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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Tofaziff Tablet 30's is used to treat rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis. It contains Tofacitinib which works by lowering inflammation and symptoms associated with arthritis. In some cases, this medicine may cause side effects such as diarrhoea, headache, upper respiratory tract infection, nausea, and vomiting. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Whats That

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Composition :

TOFACITINIB-5MG

Manufacturer/Marketer :

Alembic Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Tofaziff Tablet 30's

Tofaziff Tablet 30's is used to treat rheumatoid arthritis (an autoimmune disease which leads to joint pain and damage), psoriatic arthritis (an inflammatory condition of the joints), and ulcerative colitis (an inflammatory disease of the large intestine).

Tofaziff Tablet 30's contains 'Tofacitinib' which works by blocking the Janus kinase enzyme, thereby lowering inflammation and symptoms associated with rheumatoid and psoriatic arthritis. 

Not everyone who is taking Tofaziff Tablet 30's will get these side effects. In some cases, you may experience common side effects such as diarrhoea, headache, upper respiratory tract infection, cold, nausea, and vomiting. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

You can take Tofaziff Tablet 30's with or without food. It should be swallowed as a whole with a glass of water. Do not chew, bite, crush, or break it. Your doctor will advise you on how often you should take your tablets based on your medical condition. It is always important to complete your treatment course for better results.

Avoid taking Tofaziff Tablet 30's if you are allergic to it. Inform your doctor if you have an active infection, if you are taking immunosuppressants, medicines that affect the immune system or corticosteroids. Avoid taking Tofaziff Tablet 30's if you are pregnant or breastfeeding. Tofaziff Tablet 30's is not recommended for use in children below 18 years as safety and effectiveness have not been established. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Uses of Tofaziff Tablet 30's

'Tofaziff Tablet 30's is used in the treatment of Rheumatoid arthritis, Psoriatic arthritis, and Ulcerative colitis. The detailed uses of Tofaziff Tablet 30's are as follows:<br/> • Treatment of Rheumatoid Arthritis: Tofaziff Tablet 30's helps to manage moderate to severe rheumatoid arthritis by reducing joint pain, inflammation, and slowing disease progression.<br/> • Management of Psoriatic Arthritis: Tofaziff Tablet 30's treats active psoriatic arthritis by reducing joint pain, swelling, stiffness, and improving overall joint function.<br/> • Treatment of Ulcerative Colitis: Tofaziff Tablet 30's helps to induce and maintain remission in moderate to severe ulcerative colitis.<br/>'

Directions for Use

• Tofaziff Tablet 30's can be taken with or without food. • It is recommended to take Tofaziff Tablet 30's 1-2 times a day, depending on your medical condition, or as prescribed by your doctor. • Swallow Tofaziff Tablet 30's as a whole with a glass of water. • Do not crush, chew, or break it.

Medicinal Benefits

Tofaziff Tablet 30's belongs to a group of medicines called Janus kinase inhibitors used to treat rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis. 

Tofaziff Tablet 30's is indicated for patients with moderate to severe rheumatic arthritis, and psoriatic arthritis who have had intolerance or inadequate response to methotrexate or DMARDs (Disease-Modifying Anti-Rheumatic Drugs).

How Tofaziff Tablet 30's Works

Tofaziff Tablet 30's contains 'Tofacitinib' which works by blocking the Janus kinase enzyme, thereby lowering inflammation and symptoms associated with rheumatoid and psoriatic arthritis.

Storage

Keep Tofaziff Tablet 30's out of reach and sight of children.
Side effects of Tofaziff Tablet
  • Practice good hygiene by washing hands frequently when touching any wounds.
  • Apply creams or lotions to the dry skin and moisturize it.
  • Wear the proper clothing and footwear when working outside.
  • Cover the wounds with bandage and change it daily.
  • Avoid baths at swimming pools, lakes and rivers.
  • Drink a lot of water to control diarrhoea and prevent dehydration.
  • Avoid spicy, fatty, or high-fiber foods that may irritate the colon.
  • Reduce stress through methods such as deep breathing or meditation.
  • Include probiotics or supplements containing live bacteria to maintain the health of the gut.
  • Quit smoking since smoking makes colitis symptoms worse.
  • See your doctor right away if you experience extreme inflammation, bleeding stools, or abdominal pain.
  • To promote overall health, drink plenty of water and consume hydrating foods like watermelon and leafy greens.
  • Support gut health with probiotic-rich foods such as yoghurt and sauerkraut.
  • Eat antioxidant-rich foods like berries and green tea, while limiting sugary drinks, alcohol, and processed foods.
  • Additionally, reduce stress through relaxation techniques like deep breathing and meditation.
Managing Medication-Triggered UTIs: A Comprehensive Approach:
  • Inform your doctor about the medication you're taking and the UTI symptoms you're experiencing.
  • Your doctor may adjust your medication regimen or consider alternative medications or dosages that may reduce the risk of UTIs.
  • Drink plenty of water (at least 8-10 glasses a day) to help flush out bacteria. Avoid sugary drinks and caffeine, which can exacerbate UTI symptoms.
  • Urinate when you feel the need rather than holding it in. This can help prevent bacterial growth and reduce the risk of UTIs.
  • Consider cranberry supplements: Cranberry supplements may help prevent UTIs by preventing bacterial adhesion.
  • Monitor UTI symptoms and report any changes to your doctor.
  • If antibiotics are prescribed, take them as directed and complete the full course.

What if I have taken an overdose of Tofaziff Tablet 30's

Take Tofaziff Tablet 30's only as prescribed by the physician. Do not exceed the recommended dose, as it might cause an overdose. If you suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

  • Do not take Tofaziff Tablet 30's if you are allergic to any of its components; if you have a severe infection, bloodstream infection, or if you have severe liver problems such as cirrhosis. 
  • Inform your doctor if you have an infection, symptoms of infection, a condition that increases chances of infection, are taking any medicines that affect the immune system; have or had a history of tuberculosis, chronic lung disease, liver problems, hepatitis B/C, cancer, inflammation/ulcers of the large intestine, or kidney problems; are planning to get vaccinated; or have heart problems, high cholesterol, high blood pressure, heart attack, diabetes, or blood clotting problems. 
  • If your white blood cell count or red blood cell count is low, avoid taking Tofaziff Tablet 30's.
  • Inform your doctor if you notice painful blisters on the skin or if you experience breathing difficulties. Inform your doctor about your complete medical and medication history before starting treatment with Tofaziff Tablet 30's, which helps the physician decide the best treatment plan.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Tofaziff Tablet:
Taking carbamazepine and Tofaziff Tablet together may possibly reduce the blood levels of Tofaziff Tablet.

How to manage the interaction:
Although taking carbamazepine and Tofaziff Tablet together can possibly result in an interaction, it can be taken if your doctor has prescribed it. If your symptoms worsen or your condition changes while taking these medications, consult your doctor without delay.
How does the drug interact with Tofaziff Tablet:
When Tofaziff Tablet and Olaparib are taken together, the breakdown of Tofaziff Tablet in the body may be reduced.

How to manage the interaction:
Although there is a possible interaction between Olaparib and Tofaziff Tablet, you can take these medicines together if prescribed by your doctor. It's better to be safe and get medical help if you have a fever, chills, diarrhea, sore throat, muscle aches, trouble breathing, weight loss, or pain while urinating. Do not stop using any medications without first talking to your doctor.
How does the drug interact with Tofaziff Tablet:
Taking Cyclophosphamide with Tofaziff Tablet may increase the risk of serious infections.

How to manage the interaction:
Although there is a possible interaction, Cyclophosphamide can be taken with Tofaziff Tablet if prescribed by the doctor. Consult the doctor immediately if you develop signs and symptoms of infection such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue the medication without consulting a doctor.
How does the drug interact with Tofaziff Tablet:
Using Tofaziff Tablet together with dasatinib may increase the risk of serious infections.

How to manage the interaction:
Co-administration of Tofaziff Tablet with Dasatinib can result in an interaction, but it can be taken if a doctor has advised it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Tofaziff Tablet:
Taking Etanercept with Tofaziff Tablet can increase the risk of serious infections as well as sometimes may lead to cancers.

How to manage the interaction:
Although there is a possible interaction between Tofaziff Tablet and Etanercept, you can take these medicines together if prescribed by a doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not stop using any medications without talking to a doctor.
How does the drug interact with Tofaziff Tablet:
Coadministration of methotrexate with Tofaziff Tablet can increase the risk of developing serious infections.

How to manage the interaction:
Although there is a possible interaction between Tofaziff Tablet and methotrexate, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin and pain or burning during urination, consult a doctor. Do not stop using any medications without consulting to a doctor.
TofacitinibStreptozocin
Severe
How does the drug interact with Tofaziff Tablet:
Taking Tofaziff Tablet with Streptozocin may increase the risk of infection.

How to manage the interaction:
Although taking Streptozocin and Tofaziff Tablet together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without consulting your doctor.
How does the drug interact with Tofaziff Tablet:
Taking Tofaziff Tablet with Topotecan may increase the risk of infection.

How to manage the interaction:
Although there is a possible interaction between Tofaziff Tablet and Topotecan, you can take these medicines together if prescribed by your doctor. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without first consulting your doctor.
How does the drug interact with Tofaziff Tablet:
Taking Tofaziff Tablet and bortezomib may increase the risk of infections.

How to manage the interaction:
Although using Bortezomib and Tofaziff Tablet together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact a doctor if you experience fever, chills, diarrhea, sore throat, muscle aches, red or irritated skin, or burning during urination. Do not stop taking any medications without consulting a doctor.
How does the drug interact with Tofaziff Tablet:
Taking Imatinib and Tofaziff Tablet can increase the risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, Imatinib can be taken with Tofaziff Tablet if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not stop using any medications without consulting a doctor.

Drug-Food Interactions

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TOFACITINIB-5MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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TOFACITINIB-5MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit, Grapefruit Juice

How to manage the interaction:
Consuming grapefruit products while taking Tofaziff Tablet can increase the risk of side effects. Avoid consuming grapefruit products while being treated with Tofaziff Tablet, as it can lead to an interaction.

Diet & Lifestyle Advise

  • Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle activities like 20-30minutes of walking or swimming would be helpful.
  • Performing yoga may also help in improving joint flexibility and pain management.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Get adequate sleep, as resting the muscles can help in reducing inflammation and swelling.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Acupuncture, massage and physical therapy may also be helpful.
  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.
  • Avoid smoking and alcohol consumption.

Habit Forming

No

Therapeutic Class

ANTIRHEUMATICS, DISEASE MODIFYING ANTIRHEUMATIC DRUGS (DMARDs)
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Alcohol

Caution

It is not known if alcohol interacts with Tofaziff Tablet 30's, so please consult a doctor.

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Pregnancy

Unsafe

Tofaziff Tablet 30's must not be taken during pregnancy. If you are a woman of child-bearing potential, use effective contraception during the treatment with Tofaziff Tablet 30's and for 4 weeks after discontinuation.

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Breast Feeding

Unsafe

Avoid breastfeeding while taking Tofaziff Tablet 30's. Please consult a doctor if you have any concerns.

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Driving

Safe

Tofaziff Tablet 30's generally does not affect your ability to drive. However, drive or operate machinery only if you are alert.

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Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this. Tofaziff Tablet 30's is not recommended for patients with severe liver problems.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Unsafe

Tofaziff Tablet 30's is not recommended for children below 18 years as safety and effectiveness were not established.

Have a query?

FAQs

Tofaziff Tablet 30's is used to treat rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis.

Tofaziff Tablet 30's works by blocking Janus kinase enzyme, thereby lowers inflammation and symptoms associated with rheumatoid and psoriatic arthritis.

Hypertension/high blood pressure could be a side-effect of Tofaziff Tablet 30's. Consult your doctor before taking Tofaziff Tablet 30's if you have high blood pressure or if you are taking anti-hypertensive medicines.

Diarrhoea might be a side-effect of Tofaziff Tablet 30's. Eat non-spicy meals and drink plenty of fluids to prevent dehydration if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience severe diarrhoea, consult your doctor. Do not take anti-diarrheal medicine on your own.

Tofaziff Tablet 30's might impair fertility in females of reproductive potential. It is not known if the effect is reversible. Therefore, talk to a doctor before starting Tofaziff Tablet 30's if you are trying to become pregnant or if you have any concerns regarding this.

Tofaziff Tablet 30's affects the immune system and might lower the ability of the immune system to fight infections. Inform your doctor if you have an active infection, if you have a condition that increases the chance of having infections, if you are taking immunosuppressants, medicines that affect the immune system or corticosteroids.

Tofaziff Tablet 30's is not recommended for patients with severe liver impairment. Dose adjustment may be needed in patients with mild to moderate liver impairment. Please consult the doctor if you have liver problems.

Tofaziff Tablet 30's may increase the risk of cancer by changing the way the immune system works. Inform the doctor if you ever had any type of cancer.

Tofaziff Tablet 30's may begin working within 2-8 weeks after starting the treatment.

Tofaziff Tablet 30's should not be taken along with tocilizumab as it might increase the risk of infections. Before starting Tofaziff Tablet 30's, inform the doctor if you are taking tocilizumab.

Prior to starting Tofaziff Tablet 30's, active or latent tuberculosis test, CBC (complete blood count), LFT (liver function test), and lipid profile tests should be done.

Country of origin

India

Manufacturer/Marketer address

Alembic Road, Vadodara - 390 003, Gujarat,India
Other Info - TOF0125

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