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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Tofarus 5 Tablet 30's is used to treat rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis. It contains Tofacitinib which works by lowering inflammation and symptoms associated with arthritis. In some cases, this medicine may cause side effects such as diarrhoea, headache, upper respiratory tract infection, nausea, and vomiting. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Composition :

TOFACITINIB-5Mg

Manufacturer/Marketer :

Cyrus Remedies Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Tofarus 5 Tablet 30's

Tofarus 5 Tablet 30's is used to treat rheumatoid arthritis (an autoimmune disease which leads to joint pain and damage), psoriatic arthritis (an inflammatory condition of the joints), and ulcerative colitis (an inflammatory disease of the large intestine).

Tofarus 5 Tablet 30's contains Tofacitinib, which works by blocking the Janus kinase enzyme, thereby lowering inflammation and symptoms associated with rheumatoid and psoriatic arthritis. 

Not everyone who is taking Tofarus 5 Tablet 30's will get these side effects. In some cases, you may experience common side effects such as diarrhoea, headache, upper respiratory tract infection, cold, nausea, and vomiting. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

You can take Tofarus 5 Tablet 30's with or without food. It should be swallowed as a whole with a glass of water. Do not chew, bite, crush, or break it. Your doctor will advise you on how often you should take your tablets based on your medical condition. It is always important to complete your treatment course for better results.

Avoid taking Tofarus 5 Tablet 30's if you are allergic to it. Inform your doctor if you have an active infection, if you are taking immunosuppressants, medicines that affect the immune system or corticosteroids. Avoid taking Tofarus 5 Tablet 30's if you are pregnant or breastfeeding. Tofarus 5 Tablet 30's is not recommended for use in children below 18 years as safety and effectiveness have not been established. 

Uses of Tofarus 5 Tablet 30's

Tofarus 5 Tablet 30's is used in the treatment of Rheumatoid arthritis, Psoriatic arthritis, and Ulcerative colitis. The detailed uses of Tofarus 5 Tablet 30's are as follows:

  • Treatment of Rheumatoid Arthritis: Tofarus 5 Tablet 30's helps to manage moderate to severe rheumatoid arthritis by reducing joint pain, inflammation, and slowing disease progression.
  • Management of Psoriatic Arthritis: Tofarus 5 Tablet 30's treats active psoriatic arthritis by reducing joint pain, swelling, stiffness, and improving overall joint function.
  • Treatment of Ulcerative Colitis: Tofarus 5 Tablet 30's helps to induce and maintain remission in moderate to severe ulcerative colitis.

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Directions for Use

  • Tofarus 5 Tablet 30's can be taken with or without food.
  • It is recommended to take Tofarus 5 Tablet 30's 1-2 times a day, depending on your medical condition, or as prescribed by your doctor.
  • Swallow Tofarus 5 Tablet 30's as a whole with a glass of water.
  • Do not crush, chew, or break it.

Medicinal Benefits

  • Tofarus 5 Tablet 30's belongs to a group of medicines called Janus kinase inhibitors used to treat rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis.
  • Tofarus 5 Tablet 30's is indicated for patients with moderate to severe rheumatic arthritis, and psoriatic arthritis who have had intolerance or inadequate response to methotrexate or DMARDs (Disease-Modifying Anti-Rheumatic Drugs).
  • This medicine helps lower inflammation and symptoms associated with rheumatoid and psoriatic arthritis. 

How Tofarus 5 Tablet 30's Works

Tofarus 5 Tablet 30's contains 'Tofacitinib' which works by blocking the Janus kinase enzyme, thereby lowering inflammation and symptoms associated with rheumatoid and psoriatic arthritis.

Storage

• Store in a cool and dry place away from sunlight.• Keep Tofarus 5 Tablet 30's out of reach and sight of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Tofarus 5 Tablet
  • Practice good hygiene by washing hands frequently when touching any wounds.
  • Apply creams or lotions to the dry skin and moisturize it.
  • Wear the proper clothing and footwear when working outside.
  • Cover the wounds with bandage and change it daily.
  • Avoid baths at swimming pools, lakes and rivers.
  • Drink a lot of water to control diarrhoea and prevent dehydration.
  • Avoid spicy, fatty, or high-fiber foods that may irritate the colon.
  • Reduce stress through methods such as deep breathing or meditation.
  • Include probiotics or supplements containing live bacteria to maintain the health of the gut.
  • Quit smoking since smoking makes colitis symptoms worse.
  • See your doctor right away if you experience extreme inflammation, bleeding stools, or abdominal pain.
  • To promote overall health, drink plenty of water and consume hydrating foods like watermelon and leafy greens.
  • Support gut health with probiotic-rich foods such as yoghurt and sauerkraut.
  • Eat antioxidant-rich foods like berries and green tea, while limiting sugary drinks, alcohol, and processed foods.
  • Additionally, reduce stress through relaxation techniques like deep breathing and meditation.
Managing Medication-Triggered UTIs: A Comprehensive Approach:
  • Inform your doctor about the medication you're taking and the UTI symptoms you're experiencing.
  • Your doctor may adjust your medication regimen or consider alternative medications or dosages that may reduce the risk of UTIs.
  • Drink plenty of water (at least 8-10 glasses a day) to help flush out bacteria. Avoid sugary drinks and caffeine, which can exacerbate UTI symptoms.
  • Urinate when you feel the need rather than holding it in. This can help prevent bacterial growth and reduce the risk of UTIs.
  • Consider cranberry supplements: Cranberry supplements may help prevent UTIs by preventing bacterial adhesion.
  • Monitor UTI symptoms and report any changes to your doctor.
  • If antibiotics are prescribed, take them as directed and complete the full course.

What if I have taken an overdose of Tofarus 5 Tablet 30's

Take Tofarus 5 Tablet 30's only as prescribed by the physician. Do not exceed the recommended dose, as it might cause unwanted side effects. If you suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

  • Do not take Tofarus 5 Tablet 30's if you are allergic to any of its components; if you have a severe infection, bloodstream infection, or if you have severe liver problems such as cirrhosis. 
  • Inform your doctor if you have an infection, symptoms of infection, a condition that increases chances of infection, are taking any medicines that affect the immune system; have or had a history of tuberculosis, chronic lung disease, liver problems, hepatitis B/C, cancer, inflammation/ulcers of the large intestine, or kidney problems; are planning to get vaccinated; or have heart problems, high cholesterol, high blood pressure, heart attack, diabetes, or blood clotting problems. 
  • If your white blood cell count or red blood cell count is low, avoid taking Tofarus 5 Tablet 30's.
  • Inform your doctor if you notice painful blisters on the skin or if you experience breathing difficulties. Inform your doctor about your complete medical and medication history before starting treatment with Tofarus 5 Tablet 30's, which helps the physician decide the best treatment plan.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Tofarus 5 Tablet:
When Tofarus 5 Tablet is taken with Voriconazole may increase the risk of side effects.

How to manage the interaction:
Although taking Voriconazole and Tofarus 5 Tablet together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience dizziness, fever, shortness of breath, and pain or burning during urination, contact a doctor right away. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Tofarus 5 Tablet:
Taking Tofarus 5 Tablet and bortezomib may increase the risk of infections.

How to manage the interaction:
Although using Bortezomib and Tofarus 5 Tablet together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact a doctor if you experience fever, chills, diarrhea, sore throat, muscle aches, red or irritated skin, or burning during urination. Do not stop taking any medications without consulting a doctor.
How does the drug interact with Tofarus 5 Tablet:
Taking Tofarus 5 Tablet with Dactinomycin may increase the risk of serious infection.

How to manage the interaction:
Taking Dactinomycin with Tofarus 5 Tablet together can possibly result in an interaction, but it can be taken if your doctor has advised it. If you experience any complications, infections, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, or pain or burning when you pee, make sure to call your doctor right away. Do not stop using any medications without first talking to your doctor.
How does the drug interact with Tofarus 5 Tablet:
Co-administration of Tofarus 5 Tablet with Capecitabine may increase the risk of serious and potential infections.

How to manage the interaction:
Although there is an interaction, Capecitabine can be taken with Tofarus 5 Tablet if prescribed by the doctor. Consult the prescriber if you develop signs and symptoms of infection such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning sensation during urination. Do not discontinue the medication without consulting a doctor.
How does the drug interact with Tofarus 5 Tablet:
Taking Tofarus 5 Tablet together with lenalidomide may increase the risk of serious infections.

How to manage the interaction:
Although there is an interaction between lenalidomide and Tofarus 5 Tablet, it can be taken if prescribed by a doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, pain or burning during urination contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Tofarus 5 Tablet:
The use of Tofarus 5 Tablet with azathioprine may raise the risk of severe infections.

How to manage the interaction:
Co-administration of Azathioprine with Tofarus 5 Tablet can result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor immediately if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, and pain or burning during urination. Do not stop using any medications without a doctor's advice.
How does the drug interact with Tofarus 5 Tablet:
Combining Trastuzumab with Tofarus 5 Tablet can increase the risk of neutropenia.

How to manage the interaction:
Although there is a possible interaction between Trastuzumab and Tofarus 5 Tablet, you can take these medicines together if prescribed by your doctor. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without a doctor's advice.
How does the drug interact with Tofarus 5 Tablet:
Coadministration of Tofarus 5 Tablet and Gemcitabine can lead to or increase the risk of infection.

How to manage the interaction:
There may be a possibility of interaction between Tofarus 5 Tablet and Gemcitabine, but it can be taken if advised by a doctor. Contact your doctor immediately if you develop symptoms like fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Tofarus 5 Tablet:
Taking Tofarus 5 Tablet with Doxorubicin may increase the risk of serious infection.

How to manage the interaction:
Although taking Tofarus 5 Tablet and Doxorubicin together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. It is important to keep a close eye on your condition. Do not stop using any medications without a doctor's advice.
How does the drug interact with Tofarus 5 Tablet:
Using Tofarus 5 Tablet together with cabazitaxel may increase the risk of serious infections.

How to manage the interaction:
Taking Cabazitaxel with Tofarus 5 Tablet together can possibly result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without consulting your doctor.

Drug-Food Interactions

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TOFACITINIB-5MgGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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TOFACITINIB-5MgGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit, Grapefruit Juice

How to manage the interaction:
Consuming grapefruit products while taking Tofarus 5 Tablet can increase the risk of side effects. Avoid consuming grapefruit products while being treated with Tofarus 5 Tablet, as it can lead to an interaction.

Diet & Lifestyle Advise

  • Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle activities like 20-30minutes of walking or swimming would be helpful.
  • Performing yoga may also help in improving joint flexibility and pain management.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Get adequate sleep, as resting the muscles can help in reducing inflammation and swelling.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Acupuncture, massage and physical therapy may also be helpful.
  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.
  • Avoid smoking and alcohol consumption.

Habit Forming

No

Therapeutic Class

ANTIRHEUMATICS, DISEASE MODIFYING ANTIRHEUMATIC DRUGS (DMARDs)

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Alcohol

Caution

It is not known if alcohol interacts with Tofarus 5 Tablet 30's, so please consult a doctor.

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Pregnancy

Unsafe

Tofarus 5 Tablet 30's must not be taken during pregnancy. If you are a woman of child-bearing potential, use effective contraception during the treatment with Tofarus 5 Tablet 30's and for 4 weeks after discontinuation.

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Breast Feeding

Unsafe

Avoid breastfeeding while taking Tofarus 5 Tablet 30's. Please consult a doctor if you have any concerns.

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Driving

Safe

Tofarus 5 Tablet 30's generally does not affect your ability to drive. However, drive or operate machinery only if you are alert.

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Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this. Tofarus 5 Tablet 30's is not recommended for patients with severe liver problems.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Unsafe

Tofarus 5 Tablet 30's is not recommended for children below 18 years as safety and effectiveness were not established.

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Heart

No serious side effects were observed. But it requires careful consideration and monitoring due to increased risks of heart-related problems, particularly in patients with existing cardiovascular risk factors.

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Geriatrics

Caution

No serious adverse effects were observed; however, it requires careful consideration and caution due to the increased risk of certain adverse events, particularly infections.

FAQs

Tofarus 5 Tablet 30's is used to treat rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis.

Tofarus 5 Tablet 30's works by blocking Janus kinase enzyme, thereby lowers inflammation and symptoms associated with rheumatoid and psoriatic arthritis.

Hypertension/high blood pressure could be a side-effect of Tofarus 5 Tablet 30's. Consult your doctor before taking Tofarus 5 Tablet 30's if you have high blood pressure or if you are taking anti-hypertensive medicines.

Diarrhoea might be a side-effect of Tofarus 5 Tablet 30's. Eat non-spicy meals and drink plenty of fluids to prevent dehydration if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience severe diarrhoea, consult your doctor. Do not take anti-diarrheal medicine on your own.

Tofarus 5 Tablet 30's might impair fertility in females of reproductive potential. It is not known if the effect is reversible. Therefore, talk to a doctor before starting Tofarus 5 Tablet 30's if you are trying to become pregnant or if you have any concerns regarding this.

Country of origin

India

Manufacturer/Marketer address

A 122, Eastern Business District, Lal Bahadur Shastri Marg, Bhandup West, Mumbai, Maharashtra 400078
Other Info - TOF0177

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