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compositionComposition:NEOSTIGMINE-15MG
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Tilstigmin Tablet is used to treat myasthenia gravis (muscle problems), reverse the effect of muscle relaxants, improve small intestinal movements and reduce urinary retention after surgical procedures. It contains Neostigmine which increases levels of a neurotransmitter involved in communication between nerve impulses and muscle movements. This medicine may sometimes cause side effects such as nausea, vomiting, abdominal cramps, diarrhoea, dizziness, headache, and dry mouth. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

NEOSTIGMINE-15MG

Manufacturer/Marketer :

Tablets India Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Tilstigmin Tablet

Tilstigmin Tablet is an oral prescription medication primarily used to treat the symptoms of myasthenia gravis, a chronic condition that causes muscle weakness. It helps improve muscle strength and control by boosting the signals between your nerves and muscles. This medicine allows individuals to perform daily physical tasks more easily.

For the best results, you must take Tilstigmin Tablet regularly and consistently at the exact times prescribed by your doctor. It can be taken with or without food, but taking it with a small snack may help if you experience stomach upset. Spacing your doses evenly throughout the day helps maintain stable muscle strength, and keeping a daily log of your symptoms can assist your doctor in adjusting your schedule.

While taking Tilstigmin Tablet , you may experience mild side effects such as increased saliva, sweating, or mild stomach cramps. However, you must contact your doctor immediately if you experience serious side effects like extreme muscle weakness, difficulty breathing, or a very slow heart rate.

Before starting Tilstigmin Tablet , tell your doctor if you have asthma, heart disease, stomach ulcers, or thyroid problems. Do not take this if you have a physical blockage in your stomach, intestines, or urinary tract, as this medicine can worsen these blockages.

This medicine can interact with other drugs, including certain muscle relaxants, antibiotics, and heart medications, which may reduce its effectiveness or increase side effects. If you are pregnant, planning to become pregnant, breastfeeding, or are an older adult, consult your doctor to discuss the risks and benefits before starting this treatment.

Uses of Tilstigmin Tablet

Tilstigmin Tablet used in the treatment of myasthenia gravis and post-operative urinary retention. The detailed uses of Tilstigmin Tablet are as follows:

  • Myasthenia gravis: Tilstigmin Tablet helps improve muscle weakness and fatigue in people with this condition. By boosting nerve-to-muscle communication, it restores strength to muscles used for movement, swallowing, and breathing.
  • Post-operative urinary retention: In certain clinical situations, this medicine is used to help empty the bladder when muscles are temporarily weak after surgery, provided there is no physical blockage in the urinary tract.

Key Benefits

Tilstigmin Tablet helps improve muscle strength in people with conditions that cause muscle weakness by enhancing communication between the nerves and muscles.
The benefits of this medication include:
 

  • Helps improve muscle strength, making everyday activities such as walking, lifting, and swallowing easier.
  • Supports better muscle control and coordination, helping you move more comfortably throughout the day.
  • Reduces episodes of sudden muscle weakness and fatigue, helping you maintain a more stable daily routine.
  • Regular use of this medication supports better mobility, greater independence, and an improved quality of life.

Directions for Use

  • Tilstigmin Tablet can be taken with or without food. However, taking it with food may help reduce stomach upset.
  • It is usually taken twice daily or as prescribed by your doctor.
  • Swallow Tilstigmin Tablet as a whole with a glass of water.
  • Do not crush, chew, or break it.

How Tilstigmin Tablet Works

To understand how Tilstigmin Tablet works, it helps to look at how nerves communicate with muscles. Naturally, your body uses a chemical messenger called acetylcholine to tell your muscles to contract. After the message is delivered, an enzyme breaks down this chemical so the muscle can relax. Tilstigmin Tablet works by temporarily blocking this enzyme. By preventing the breakdown of acetylcholine, the medication allows more of this chemical messenger to build up at the connection point between nerves and muscles. This stronger signal helps weak muscles contract more effectively, improving your overall strength and physical control.
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Alcohol

Caution

Avoid consuming alcohol while taking Tilstigmin Tablet to prevent any undesirable side effects.

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Pregnancy

Caution

There is limited information on how Tilstigmin Tablet affects pregnancy. Please consult your doctor before taking this medicine if you are pregnant or planning to conceive.

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Breast Feeding

Caution

It is not known if Neostigmine is excreted into breast milk. Please consult your doctor before taking Tilstigmin Tablet if you are a breastfeeding mother.

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Driving

Caution

Tilstigmin Tablet can make you feel dizzy and affect your ability to drive. It is advised not to drive or operate machinery while on treatment with Tilstigmin Tablet if you are not mentally alert and focused.

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Liver

Caution

Please consult your doctor before taking Tilstigmin Tablet if you have liver impairment/liver disease.

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Kidney

Caution

Please consult your doctor before taking Tilstigmin Tablet if you have kidney impairment/kidney disease.

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Children

Safe if prescribed

Tilstigmin Tablet is recommended in children below 12 years of age only when prescribed by the doctor. The dosage depends on the child’s age and weight.

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Heart

Unsafe

Tilstigmin Tablet is contraindicated in cardiac patients due to its adverse effects.

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Geriatrics

Caution

Tilstigmin Tablet can be given in elderly patients with extreme caution, due to the cause of adverse effects.

What if I have taken an overdose of Tilstigmin Tablet

In case of an accidental overdose, seek emergency medical attention or contact a poison control centre immediately. Symptoms of an overdose can include severe muscle weakness, extreme sweating, excessive saliva, vomiting, slow heart rate, and difficulty breathing.

Diet & Lifestyle Advise

  • Time your meals carefully: Plan to eat your main meals when your muscle strength is at its peak, which is usually 30 to 45 minutes after taking a dose of Tilstigmin Tablet .
  • Choose soft foods if swallowing is difficult: Opt for softer, easy-to-chew foods (like soups, stews, or purees) to reduce the risk of choking and save physical energy during meals.
  • Take frequent rest breaks: Space out your physical activities throughout the day and take planned rest periods to conserve muscle strength.
  • Stay cool: High temperatures can worsen muscle weakness. Avoid hot showers, saunas, and direct exposure to intense heat during the day.
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How Soon It Starts Working

The time required for Tilstigmin Tablet to start to work: The time required for Tilstigmin Tablet to show its action is unknown. The time for which the effects of Tilstigmin Tablet last: The duration of action for Tilstigmin Tablet is clinically unknown.

What if you forget to take Tilstigmin Tablet

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and resume your regular schedule. Do not take two doses at the same time to make up for a missed one. If you are unsure, talk to your doctor or pharmacist.

Storage

• Store Tilstigmin Tablet tablets at controlled room temperature, ideally between 20°C and 25°C (68°F to 77°F).

Drug Warnings

  • Keep a daily symptom log: Note the exact times you take Tilstigmin Tablet and how your muscle strength feels. Share this with your doctor to help them optimise your schedule.
  • Differentiate between weakness types: Both too little and too much of this medicine can cause muscle weakness. If you experience sudden, severe weakness, contact your doctor immediately instead of taking extra medicine.
  • Check your tablets: Always inspect your tablets before taking them; do not use them if they appear discoloured, chipped, or damp.
  • Inform all healthcare providers: Let your dentist, surgeon, and other doctors know you are taking Tilstigmin Tablet before undergoing any procedures or receiving anaesthesia.
  • Wear medical identification: Carry a medical alert card or wear a bracelet stating that you have myasthenia gravis and are taking this medication in case of emergency.

Drug-Drug Interactions

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  • Anticholinergic drugs (e.g., Atropine): May block the beneficial muscle-strengthening effects of Tilstigmin Tablet , though doctors sometimes use them specifically to treat side effects.
  • Beta-blockers (e.g., Metoprolol): May increase the risk of a dangerously slow heart rate when taken together.
  • Certain antibiotics (e.g., Gentamicin, Amikacin): Can worsen muscle weakness, reducing the effectiveness of Tilstigmin Tablet .
  • Other cholinesterase inhibitors (e.g., Pyridostigmine, Donepezil): May increase the risk of toxicity and severe side effects when combined.

Drug-Drug Interactions

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How does the drug interact with Tilstigmin Tablet:
Co-administration of tramadol with Tilstigmin Tablet can increase the effect of tramadol.

How to manage the interaction:
Taking Tilstigmin Tablet with tramadol together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience any symptoms such as confusion, hallucination, seizure, increased heart rate, blurred vision, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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  • Alcohol: Avoid or limit alcohol intake to prevent disease worsening and unwanted side effects.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[MUSCLE STIMULANTS AND CHOLINESTERASE INHIBITORS]

FAQs

No. Do not stop taking Tilstigmin Tablet or change your dose without consulting your doctor, even if you feel better. Stopping treatment suddenly can cause your muscle weakness to return or worsen, which may affect your breathing or swallowing. Continue taking the medicine exactly as prescribed and speak with your doctor if you think your treatment needs to be changed.
Yes, you can take Tilstigmin Tablet with or without food. However, if it causes stomach cramps or nausea, taking it with a small meal or milk can help ease these symptoms. Talk to your doctor if stomach upset persists.
When taken orally, Tilstigmin Tablet typically begins to work within 30 to 45 minutes, with its peak effect occurring within 1 to 2 hours. Talk to your doctor if you do not feel an improvement in your symptoms.
Worsening muscle weakness can be a sign of either too little medicine or an excessive dose (a cholinergic crisis). Do not take more medicine on your own; contact your doctor or seek emergency medical help immediately.
It is best to avoid or strictly limit alcohol while taking Tilstigmin Tablet . Alcohol can increase stomach irritation and drowsiness, making it harder to monitor your muscle symptoms. Talk to your doctor about your alcohol consumption.
The safety of Tilstigmin Tablet during pregnancy is not fully established. It should only be used if clearly needed and prescribed by your doctor. Talk to your doctor to weigh the risks and benefits.
No, Tilstigmin Tablet does not cure myasthenia gravis. It is a symptomatic treatment that helps manage muscle weakness and improve your physical function on a daily basis. Talk to your doctor about long-term management plans.
If swallowing tablets is difficult due to muscle weakness, try timing your dose to a period of better muscle strength, or speak with your doctor. They may suggest alternative ways to manage your therapy. Talk to your doctor or pharmacist for guidance.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

INDIA

Manufacturer/Marketer address

Tablets (India) Limited, “Jhaver Centre”, 72 Marshalls Road, Chennai 600 008.
Other Info - TIL0001
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