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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

THROMBOFLUX 1500000IU INJECTION is used to dissolve blood clots that have formed in the blood vessels in various conditions such as Intravascular dissolution of thrombi and emboli in extensive deep vein thrombosis, Pulmonary embolism, Acute or subacute occlusion of peripheral arteries, Central retinal venous and Arterial thrombosis. THROMBOFLUX 1500000IU INJECTION contains Streptokinase, which works by dissolving the harmful blood clots in the blood vessels; this restores the blood flow to the affected tissue, thereby preventing tissue death and improving outcomes.

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Manufacturer/Marketer :

Vh Bhagat & Company

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About THROMBOFLUX 1500000IU INJECTION

THROMBOFLUX 1500000IU INJECTION belongs to the class of medicines called antifibrinolytic agents. It is used to dissolve blood clots that have formed in the blood vessels in various conditions such as Intravascular dissolution of thrombi and emboli in extensive deep vein thrombosis, Pulmonary embolism, Acute or subacute occlusion of peripheral arteries, Central retinal venous and Arterial thrombosis.

THROMBOFLUX 1500000IU INJECTION contains Streptokinase. Streptokinase creates a highly specific 1:1 enzymatic complex with plasminogen that transforms inactive plasminogen molecules into active plasmin. Plasmin destroys fibrin clots, as well as fibrinogen and other plasma proteins. This, in turn, causes the breakdown of blood clots.

THROMBOFLUX 1500000IU INJECTION should be administered to patients only in a hospital setting by an experienced healthcare professional. THROMBOFLUX 1500000IU INJECTION may cause certain common side effects, including allergic reactions, hypotension, tachycardia, bradycardia, hypotension, heart rate and rhythm disorders, angina pectoris, nausea, diarrhoea, epigastric pain, vomiting, headache, back pain, musculoskeletal pain, chills, fever, asthenia, elevations of serum transaminases and bilirubin. These side effects usually go away on their own. If you develop any other serious side effects, such as vision problems while using THROMBOFLUX 1500000IU INJECTION, consult your doctor immediately.

THROMBOFLUX 1500000IU INJECTION is indicated in adults. THROMBOFLUX 1500000IU INJECTION is not recommended for children below 18 years of age as the safety and effectiveness were not established. Inform your doctor if you are pregnant or planning for pregnancy or breastfeeding since THROMBOFLUX 1500000IU INJECTION is contra-indicated in pregnancy, especially within the first 18 weeks of pregnancy. It is unknown whether Streptokinase is excreted in human milk. Breast milk should be discarded during the first 24 hours following thrombolytic therapy.

Uses of THROMBOFLUX 1500000IU INJECTION

THROMBOFLUX 1500000IU INJECTION is used to dissolve blood clots that have formed in the blood vessels and Treatment of Pulmonary embolism, Acute or subacute occlusion of peripheral arteries, Central retinal venous, and Arterial thrombosis. The detailed uses of THROMBOFLUX 1500000IU INJECTION are as follows:<br/>• Treat acute myocardial infarction (heart attack): THROMBOFLUX 1500000IU INJECTION dissolves clots in coronary arteries, restoring blood flow to the heart muscle and reducing damage when administered within hours of symptom onset.<br/>• Manage pulmonary embolism: THROMBOFLUX 1500000IU INJECTION breaks down clots in the lungs, improving oxygen exchange and reducing the risk of life-threatening complications.<br/>• Treat deep vein thrombosis (DVT): THROMBOFLUX 1500000IU INJECTION helps dissolve clots in deep veins, typically in the legs, preventing progression to pulmonary embolism.<br/>• Address arterial thrombosis and embolism: THROMBOFLUX 1500000IU INJECTION is used to lyse clots in arteries that may cause strokes or limb ischemia, improving circulation and preventing tissue damage.<br/>

Directions for Use

• Follow your doctor's instructions on the dosage and timing of this medication, to improve effectiveness.• THROMBOFLUX 1500000IU INJECTION will be administered by a healthcare professional.• Do not self-administer it.

Medicinal Benefits

THROMBOFLUX 1500000IU INJECTION contains ‘Streptokinase’, which belongs to the class of anti-fibrinolytic agents. It acts by regulating the breakdown of blood clots in the body. It blocks the release and action of plasmin, an enzyme essential for the breakdown of clots in the blood. This effect helps to slow down abnormal bleeding.

How THROMBOFLUX 1500000IU INJECTION Works

THROMBOFLUX 1500000IU INJECTION contains Streptokinase. Streptokinase creates a highly specific 1:1 enzymatic complex with plasminogen that transforms inactive plasminogen molecules into active plasmin. Plasmin destroys fibrin clots, as well as fibrinogen and other plasma proteins. This, in turn, causes the breakdown of blood clots.

Storage

• Store in a cool and dry place away from sunlight.
• Keep THROMBOFLUX 1500000IU INJECTION out of reach and sight of children.
• Cold chain - To be stored in cold places at 2ºC to 8ºC.
Side effects of Thromboflux 1500000iu Injection
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.

What if I have taken an overdose of THROMBOFLUX 1500000IU INJECTION

As THROMBOFLUX 1500000IU INJECTION is a parenteral formulation administered by experienced medical staff, the chance of overdose may be less. However, if you think there has been an overdose or experiencing any adverse events, get medical care right away.

Drug Warnings

Before taking THROMBOFLUX 1500000IU INJECTION, let your doctor know about all your medical conditions, sensitivities, and medications you are using. Also, inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Usage of THROMBOFLUX 1500000IU INJECTION contraindicated to use in persons with certain medical conditions that cause risk of bleeding such as existing or recent internal haemorrhage (internal bleeding), recent cerebrovascular accident, intracranial or intraspinal surgery, intracranial neoplasm (brain tumour), recent head trauma, arteriovenous malformation (an abnormal connection between arteries and veins), neoplasm  (a cancerous tumour) with risk of bleeding, pancreas inflammation, severe liver or kidney damage and simultaneous or recent treatment with oral anticoagulants. So, let your doctor know about all your medical conditions, sensitivities, and all medications you are using.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Thromboflux 1500000iu Injection:
Taking Heparin with Thromboflux 1500000iu Injection can increase the risk of bleeding.

How to manage the interaction:
Although taking Heparin and Thromboflux 1500000iu Injection together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience any unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with Thromboflux 1500000iu Injection:
Combining Thromboflux 1500000iu Injection with Deferasirox can increase the risk of gastrointestinal bleeding.

How to manage the interaction:
Co-administration of Thromboflux 1500000iu Injection with Deferasirox can possibly result in an interaction, but it can be taken if your doctor has advised it. This risk is higher in older people with certain blood disorders or low platelet counts.If you have symptoms like stomach pain, bloating, dizziness, or black stools, it's important to consult a doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Thromboflux 1500000iu Injection:
Coadministration of Dasatinib with Thromboflux 1500000iu Injection can increase the risk of bleeding.

How to manage the interaction:
Co-administration of Thromboflux 1500000iu Injection with Dasatinib can result in an interaction, but it can be taken if a doctor has advised it. You should seek immediate medical attention if you experience bruising, dizziness; red or black, tarry stools; severe headache; and weakness. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Thromboflux 1500000iu Injection:
Taking Thromboflux 1500000iu Injection with fondaparinux can increase the risk of bleeding.

How to manage the interaction:
There may be a possibility of interaction between Thromboflux 1500000iu Injection and Fondaparinux, but it can be taken if prescribed by a doctor. However, if you experience bleeding, severe back pain, dizziness, black or red stools, severe headache, weakness, and vomiting contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
How does the drug interact with Thromboflux 1500000iu Injection:
Coadministration of Warfarin with Thromboflux 1500000iu Injection can increase the risk of bleeding.

How to manage the interaction:
Although taking Thromboflux 1500000iu Injection and warfarin together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you have unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult a doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Thromboflux 1500000iu Injection:
Co-administration of Cangrelor with Thromboflux 1500000iu Injection can increase the risk of bleeding.

How to manage the interaction:
There may be a possibility of interaction between Thromboflux 1500000iu Injection and Cangrelor, but it can be taken if prescribed by a doctor. However, consult doctor immediately if you experience any unusual bleeding or bruising, or have other signs and symptoms of bleeding such as dizziness; lightheadedness; red or black, tarry stools; coughing up or vomiting fresh or dried blood that looks like coffee grounds; severe headache; and weakness. Do not stop using any medications without talking to a doctor.
How does the drug interact with Thromboflux 1500000iu Injection:
Taking Thromboflux 1500000iu Injection can enhance the blood-thinning effects of Enoxaparin which can increase the risk or severity.

How to manage the interaction:
Taking Enoxaparin with Thromboflux 1500000iu Injection together can result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms like pain in the middle of your back, feeling numb, problems with your bowels or bladder, bleeding, very heavy bleeding that could be dangerous, complications, bruises, feeling dizzy or lightheaded, seeing red or black stools, having a severe headache, bleeding, vomiting, or feeling weak it's important to contact a doctor right away. Do not stop using any medications without a doctor's advice.
How does the drug interact with Thromboflux 1500000iu Injection:
Co-administration of Thromboflux 1500000iu Injection and Rivaroxaban can increase the risk of bleeding problems.

How to manage the interaction:
Co-administration of Thromboflux 1500000iu Injection and Rivaroxaban can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with Thromboflux 1500000iu Injection:
Co-administration of Prasugrel with Thromboflux 1500000iu Injection can increase the risk of bleeding.

How to manage the interaction:
Co-administration of Thromboflux 1500000iu Injection with Prasugrel can possibly result in an interaction, but it can be taken if a doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Thromboflux 1500000iu Injection:
Using Thromboflux 1500000iu Injection together with dalteparin may increase the risk of bleeding.

How to manage the interaction:
Although taking Dalteparin with Thromboflux 1500000iu Injection may possibly lead to an interaction, they can be taken if a doctor prescribes it. Consult a doctor if you have any symptoms including dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that resembles coffee grounds, severe headache, and weakness. Without consulting a doctor, never stop taking any medication.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Ask your doctor about the preferred exercises to do based on your health condition.
  • Stay hydrated and consume plenty of fluids. Fluids are necessary to maintain blood flow in your body.
  • Consume fresh fruits and vegetables. Consult a dietitian and prepare a diet plan. Eating healthy can help you to recover faster.

Habit Forming

No

Therapeutic Class

ANTIFIBRINOLYTIC AGENTS
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Alcohol

Caution

THROMBOFLUX 1500000IU INJECTION may not interact with alcohol. However, avoid the consumption of alcohol as it may worsen your health condition.

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Pregnancy

Caution

THROMBOFLUX 1500000IU INJECTION is contra-indicated in pregnancy, especially within the first 18 weeks of pregnancy.

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Breast Feeding

Caution

It is unknown whether streptokinase is excreted in human milk. Breast milk should be discarded during the first 24 hours following thrombolytic therapy.

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Driving

Caution

It is not known whether THROMBOFLUX 1500000IU INJECTION alters the ability to drive. Do not drive or operate machinery if you experience any symptoms that affect your ability to concentrate and react. Seek medical attention if the symptoms persist longer.

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Liver

Caution

Inform your doctor before receiving THROMBOFLUX 1500000IU INJECTION if you have had a liver impairment/disorder history. Your doctor will prescribe only if the benefits outweigh the risks.

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Kidney

Caution

Inform your doctor before receiving THROMBOFLUX 1500000IU INJECTION if you have had a kidney impairment/disorder history. Your doctor will prescribe only if the benefits outweigh the risks.

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Children

Unsafe

THROMBOFLUX 1500000IU INJECTION is not recommended in neonates, infants and children.

Have a query?

FAQs

THROMBOFLUX 1500000IU INJECTION is used to dissolve blood clots that have formed in the blood vessels in various conditions such as Intravascular dissolution of thrombi and emboli in extensive deep vein thrombosis, Pulmonary embolism, Acute or subacute occlusion of peripheral arteries, Central retinal venous and Arterial thrombosis.

THROMBOFLUX 1500000IU INJECTION contains Streptokinase. Streptokinase creates a highly specific 1:1 enzymatic complex with plasminogen that transforms inactive plasminogen molecules into active plasmin. Plasmin destroys fibrin clots, as well as fibrinogen and other plasma proteins. This, in turn, causes the breakdown of blood clots.

THROMBOFLUX 1500000IU INJECTION may cause Arrhythmia. Arrhythmia monitoring is advised during and soon following delivery of Streptokinase.

The most frequent adverse reaction associated with this therapy is bleeding. In most cases, this condition gradually resolves over time. However, if bleeding persists, contact your doctor.

Do not take anticoagulants; drugs that inhibit platelet function increase the risk of bleeding when administered THROMBOFLUX 1500000IU INJECTION.

THROMBOFLUX 1500000IU INJECTION may cause side effects in some individuals. Commonly reported side effects include allergic reactions, fluctuations in blood pressure and heart rate, chest pain, gastrointestinal issues like nausea and diarrhea, muscle pain, headache, chills, fever, and general weakness. Additionally, it may occasionally affect liver function, leading to elevated serum transaminase and bilirubin levels. Most side effects are temporary and resolve without needing further treatment. However, if you experience severe side effects, such as vision problems, seek immediate medical attention for proper evaluation and guidance.

Country of origin

India
Other Info - THR0037

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Keep Refrigerated. Do not freeze.

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