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compositionComposition:TIROFIBAN-5MG
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Prescription Medicine
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TIROFUSE INJECTION is used to Prevent blood clots, heart attacks, and chest pain. It contains Tirofiban, an antiplatelet that prevents platelets (blood cells) from sticking together to form blood clots. Thus, it is used to prevent blood clots. It also helps blood flow to the heart and prevents heart attack and chest pain. Additionally, it may be used in patients whose heart vessels are dilated with a balloon (percutaneous coronary intervention or PCI). It is intended for use with unfractionated heparin and aspirin.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

TIROFIBAN-5MG

Manufacturer/Marketer :

Lupin Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About TIROFUSE INJECTION

TIROFUSE INJECTION is a specialised medicine given directly into a vein to prevent dangerous blood clots from forming in your heart. It is primarily used for people experiencing severe, sudden chest pain or those undergoing procedures to open blocked heart blood vessels. By keeping your blood flowing smoothly, it helps protect your heart during critical medical situations.

Because this medicine is administered in a hospital setting, it is given continuously as a drip for a specific period decided by your medical team. You do not need to worry about taking it with or without food, but your doctor will monitor your overall nutrition. Adopting a low-salt, heart-healthy diet and resting quietly during recovery are essential lifestyle steps that support the success of this treatment.

The most common side effect of this medicine is bleeding, which can happen at the injection site or inside the body. You must tell your healthcare team immediately if you notice unusual bruising, blood in your urine, black stools, or bleeding that will not stop. Your medical team is trained to monitor you closely and manage these symptoms quickly.

Before you receive this medicine, tell your doctor if you have a history of bleeding disorders, recent major surgery, or kidney problems. Do not take this if you have active internal bleeding, a history of bleeding in the brain, or severe, uncontrolled high blood pressure. Your medical team will carefully evaluate your health history to ensure this treatment is safe for you.

TIROFUSE INJECTION can interact with other blood-thinning medicines, daily pain relievers, and certain herbal supplements, which may significantly increase your risk of bleeding. It is also important to tell your doctor if you are pregnant, breastfeeding, or if you are an older adult, as these situations require extra care and specific dosage adjustments. Talk to your doctor or pharmacist to discuss your full list of medicines and supplements before treatment begins.

Uses of TIROFUSE INJECTION

TIROFUSE INJECTION is used to help prevent the formation of harmful blood clots during certain heart conditions and cardiac procedures. It may be prescribed for the following conditions:

  • Severe chest pain and heart attacks: TIROFUSE INJECTION helps by preventing blood clots from forming or growing larger in people experiencing unstable chest pain or a mild heart attack.
  • Heart artery procedures: This medicine protects your heart during procedures like angioplasty, where a doctor opens up narrowed or blocked blood vessels to restore normal blood flow.

Key Benefits

TIROFUSE INJECTION provides several benefits by reducing the formation of blood clots and protecting the heart during emergency treatment:

  • Helps prevent clot formation: Stops platelets from clumping together, reducing the risk of new or enlarging blood clots.
  • Protects the heart from further damage: Helps maintain blood flow to the heart muscle, reducing the risk of additional injury during acute coronary events.
  • Supports safer heart procedures: Lowers the risk of clot-related complications during angioplasty and other coronary interventions, helping improve treatment outcomes.
  • Promotes recovery after cardiac events: By keeping blood vessels open and reducing the risk of recurrent clot formation, it supports a more stable recovery following heart-related emergencies or procedures.
Side effects of Tirofuse Injection 100ml
  • Apply an ice pack to slow bleeding and reduce swelling.
  • Keep your head raised to help blood drain away from your eye.
  • Take rest and avoid intense activities that raise pressure in the eye.
  • If the bleeding is severe or does not improve within 24 hours, consult a doctor.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication to ensure safe and effective use.
  • TIROFUSE INJECTION will be administered by the doctor or healthcare professional in a medical setting.
  • Do not self-administer.

How TIROFUSE INJECTION Works

TIROFUSE INJECTION contains tirofiban, an antiplatelet medicine that helps prevent the formation of harmful blood clots in the arteries. TIROFUSE INJECTION works by blocking a specific protein on the surface of platelets, the blood cells responsible for clot formation. This prevents platelets from sticking to one another and forming clots that can block blood flow in the arteries. By keeping platelets from clumping together, TIROFUSE INJECTION helps maintain smooth blood flow to the heart. This reduces the risk of blood clots that can lead to heart attacks or other serious complications, particularly in people with acute coronary syndromes or those undergoing certain heart procedures. Together, these actions help prevent harmful blood clot formation, maintain blood flow to the heart, and reduce the risk of heart-related complications.
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Alcohol

Unsafe

You are recommended to avoid the consumption of alcohol with TIROFUSE INJECTION as it may increase the risk of bleeding in the stomach or intestines.

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Pregnancy

Consult your doctor

Limited data is available on the effect of TIROFUSE INJECTION in pregnancy. Hence, if you are pregnant or planning pregnancy, inform your doctor before receiving TIROFUSE INJECTION . Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Breast Feeding

Consult your doctor

Limited data is available on the effect of TIROFUSE INJECTION on breastfeeding mothers. Hence, if you are a nursing mother, inform your doctor before receiving TIROFUSE INJECTION . Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Driving

Not applicable

Due to your disease state, you will not be able to drive or operate machinery while receiving TIROFUSE INJECTION .

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Liver

Caution

TIROFUSE INJECTION is not recommended if you have severe liver disease. Therefore, if you have any liver disorder, inform your doctor before receiving TIROFUSE INJECTION .

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Kidney

Caution

If you have kidney disease/condition, inform your doctor before receiving TIROFUSE INJECTION . The dose may be adjusted in patients with severe kidney failure.

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Children

Unsafe

TIROFUSE INJECTION is not recommended for children as the safety and effectiveness were not established.

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Heart

Caution

TIROFUSE INJECTION is used in certain heart conditions to prevent clot-related complications. However, it should be avoided in severe cardiac cases unless absolutely necessary and administered under strict medical supervision.

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Geriatrics

Caution

TIROFUSE INJECTION may be used in geriatric patients for certain heart conditions, but only under strict medical supervision. Due to increased bleeding risks and age-related health concerns, careful monitoring is essential.

What if I have taken an overdose of TIROFUSE INJECTION

An overdose of this medicine can cause a high risk of severe bleeding. Because you will be in a hospital under constant supervision, your healthcare team will monitor you closely. If an overdose occurs, they can stop the infusion immediately and take appropriate steps to manage any bleeding. Talk to your doctor if you have concerns about your treatment.

Diet & Lifestyle Advise

  • Follow a heart-healthy diet: Eat foods low in salt, saturated fat, and cholesterol to support your heart and blood vessel health.
  • Avoid activities that increase bleeding risk: Stay away from sharp objects, contact sports, or activities with a high risk of falls or injury, as TIROFUSE INJECTION increases your tendency to bleed.
  • Use gentle personal care products: Brush your teeth with a soft-bristled toothbrush and use an electric razor to reduce the risk of cuts and bleeding.
  • Consult your doctor before taking supplements: Do not start any new herbal products or vitamin supplements, especially those containing garlic, ginkgo biloba, or high-dose vitamin E, without medical advice.
health query

Have a query?

How Soon It Starts Working

The time required for TIROFUSE INJECTION to start to work: TIROFUSE INJECTION ideally shows its action within 30 minutes after administration. The time for which the effects of TIROFUSE INJECTION last: The effect of TIROFUSE INJECTION lasts for 4 to 6 hours.

What if you forget to take TIROFUSE INJECTION

Since this medicine is administered by healthcare professionals in a hospital, a missed dose is extremely unlikely. The medical team will manage your treatment schedule continuously to ensure you receive the right amount at the right time.

Storage

• TIROFUSE INJECTION is stored and handled by the hospital pharmacy or healthcare facility.

Drug Warnings

  • Inspect the solution before use: Ensure the infusion solution is clear, colourless, and free from visible particles before administration.
  • Inform all healthcare providers: Tell your doctor, dentist, or any other healthcare professional that you are receiving or have recently received TIROFUSE INJECTION before undergoing any medical or dental procedures.
  • Avoid certain pain relievers: Do not take over-the-counter NSAIDs such as ibuprofen or naproxen unless your doctor specifically advises you to, as they can increase the risk of bleeding.
  • Limit movement during the infusion: Remain in bed or limit physical movement as instructed by your healthcare team to reduce the risk of falls, bleeding, or accidental removal of the intravenous line.

Drug-Drug Interactions

verifiedApollotooltip

The medicines below may interact with TIROFUSE INJECTION and increase the risk of bleeding or other complications:

  • Other blood thinners (like heparin, warfarin, or clopidogrel): Combining these with TIROFUSE INJECTION can greatly increase your risk of severe bleeding.
  • Pain relievers (like ibuprofen, naproxen, or high-dose aspirin): These medicines can irritate your stomach lining and thin your blood further, increasing the risk of internal bleeding.

 

TirofibanDeferasirox
Severe
TirofibanDabigatran etexilate
Severe

Drug-Drug Interactions

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TirofibanDeferasirox
Severe
How does the drug interact with Tirofuse Injection 100ml:
Using deferasirox together with Tirofuse Injection 100ml may increase the risk of gastrointestinal ulcers.

How to manage the interaction:
Co-administration of Tirofuse Injection 100ml with Deferasirox can possibly result in an interaction, but it can be taken if your doctor has advised it. This risk is higher in older people with certain blood disorders or low platelet counts.If you have symptoms like stomach pain, bloating, dizziness, or black stools, it's important to consult a doctor. Do not stop using any medications without a doctor's advice.
TirofibanDabigatran etexilate
Severe
How does the drug interact with Tirofuse Injection 100ml:
Taking Dabigatran etexilate with Tirofuse Injection 100ml can increase the risk of bleeding leading to serious blood loss.

How to manage the interaction:
Taking Dabigatran etexilate with Tirofuse Injection 100ml together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.
TirofibanDalteparin
Severe
How does the drug interact with Tirofuse Injection 100ml:
Combining Tirofuse Injection 100ml with Dalteparin can increase the risk of bleeding.

How to manage the interaction:
Although taking Dalteparin with Tirofuse Injection 100ml may possibly lead to an interaction, they can be taken if a doctor prescribes it. Consult a doctor if you have any symptoms including dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that resembles coffee grounds, severe headache, and weakness. Without consulting a doctor, never stop taking any medication.
TirofibanAspirin
Severe
How does the drug interact with Tirofuse Injection 100ml:
Using aspirin together with Tirofuse Injection 100ml can cause you to bleed more easily.

How to manage the interaction:
Co-administration of Aspirin with Tirofuse Injection 100ml can result in an interaction, but it can be taken if a doctor has advised it. If you notice any of these signs, it's important to contact a doctor right away: bleeding, bruising, throwing up, headache, feeling dizzy, weakness, or seeing blood in your urine or stools. Do not stop using any medications without talking to a doctor.
TirofibanWarfarin
Severe
How does the drug interact with Tirofuse Injection 100ml:
Coadministration of warfarin with Tirofuse Injection 100ml can increase the risk of bleeding.

How to manage the interaction:
Although taking Tirofuse Injection 100ml and warfarin together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult a doctor. Do not stop using any medications without a doctor's advice.
TirofibanRivaroxaban
Severe
How does the drug interact with Tirofuse Injection 100ml:
Co-administration of Tirofuse Injection 100ml and Rivaroxaban can increase the risk of bleeding problems.

How to manage the interaction:
Co-administration of Tirofuse Injection 100ml and Rivaroxaban can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
TirofibanClopidogrel
Severe
How does the drug interact with Tirofuse Injection 100ml:
Taking Clopidogrel with Tirofuse Injection 100ml can make the antiplatelet effects of Tirofuse Injection 100ml stronger.

How to manage the interaction:
There may be a possibility of interaction between Tirofuse Injection 100ml and Clopidogrel, but it can be taken if prescribed by a doctor. Do not discontinue any medications without consulting your doctor.
TirofibanPrasugrel
Severe
How does the drug interact with Tirofuse Injection 100ml:
Co-administration of Tirofuse Injection 100ml with Prasugrel can increase the risk of bleeding.

How to manage the interaction:
Although there is a possible interaction between Tirofuse Injection 100ml and Prasugrel, you can take these medicines together if prescribed by a doctor. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.
TirofibanEnoxaparin
Severe
How does the drug interact with Tirofuse Injection 100ml:
Combining Tirofuse Injection 100ml with Enoxaparin can increase the risk of bleeding.

How to manage the interaction:
Taking Enoxaparin with Tirofuse Injection 100ml together can result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms, it's important to contact a doctor right away back pain, numbness, constipation, bleeding, bruises, dizziness, lightheaded, red or black stools, severe headache, weakness, or vomiting blood. Do not discontinue any medications without consulting a doctor.
TirofibanCangrelor
Severe
How does the drug interact with Tirofuse Injection 100ml:
Co-administration of Tirofuse Injection 100ml with Cangrelor can increase the risk of bleeding.

How to manage the interaction:
Although there is a possible interaction between Tirofuse Injection 100ml and Cangrelor, you can take these medicines together if prescribed by your doctor. However, consult doctor immediately if you experience any unusual bleeding or bruising, or have other signs and symptoms of bleeding such as dizziness; lightheadedness; red or black, tarry stools; coughing up or vomiting fresh or dried blood that looks like coffee grounds; severe headache; and weakness. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip

The following supplements may increase the risk of bleeding while receiving TIROFUSE INJECTION :

  • Herbal supplements: Supplements such as ginger, garlic, ginkgo biloba, and ginseng can interfere with blood clotting and should be avoided while using this medicine.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTICOAGULANT/ANTITHROMBOTIC]

FAQs

TIROFUSE INJECTION is administered as a continuous intravenous (IV) infusion directly into a vein by a trained healthcare professional in a hospital. Your healthcare team will monitor you closely throughout treatment to ensure the medicine is given safely and effectively.
Tell your doctor about all medicines you are taking while receiving TIROFUSE INJECTION . Avoid taking NSAID pain relievers such as ibuprofen or naproxen unless your doctor specifically recommends them, as they can increase your risk of bleeding. Other medicines that may also increase bleeding risk include anticoagulants (such as heparin or warfarin), thrombolytic medicines, other antiplatelet medicines (such as clopidogrel), and some antidepressants (SSRIs). Always consult your healthcare provider before taking any new medicine.
Bleeding is a possible side effect of TIROFUSE INJECTION . Tell your doctor or nurse immediately if you notice bleeding from your gums, nose, injection site, or if you see blood in your urine or stool, cough up blood, or experience unusual bruising. Prompt medical attention is important because bleeding can occasionally be serious.
This medicine makes it very easy for you to bruise or bleed if you bump into something or fall. Staying in bed keeps you safe and ensures your intravenous line remains securely in place. Talk to your doctor or nurse if you need assistance.
Once the hospital drip is stopped, the effects of the medicine on your blood clotting cells usually wear off within a few hours. Talk to your doctor if you want to know more about your specific recovery timeline.
No, it does not dissolve clots that have already formed, but it stops them from getting bigger and prevents new, dangerous clots from blocking your arteries. Talk to your doctor for more details on how clots are treated.
This medicine is only used during pregnancy if the potential benefits clearly outweigh the risks, as there is very little safety data available for pregnant women. Talk to your doctor if you are pregnant or planning to become pregnant.
Yes, your medical team will continuously monitor your heart rate, blood pressure, and perform regular blood tests to check your platelet levels and look for signs of bleeding. Talk to your doctor to understand what these tests mean for your care.

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Country of origin

India

Manufacturer/Marketer address

Lupin Ltd, 3rd floor Kalpataru Inspire, Off. W E Highway, Santacruz (East), Mumbai 400 055. India.
Other Info - TIR0001
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