised cholesterol levels in our body. Tonact Plus Tablet is a combination of two medicines, namely atorvastatin and nicotinic acid (vitamin B3). Atorvastatin is a lipid-lowering medication that blocks the enzyme required to make cholesterol in the body. It reduces the bad cholesterol (also known as low-density lipoproteins or LDL), triglycerides (TG) and increases the levels of good cholesterol (also known as high-density lipoproteins or HDL). On the other hand, Tonact Plus Tablet contains nicotinic acid, which is a form of vitamin B that further increases good cholesterol levels (HDL).

Yes. Muscle weakness can be the long-term side effects of Tonact Plus Tablet . You may have muscle fatigue or muscle pain which affects your daily activity. Try to contact a doctor if you have muscle weakness or fatigue.

Tonact Plus Tablet can raise your blood sugar a little. If you already have type 2 diabetes, please consult your doctor. Your doctor may adjust the dosage of Tonact Plus Tablet .

Yogurt has the ability to lower cholesterol to its probiotic content. Yogurt eaters have a better metabolic profile than those who did not eat yogurt.

Most of the time, high cholesterol levels are associated with an unhealthy lifestyle. The most common causes include obesity, smoking, genetic factors, sedentary lifestyle, unhealthy eating habits, and family history.

You are recommended not to stop taking Tonact Plus Tablet suddenly, as it may raise your cholesterol levels and increase the risk of stroke or heart attack. Always consult your doctor before stopping Tonact Plus Tablet .

Tonact Plus Tablet can cause an increase in blood sugar levels in people with diabetes. There is no need to stop Tonact Plus Tablet , but you should consult your diabetologist for advice on managing your diabetes. If necessary, the doctor may adjust your treatment or change the medication to avoid potential interactions.

Cholesterol is a precursor to lipids or fats in the body and is an essential component of cell membranes. However, an elevated level of LDL cholesterol (responsible for transporting cholesterol to tissues) can result in plaque formation, atherosclerosis, and narrowing of blood vessels. This restricts blood flow and increases the risk of coronary heart disease. Tonact Plus Tablet , containing Atorvastatin, helps reduce cholesterol build-up in the body. By lowering cholesterol levels, it lowers atherosclerosis, reducing the likelihood of heart attacks and delaying complications related to the heart and blood vessels.

Tonact Plus Tablet causes side effects such as constipation, nausea, vomiting, weakness, muscle pain, headache, dizziness, diarrhea, itching, peripheral edema, and increased glucose in the blood. However, consult a doctor if these persist longer.

Country of origin

India

Manufacturer/Marketer address

Lupin Ltd, 3rd floor Kalpataru Inspire, Off. W E Highway, Santacruz (East), Mumbai 400 055. India Country of Origin: India
Other Info - TON0014

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