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  3. Tofocom 200 mg/300 mg Tablet

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Tofocom 200 mg/300 mg Tablet, Pack of 1 Tablet
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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Santoshini Reddy G , M Pharmacy
Tofocom 200 mg/300 mg Tablet belongs to the class of antiretroviral drugs used in the treatment of HIV infection. This combination medicine work by inhibiting the reverse transcriptase enzyme production, which is necessary for the multiplication of the viruses. Common side effects include dizziness, headache, diarrhoea, nausea, vomiting, rashes, and feeling weak
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Composition :

EMTRICITABINE-200MG + TENOFOVIR DISOPROXIL FUMARATE-300MG

Manufacturer/Marketer :

Alkem Laboratories Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

About Tofocom 200 mg/300 mg Tablet

Tofocom 200 mg/300 mg Tablet belongs to a group of antiretroviral medicines used to treat HIV infection. Tofocom 200 mg/300 mg Tablet helps decrease the chance of developing AIDS (acquired immunodeficiency syndrome) and other HIV-related illnesses. Tofocom 200 mg/300 mg Tablet also helps reduce the risk of getting HIV-1 infection when used as a daily treatment and practising safe sex.

Tofocom 200 mg/300 mg Tablet is a combination of two drugs: Emtricitabine and Tenofovir disoproxil fumarate. Emtricitabine is a nucleoside reverse transcriptase inhibitor, whereas Tenofovir disoproxil fumarate is a nucleotide reverse transcriptase inhibitor. Tofocom 200 mg/300 mg Tablet works by interfering with the working of nucleotide and nucleoside reverse transcriptase enzymes necessary for virus reproduction. Together, Tofocom 200 mg/300 mg Tablet helps in treating HIV infection.

Take Tofocom 200 mg/300 mg Tablet as prescribed. Depending on your medical condition, you are advised to take Tofocom 200 mg/300 mg Tablet for as long as your doctor has prescribed it for you. Sometimes, you may experience certain common side effects such as headache, dizziness, nausea, vomiting, diarrhoea, weakness, and rash. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Practise safe sex and take necessary precautions, as Tofocom 200 mg/300 mg Tablet does not prevent the spread of HIV infection. Consult your doctor if you are pregnant or planning for pregnancy. Avoid breastfeeding while taking Tofocom 200 mg/300 mg Tablet. Tofocom 200 mg/300 mg Tablet may cause dizziness, so drive with caution. Tofocom 200 mg/300 mg Tablet is not recommended for children below 12 years. Keep your doctor informed about your health condition and medicines to prevent side effects/interactions.

Uses of Tofocom 200 mg/300 mg Tablet

Tofocom 200 mg/300 mg Tablet is used in the treatment of HIV infection. The detailed uses of Tofocom 200 mg/300 mg Tablet are as follows:<br/>• HIV-1 Treatment: Tofocom 200 mg/300 mg Tablet is used to treat HIV-1 infection in adults and children and helps reduce viral load and increase CD4+ T-cell counts, slowing disease progression.<br/>• HIV-1 Pre-Exposure Prophylaxis (PrEP): Tofocom 200 mg/300 mg Tablet is used to reduce the risk of acquiring HIV-1 in high-risk individuals and approved for adults and adolescents.<br/>

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Directions for Use

• Tofocom 200 mg/300 mg Tablet can be taken with or without food, or as advised by a doctor.• It is usually recommended to be taken once a day. However, follow your doctor's instructions regarding dosage and timing for optimal results. • Swallow Tofocom 200 mg/300 mg Tablet as a whole with a glass of water. • Do not crush, chew, or break it.

Medicinal Benefits

Tofocom 200 mg/300 mg Tablet belongs to a group of antiretroviral medicines used to treat HIV infection. Tofocom 200 mg/300 mg Tablet helps in decreasing the chance of developing AIDS (acquired immunodeficiency syndrome) and other HIV-related illnesses. Tofocom 200 mg/300 mg Tablet is a combination of two drugs: Emtricitabine and Tenofovir disoproxil fumarate. Emtricitabine is a nucleoside reverse transcriptase inhibitor, whereas Tenofovir disoproxil fumarate is a nucleotide reverse transcriptase inhibitor. Tofocom 200 mg/300 mg Tablet works by interfering with the working of nucleotide and nucleoside reverse transcriptase enzymes which are necessary for the reproduction of the virus. Together, Tofocom 200 mg/300 mg Tablet helps in treating HIV infection. Taking Tofocom 200 mg/300 mg Tablet along with practising safe sex and lifestyle changes may reduce the risk of getting or transmitting the HIV virus to others.

How Tofocom 200 mg/300 mg Tablet Works

Tofocom 200 mg/300 mg Tablet is a combination of two drugs: Emtricitabine and Tenofovir disoproxil fumarate. Emtricitabine is a nucleoside reverse transcriptase inhibitor, whereas Tenofovir disoproxil fumarate is a nucleotide reverse transcriptase inhibitor. Tofocom 200 mg/300 mg Tablet works by interfering with the working of nucleotide and nucleoside reverse transcriptase enzymes necessary for virus reproduction. Together, Tofocom 200 mg/300 mg Tablet helps in treating HIV infection.

Storage

Keep Tofocom 200 mg/300 mg Tablet out of the sight and reach of children.
Side effects of Tofocom 200 mg/300 mg Tablet
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Managing back pain as a side effect of medication requires a combination of self-care techniques, lifestyle modifications, and medical interventions. Here are the steps:
  • Talk to your doctor about your back pain and potential medication substitutes or dose changes.
  • Try yoga or Pilates and other mild stretching exercises to increase flexibility and strengthen your back muscles.
  • To lessen the tension on your back, sit and stand upright and maintain proper posture.
  • To alleviate discomfort and minimize inflammation, apply heat or cold packs to the afflicted area.
  • Under your doctor's supervision, think about taking over-the-counter painkillers like acetaminophen or ibuprofen.
  • Make ergonomic adjustments to your workspace and daily activities to reduce strain on your back.
  • To handle tension that could make back pain worse, try stress-reduction methods like deep breathing or meditation.
  • Use pillows and a supportive mattress to keep your spine in the right posture as you sleep.
  • Back discomfort can worsen by bending, twisting, and heavy lifting.
  • Speak with a physical therapist to create a customized training regimen to increase back strength and flexibility.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.

What if I have taken an overdose of Tofocom 200 mg/300 mg Tablet

Never take more than the prescribed dose of Tofocom 200 mg/300 mg Tablet. If you experience any of the following symptoms: clay-colored stools, dark urine, headache, fever, itching, nausea, vomiting, skin rash, stomach pain or tenderness, swelling of the lower legs or feet, unusual weakness or tiredness, yellow eyes or skin, or any combination of these, get medical attention right away.

Drug Warnings

Do not take Tofocom 200 mg/300 mg Tablet if you are allergic to any of its contents. Inform your doctor if you have a history of hepatitis B infection, kidney or liver problems; if you are older than 65years. Regularly get blood and urine tests done while taking Tofocom 200 mg/300 mg Tablet. Practise safe sex and take other necessary precautions as Tofocom 200 mg/300 mg Tablet does not prevent the spread of HIV infection. Consult your doctor if you are pregnant or planning for pregnancy. Avoid breastfeeding while taking Tofocom 200 mg/300 mg Tablet. Tofocom 200 mg/300 mg Tablet may cause dizziness, so drive with caution. Tofocom 200 mg/300 mg Tablet is not recommended for children below 12years. Talk to your doctor immediately if you notice any signs or symptoms of infection or inflammation.

Drug-Drug Interactions

verifiedApollotooltip
Tenofovir disoproxilDidanosine
Critical
Tenofovir disoproxilStreptozocin
Critical

Drug-Drug Interactions

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Tenofovir disoproxilDidanosine
Critical
How does the drug interact with Tofocom 200 mg/300 mg Tablet:
Coadministration of Didanosine with Tofocom 200 mg/300 mg Tablet can increase the levels and risk of Didanosine side effects.

How to manage the interaction:
Taking Didanosine with Tofocom 200 mg/300 mg Tablet is not recommended, please consult your doctor before taking it. It can be taken if your doctor prescribes it. However, if you experience severe headaches, confusion, weakness, trouble walking, muscle pain, or high fever, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
Tenofovir disoproxilStreptozocin
Critical
How does the drug interact with Tofocom 200 mg/300 mg Tablet:
Combining Tofocom 200 mg/300 mg Tablet and Streptozocin can increase the risk of kidney problems.

How to manage the interaction:
Taking Tofocom 200 mg/300 mg Tablet with Streptozocin is not recommended, as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not stop using any medications without talking to your doctor.
EmtricitabineLamivudine
Critical
How does the drug interact with Tofocom 200 mg/300 mg Tablet:
Combining these two medications may reduce overall effectiveness due to potential antagonistic effects (opposite actions).

How to manage the interaction:
Taking Tofocom 200 mg/300 mg Tablet with Lamivudine is not recommended, but it can be taken if your doctor prescribes it. Contact your doctor if your symptoms do not improve. Do not stop taking any medication without consulting your doctor.
Tenofovir disoproxilAmikacin
Severe
How does the drug interact with Tofocom 200 mg/300 mg Tablet:
Coadministration of Tofocom 200 mg/300 mg Tablet with Amikacin can increase the risk of developing kidney problems.

How to manage the interaction:
Although taking Amikacin and Tofocom 200 mg/300 mg Tablet together can result in an interaction, it can be taken when a doctor has prescribed it. Consult the doctor if you experience vomiting, loss of appetite, irregular urination, sudden weight gain or loss, shortness of breath, weakness, or dizziness. Do not discontinue any medications without a doctor's advice.
Tenofovir disoproxilKetorolac
Severe
How does the drug interact with Tofocom 200 mg/300 mg Tablet:
Coadministration of Ketorolac with Tofocom 200 mg/300 mg Tablet may increase the risk of developing kidney problems.

How to manage the interaction:
Although taking Ketorolac and Tofocom 200 mg/300 mg Tablet together can possibly result in an interaction, it can be taken when your doctor has prescribed it. However, if you experience symptoms like nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, shortness of breath, fatigue, dizziness, confusion, and irregular heartbeat, consult a doctor. Do not discontinue any medications without consulting a doctor.
Tenofovir disoproxilKetoconazole
Severe
How does the drug interact with Tofocom 200 mg/300 mg Tablet:
Coadministration of Ketoconazole and Tofocom 200 mg/300 mg Tablet may increase the risk of developing liver damage.

How to manage the interaction:
Although taking Ketoconazole and Tofocom 200 mg/300 mg Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you have any symptoms like fever, chills, joint pain or swelling, unusual bleeding, fatigue, vomiting, abdominal pain, dark urine, light stools, and/or yellowing of the skin or eyes, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
Tenofovir disoproxilIbuprofen
Severe
How does the drug interact with Tofocom 200 mg/300 mg Tablet:
Coadministration of Tofocom 200 mg/300 mg Tablet and Ibuprofen can increase the risk of developing kidney problems.

How to manage the interaction:
Co-administration of Tofocom 200 mg/300 mg Tablet and Ibuprofen can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like nausea, vomiting, irregular urination, sudden weight gain or weight loss, shortness of breath, muscle cramps, weakness, and irregular heart rhythm, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
Tenofovir disoproxilPhenylbutazone
Severe
How does the drug interact with Tofocom 200 mg/300 mg Tablet:
Coadministration of Phenylbutazone and Tofocom 200 mg/300 mg Tablet can increase the risk of developing kidney problems.

How to manage the interaction:
Taking Phenylbutazone and Tofocom 200 mg/300 mg Tablet can lead to an interaction, it can be taken when your doctor advises. However, if you experience any symptoms like vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, shortness of breath, muscle cramps, dizziness, and irregular heart rhythm, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
Tenofovir disoproxilVoclosporin
Severe
How does the drug interact with Tofocom 200 mg/300 mg Tablet:
Co-administration of Voclosporin and Tofocom 200 mg/300 mg Tablet can increase the risk of developing kidney problems.

How to manage the interaction:
Taking Voclosporin and Tofocom 200 mg/300 mg Tablet together can lead to an interaction, it can be taken when your doctor advises. However, if you experience any symptoms like vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, shortness of breath, muscle cramps, dizziness, and irregular heart rhythm, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
Tenofovir disoproxilPhenobarbital
Severe
How does the drug interact with Tofocom 200 mg/300 mg Tablet:
Coadministration of Phenobarbital and Tofocom 200 mg/300 mg Tablet can reduce the levels of Tofocom 200 mg/300 mg Tablet, which can lead to low treatment outcomes.

How to manage the interaction:
Taking Tofocom 200 mg/300 mg Tablet with Phenobarbital can result in an interaction, it can be taken when a doctor has advised it. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  •  
  • Practise safe sex by using condoms; it helps in reducing contact with semen and vaginal fluids.
  • Never share personal items with body fluids or blood on them, such as razor blades or toothbrushes.
  • Avoid sharing used needles, other injections or drug equipment.
  • Get tested for other sexually transmitted infections such as gonorrhoea or syphilis, as they can make you prone to HIV infection.
  • Eat a healthy and balanced diet. Eat vitamin and nutrient-rich food such as vegetables and fruits as it helps to boost your immune system. Opt for lean protein and whole grains.
  • Avoid eating raw meat and eggs. Consume properly boiled and cooked meat, poultry or seafood.
  • Eat bland and low-fat foods and avoid spicy or oily foods if you experience nausea or vomiting.
  • Try to reduce emotional and physical stress by spending time with family or doing whatever makes you happy.
  •  

Habit Forming

No

Therapeutic Class

ANTIRETROVIRAL AGENTS

Tofocom 200 mg/300 mg Tablet Substitute

Substitutes safety advice
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Alcohol

Caution

It is not known whether Tofocom 200 mg/300 mg Tablet interacts with alcohol. Please consult your doctor.

bannner image

Pregnancy

Caution

Please consult your doctor if you have any concerns regarding this, your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Unsafe

Avoid breastfeeding while taking Tofocom 200 mg/300 mg Tablet as it may pass into breastmilk.

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Driving

Caution

Tofocom 200 mg/300 mg Tablet may cause dizziness. So, drive or operate machinery only if you are alert.

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Liver

Caution

Dose adjustment may be needed. Please consult your doctor before taking Tofocom 200 mg/300 mg Tablet if you have a liver impairment or any concerns regarding this.

bannner image

Kidney

Caution

Dose adjustment may be needed. Please consult your doctor before taking Tofocom 200 mg/300 mg Tablet if you have kidney impairment or any concerns regarding this.

bannner image

Children

Unsafe

Tofocom 200 mg/300 mg Tablet is not recommended for children below 12years.

FAQs

Tofocom 200 mg/300 mg Tablet belongs to a group of antiretroviral medicines used to treat HIV infection. Tofocom 200 mg/300 mg Tablet helps decrease the chance of developing AIDS (acquired immunodeficiency syndrome) and other HIV-related illnesses.

Tofocom 200 mg/300 mg Tablet is a combination of two drugs: Emtricitabine and Tenofovir disoproxil fumarate. Tofocom 200 mg/300 mg Tablet works by interfering with the working of nucleotide and nucleoside reverse transcriptase enzymes necessary for the reproduction of the virus. Together, Tofocom 200 mg/300 mg Tablet helps in treating HIV infection.

Please do not stop taking Tofocom 200 mg/300 mg Tablet without consulting your doctor, as it may reduce the effectiveness of anti-HIV therapy. Continue taking Tofocom 200 mg/300 mg Tablet for as long as your doctor has prescribed it to treat your condition effectually. Do not be reluctant to speak with your doctor if you experience any difficulty taking Tofocom 200 mg/300 mg Tablet.

Tofocom 200 mg/300 mg Tablet might cause lactic acidosis (excess of lactic acid in the blood), a rare but severe side effect, especially in women who are obese and people with liver disease. Consult a doctor immediately if you experience stomach pain, vomiting, nausea, drowsiness, and deep rapid breathing while taking Tofocom 200 mg/300 mg Tablet.

Tofocom 200 mg/300 mg Tablet does not cure HIV infection. However, Tofocom 200 mg/300 mg Tablet helps to decrease the chance of developing AIDS (acquired immunodeficiency syndrome) and other HIV-related illnesses such as cancer or serious infections.

HIV negative patients can take Tofocom 200 mg/300 mg Tablet to lower the chance of getting HIV infection if prescribed by the doctor. Before starting the treatment, you should have a negative HIV test and whilst taking Tofocom 200 mg/300 mg Tablet regular HIV tests for at least every 3months is advised.

Tofocom 200 mg/300 mg Tablet may cause bone problems such as soft bones, thin bones, and bone pain. A regular bone density test is advised while taking Tofocom 200 mg/300 mg Tablet. For good bone health, take calcium and vitamin D supplements as told by the doctor.

Country of origin

India
Other Info - TO53539

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Santoshini Reddy GDoctor badge

Reviewed By

Santoshini Reddy G

M Pharmacy

Last Updated

Jul 18, 2025 | 6:56 AM IST

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Reference

  1. https://www.medicines.org.uk/emc/files/pil.9028.pdf
  2. https://www.drugs.com/cdi/emtricitabine-and-tenofovir-disoproxil-fumarate.html
  3. https://medlineplus.gov/druginfo/meds/a612036.html
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