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compositionComposition:THIOPENTAL SODIUM-500MG
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Prescription Medicine
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Thiosol Sodium 500mg Injection is indicated for initiating general anaesthesia (a state of heavy sleep), providing hypnosis (partial sleepiness), treating cramps, and reducing pressure in the skull in patients with increased pressure (if respiratory assistance is provided). It is also used to control seizures. It contains Thiopental sodium, which works by slowing the activity of the brain or nervous system. It creates a sleep-like state and loss of consciousness to prevent pain and discomfort during surgery.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

THIOPENTAL SODIUM-500MG

Manufacturer/Marketer :

Neon Laboratories Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Thiosol Sodium 500mg Injection

Thiosol Sodium 500mg Injection is an injectable medicine used to help patients fall asleep before surgery or other medical procedures. It is also used to control severe, ongoing seizures and to lower high pressure inside the skull during medical emergencies. This medicine belongs to a class of medications that calm down excessive brain and nerve activity.

Because this medicine is an injection given for specific medical procedures, it is not used on a daily schedule. It is injected directly into a vein by a trained healthcare professional, meaning you do not need to worry about taking it with or without food. However, your surgical team will give you specific fasting guidelines, such as avoiding food or drink for several hours before your procedure, to ensure the medicine can be given safely.

While receiving Thiosol Sodium 500mg Injection, you may experience temporary side effects like shivering, coughing, or feeling sleepy as you wake up. Your medical team will monitor you closely, but you must tell them immediately if you feel severe breathing difficulties, chest tightness, or extreme dizziness. Consulting your doctor about any unexpected symptoms after waking up is vital for a safe recovery.

Do not receive this medicine if you have certain health conditions like severe heart disease, status asthmaticus, or a rare blood disorder called porphyria. 

Before your procedure, tell your doctor if you have liver damage, kidney issues, severe asthma, or muscle weakness disorders. Discussing these conditions beforehand helps your medical team adjust your care plan safely.

This medicine can interact with other substances, including alcohol, sleeping pills, and some blood pressure medications, which can cause your breathing or heart rate to slow down dangerously. It is important to tell your doctor about all the medications you use, including herbal supplements. If you are pregnant, breastfeeding, or an older adult, talk to your doctor or pharmacist about the risks and benefits of receiving this medicine.
 

Uses of Thiosol Sodium 500mg Injection

Your doctor may use Thiosol Sodium 500mg Injection for the following conditions: 

  • Inducing general anaesthesia: Thiosol Sodium 500mg Injection helps patients fall asleep quickly and smoothly before undergoing surgical operations.
  • Controlling severe seizures: It works rapidly to halt continuous, life-threatening seizures when other standard treatments fail.
  • Reducing brain pressure: It is used in critical care settings to lower high pressure inside the skull caused by head injuries or brain swelling.
  • Providing deep sedation: It helps calm the nervous system during short, specialised medical procedures that require you to remain completely still.
     

Key Benefits

When used as directed as part of your treatment plan, Thiosol Sodium 500mg Injection may provide the following benefits:

  • Rapid onset of sleep: Because it is injected directly into the bloodstream, Thiosol Sodium 500mg Injection works within seconds. This helps minimise pre-surgery anxiety by allowing you to drift into a deep sleep almost instantly.
  • Effective brain protection: By calming down hyperactive brain cells, this medicine helps reduce the amount of oxygen the brain needs. This protection is vital during neurological emergencies or severe head injuries.
  • Reliable emergency control: In life-threatening seizure states, this medicine acts as a fast-acting emergency brake, helping to stop harmful brain storms and protecting the nervous system from long-term damage.
     

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication.
  • healthcare professional trained in anesthesiology will administer Thiosol Sodium 500mg Injection.
  • Do not self-administer it.

How Thiosol Sodium 500mg Injection Works

Thiosol Sodium 500mg Injection contains thiopental sodium. It works by slowing down the communication lines within your brain and central nervous system. It targets specific microscopic docking sites in the brain called GABA receptors, which act as your body's natural soothing system. When the medicine attaches to these sites, it amplifies the calming signals, shutting down rapid electrical pathways. This sudden calming effect stops abnormal electrical surges, which is why it can instantly halt a severe seizure. At the same time, it relaxes your muscles and reduces brain activity, allowing you to fall into a deep, pain-free sleep. By lowering brain activity, it also reduces blood flow to the head, which effectively lowers dangerous pressure inside the skull.
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Alcohol

Caution

The dose of Thiosol Sodium 500mg Injection may need to be adjusted if you are addicted to alcohol or regularly consume large amounts of alcohol. Inform the doctor if you consume alcohol.

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Pregnancy

Caution

Thiopental sodium belongs to pregnancy category C. It should be used during pregnancy only if clearly needed.

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Breast Feeding

Unsafe

Thiopental sodium passes into breast milk. Avoid breastfeeding for at least 12 hours after receiving Thiosol Sodium 500mg Injection.

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Driving

Unsafe

Thiosol Sodium 500mg Injection has a major influence on your ability to drive and use machines. Therefore, avoid driving and operating machinery for 24 to 36 hours after receiving Thiosol Sodium 500mg Injection.

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Liver

Caution

If you have a history of liver impairment, inform the doctor before receiving Thiosol Sodium 500mg Injection. Your doctor may adjust the dose depending on your condition.

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Kidney

Caution

If you have a history of kidney impairment, inform the doctor before receiving Thiosol Sodium 500mg Injection. Your doctor may adjust the dose depending on your condition.

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Children

Caution

Please consult the doctor if you have any concerns regarding the usage of Thiosol Sodium 500mg Injection in children. The doctor may adjust the dose depending on the condition.

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Heart

Caution

Thiosol Sodium 500mg Injection should be used with extreme caution in heart patients due to risks like hypotension and cardiac depression. If necessary, it must be administered under strict medical supervision with continuous monitoring.

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Geriatrics

Caution

Thiosol Sodium 500mg Injection can be used in geriatric patients, but with reduced doses and careful monitoring, as older adults metabolize the drug more slowly and are more sensitive to its effects. Medical supervision is essential to avoid complications like respiratory depression or prolonged sedation.

What if I have taken an overdose of Thiosol Sodium 500mg Injection

Because this medicine is given under strict clinical supervision, an overdose is extremely rare. If an excess amount is injected, the medical team is fully equipped to handle it immediately. They will provide breathing support, oxygen, and medications to stabilise your blood pressure and heart rate. If you suspect any unusual symptoms after a procedure, talk to your doctor or pharmacist.

Diet & Lifestyle Advise

Follow strict fasting rules: Do not eat or drink anything for the exact number of hours specified by your surgical team before your procedure. This helps prevent serious complications like stomach contents entering your lungs while you are aslee

  • Follow strict fasting rules: Do not eat or drink anything for the exact number of hours specified by your surgical team before your procedure. This helps prevent serious complications like stomach contents entering your lungs while you are asleep.
  • Arrange a safe ride home: Plan to have a family member or friend drive you home after your procedure. You should not drive or travel alone, as your coordination and alertness will be affected for several hours.
  • Plan for full rest: Set aside at least 24 hours after receiving Thiosol Sodium 500mg Injection to rest completely. Avoid making major decisions, signing legal documents, or operating any machinery during this recovery window.
  • Avoid sedatives and alcohol: Do not consume alcohol or take any over-the-counter sleep aids or calming supplements for at least 24 hours after your injection, as they can cause severe drowsiness.
     
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How Soon It Starts Working

The time required for Thiosol Sodium 500mg Injection to start to work: Thiosol Sodium 500mg Injection ideally shows its action within 15 to 30 seconds after administration. The time for which the effects of Thiosol Sodium 500mg Injection last: The effect of Thiosol Sodium 500mg Injection lasts for 5 to 10 minutes.

What if you forget to take Thiosol Sodium 500mg Injection

Since this medicine is injected only by healthcare professionals in a hospital setting for specific procedures, you do not need to worry about missing a dose. The medical team will manage your schedule precisely.

Storage

• Unopened vials of this medicine are stored in a controlled clinical environment at room temperature, between 20°C and 25°C (68°F to 77°F). They must be kept away from excessive heat, moisture, and direct light to maintain their stability.

Drug Warnings

  • Check the liquid: Always ensure the healthcare provider inspects the solution before use; it should be clear, colourless to pale yellow, and completely free of any visible floating particles or cloudiness.
  • Report burning immediately: Tell your medical provider right away if you feel any burning, stinging, or sharp pain where the needle is inserted, as this can mean the liquid is leaking into surrounding tissues.
  • Declare your medical history: Ensure your surgical team knows if you or anyone in your family has ever had porphyria, as this medicine can trigger life-threatening attacks in people with this genetic condition.
  • Keep a list of your medicines: Provide your anaesthesiologist with a complete list of all prescriptions, over-the-counter drugs, and herbal products you have used recently.
  • Wait before breastfeeding: If you are breastfeeding, ask your doctor how long you should wait to resume feeding after receiving Thiosol Sodium 500mg Injection, as small amounts of the medicine can pass into breast milk.
     

Drug-Drug Interactions

verifiedApollotooltip

Central nervous system depressants: Medicines like opioid pain relievers, sleeping pills, muscle relaxants, and anxiety drugs can greatly increase the risk of extreme drowsiness and dangerously slow breathing when combined with $nam

  • Central nervous system depressants: Medicines like opioid pain relievers, sleeping pills, muscle relaxants, and anxiety drugs can greatly increase the risk of extreme drowsiness and dangerously slow breathing when combined with Thiosol Sodium 500mg Injection.
  • Blood pressure medicines: Taking certain blood pressure-lowering medications right before receiving this injection can cause a sudden, severe drop in your blood pressure.
     
ThiopentalTranylcypromine
Critical
ThiopentalSelegiline
Critical

Drug-Drug Interactions

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ThiopentalTranylcypromine
Critical
How does the drug interact with Thiosol Sodium 500mg Injection:
Co-administration of tranylcypromine and Thiosol Sodium 500mg Injection may significantly affect your blood pressure.

How to manage the interaction:
Taking tranylcypromine with Thiosol Sodium 500mg Injection is not recommended as it can possibly result in an interaction. However, consult your doctor if you experience any unusual symptoms. Do not discontinue any medications without consulting a doctor.
ThiopentalSelegiline
Critical
How does the drug interact with Thiosol Sodium 500mg Injection:
Co-administration of Selegiline with Thiosol Sodium 500mg Injection can reduce blood pressure.

How to manage the interaction:
Taking Selegiline with Thiosol Sodium 500mg Injection together can possibly result in an interaction, but it can be taken if a doctor has advised it. In case you experience any symptoms like lightheadedness, blurred vision, fainting or confusion, consult a doctor. Do not discontinue any medications without consulting a doctor.
ThiopentalTirzepatide
Severe
How does the drug interact with Thiosol Sodium 500mg Injection:
Tirzepatide is one medication that can cause your stomach to empty more slowly. Even if you follow your doctor's orders to fast, you can still have stomach contents if you have a surgery or treatment that calls for general anesthesia with Thiosol Sodium 500mg Injection. This may make indigestion more likely while under anesthesia.

How to manage the interaction:
The doctor may advise you to temporarily stop taking tirzepatide beforehand, or they may take extra precautions during anesthesia and your operation or procedure to reduce the dangers, depending on your condition and unique situation. If you have any queries or worries, speak with your physician. Your physician might be able to recommend substitutes that don't compromise the security of your anesthetic.
ThiopentalWarfarin
Severe
How does the drug interact with Thiosol Sodium 500mg Injection:
Taking warfarin and Thiosol Sodium 500mg Injection can reduce the blood levels of warfarin, which may make the medication less effective.

How to manage the interaction:
Although taking Thiosol Sodium 500mg Injection together with Warfarin can result in an interaction, they can be taken together if prescribed by a doctor. However, if you experience chest pain, shortness of breath, sudden loss of vision, pain, redness, or swelling in an extremity, consult a doctor immediately. Do not discontinue any medicine without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Alcohol: Drinking alcohol before or shortly after your procedure can severely multiply the sedative effects of this medicine, leading to dangerous breathing difficulties and extreme drowsiness.
     
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

Yes

Therapeutic Class

[GENERAL ANESTHETICS]

FAQs

Thiosol Sodium 500mg Injection is used for initiating general anaesthesia (a state of heavy sleep), providing hypnosis (partial sleepiness), treating cramps, and reducing pressure in the skull in patients with increased pressure (if respiratory assistance is provided). It is also used to control seizures.
Thiosol Sodium 500mg Injection works by slowing the activity of the brain or nervous system. Thereby, it prevents pain and discomfort during surgery.
Thiosol Sodium 500mg Injection may cause low blood pressure. Therefore, if you have hypotension/low blood pressure, inform the doctor.
Thiosol Sodium 500mg Injection may cause breathing difficulty. However, consult the doctor immediately if you experience difficulty breathing, rash, wheezing, hives, itching, and dizziness, as these may be signs of a severe allergic reaction.
You may feel a slight pinch when the intravenous line is placed, and sometimes a mild warm or stinging sensation as the medicine is injected. However, because it works so quickly, you will fall asleep almost immediately and will not feel any pain during your procedure. Talk to your doctor if you are anxious about the injection.
No, this medicine cannot be used at home. It must only be injected by trained healthcare professionals in a hospital or specialised clinic where advanced monitoring and breathing equipment are readily available. Talk to your doctor for more information on how your treatment is managed.
The initial sleep-inducing effect is very short, usually lasting only 5 to 10 minutes as the medicine moves from your brain into other body tissues. However, you may continue to feel drowsy, dizzy, or lightheaded for several hours afterward. Talk to your doctor about your specific recovery time.
This medicine is generally reserved for pregnant women only when the potential benefits outweigh the risks, such as during emergency surgeries or caesarean sections. It can cross the placenta and affect the baby's breathing. Talk to your doctor if you are pregnant or planning to become pregnant.
You must tell your doctor about your complete medical history, especially if you have severe asthma, heart disease, liver damage, kidney issues, or a genetic condition called porphyria. You should also share a list of all medications and supplements you take. Talk to your doctor if you have any concerns.
No, you must not drink alcohol for at least 24 hours after receiving this injection. Alcohol can interact dangerously with the lingering medicine in your body, leading to extreme drowsiness and slow breathing. Talk to your doctor or pharmacist about safe recovery practices.
If the medicine leaks into the surrounding tissues, it can cause severe irritation, burning, and potential tissue damage. The medical team will monitor the injection site closely and treat it immediately if any leakage occurs. Talk to your doctor or nurse right away if you feel any sudden pain during the injection.

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Country of origin

INDIA

Manufacturer/Marketer address

140, Damji Samji Industrial Complex, Mahakali Caves Rd., Andheri(East), Mumbai-93.
Other Info - THI0012
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