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  3. Thiotis-MR 4 Tablet 10's

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Thiotis-MR 4 Tablet 10's, Pack of 10
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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Thiotis-MR 4 Tablet 10's is used to reduce and relieve orthopaedic, traumatic, and rheumatologic disorders. It helps relieve muscle spasms (painful muscular contractions) associated with degenerative vertebral disorders, vertebral static problems, dorsal pain, low back pain, and torticollis (neck muscle contractions). It contains Paracetamol and Thiocolchicoside, which works by inhibiting certain chemical messengers in the brain known as prostaglandins responsible for pain, inflammation and fever. Also, it acts on the centres of the spinal cord and brain and helps relieve muscle stiffness and improves muscle movements, thereby relieves pain due to muscle spasms. In some cases, it may cause side effects such as diarrhoea, drowsiness or stomach pain.
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Composition :

PARACETAMOL-325MG + THIOCOLCHICOSIDE-4MG

Manufacturer/Marketer :

Heotis Biotech

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Thiotis-MR 4 Tablet 10's

Thiotis-MR 4 Tablet 10's is a combination medication used to reduce and relieve orthopaedic, traumatic,  and rheumatologic disorders. It helps relieve muscle spasms (painful muscular contractions) associated with degenerative vertebral disorders, vertebral static problems, dorsal pain, low back pain, and torticollis (neck muscle contractions). 

Thiotis-MR 4 Tablet 10's is a combination of two drugs: Paracetamol (mild analgesic and antipyretic) and Thiocolchicoside (muscle relaxant). Paracetamol is an analgesic (relieves pain) and antipyretic (reduces fever) that works by inhibiting certain chemical messengers in the brain known as prostaglandins responsible for pain, inflammation and fever. Thiocolchicoside is a muscle relaxant that works on the centres of the spinal cord and brain. This helps relieve muscle stiffness and improves muscle movements, thereby relieves pain due to muscle spasms.

Take Thiotis-MR 4 Tablet 10's as prescribed. Your doctor will advise you on how often you take your tablets based on your medical condition. In some cases, you may experience diarrhoea, drowsiness or stomach pain. Most of these side effects of Thiotis-MR 4 Tablet 10's do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Thiotis-MR 4 Tablet 10's or any other medicines, please tell your doctor. Thiotis-MR 4 Tablet 10's is not recommended for children below 16 years of age. Avoid taking Thiotis-MR 4 Tablet 10's if you are pregnant as it may cause harm to the foetus. Thiotis-MR 4 Tablet 10's is excreted in breast milk. Therefore, Thiotis-MR 4 Tablet 10's is contraindicated in breastfeeding women as it may cause adverse effects on the baby. Inform your doctor if you experience abdominal pain or discomfort, dark urine, itching, fever, weakness, or yellowing of skin and eyes while taking Thiotis-MR 4 Tablet 10's as it indicates liver problems. Do not consume alcohol with Thiotis-MR 4 Tablet 10's as it may increase the risk of liver damage. If you have galactose intolerance, Lapp lactase deficiency, glucose-galactose malabsorption, G-6-PD deficiency (a hereditary condition resulting in low red blood cell counts), fits (epilepsy), muscular hypotonia (decreased muscle tone), flaccid paresis (loose and floppy limbs), kidney or liver diseases, inform your doctor before taking Thiotis-MR 4 Tablet 10's.

Uses of Thiotis-MR 4 Tablet 10's

Treatment of Musculoskeletal pain, Muscle spasms

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Directions for Use

• Take Thiotis-MR 4 Tablet 10's with food to avoid stomach upset or as advised by a doctor.• Follow your doctor's instructions on the dosage and timing of this medication, to ensure the safety.• Swallow the medicine as a whole with glass of water.• Do not crush, break, or chew it.

Medicinal Benefits

Thiotis-MR 4 Tablet 10's is a combination of two drugs, namely: Paracetamol and Thiocolchicoside used to treat pain due to muscle spasms. Paracetamol is an analgesic (relieves pain) and antipyretic (reduces fever) that works by inhibiting the production of certain chemical messengers in the brain known as prostaglandins responsible for pain and fever. Thiocolchicoside is a muscle relaxant that works on the centers of the spinal cord and brain. This helps relieve muscle stiffness and improves muscle movements, thereby relieves pain due to muscle spasms.

How Thiotis-MR 4 Tablet 10's Works

Thiotis-MR 4 Tablet 10's is a combination of two drugs: Paracetamol (mild analgesic and antipyretic) and Thiocolchicoside (muscle relaxant). Paracetamol is an analgesic (relieves pain) and antipyretic (reduces fever) that works by inhibiting certain chemical messengers in the brain known as prostaglandins responsible for pain, inflammation and fever. Thiocolchicoside is a muscle relaxant that works on the centres of the spinal cord and brain. This helps relieve muscle stiffness and improves muscle movements, thereby relieves pain due to muscle spasms.

Storage

Keep Thiotis-MR 4 Tablet 10's out of reach and sight of children.
Side effects of Thiotis-MR 4 Tablet
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Consume more fruits, vegetables, and cruciferous foods like cabbage, kale, and broccoli.
  • Reduced alcohol intake can enhance liver enzyme function.
  • Oxidative stress can be managed by eating foods rich in antioxidants, such as vitamins C and E.
  • Liver function tests regularly can help manage increased levels of AST.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
  • Rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
Here are the seven steps to manage medication-triggered Dyspnea (Difficulty Breathing or Shortness of Breath):
  • Tell your doctor immediately if you experience shortness of breath after taking medication.
  • Your doctor may adjust the medication regimen or dosage or give alternative medical procedures to minimize the symptoms of shortness of breath.
  • Monitor your oxygen levels and breathing rate regularly to track changes and potential side effects.
  • For controlling stress and anxiety, try relaxation techniques like deep breathing exercises, meditation, or yoga.
  • Make lifestyle changes, such as quitting smoking, exercising regularly, and maintaining a healthy weight.
  • Seek emergency medical attention if you experience severe shortness of breath, chest pain, or difficulty speaking.
  • Follow up regularly with your doctor to monitor progress, adjust treatment plans, and address any concerns or questions.

What if I have taken an overdose of Thiotis-MR 4 Tablet 10's

Do not take more than the prescribed dose of Thiotis-MR 4 Tablet 10's as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.

Drug Warnings

If you are allergic to Thiotis-MR 4 Tablet 10's or any other medicines, please tell your doctor. Thiotis-MR 4 Tablet 10's is not recommended for children below 16 years of age. Avoid taking Thiotis-MR 4 Tablet 10's if you are pregnant as it may cause harm to the fetus. Thiotis-MR 4 Tablet 10's is excreted in breast milk, so Thiotis-MR 4 Tablet 10's is contraindicated in breastfeeding women as it may cause adverse effects in the baby. Inform your doctor if you experience abdominal pain or discomfort, dark urine, itching, fever, weakness, yellowing of skin and eyes while taking Thiotis-MR 4 Tablet 10's as it indicates liver problems. Do not consume alcohol with Thiotis-MR 4 Tablet 10's as it may increase the risk of liver damage and gastrointestinal bleeding. If you have galactose intolerance, Lapp lactase deficiency, glucose-galactose malabsorption, G-6-PD deficiency (a hereditary condition resulting in low red blood cell counts), epilepsy (fits), muscular hypotonia (decreased muscle tone), flaccid paresis (loose and floppy limbs), kidney or liver diseases, inform your doctor before taking Thiotis-MR 4 Tablet 10's.

Drug-Drug Interactions

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ParacetamolLeflunomide
Severe
ParacetamolMipomersen
Severe

Drug-Drug Interactions

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ParacetamolLeflunomide
Severe
How does the drug interact with Thiotis-MR 4 Tablet:
Co-administration of Thiotis-MR 4 Tablet and Leflunomide may increase the risk of liver problems.

How to manage the interaction:
Although there is a possible interaction between Thiotis-MR 4 Tablet and Leflunomide, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
ParacetamolMipomersen
Severe
How does the drug interact with Thiotis-MR 4 Tablet:
Co-administration of Mipomersen with Thiotis-MR 4 Tablet may increase the risk or severity of liver injury.

How to manage the interaction:
There may be a possibility of interaction between Thiotis-MR 4 Tablet and Mipomersen, but it can be taken if prescribed by a doctor. Do not stop using any medications without talking to a doctor.
ParacetamolOxazepam
Severe
How does the drug interact with Thiotis-MR 4 Tablet:
Co-administration of Thiotis-MR 4 Tablet may decrease the excretion rate of Oxazepam which could result in a higher serum level.

How to manage the interaction:
Although there is a possible interaction between Oxazepam and Thiotis-MR 4 Tablet, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without a doctor's advice.
ParacetamolKetoconazole
Severe
How does the drug interact with Thiotis-MR 4 Tablet:
Co-administration of Thiotis-MR 4 Tablet and Ketoconazole may increase the risk of liver injury.

How to manage the interaction:
Although there is a possible interaction between Thiotis-MR 4 Tablet and Ketoconazole, you can take these medicines together if prescribed by a doctor. However, if you have joint pain or swelling, fever, chills, unusual bleeding or bruising, skin rash, itching, over-tiredness, nausea, vomiting, loss of appetite, stomach pain, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes, contact a doctor immediately as these may be signs and symptoms of liver damage. Do not discontinue the medication without consulting a doctor.
ParacetamolTeriflunomide
Severe
How does the drug interact with Thiotis-MR 4 Tablet:
Co-administration of Teriflunomide with Thiotis-MR 4 Tablet may increase the risk or severity of Liver problems.

How to manage the interaction:
Taking Thiotis-MR 4 Tablet with Teriflunomide together can possibly result in an interaction, but it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
ParacetamolValdecoxib
Severe
How does the drug interact with Thiotis-MR 4 Tablet:
Co-administration of Thiotis-MR 4 Tablet and Valdecoxib may increase the risk or severity of adverse effects.

How to manage the interaction:
Although there is a possible interaction between Thiotis-MR 4 Tablet and Valdecoxib, you can take these medicines together if prescribed by a doctor. However, if the side effects worsen, please consult a doctor.
ParacetamolLomitapide
Severe
How does the drug interact with Thiotis-MR 4 Tablet:
Co-administration of Lomitapide and Thiotis-MR 4 Tablet may increase the risk of severity of liver injury.

How to manage the interaction:
Although there is a possible interaction between Thiotis-MR 4 Tablet and Lomitapide, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without a doctor's advice.
ParacetamolKetamine
Severe
How does the drug interact with Thiotis-MR 4 Tablet:
Co-administration of ketamine and Thiotis-MR 4 Tablet may decrease the effectiveness of Ketamine which could result in a higher blood level.

How to manage the interaction:
Although taking Ketamine and Thiotis-MR 4 Tablet together can evidently cause an interaction, it can be taken if a doctor has suggested it. If you're feeling very sleepy or having trouble breathing, it's important to contact your doctor right away. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Regular exercise helps in muscle stretching so that they are less likely to spasm, tear and sprain. Mild exercises such as jogging and walking are helpful for muscle stretching.
  • Avoid wearing tight-fitting clothes, instead, wear loose garments.
  • Rest well, and get plenty of sleep for at least 8 hours. 
  • To avoid developing pressure sores, change your position at least every two hours.
  • Hot or cold therapy can help treat muscle spasms. Apply an ice pack or hot-pack to the muscle for 15-20 minutes. 

Habit Forming

No

Therapeutic Class

MUSCLE RELAXANTS

Thiotis-MR 4 Tablet 10's Substitute

Substitutes safety advice
bannner image

Alcohol

Unsafe

You are recommended to avoid consumption of alcohol with Thiotis-MR 4 Tablet 10's as it may increase the risk of liver damage.

bannner image

Pregnancy

Unsafe

Thiotis-MR 4 Tablet 10's is not recommended for pregnant women as it may cause harm to the foetus. However, please consult your doctor if you are pregnant.

bannner image

Breast Feeding

Unsafe

Avoid breastfeeding while taking Thiotis-MR 4 Tablet 10's as it may be excreted in breast milk and cause adverse effects in the baby. However, please consult a doctor if you are breastfeeding.

bannner image

Driving

Caution

Thiotis-MR 4 Tablet 10's may cause drowsiness in some people. Therefore, avoid driving if you feel drowsy after taking Thiotis-MR 4 Tablet 10's.

bannner image

Liver

Caution

Take Thiotis-MR 4 Tablet 10's with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required.

bannner image

Kidney

Caution

Take Thiotis-MR 4 Tablet 10's with caution, especially if you have a history of Kidney diseases/conditions. The dose may be adjusted by your doctor as required.

bannner image

Children

Unsafe

Thiotis-MR 4 Tablet 10's is not recommended for children as the safety and effectiveness were not established.

FAQs

Thiotis-MR 4 Tablet 10's is used to reduce and relieve orthopaedic, traumatic, and rheumatologic disorders. It helps relieve muscle spasms (painful muscular contractions) associated with degenerative vertebral disorders, vertebral static problems, dorsal pain, low back pain, and torticollis (neck muscle contractions).

Thiotis-MR 4 Tablet 10's contains Paracetamol and Thiocolchicoside. Paracetamol is an analgesic (relieves pain) and antipyretic (reduces fever) that works by inhibiting the production of certain chemical messengers in the brain known as prostaglandins responsible for pain and fever. Thiocolchicoside is a skeletal muscle relaxant that works on the centers of the spinal cord and brain. This helps relieve muscle stiffness and improves muscle movements, thereby relieves pain due to muscle spasms.

Thiotis-MR 4 Tablet 10's may affect sperm cells and thereby causes problems with male fertility. Therefore, please consult your doctor before taking Thiotis-MR 4 Tablet 10's.

Thiotis-MR 4 Tablet 10's may cause diarrhoea as a side effect. It is not necessary for everyone taking Thiotis-MR 4 Tablet 10's to experience this side effect. However, if the condition persists or worsens, please consult a doctor.

You are not recommended to take Thiotis-MR 4 Tablet 10's with warfarin (blood thinner) as co-administration of these two medicines may increase bleeding risk. So you are advised to contact your doctor so that the dose may be adjusted appropriately to use safely.

Thiotis-MR 4 Tablet 10's may trigger episodes of epilepsy (fits), especially in patients who are at risk for fits or those suffering from fits. Therefore, please inform your doctor if you have a history of fits before taking Thiotis-MR 4 Tablet 10's.

You are recommended to use Thiotis-MR 4 Tablet 10's for as long as your doctor has prescribed it. However, if the symptoms persist even after using Thiotis-MR 4 Tablet 10's for 7 days, stop taking Thiotis-MR 4 Tablet 10's and consult a doctor.

Though Thiotis-MR 4 Tablet 10's contains paracetamol it is not used to reduce fever. Thiotis-MR 4 Tablet 10's is used to relieve musculoskeletal pain and spasms.

Thiotis-MR 4 Tablet 10's may cause side effects like diarrhoea, drowsiness or stomach pain. Most of these side effects of Thiotis-MR 4 Tablet 10's do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Thiotis-MR 4 Tablet 10's should be swallowed as a whole with water; do not crush or chew it.

Thiotis-MR 4 Tablet 10's may cause drowsiness in some people. Therefore, avoid driving if you feel drowsy after taking Thiotis-MR 4 Tablet 10's. You are recommended to avoid consumption of alcohol with Thiotis-MR 4 Tablet 10's as it may increase the risk of liver damage.

Thiotis-MR 4 Tablet 10's is not recommended for children as the safety and effectiveness were not established.

Country of origin

India

Manufacturer/Marketer address

3607, B Type, Tamilnadu Housing Board, Avadi, TNHB, Avadi, Tiruvallur-600054, Tamil Nadu, India
Other Info - THI0522

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Author Details

Veda MaddalaDoctor badge

Written By

Veda Maddala

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 6:43 AM IST

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Reference

  1. https://www.sanofi.in/-/media/Project/One-Sanofi-Web/Websites/Asia-Pacific/Sanofi-IN/Home/science-and-innovation/for-healthcare-professionals/product-information/Myoril.pdf?la=en
  2. https://www.ema.europa.eu/en/documents/referral/thiocolchicoside-article-31-referral-annex-iii_en.pdf
  3. https://iasispharma.com/wp-content/uploads/pdf/RELIEF_PIL_ENG.pdf
  4. https://www.medicines.org.uk/emc/files/pil.11899.pdf
  5. https://www.drugs.com/paracetamol.html

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