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  1. Home
  2. Medicine

  3. Thriomesar Tablet

Prescription drug
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Thriomesar Tablet, Pack of 1 Tablet
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Composition :

AMLODIPINE-5MG + HYDROCHLOROTHIAZIDE-12.5MG + OLMESARTAN MEDOXOMIL-40MG

Manufacturer/Marketer :

Macleods Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

About Thriomesar Tablet

Thriomesar Tablet is primarily used for lowering high blood pressure (hypertension) by removing extra fluid (electrolytes) from the body. High blood pressure is a chronic condition in which the force of blood against the artery walls is high.

Thriomesar Tablet is a combination of Olmesartan, Amlodipine, and Hydrochlorothiazide. Olmesartan blocks the hormone angiotensin, thereby relaxing and widening the narrowed blood vessels. Amlodipine reduces the heart's workload and makes it more efficient at pumping blood throughout the body. Hydrochlorothiazide removes extra water/fluid and certain electrolyte overload from the body.

The most common side effects of Thriomesar Tablet are nausea, upset stomach, dehydration, headache, diarrhoea, electrolyte imbalance, feeling exhausted, swollen ankles, dizziness, and decreased blood pressure in some cases. Most of these side effects do not require medical attention and typically resolve on their own over time. However, if the side effects are persistent, reach out to your doctor.

If you are pregnant or breastfeeding, do not take Thriomesar Tablet as it is a category D pregnancy drug and may harm the baby. Do not use Thriomesar Tablet if you cannot urinate, are dehydrated, have low blood pressure (hypotension), or have had cardiogenic shock (sudden stopping of blood flow to the heart). Please tell your doctor if you are taking any other medicines or are allergic to this medicine.

Uses of Thriomesar Tablet

Thriomesar Tablet is used in the treatment of high blood pressure (hypertension). The detailed uses of Thriomesar Tablet are as follows:

  • Lowers High Blood Pressure effectively: Thriomesar Tablet used to relax blood vessels, reduce fluid retention, and lower resistance in the arteries, helping to bring down high blood pressure.
  • Prevents Heart and Kidney Complications: By maintaining optimal blood pressure levels, Thriomesar Tablet helps to reduce the risk of stroke, heart attack, kidney damage, and other related complications.
  • Improves Blood Flow and Reduces Swelling: Thriomesar Tablet promotes better circulation and reduces swelling or fluid buildup in the body due to its diuretic component.

Have a query?

Directions for Use

  • Thriomesar Tablet can be taken with or without food as advised by your doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
  • Swallow Thriomesar Tablet as a whole with a glass of water.
  • Do not chew, crush, or break it.

Medicinal Benefits

  • Thriomesar Tablet belongs to a group of medications called 'anti-hypertensives' primarily used for lowering high blood pressure (hypertension) by removing extra fluid (electrolytes) from the body.
  • Thriomesar Tablet is a combination of three medicines: Olmesartan medoximil, Amlodipine, and Hydrochlorothiazide.
  • Olmesartan medoximil is a prodrug and breaks down into active form, i.e., olmesartan once absorbed in the GIT (Gastrointestinal tract). An angiotensin receptor blocker (ARB) blocks the hormone angiotensin, thereby relaxing and widening the narrowed blood vessels.
  • Amlodipine is a calcium channel blocker; it reduces the heart's workload and makes it more efficient at pumping blood throughout the body.
  • Hydrochlorothiazide is a diuretic or water pill that removes extra water/fluid and certain electrolyte overload from the body. Together, Thriomesar Tablet lowers fluid overload, raises blood pressure, improves blood flow, and reduces the future risk of a heart attack and stroke.

How Thriomesar Tablet Works

Thriomesar Tablet is a combination of three medicines: Olmesartan medoximil, Amlodipine, and Hydrochlorothiazide. Olmesartan medoximil is a prodrug and breaks down into active form, i.e., olmesartan once absorbed in the GIT (Gastrointestinal tract). An angiotensin receptor blocker (ARB) blocks the hormone angiotensin, thereby relaxing and widening the narrowed blood vessels. Amlodipine is a calcium channel blocker; it reduces the heart's workload and makes it more efficient at pumping blood throughout the body. Hydrochlorothiazide is a diuretic or water pill that removes extra water/fluid and certain electrolyte overload from the body. Together, Thriomesar Tablet lowers fluid overload, raises blood pressure, improves blood flow, and reduces the future risk of a heart attack and stroke.<

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Thriomesar Tablet
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.

What if I have taken an overdose of Thriomesar Tablet

Do not take more than the prescribed dose of Thriomesar Tablet as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.

Drug Warnings

  • Do not use Thriomesar Tablet if you are pregnant, planning for pregnancy, or unable to urinate (anuria).
  • If you have diabetes and are taking Thriomesar Tablet with other blood pressure-lowering pills like 'aliskiren,' immediately stop taking both together and consult a doctor.
  • Besides this, it is contraindicated in low blood pressure (hypotension), cardiogenic shock (sudden stopping of blood flow to the heart), and aortic stenosis (heart valve problem).
  • Thriomesar Tablet may pass into breast milk, so before starting Thriomesar Tablet, either you need to stop nursing or you should not take Thriomesar Tablet while breastfeeding.
  • Please inform your doctor before surgery if you are taking Thriomesar Tablet, as it needs to be stopped because it might lower the blood pressure further if taken along with local anaesthesia.
  • Avoid potassium salt or its substitute intake while using Thriomesar Tablet to avoid any electrolyte imbalance.
  • Thriomesar Tablet can pass into breast milk, but its effect on the baby is unknown. So, it is better to tell your doctor if you take Thriomesar Tablet and are breastfeeding.
  • In rare cases, Thriomesar Tablet can cause a condition that results in a skeletal muscle problem, leading to further kidney failure. If you notice unexplained muscle pain, dark-colored urine, tenderness, or weakness, especially if you also have a fever or unexplained tiredness, immediately contact the doctor.
  • Try not to stop taking this medicine on your own. Let your doctor know about this, as it may cause a rise in blood pressure and increase the risk of heart disease and stroke.

Drug-Drug Interactions

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Olmesartan medoxomilAliskiren
Critical
AmlodipineDantrolene
Critical

Drug-Drug Interactions

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Olmesartan medoxomilAliskiren
Critical
How does the drug interact with Thriomesar Tablet:
Using aliskiren together with olmesartan may increase the risk of serious side effects (kidney problems, low blood pressure, and high potassium levels in the blood).

How to manage the interaction:
Taking Thriomesar Tablet with Aliskiren is not recommended as it can cause an interaction, they can be taken if advised by a doctor. You should seek medical attention if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, a weak pulse, or a slow or irregular heartbeat.It is crucial that you continue to consume enough fluids while taking these medications. Do not stop using any medications without consulting a doctor.
AmlodipineDantrolene
Critical
How does the drug interact with Thriomesar Tablet:
Using Thriomesar Tablet together with dantrolene may increase the risk of hyperkalemia (high blood potassium).

How to manage the interaction:
Taking Thriomesar Tablet with Dantrolene can cause an interaction, consult a doctor before taking it. You should seek medical attention if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, a weak pulse, or a slow or irregular heartbeat. Do not stop using any medications without talking to a doctor.
HydrochlorothiazideDofetilide
Critical
How does the drug interact with Thriomesar Tablet:
Taking Dofetilide and Thriomesar Tablet can increase the risk of an irregular heart rhythm which can be severe. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Combining Dofetilide and Thriomesar Tablet together is not recommended as it can possibly result in an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
HydrochlorothiazideCisapride
Critical
How does the drug interact with Thriomesar Tablet:
Taking Cisapride and Thriomesar Tablet can increase the risk of an irregular heart rhythm which can be severe. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Combining Cisapride and Thriomesar Tablet together is generally avoided as it can possibly result in an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like dizziness, lightheadedness, fainting, or fast or pounding heartbeats, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
Olmesartan medoxomilTrimethoprim
Severe
How does the drug interact with Thriomesar Tablet:
Taking Thriomesar Tablet with trimethoprim may increase potassium levels in the blood.

How to manage the interaction:
Although taking Thriomesar Tablet with trimethoprim may lead to an interaction but can be taken if prescribed by the doctor. However, consult the doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, feelings of heaviness in your legs, a weak pulse, or a slow or irregular heartbeat. Do not stop using any medications without talking to a doctor.
Olmesartan medoxomilPotassium citrate
Severe
How does the drug interact with Thriomesar Tablet:
Coadministration of Thriomesar Tablet may increase potassium levels in the blood, which can lead to kidney failure, muscular paralysis, and abnormal heart rhythm.

How to manage the interaction:
Although taking Thriomesar Tablet together with potassium citrate may result in an interaction, they can be taken together if prescribed by your doctor. However, consult the doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, feelings of heaviness in your legs, a weak pulse, or a slow or irregular heartbeat. It is essential to maintain proper fluid intake while taking these medications. Do not discontinue any medications without a doctor's advice.
Olmesartan medoxomilpotassium phosphate
Severe
How does the drug interact with Thriomesar Tablet:
Using potassium phosphate together with olmesartan may significantly increase potassium levels in the blood.

How to manage the interaction:
Although taking Thriomesar Tablet and potassium phosphate together can cause an interaction, it can be taken if a doctor has suggested it. However if you experience symptoms such as nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, a weak pulse, or a slow or irregular heartbeat, consult a doctor. It is crucial that you continue to consume enough fluids while taking these medications. Do not discontinue any medications without consulting a doctor.
Olmesartan medoxomilCaptopril
Severe
How does the drug interact with Thriomesar Tablet:
When Thriomesar Tablet is taken with captopril, it may cause low blood pressure, kidney problems, and may increase potassium levels in the blood.

How to manage the interaction:
Although taking Thriomesar Tablet with captopril may lead to an interaction but can be taken if prescribed by the doctor. However, consult the doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, feelings of heaviness in your legs, a weak pulse, or a slow or irregular heartbeat. Do not stop using any medications without talking to a doctor.
Olmesartan medoxomilRamipril
Severe
How does the drug interact with Thriomesar Tablet:
Taking ramipril together with olmesartan may increase the risk of side effects (blood pressure, kidney function impairment, and a condition called Hyperkalemia - high blood potassium).

How to manage the interaction:
Although taking Thriomesar Tablet with ramipril may lead to an interaction but can be taken if prescribed by the doctor. However, consult the doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, feelings of heaviness in your legs, a weak pulse, or a slow or irregular heartbeat. Do not stop using any medications without talking to a doctor.
Olmesartan medoxomilLithium
Severe
How does the drug interact with Thriomesar Tablet:
Taking lithium with Thriomesar Tablet may significantly increase the blood levels of lithium .

How to manage the interaction:
Although taking Thriomesar Tablet alongside lithium can lead to interaction, they can be taken if prescribed by a doctor. However, if you develop sleepiness, dizziness, confusion, loose stools, vomiting, muscular weakness, muscle incoordination, a shaking sensation, blurred vision, ringing in the ears, excessive thirst, and/or increased urination, consult a doctor. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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AMLODIPINE-5MG+HYDROCHLOROTHIAZIDE-12.5MG+OLMESARTAN MEDOXOMIL-40MGPotassium rich foods
Moderate

Drug-Food Interactions

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AMLODIPINE-5MG+HYDROCHLOROTHIAZIDE-12.5MG+OLMESARTAN MEDOXOMIL-40MGPotassium rich foods
Moderate
Common Foods to Avoid:
Lentils, Orange Juice, Oranges, Raisins, Potatoes, Salmon Dried, Spinach, Sweet Potatoes, Tomatoes, Coconut Water, Beans, Beetroot, Broccoli, Bananas, Apricots, Avocado, Yogurt

How to manage the interaction:
Taking Thriomesar Tablet with potassium-containing salt substitutes or potassium supplements can cause high levels of potassium in the blood. Avoid taking potassium-containing salt substitutes or potassium supplements while being treated with Thriomesar Tablet.

Diet & Lifestyle Advise

  • Create a well-balanced and healthy diet that includes vegetables, fruits, whole grains, legumes, omega-3-rich foods, and lean protein sources.
  • Keep your weight under control with a BMI of 19.5-24.9.
  • Avoid chronic stress, as it can raise your blood pressure.
  • Spend time with your loved ones to cope with stress and practice mindfulness techniques.
  • Be mindful of salt; consume no more than 2,300 mg each day.
  • Limit or avoid alcohol consumption.
  • Quitting smoking is the best strategy to lower the risk of heart disease.

Habit Forming

No

Therapeutic Class

ANTI- HYPERTENSIVES

Thriomesar Tablet Substitute

Substitutes safety advice
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Alcohol

Unsafe

You are recommended not to consume alcohol and Thriomesar Tablet to avoid unpleasant side effects like drowsiness, dizziness, and liver damage.

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Pregnancy

Unsafe

Thriomesar Tablet is not recommended during pregnancy as it contains Olmesartan, which is a category D pregnancy drug. This medicine may cause fetal damage and can affect the unborn baby (fetus).

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Breast Feeding

Unsafe

Thriomesar Tablet is known to pass breast milk, but its effect on the baby is unknown. So, before breastfeeding, let your doctor know about this. Either you need to stop breastfeeding for using Thriomesar Tablet or stop taking Thriomesar Tablet.

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Driving

Caution

Drive with caution; Thriomesar Tablet usually causes drowsiness and affects driving ability.

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Liver

Caution

Thriomesar Tablet to be taken with caution, especially if you have or have had a history of liver disease. Your doctor will change the dosage depending on your medical condition and your reaction to treatment.

bannner image

Kidney

Caution

Thriomesar Tablet to be taken with caution, especially if you have had a history of kidney disease. Your doctor will have to change the dosage depending on your medical condition and your reaction to treatment.

bannner image

Children

Caution

Efficacy and safety of Thriomesar Tablet have not been established in children. If prescribed, it should be strictly under medical supervision and only if the benefits outweigh the harm.

FAQs

Thriomesar Tablet is used for lowering high blood pressure (hypertension) by removing extra fluid (electrolytes) from the body.

Thriomesar Tablet is a combination of three‚ medicines: Olmesartan medoximil, Amlodipine, and Hydrochlorothiazide. Olmesartan medoximil relaxes and widens the narrowed blood vessels. Amlodipine reduces the heart's workload and makes the heart more efficient at pumping blood throughout the body. Hydrochlorothiazide is a diuretic or water pill that removes extra water/fluid and certain electrolyte overload from the body. Together, Thriomesar Tablet lowers fluid overload, raises blood pressure, improves blood flow, and reduces the future risk of a heart attack and stroke.

Thriomesar Tablet can be safely taken as long as your doctor prescribes it. Conditions such as high blood pressure are life-long conditions, and one should not abruptly discontinue it without discussing it with a doctor. Discontinuing Thriomesar Tablet may lead to increased blood pressure and a high risk of heart attack and stroke.

It is unlikely that Thriomesar Tablet affects fertility in men or women. However, in some cases, some water pills like hydrochlorothiazide may lead to erectile dysfunction. For the best advice, please consult your doctor.

Please inform your doctor before surgery if you are taking Thriomesar Tablet as it needs to be stopped because it might lower the blood pressure further if taken along with local anesthesia.

Do not use Thriomesar Tablet if you are pregnant, planning for pregnancy, or unable to urinate. If you have diabetes and taking Thriomesar Tablet with other blood pressure-lowering pills like aliskiren, immediately stop taking both together and consult a doctor.

High blood pressure during pregnancy is called Pregnancy-induced hypertension (PIH). It is harmful to both the baby and the mother. In the mother, very high blood pressure can cause seizures (fits), headache, swelling of feet, kidney damage, and a higher risk of bleeding during pregnancy and delivery. This can also affect the baby by causing abnormal fetal heart rate, risk of stillbirth, and a small baby. So, during pregnancy, you should have regular blood pressure monitoring. Visit your Obstetrician if you have any concerns about blood pressure during pregnancy.

Yes, Thriomesar Tablet is known to cause ankle swelling (oedema) upon long-term use as Thriomesar Tablet amlodipine. Please try to keep your feet up when sitting for long hours. If the problem persists still, consult your doctor and do as advised.

Thriomesar Tablet can be taken with or without food or as advised by the doctor.

You are not recommended to stop Thriomesar Tablet, as stopping it may raise blood pressure and increase the risk of heart disease and stroke. Therefore, inform your doctor if you intend to stop taking Thriomesar Tablet or if you experience any difficulty while taking Thriomesar Tablet.

To control high blood pressure, it’s important to follow a balanced diet that includes proteins, whole grains, and fiber-rich fruits and vegetables. Limit your intake of carbohydrates, salt, and sugar. Before making any changes to your diet or eating habits, consult your doctor. Regular exercise and weight loss are also recommended. Avoid smoking and drinking.

You may observe a decrease in your blood pressure within 2 weeks of starting Thriomesar Tablet. But to notice the full effects of Thriomesar Tablet, it may take up to 8 weeks.

You are recommended to take the first dose before bedtime, as Thriomesar Tablet can cause dizziness. After the first dose, you can take Thriomesar Tablet at any time of day, but it’s essential to take it at the same time each day for consistency and to help you remember.

You may feel dizzy after taking Thriomesar Tablet as it is one of its side effects. Avoid driving if you feel dizzy. This condition doesn’t require any medical treatment as it will gradually reduce over time. Consult your doctor, if the condition persists longer.

Thriomesar Tablet does not usually cause weight gain. Change your lifestyle and maintain a balanced diet if you observe any changes in your weight. However, in rare cases, chronic diarrhea with weight loss may occur. If the patient experiences diarrhea while taking Thriomesar Tablet and the cause is unknown, consult a doctor.

Thriomesar Tablet includes side effects such as painful joints, fast heartbeat, skin rash or itchiness, chest tightness, shortness of breath, weak muscles, swelling of feet, hands, or ankles. Please, consult your doctor if you experience any of these side effects.

Take the Thriomesar Tablet whole with a glass of water; do not crush or chew it. To help you remember, try to take it at the same time every day.

Before taking Thriomesar Tablet, inform your doctor if you have kidney, liver or heart disease, diabetes, or asthma. Also, let your doctor know about all the medications you might be taking.

You are recommended to be cautious while driving or operating machinery after taking Thriomesar Tablet as it may cause drowsiness which affects the driving ability.

Inform your doctor about all the medications you are currently taking, as Thriomesar Tablet may interact with other drugs, potentially causing harmful reactions. It may interact with medications such as antidepressants (lithium), heart rhythm drugs (digoxin), blood thinners (aspirin), antidiabetics (metformin, insulin), erectile dysfunction treatments (sildenafil), cholesterol-lowering drugs (simvastatin), immune-suppressants (cyclosporine), other anti-hypertensives (atenolol), pain relievers (ibuprofen), and ulcer medications (carbenoxolone).

Country of origin

India
Other Info - TH61878

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Sep 17, 2025 | 2:14 PM IST

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Reference

  1. https://www.medicines.org.uk/emc/files/pil.8529.pdf
  2. https://www.drugs.com/uk/pdf/leaflet/1043114.pdf
  3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1994014/
  4. https://www.drugs.com/amlodipine.html
  5. https://www.nhs.uk/medicines/amlodipine/
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