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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Thiole D 2mg/37.5mg Injection is used to treat acute musculoskeletal pain and muscle spasms. It contains Diclofenac and Thiocolchicoside. Diclofenac is a non-steroidal anti-inflammatory drug (pain killer/NSAID) with analgesic properties. It inhibits cyclo-oxygenase (COX) enzymes and further prevents the formation of chemical messengers, 'prostaglandins' (PGs), that cause pain and swelling at the injured or damaged site. Thiocolchicoside is a muscle relaxant that works on the spinal cord and brain centres. This process helps reduce muscle stiffness and improves muscle movements, thus relieving pain due to muscle spasms.
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Manufacturer/Marketer :

Zodley Pharmaceuticals Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

About Thiole D 2mg/37.5mg Injection

Thiole D 2mg/37.5mg Injection is a combination medication primarily used to treat acute musculoskeletal pain and muscle spasms. Pain is a symptom triggered by the nervous system, causing uncomfortable sensations in the body.

Thiole D 2mg/37.5mg Injection is a combination of Diclofenac and Thiocolchicoside. Diclofenac is a non-steroidal anti-inflammatory drug (pain killer/NSAID) with analgesic properties. It inhibits cyclo-oxygenase (COX) enzymes and further prevents the formation of chemical messengers, 'prostaglandins' (PGs), that cause pain and swelling at the injured or damaged site. Thiocolchicoside is a muscle relaxant that works on the centres of the spinal cord and brain. This process helps reduce muscle stiffness and improves muscle movements, thus relieving pain due to muscle spasms.

A healthcare professional will administer this medicine. Common side effects of Thiole D 2mg/37.5mg Injection include headache, stomach upset, constipation, dizziness, drowsiness, diarrhoea, pain, swelling, and redness at the injection site. These side effects are not familiar to everyone and vary individually. However, if the side effects are persistent, please consult your doctor.

Before starting Thiole D 2mg/37.5mg Injection, inform your doctor if you have any liver, heart or kidney diseases, high blood pressure, diabetes, stomach ulcers, asthma, and auto-immune conditions like systemic lupus erythematosus. Pregnant and breastfeeding women should consult their doctor before using Thiole D 2mg/37.5mg Injection. Avoid consuming alcohol while undergoing treatment with Thiole D 2mg/37.5mg Injection. This medicine is not recommended for children and adolescents below 18 years of age as safety has not been established. However, please seek medical advice.

Uses of Thiole D 2mg/37.5mg Injection

Treatment of Acute musculoskeletal pain and muscle spasms

Directions for Use

• Your doctor will determine the dosage and frequency depending on your condition.• Thiole D 2mg/37.5mg Injection will be administered by a healthcare professional.• Do not self-administer.

Medicinal Benefits

Thiole D 2mg/37.5mg Injection treats acute musculoskeletal pain and muscle spasms. It contains Diclofenac and Thiocolchicoside. Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) and relieves pain. It inhibits cyclo-oxygenase (COX) enzymes that further prevent the formation of chemical messengers called 'prostaglandins' (PGs). These prostaglandins are produced at injury sites and cause pain and swelling. By blocking the COX enzymes' effect, lesser PGs are produced, which reduces mild to moderate pain and inflammation at the injured or damaged site. Thiocolchicoside is a muscle relaxant that works on the centres of the spinal cord and brain. This process helps reduce muscle stiffness and improves muscle movements, thus relieving pain due to muscle spasms.

How Thiole D 2mg/37.5mg Injection Works

Thiole D 2mg/37.5mg Injection is a combination of Diclofenac and Thiocolchicoside. Diclofenac is a non-steroidal anti-inflammatory drug (pain killer/NSAID) with analgesic properties. It inhibits cyclo-oxygenase (COX) enzymes and further prevents the formation of chemical messengers, 'prostaglandins' (PGs), that cause pain and swelling at the injured or damaged site. Thiocolchicoside is a muscle relaxant that works on the centres of the spinal cord and brain. This process helps reduce muscle stiffness and improves muscle movements, thus relieving pain due to muscle spasms.

Storage

• Store in a cool and dry place away from sunlight.
• Keep out of the sight and reach of children.
• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

What if I have taken an overdose of Thiole D 2mg/37.5mg Injection

As Thiole D 2mg/37.5mg Injection is a parenteral formulation administered by experienced medical staff, the chance of overdose may be less. However, if you think there has been an overdose or experiencing any adverse events, get medical care right away.

Drug Warnings

Inform your doctor if you have any liver, heart or kidney diseases, high blood pressure, diabetes, stomach ulcers, gastrointestinal diseases, asthma, and autoimmune diseases (systemic lupus erythematosus) before being treated with Thiole D 2mg/37.5mg Injection. Please consult your doctor before starting Thiole D 2mg/37.5mg Injection if you have high cholesterol, chickenpox, porphyria (rare inherited disorder), hereditary disorders like Lapp lactase deficiency (lactose intolerance), galactose intolerance, glucose-galactose malabsorption (small intestines not being able to absorb and use glucose and galactose), fits, and blood clotting disorders. Do not take any other NSAIDs for pain relief along with Thiole D 2mg/37.5mg Injection unless prescribed. Stop using Thiole D 2mg/37.5mg Injection and consult your doctor immediately if you have stomach pain or any signs of bleeding in the intestine or stomach, such as blood in stools. Thiole D 2mg/37.5mg Injection is not recommended for pregnant and breastfeeding women; hence, please seek medical advice. This medicine may cause dizziness and drowsiness, so drive only if you are alert and focused. Thiole D 2mg/37.5mg Injection is not recommended in children and adolescents below 18 years as safety and efficacy are not established.

Drug-Drug Interactions

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DiclofenacVorapaxar
Severe

Drug-Drug Interactions

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How does the drug interact with Thiole D 2mg/37.5mg Injection:
Co-administration of Thiole D 2mg/37.5mg Injection with Meloxicam can increase the risk or severity of gastrointestinal side effects.

How to manage the interaction:
Taking Meloxicam with Thiole D 2mg/37.5mg Injection is not recommended as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, consult your doctor immediately if you experience symptoms such as dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness. Do not stop any medication without doctor's advise.
DiclofenacVorapaxar
Severe
How does the drug interact with Thiole D 2mg/37.5mg Injection:
Taking Thiole D 2mg/37.5mg Injection with Vorapaxar can increase the risk of bleeding complications.

How to manage the interaction:
There may be a possible interaction between Thiole D 2mg/37.5mg Injection and Vorapaxar, but they can be taken together if your doctor has prescribed them. However, consult your doctor immediately if you experience any unusual bleeding, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headaches. Do not discontinue any medications without consulting your doctor.
How does the drug interact with Thiole D 2mg/37.5mg Injection:
The combined use of Thiole D 2mg/37.5mg Injection and Indomethacin can increase the risk of stomach bleeding and ulcers.

How to manage the interaction:
Co-administration of Thiole D 2mg/37.5mg Injection and Indomethacin can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with Thiole D 2mg/37.5mg Injection:
Coadministration of Thiole D 2mg/37.5mg Injection with Ketoconazole may increase the risk of liver problems.

How to manage the interaction:
There may be a possible interaction between Thiole D 2mg/37.5mg Injection and Ketoconazole, but they can be taken together if a doctor has prescribed them. However, consult a doctor immediately if you have fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark colored urine, light colored stools, and/or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Thiole D 2mg/37.5mg Injection:
Co-administration of Thiole D 2mg/37.5mg Injection and deferasirox may increase your risk of developing stomach bleeding.

How to manage the interaction:
There may be a possible interaction between Thiole D 2mg/37.5mg Injection and deferasirox but they can be taken together if your doctor has prescribed them. However, consult your doctor immediately if you experience symptoms such as severe abdominal pain, bloating, sudden dizziness or lightheadedness, nausea, vomiting (especially with blood), loss of appetite, and/or black, tarry stools, increased or decreased urination, fluid retention, swelling, shortness of breath, muscle cramps, weakness, confusion, and irregular heart rhythm. Do not stop using any medications without first talking to your doctor.
How does the drug interact with Thiole D 2mg/37.5mg Injection:
Co-administration of Rivaroxaban together with Thiole D 2mg/37.5mg Injection may increase the risk of unsual bleeding.

How to manage the interaction:
Co-administration of Thiole D 2mg/37.5mg Injection and Rivaroxaban can lead to an interaction; it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult your doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with Thiole D 2mg/37.5mg Injection:
Taking amiloride with Thiole D 2mg/37.5mg Injection can increase the risk of kidney problems, hyperkalemia(high potassium levels in blood), and high blood pressure.

How to manage the interaction:
There could be a possible interaction between Thiole D 2mg/37.5mg Injection and amiloride, but they can be taken together if your doctor has prescribed them. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
How does the drug interact with Thiole D 2mg/37.5mg Injection:
Co-administration of Thiole D 2mg/37.5mg Injection with Celecoxib may increase the risk of stomach bleeding and ulcers.

How to manage the interaction:
Although there is a interaction between Thiole D 2mg/37.5mg Injection and Celecoxib, but it can be taken if your doctor has advised it. Consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), severe bruising, prolonged nosebleeds, feeling dizzy or lightheaded, weakness or severe headache, vomiting blood or coughing up blood, heavy menstrual bleeding (in women), difficulty breathing, or chest pain. Do not discontinue any medication without consulting a doctor.
DiclofenacPonatinib
Severe
How does the drug interact with Thiole D 2mg/37.5mg Injection:
Taking Thiole D 2mg/37.5mg Injection with Ponatinib can increase the risk of bleeding complications.

How to manage the interaction:
There may be a possible interaction between Thiole D 2mg/37.5mg Injection and Ponatinib, but they can be taken together if your doctor has prescribed them. However, consult your doctor immediately if you experience any unusual bleeding, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headaches. Do not discontinue any medications without consulting your doctor.
How does the drug interact with Thiole D 2mg/37.5mg Injection:
Taking Thiole D 2mg/37.5mg Injection with Panobinostat can increase the risk of bleeding complications.

How to manage the interaction:
There may be a possible interaction between Thiole D 2mg/37.5mg Injection and Panobinostat, but they can be taken together if your doctor has prescribed them. However, consult your doctor immediately if you experience any unusual bleeding or have other signs of bleeding like dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headaches. Do not discontinue any medications without consulting your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Exercising regularly helps in muscle stretching, reducing spasm, tear and sprain incidence. Mild exercises, such as jogging and walking, are helpful for muscle stretching.
  • Massages can also be helpful to ease the pain.
  • Avoid wearing tight-fitting clothes; wear loose garments for proper blood circulation.
  • Rest well and get plenty of sleep.
  • Hot or cold therapy can help treat muscle spasms. Apply an ice or hot pack on the muscle for 15-20 minutes.
  • Stay hydrated; drink plenty of water.

Habit Forming

No

Therapeutic Class

MUSCLE RELAXANTS
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Alcohol

Caution

Please seek medical advice if you have a regular alcohol intake habit before taking Thiole D 2mg/37.5mg Injection

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Pregnancy

Unsafe

Thiole D 2mg/37.5mg Injection is not recommended during pregnancy as it may harm your developing baby. Please consult your doctor for more information.

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Breast Feeding

Unsafe

Thiole D 2mg/37.5mg Injection is not recommended during breastfeeding as it may be excreted in breast milk. Please consult your doctor for more information.

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Driving

Caution

Thiole D 2mg/37.5mg Injection may make you feel dizzy and sleepy. Do not drive or operate machinery if you experience dizziness or drowsiness after taking Thiole D 2mg/37.5mg Injection.

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Liver

Caution

Thiole D 2mg/37.5mg Injection should be used cautiously in patients with liver impairment/liver disease. If you have liver disease, please inform your doctor before receiving this medicine.

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Kidney

Caution

Thiole D 2mg/37.5mg Injection should be used cautiously in patients with kidney impairment/liver disease. If you have kidney disease, please inform your doctor before receiving this medicine.

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Children

Unsafe

Thiole D 2mg/37.5mg Injection is not recommended for use in children as the safety and efficacy data are not established. Please seek medical advice for more information.

Have a query?

FAQs

Thiole D 2mg/37.5mg Injection is used to treat Acute musculoskeletal pain and muscle spasms.

Thiole D 2mg/37.5mg Injection contains Diclofenac and Thiocolchicoside. Diclofenac works by blocking the action of certain chemical messengers that cause pain and inflammation at the injured or damaged site. Thiocolchicoside is a muscle relaxant which relieves muscle stiffness due to muscle spasms and improves muscle movements.

Diarrhoea can be a side-effect of Thiole D 2mg/37.5mg Injection. Drink enough fluids and eat fibre-rich food if you experience diarrhoea. If you find blood in the stools (tarry stools) or experience excess diarrhoea, consult your doctor. Do not take anti-diarrhoeal medicine on your own.

Using other NSAIDs or painkillers is not advised while using Thiole D 2mg/37.5mg Injection. Please seek medical advice for further information.

You are not recommended to take Thiole D 2mg/37.5mg Injection with warfarin as simultaneous use of these two medicines may increase the effect of anti-coagulants/blood thinners and cause bleeding risk. Please seek medical advice for more information.

Country of origin

India
Other Info - TH57752

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