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compositionComposition:TENECTEPLASE-40MG
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Prescription Medicine
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Tenectelex 40 Injection Kit is a clot-busting drug indicated to reduce the risk of death in people who have had a severe type of heart attack known as acute ST-elevation myocardial infarction (STEMI). It contains Tenecteplase, which helps to dissolve unwanted blood clots in the heart's blood vessels. Thus, it helps to prevent damage caused by heart attacks and has been shown to save lives.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

TENECTEPLASE-40MG

Manufacturer/Marketer :

Abbott India Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Tenectelex 40 Injection Kit

Tenectelex 40 Injection Kit is a specialised injection used to treat a sudden, acute heart attack by dissolving blood clots that block blood flow to the heart. It is given as an emergency medical treatment to help restore normal blood circulation as quickly as possible. By clearing the blocked artery, this medicine helps minimise permanent damage to the heart muscle.

Because this medicine is an emergency treatment, it is given as a single, one-time injection rather than on a regular daily schedule. It is injected directly into a vein, so it does not require any food considerations. After emergency recovery, adopting a heart-healthy diet low in salt and saturated fats, along with regular physical activity, is crucial to support long-term heart health.

Common side effects of this medication include minor bleeding from the injection site, bruising, and nosebleeds. You must inform your doctor immediately if you experience serious side effects, such as severe internal bleeding or sudden difficulty speaking or moving.

Do not receive this medicine if you have active internal bleeding, a history of stroke, severe uncontrolled high blood pressure, or if you have recently had major surgery. Talk to your doctor to ensure this treatment is safe for your specific condition before it is given.

This injection can interact with blood thinners and other medications, which can significantly increase your risk of bleeding. If you are pregnant, breastfeeding, or are an older adult, discuss the potential risks and benefits with your doctor before receiving this treatment.

Uses of Tenectelex 40 Injection Kit

Tenectelex 40 Injection Kit is used as an emergency treatment to rapidly dissolve blood clots and restore blood flow to the heart. It may be prescribed for the following condition:

  • Acute Heart Attack: Tenectelex 40 Injection Kit is used to dissolve dangerous blood clots in the coronary arteries, restoring vital oxygen and blood flow to the heart muscle to prevent further tissue damage.

Key Benefits

Tenectelex 40 Injection Kit provides important benefits by restoring blood flow quickly during a heart attack and supporting better recovery outcomes:

  • Rapid clot dissolution: Quickly breaks down the blood clot blocking the coronary artery, helping restore oxygen-rich blood flow to the heart muscle.
  • Limits heart muscle damage: Early treatment reduces the extent of permanent damage to the heart, improving the chances of recovery and preserving heart function.
  • Improves survival and recovery: Prompt restoration of blood flow reduces the risk of serious complications associated with acute heart attacks.
  • Convenient single-bolus administration: Unlike some older clot-dissolving medicines that require prolonged infusions, Tenectelex 40 Injection Kit is administered as a single intravenous injection, allowing faster treatment during emergencies.
Side effects of Tenectelex 40 Injection Kit
Managing Medication-Triggered Epistaxis (Nosebleed): A Step-by-Step Guide:
  • If you experience nosebleeds or unusual bleeding after taking medication, seek medical attention right away and schedule an appointment to discuss your symptoms with your doctor.
  • Your doctor may adjust your treatment plan by changing the dosage, switching to a different medication, or stopping the medication.
  • If your doctor advises, take steps to manage bleeding and promote healing, such as applying pressure, using saline nasal sprays, or applying a cold compress, using humidifiers, avoiding blowing or picking your nose, and applying petroleum jelly to the nostrils.
  • Schedule follow-up appointments with your doctor to monitor progress, adjust treatment plans, and prevent future episodes.
  • Stay hydrated to support kidney and bladder health.
  • Rest on your back as advised by your doctor.
  • Limit physical strain for 1-2 weeks.
  • Avoid strenuous activities like running and contact sports.
  • Quit smoking to improve overall health.
  • Use pain medication responsibly.
  • Avoid foods that can irritate the urinary track, such as spicy or acidic foods.
  • Remember to consult your doctor for personalized advice and guidance on managing your symptoms and developing a treatment plan.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication to ensure safe and effective use.
  • Tenectelex 40 Injection Kit will be administered by the doctor or healthcare professional in a medical setting.
  • Do not self-administer.

How Tenectelex 40 Injection Kit Works

Tenectelex 40 Injection Kit contains tenecteplase, a thrombolytic medicine that helps dissolve blood clots and restore blood flow to the heart. Tenectelex 40 Injection Kit works by attaching to fibrin, a protein that forms the structural framework of a blood clot. Once bound to the clot, it activates plasmin, a naturally occurring enzyme in the blood that breaks down fibrin. This process dissolves the clot, allowing blood to flow freely through the affected blood vessel. By restoring blood flow to the heart muscle, Tenectelex 40 Injection Kit helps limit damage caused by a heart attack and improves the supply of oxygen and nutrients to the affected tissue. Together, these actions help dissolve blood clots, restore normal blood circulation, and reduce damage to the heart following an acute heart attack.
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Alcohol

Not applicable

Tenectelex 40 Injection Kit is administered to hospitalized patients.

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Pregnancy

Consult your doctor

Limited data is available on the effect of Tenectelex 40 Injection Kit in pregnant women. If you are pregnant or planning pregnancy, inform your doctor before receiving Tenectelex 40 Injection Kit. Your doctor may give this medicine if the benefits outweigh the risks.

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Breast Feeding

Consult your doctor

It is unknown whether Tenecteplase is excreted in breast milk. Hence, if you are a nursing mother, inform your doctor before receiving Tenectelex 40 Injection Kit. Your doctor may give this medicine if the benefits outweigh the risks.

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Driving

Not applicable

Tenectelex 40 Injection Kit is administered to hospitalized patients.

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Liver

Consult your doctor

The effect of liver impairment on the actions of Tenectelex 40 Injection Kit in humans has not been particularly studied. However, if you have severe liver failure, inform your doctor before receiving Tenectelex 40 Injection Kit.

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Kidney

Consult your doctor

The effect of kidney impairment on the actions of Tenectelex 40 Injection Kit in humans has not been particularly studied. However, if you have severe kidney problems, inform your doctor before receiving Tenectelex 40 Injection Kit.

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Children

Unsafe

Tenectelex 40 Injection Kit is not recommended for children below 18 years of age as the safety and effectiveness were not established.

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Heart

Safe if prescribed

Tenectelex 40 Injection Kit is used to treat certain heart attacks by dissolving clots and restoring blood flow. However, it should be avoided in patients with heart problems unless absolutely necessary and under strict medical supervision.

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Geriatrics

Caution

Tenectelex 40 Injection Kit may be used in geriatric patients for treating certain heart attacks, but only under strict medical supervision. Due to increased bleeding risks and age-related health concerns, careful assessment and monitoring are essential.

What if I have taken an overdose of Tenectelex 40 Injection Kit

Because this medication is prepared and injected by medical experts, an overdose is highly unlikely. However, if an excess amount is injected, it can increase the risk of severe bleeding. Hospital staff will monitor you closely and are fully equipped to manage and treat any bleeding complications immediately.

Diet & Lifestyle Advise

  • Eat a heart-healthy diet: Focus on foods low in saturated fats, trans fats, and cholesterol. Increase your intake of fresh vegetables, fruits, whole grains, and lean proteins.
  • Reduce salt intake: Limit sodium in your meals to help manage your blood pressure and reduce strain on your heart.
  • Avoid tobacco: Quit smoking and avoid secondhand smoke, as nicotine constricts blood vessels and worsens heart health.
  • Gradually resume activity: Work closely with your healthcare team or a cardiac rehabilitation program to safely restart physical exercise.
  • Manage stress: Practice stress-reduction techniques such as deep breathing, meditation, or gentle yoga to protect your heart.
health query

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How Soon It Starts Working

The time required for Tenectelex 40 Injection Kit to start to work: Tenectelex 40 Injection Kit ideally shows its action within 30 minutes after administration. The time for which the effects of Tenectelex 40 Injection Kit last: The effect of Tenectelex 40 Injection Kit lasts for 2 hours.

What if you forget to take Tenectelex 40 Injection Kit

Since this medicine is given as a single emergency injection by a healthcare professional in a hospital setting, it is not possible to miss a dose.

Storage

• Unopened vials of Tenectelex 40 Injection Kit should be stored at controlled room temperature below 30°C (86°F) or kept in a refrigerator between 2°C to 8°C (36°F to 46°F).
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Keep Refrigerated. Do not freeze.Prepaid payment required.

Drug Warnings

  • Inform your healthcare team about recent injuries: Tell your doctor if you have had any recent falls, head injuries, surgery, or bleeding problems before receiving the injection.
  • Check the medicine before administration: Your healthcare provider should ensure the reconstituted solution is clear and colourless to pale yellow before it is administered.
  • Limit unnecessary movement: Remain in bed or move only with assistance after the injection to reduce the risk of falls, bruising, or bleeding.
  • Avoid unnecessary injections and procedures: Intramuscular injections and non-urgent invasive procedures should be avoided for several hours after treatment to minimise bleeding.
  • Report warning symptoms immediately: Tell your doctor or nurse at once if you develop a severe headache, dizziness, confusion, weakness, or any unusual bleeding after treatment.

Drug-Drug Interactions

verifiedApollotooltip

The following medicines may increase the risk of bleeding or require careful monitoring when used with Tenectelex 40 Injection Kit:

  • Blood thinners (such as heparin or warfarin): May significantly increase the risk of serious internal bleeding.
  • Antiplatelet drugs (such as aspirin or clopidogrel): Can increase the risk of bleeding when present in the body at the same time as this medicine.
  • Pain relievers (NSAIDs like ibuprofen or naproxen): May increase bleeding risks and should be avoided immediately after treatment unless advised by your doctor.
TenecteplaseHeparin
Critical
TenecteplaseApixaban
Severe

Drug-Drug Interactions

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TenecteplaseHeparin
Critical
How does the drug interact with Tenectelex 40 Injection Kit:
Taking Tenectelex 40 Injection Kit with Heparin can increase the risk of bleeding.

How to manage the interaction:
Taking Heparin with Tenectelex 40 Injection Kit is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you notice unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
TenecteplaseApixaban
Severe
How does the drug interact with Tenectelex 40 Injection Kit:
Coadministration of Tenectelex 40 Injection Kit and Apixaban co-administration may raise the risk of bleeding.

How to manage the interaction:
Even though combining Tenectelex 40 Injection Kit and Apixaban may cause an interaction, it is still possible to take it if your doctor advises you to. Consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), severe bruising, prolonged nosebleeds, feeling dizzy or lightheaded, weakness or severe headache, vomiting blood or coughing up blood, heavy menstrual bleeding (in women), difficulty breathing, or chest pain. Without consulting a doctor, never stop taking any medications.
TenecteplasePrasugrel
Severe
How does the drug interact with Tenectelex 40 Injection Kit:
Taking Prasugrel with Tenectelex 40 Injection Kit can increase the risk of bleeding.

How to manage the interaction:
Taking Tenectelex 40 Injection Kit with Prasugrel together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.
TenecteplaseRivaroxaban
Severe
How does the drug interact with Tenectelex 40 Injection Kit:
Co-administration of Tenectelex 40 Injection Kit and Rivaroxaban can increase the risk of bleeding.

How to manage the interaction:
Co-administration of Tenectelex 40 Injection Kit and Rivaroxaban can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
TenecteplaseEnoxaparin
Severe
How does the drug interact with Tenectelex 40 Injection Kit:
Combining Tenectelex 40 Injection Kit with Enoxaparin can increase the risk of bleeding.

How to manage the interaction:
Co-administration of Tenectelex 40 Injection Kit with Enoxaparin can result in an interaction, but it can be taken if your doctor has advised it. You should seek immediate medical attention if you experience any unusual bleeding or bruising or have other signs and symptoms of bleeding such as dizziness; lightheadedness; red or black, tarry stools; coughing up or vomiting fresh or dried blood that looks like coffee grounds; severe headache; and weakness. Using more than one of these medications can increase the risk of bleeding even more, but it may not give you much extra protection. Do not discontinue any medications without consulting a doctor.
TenecteplaseDasatinib
Severe
How does the drug interact with Tenectelex 40 Injection Kit:
Taking Dasatinib with Tenectelex 40 Injection Kit can increase the risk and severity of bleeding and hemorrhage.

How to manage the interaction:
Although taking Tenectelex 40 Injection Kit and Dasatinib together can cause an interaction, it can be taken if a doctor has suggested it. You should seek immediate medical attention if you experience dizziness; red or black, tarry stools; severe headache; and weakness. Do not discontinue any medications without consulting a doctor.
TenecteplaseDeferasirox
Severe
How does the drug interact with Tenectelex 40 Injection Kit:
Combining Tenectelex 40 Injection Kit with Deferasirox can increase the risk of gastrointestinal bleeding.

How to manage the interaction:
Co-administration of Tenectelex 40 Injection Kit with Deferasirox can possibly result in an interaction, but it can be taken if your doctor has advised it. This risk is higher in older people with certain blood disorders or low platelet counts.If you have symptoms like stomach pain, bloating, dizziness, or black stools, it's important to consult a doctor. Do not stop using any medications without a doctor's advice.
TenecteplaseCangrelor
Severe
How does the drug interact with Tenectelex 40 Injection Kit:
Co-administration of Cangrelor with Tenectelex 40 Injection Kit can increase the risk of bleeding.

How to manage the interaction:
Although taking Tenectelex 40 Injection Kit and Cangrelor together can evidently cause an interaction, it can be taken if a doctor has suggested it. However, consult doctor immediately if you experience any unusual bleeding or bruising, or have other signs and symptoms of bleeding such as dizziness; lightheadedness; red or black, tarry stools; coughing up or vomiting fresh or dried blood that looks like coffee grounds; severe headache; and weakness. Do not stop using any medications without a doctor's advice.
TenecteplaseWarfarin
Severe
How does the drug interact with Tenectelex 40 Injection Kit:
Coadministration of warfarin with Tenectelex 40 Injection Kit can increase the risk of bleeding.

How to manage the interaction:
Although taking Tenectelex 40 Injection Kit and warfarin together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult a doctor. Do not stop using any medications without a doctor's advice.
TenecteplaseDalteparin
Severe
How does the drug interact with Tenectelex 40 Injection Kit:
Combining Tenectelex 40 Injection Kit with Dalteparin can increase the risk of bleeding.

How to manage the interaction:
Although taking Dalteparin with Tenectelex 40 Injection Kit may possibly lead to an interaction, they can be taken if a doctor prescribes it. Consult a doctor if you have any symptoms including dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that resembles coffee grounds, severe headache, and weakness. Without consulting a doctor, never stop taking any medication.

Drug-Food Interactions

verifiedApollotooltip

No clinically significant food interactions are known with Tenectelex 40 Injection Kit when used as directed.

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[THROMBOLYTIC ENZYME]

FAQs

No. Tenectelex 40 Injection Kit must only be administered as an intravenous (IV) injection by a trained healthcare professional in a hospital or emergency medical setting where your heart and vital signs can be continuously monitored. Do not self-administer this medicine. Talk to your doctor or pharmacist if you would like more information about emergency cardiac care.
Tenectelex 40 Injection Kit is an emergency injection used to dissolve blood clots that cause an acute heart attack, helping to restore normal blood flow to the heart muscle. Talk to your doctor if you have questions about your recovery plan.
The most serious risk is severe bleeding, including bleeding inside the brain (stroke) or internal bleeding in the stomach or intestines. Your medical team will monitor you closely to minimise these risks. Talk to your doctor if you have concerns.
This medicine is typically only used during pregnancy if the potential benefit justifies the risk to the unborn baby, as it can increase the risk of bleeding. Talk to your doctor to understand the risks and benefits in emergency situations.
Unlike daily blood thinners that prevent new clots from forming, Tenectelex 40 Injection Kit is an emergency "clot-buster" designed to actively dissolve an existing clot that is blocking blood flow. Talk to your doctor or pharmacist for more information.
Your doctor will determine exactly when it is safe to start or resume taking aspirin or other blood thinners after your injection. Do not take any medication without consulting your healthcare team first. Talk to your doctor for personalised advice.
If you notice any unusual bleeding, severe bruising, or blood in your urine or stool after being discharged, seek emergency medical care immediately. Talk to your doctor or pharmacist if you have questions about post-discharge safety.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

401, Lsc, C-Block, Mohan Place Saraswati Vihar Delhi Dl 110034 In
Other Info - TEN0635
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