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compositionComposition:PALONOSETRON-250MCG
prescriptionPrescription Medicine
Themiset Injection 5 ml
Themiset Injection 5 ml is used to prevent nausea and vomiting during chemotherapy. It contains Palonosetron, which blocks the action of serotonin, a chemical that stimulates the vomiting centre (chemoreceptor trigger zone) located in the brain. Thus, it prevents nausea and vomiting. Common side effects of Themiset Injection 5 ml are diarrhoea, constipation, dizziness or headache.
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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

PALONOSETRON-250MCG

Manufacturer/Marketer :

Themis Medicare Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Themiset Injection 5 ml

Themiset Injection 5 ml belongs to a class of drugs called antiemetics used to prevent nausea and vomiting during chemotherapy. Nausea is a feeling of uneasiness of the stomach that often comes before vomiting. On the other hand, vomiting is the forcible voluntary or involuntary emptying of stomach contents through the mouth.

Themiset Injection 5 ml contains Palonosetron which works by blocking the action of serotonin, a chemical that stimulates the vomiting centre (chemoreceptor trigger zone – CTZ) located in the brain. Thus, it prevents nausea and vomiting.

Themiset Injection 5 ml will be administered by a healthcare professional; do not self-administer. In some cases, you may experience diarrhoea, constipation, dizziness or headache. Most of these side effects of Themiset Injection 5 ml do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Themiset Injection 5 ml or any other medicines, please tell your doctor. Themiset Injection 5 ml may be given to children above 1 month in doses as advised by a doctor based on the child's body weight. If you are pregnant or breastfeeding, please inform your doctor before taking Themiset Injection 5 ml. Drive only if you are alert as Themiset Injection 5 ml may cause tiredness or dizziness. You are recommended to avoid heavy meals and take small nourishing snacks throughout the day. Drink plenty of water to avoid dehydration.

Uses of Themiset Injection 5 ml

Themiset Injection 5 ml is used in the treatment of Nausea and vomiting. The detailed uses of Themiset Injection 5 ml are as follows:

  • Chemotherapy-Induced Nausea and Vomiting (CINV): Themiset Injection 5 ml prevents acute and delayed CINV, providing long-lasting relief and improving patient quality of life during chemotherapy.
  • Postoperative Nausea and Vomiting (PONV): Themiset Injection 5 ml prevents PONV, reducing patient discomfort and promoting smoother recovery after surgery.

Key Benefits

Themiset Injection 5 ml contains Palonosetron which blocks the action of serotonin, a chemical that stimulates the vomiting centre (chemoreceptor trigger zone – CTZ) located in the brain. Thus, it prevents nausea and vomiting during chemotherapy.

Side effects of Themiset Injection 5 ml
Managing Medication-Triggered Anxiety: A Comprehensive Approach:
  • Inform your doctor about your anxiety symptoms so that you doctor may explore potential drug interactions and alter your treatment plan.
  • Work with your doctor to adjust your medication regimen or dosage to minimize anxiety symptoms.
  • Reduce anxiety symptoms by practicing relaxation techniques like meditation, deep breathing, or yoga.
  • Regular self-care activities, such as exercise, healthy food, and adequate sleep, can assist control anxiety.
  • Surround yourself with a supportive network of friends, family, or a support group to help manage anxiety and stay motivated.
  • Regularly track anxiety symptoms and report any changes to your doctor to ensure your treatment plan is effective and adjusted as needed.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Here are the few steps for dealing with itching caused by drug use:
  • Report the itching to your doctor immediately; they may need to change your medication or dosage.
  • Use a cool, damp cloth on the itchy area to help soothe and calm the skin, reducing itching and inflammation.
  • Keep your skin hydrated and healthy with gentle, fragrance-free moisturizers.
  • Try not to scratch, as this can worsen the itching and irritate your skin.
  • If your doctor prescribes, you can take oral medications or apply topical creams or ointments to help relieve itching.
  • Track your itching symptoms and follow your doctor's guidance to adjust your treatment plan if needed. If the itching persists, consult your doctor for further advice.

Directions for Use

  • Themiset Injection 5 ml is administered only in clinical settings by healthcare professionals, usually through intravenous or intramuscular injections.
  • The dosage and timing are decided by the doctor, depending on the cause and severity of symptoms.
  • Do not self-administer this medication.
  • Patients are monitored during and after administration to ensure safety and effective control of symptoms.

How Themiset Injection 5 ml Works

Themiset Injection 5 ml contains Palonosetron which works by blocking the action of serotonin, a chemical that stimulates the vomiting centre (chemoreceptor trigger zone – CTZ) located in the brain. Thus, it prevents nausea and vomiting.
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Alcohol

Caution

The interaction of alcohol with Themiset Injection 5 ml is unknown. Please consult a doctor before consuming alcohol with Themiset Injection 5 ml.

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Pregnancy

Consult your doctor

Themiset Injection 5 ml is given to pregnant women only if the doctor thinks the benefits outweigh the risks. Please inform your doctor if you are pregnant.

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Breast Feeding

Consult your doctor

Please inform your doctor before taking Themiset Injection 5 ml if you are breastfeeding. Themiset Injection 5 ml is given to breastfeeding women only if the doctor thinks the benefits are greater than the risks.

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Driving

Caution

Themiset Injection 5 ml may cause tiredness or dizziness in some people. Therefore, avoid driving or operating heavy machinery if you feel tired or dizzy after taking Themiset Injection 5 ml.

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Liver

Safe if prescribed

Themiset Injection 5 ml may be safe to use in patients with liver problems if prescribed by a doctor. However, if you have any concerns regarding this, please discuss them with your doctor.

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Kidney

Safe if prescribed

Themiset Injection 5 ml may be safe to use in patients with kidney problems if prescribed by a doctor. However, if you have any concerns regarding this, please discuss them with your doctor.

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Children

Caution

Themiset Injection 5 ml may be given to children above 1 month in doses as advised by a doctor based on the child's body weight.

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Heart

Caution

If you have a pre-existing condition or a history of heart disease, inform your doctor before receiving Themiset Injection 5 ml.

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Geriatrics

Consult your doctor

Please consult a doctor if you have any concerns regarding the use of Themiset Injection 5 ml in elderly patients.

What if I have taken an overdose of Themiset Injection 5 ml

As Themiset Injection 5 ml is a parenteral formulation administered by experienced medical staff, the chance of overdose may be less. However, if you think there has been an overdose or experiencing any adverse events, get medical care right away. Overdose of Themiset Injection 5 ml may cause bluish colour of the fingernails, lips, skin, palms, or nail beds, collapse, gasping to breathe, paleness of the skin, and seizures.

Diet & Lifestyle Advise

  • Eat a healthy diet and a low-fat diet, especially in small portions, as it will be easy for digestion. Avoid eating over-sweet food and include more salty food, especially if you have been vomiting.
  • Also, if you like to vomit at a specific time, avoid eating your favourite food at that particular time as your taste for that food may get turned off.
  • Drink any other liquid at least 30 minutes after eating food.
  • If the smell of food makes you feel sick (vomit), do not cook food as it may worsen your condition. Let someone else do the cooking or use prepared food from the freezer.

Have a query?

How Soon It Starts Working

The time required for Themiset Injection 5 ml to start to work: Themiset Injection 5 ml ideally shows its effects in 30 minutes. The time for which the effects of Themiset Injection 5 ml last: Themiset Injection 5 ml effect lasts for a few days.

What if you forget to take Themiset Injection 5 ml

Since it is given in a clinical setting and usually only when needed, missing a dose is unlikely. Your doctor will decide whether it needs to be given or not. Do not try to take the dose on your own.

Storage

• Store in a cool and dry place away from sunlight. • Keep Themiset Injection 5 ml out of reach and sight of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

If you are allergic to Themiset Injection 5 ml or any other medicines, please tell your doctor. Themiset Injection 5 ml may be given to children above 1 month in doses as advised by a doctor based on the child's body weight. If you are pregnant or breastfeeding, please inform your doctor before taking Themiset Injection 5 ml. Drive only if you are alert as Themiset Injection 5 ml may cause tiredness or dizziness. You are recommended to avoid heavy meals and take small nourishing snacks throughout the day. Drink plenty of water to avoid dehydration.

Drug-Drug Interactions

verifiedApollotooltip

Drug-Drug Interaction: Themiset Injection 5 ml may interact with antidepressants (citalopram, fluoxetine, fluvoxamine, paroxetine, sertraline, escitalopram, duloxetine, venlafaxine), heart-related drugs or high blood pressure (quinidine, amiodarone, nicardipine), antibiotics (moxifloxacin, erythromycin), antiemetic (domperidone), antipsychotic drugs (thioridazine, quetiapine, chlorpromazine, haloperidol).

Drug-Food Interaction: No interactions found.

Drug-Disease Interaction: If you have blocked bowel, repeated constipation, heart problems or imbalance of potassium and magnesium in the blood, inform your doctor before taking Themiset Injection 5 ml.

PalonosetronZiprasidone
Critical
PalonosetronFentanyl
Severe

Drug-Drug Interactions

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PalonosetronZiprasidone
Critical
How does the drug interact with Themiset Injection 5 ml:
Combining Themiset Injection 5 ml with Ziprasidone can increase the risk of side effects.

How to manage the interaction:
Taking Ziprasidone with Themiset Injection 5 ml is not recommended, please consult your doctor before taking it.
PalonosetronFentanyl
Severe
How does the drug interact with Themiset Injection 5 ml:
Taking fentanyl with Themiset Injection 5 ml may increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Although taking Fentanyl with Themiset Injection 5 ml can result in an interaction, they can be taken together if prescribed by a doctor. However, if you experience confusion, hallucinations (seeing and hearing things that do not exist), increased heart rate, fever, excessive sweating, muscle pain or stiffness, stomach cramps, vomiting, or diarrhoea, consult a doctor. Do not discontinue any medications without consulting your doctor.
PalonosetronDextromethorphan
Severe
How does the drug interact with Themiset Injection 5 ml:
Co-administration of Dextromethorphan and Themiset Injection 5 ml may increase the risk of serotonin syndrome (A condition in which a chemical called serotonin builds up in your body).

How to manage the interaction:
Although there is a possible interaction between Dextromethorphan and Themiset Injection 5 ml, you can take these medicines together if prescribed by a doctor. However, if you experience symptoms such as seizures (fits), extreme changes in blood pressure, confusion, hallucination, increased heart rate, fever, excessive sweating, shivering or shaking, tremors, incoordination, blurred vision, muscle spasms or stiffness, nausea, vomiting, stomach cramp, and diarrhea, contact a doctor immediately. Do not discontinue the medication without consulting a doctor.
PalonosetronClomipramine
Severe
How does the drug interact with Themiset Injection 5 ml:
The combined use of Themiset Injection 5 ml with clomipramine can increase the risk of serotonin syndrome (Serotonin syndrome is a condition in which a chemical called serotonin builds up in your body, causing signs and symptoms ranging from mild (shivering and diarrhea) to severe (muscle rigidity, fever, and seizures)).

How to manage the interaction:
Although taking clomipramine and Themiset Injection 5 ml together can cause an interaction, it can be taken if your doctor has suggested it. However, if you have sudden dizziness, lightheadedness, fainting, confusion, hallucination, fits, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles, or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea, or fast or rapid heartbeats during therapy, consult the doctor.
PalonosetronPentazocine
Severe
How does the drug interact with Themiset Injection 5 ml:
Taking Themiset Injection 5 ml with Pentazocine may increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Although there is a possible interaction between Pentazocine and Themiset Injection 5 ml, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting your doctor.
PalonosetronParoxetine
Severe
How does the drug interact with Themiset Injection 5 ml:
Using Themiset Injection 5 ml together with paroxetine can increase the risk of condition called the serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Paroxetine with Themiset Injection 5 ml together can possibly result in an interaction, but it can be taken if your doctor has advised it. If you notice any of these symptoms like confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramps, nausea, vomiting, diarrhea, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
PalonosetronCeritinib
Severe
How does the drug interact with Themiset Injection 5 ml:
Taking Ceritinib with Themiset Injection 5 ml can increase the risk of an irregular heart rhythm and other side effects.

How to manage the interaction:
Although taking Ceritinib and Themiset Injection 5 ml together can evidently cause an interaction, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
PalonosetronHydroxychloroquine
Severe
How does the drug interact with Themiset Injection 5 ml:
The combined use of Themiset Injection 5 ml and Hydroxychloroquine can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Co-administration of palponosetron and Hydroxychloroquine can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
PalonosetronVenlafaxine
Severe
How does the drug interact with Themiset Injection 5 ml:
When venlafaxine is taken with Themiset Injection 5 ml, it can cause serotonin syndrome. (a condition in which a chemical called serotonin builds up in your body).

How to manage the interaction:
Although there is a possible interaction between Venlafaxine and Themiset Injection 5 ml, you can take these medicines together if prescribed by a doctor. However, if you experience any of the following symptoms: confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhoea, seek immediate medical attention. Do not discontinue any medications without consulting a doctor.
PalonosetronVilazodone
Severe
How does the drug interact with Themiset Injection 5 ml:
When Vilazodone is taken with Themiset Injection 5 ml, may increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
There may be a possibility of interaction between Vilazodone and Themiset Injection 5 ml, but it can be taken if prescribed by a doctor. If you notice any of these signs - like confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea-call a doctor right away. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTIEMETICS]

FAQs

Themiset Injection 5 ml is used to treat nausea and vomiting.

Themiset Injection 5 ml contains Palonosetron which works by blocking the action of serotonin, a chemical that stimulates the vomiting centre (chemoreceptor trigger zone – CTZ) located in the brain. Thus, it prevents nausea and vomiting.

You are not recommended to take erythromycin with Themiset Injection 5 ml as it may increase the risk of severe irregular heart rhythm. However, please consult your doctor before taking other medicines with Themiset Injection 5 ml.

Themiset Injection 5 ml may cause constipation as a side effect. It is not necessary for everyone taking Themiset Injection 5 ml to experience this side effect. However, if the condition persists or worsens, please consult a doctor.

Themiset Injection 5 ml should be used with caution in patients suffering from heart problems as it may worsen the condition. Therefore, inform your doctor if you have any heart problems before taking have Themiset Injection 5 ml so that the dose may be adjusted appropriately.

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Author Details

Veda MaddalaDoctor badge

Written By

  • Veda Maddala

    M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

  • Dr Aneela Siddabathuni

    MPharma., PhD

Last Updated

Doctor imageWe provide you with authentic, trustworthy and relevant information

Country of origin

INDIA

Manufacturer/Marketer address

11/12, Udyog Nagar, S. V. Road, Goregaon (W), Mumbai- 400104.
Other Info - THE0180

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