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compositionComposition:ALPRAZOLAM-0.5MG+FLUOXETINE-20MG
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Prescription Medicine
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TALECELM PLUS TABLET is used to treat depression. It contains Alprazolam and Fluoxetine which improve mood and suppress the abnormal activity of the nerve cells in the brain. In some cases, this medicine may cause side effects such as nausea, vomiting, diarrhoea, confusion, drowsiness, tiredness, and low sexual desire. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

ALPRAZOLAM-0.5MG+FLUOXETINE-20MG

Manufacturer/Marketer :

Talent India Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About TALECELM PLUS TABLET

TALECELM PLUS TABLET is a prescription oral medicine used to treat depression accompanied by moderate to severe anxiety. This medication works by balancing specific chemical messengers in the brain to improve your mood and relieve tension.

You should take this medicine daily at the same time to ensure a consistent level remains in your body. It can be taken with or without food, but taking it with meals can help prevent stomach upset. Combining this treatment with regular physical activity and a structured sleep routine can greatly improve your overall results.

Common side effects of TALECELM PLUS TABLET include drowsiness, dry mouth, and changes in appetite. However, if you experience any serious side effects such as severe mood changes, worsening depression, or suicidal thoughts, you must seek medical attention immediately.

Before starting TALECELM PLUS TABLET, tell your doctor if you have a history of liver damage, kidney issues, glaucoma, or seizures. Do not take this if you are allergic to any active components in this medicine or if you are currently taking monoamine oxidase inhibitors (MAOIs).

This medicine can interact with alcohol, blood-thinning drugs, and other medicines that increase serotonin levels, such as certain antidepressants, tramadol, and some migraine medicines (triptans). These combinations can increase the risk of serious side effects, including serotonin syndrome. Tell your doctor about all medicines and supplements you are taking before starting treatment. Pregnant, breastfeeding, elderly, and children or adolescents should consult their doctor before using this medicine to ensure it is appropriate and safe for them. Extra caution is needed for older adults, as they may be more sensitive to drowsiness, dizziness, and falls.

Uses of TALECELM PLUS TABLET

TALECELM PLUS TABLET used in the treatment of depression. The detailed uses of TALECELM PLUS TABLET are as follows:

  • Depression with Anxiety: TALECELM PLUS TABLET helps relieve persistent feelings of sadness and loss of interest while simultaneously calming the excessive worry and physical tension associated with anxiety.
  • Panic Disorder: It helps reduce the frequency and severity of sudden, unexpected panic attacks and the constant fear of future attacks.

Key Benefits

TALECELM PLUS TABLET helps manage the symptoms of anxiety and depression, making it easier to cope with everyday challenges.
The following are the benefits of this medication:

  • Helps reduce anxiety, nervousness, and excessive worry
  • Improves mood and emotional well-being over time
  • Reduces panic symptoms and promotes a greater sense of calm
  • Supports better sleep and improved daily functioning
  • Helps restore interest in everyday activities
  • Provides relief from both anxiety and depression with a single treatment
Side effects of Talecelm Plus Tablet
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Here are the steps to manage medication-triggered Nervousness:
  • Tell your doctor immediately if you experience symptoms of Nervousness, such as anxiety, jitteriness, or an increased heart rate, after taking medication or adjusting your medication regimen.
  • Your doctor may adjust your medication regimen to alleviate symptoms of Nervousness. This can include switching to a different medication, reducing the dosage, or temporarily stopping the medication. Your doctor may also recommend alternative techniques like relaxation, mindfulness meditation, or journaling. These techniques can help reduce anxiety and Nervousness.
  • Practice stress-reducing techniques, such as deep breathing exercises, yoga, or journaling, to help manage Nervousness.
  • Engage in regular physical activity, such as walking or jogging, to help reduce anxiety and improve mood.
  • Your doctor may advise considering cognitive-behavioural therapy (CBT) or other forms of talk therapy to address underlying anxiety or Nervousness.
  • You should maintain regular follow-up appointments with your doctor to monitor nervousness symptoms, adjust treatment plans as needed, and discuss any concerns or questions.
  • Avoid driving or operating machinery or activities that require high focus until you know how the medication affects you.
  • Maintain a fixed sleeping schedule, create a relaxing bedtime routine and ensure your sleeping space is comfortable to maximize your sleep quality.
  • Limit alcohol and caffeine as these may worsen drowsiness and disturb sleep patterns.
  • Drink plenty of water as it helps with alertness and keeps you hydrated and for overall well-being.
  • Moderate physical activity can improve energy levels, but avoid intense workouts right before bedtime.
  • Do pelvic floor exercises (Kegel exercises) to gain more control over urinary sphincters (muscles used to control flow of urine out of the bladder).
  • Drink fluids only at certain times to control when you will urinate.
  • If you feel frequent urge to urinate or have problems starting to urinate or if your urine stream is weak or starts and stops, or feel pain in your genitals, lower abdomen or lower back, consult your doctor.

Directions for Use

  • TALECELM PLUS TABLET can be taken with or without food, but it is better to take it at a fixed time.
  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Swallow TALECELM PLUS TABLET as a whole with a glass of water.
  • Do not crush, chew, or break it.

How TALECELM PLUS TABLET Works

TALECELM PLUS TABLET combines two active ingredients that work in harmony to restore chemical balance in the brain. Each component targets a different pathway to address both depressive and anxious symptoms effectively. Fluoxetine is a Selective Serotonin Reuptake Inhibitor (SSRI) that works by increasing the levels of serotonin, a natural chemical messenger in the brain that plays a vital role in regulating mood, sleep, and emotional stability. Alprazolam belongs to a class of medicines called benzodiazepines. It works by boosting the activity of a natural calming chemical in the brain called GABA. This action slows down excessive nerve activity, providing rapid relief from acute anxiety, panic, and muscle tension.
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Alcohol

Unsafe

Avoid consumption of alcohol with TALECELM PLUS TABLET as it may increase the risk of drowsiness and other adverse effects.

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Pregnancy

Unsafe

TALECELM PLUS TABLET is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. If the benefits are more than the potential risks, a doctor may rarely prescribe it in some life-threatening situations. Please consult your doctor. 

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Breast Feeding

Unsafe

Avoid breastfeeding while taking TALECELM PLUS TABLET as it may be excreted in breast milk and cause adverse effects in the baby.

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Driving

Caution

TALECELM PLUS TABLET may cause dizziness or drowsiness in some people. It is an offence to drive if TALECELM PLUS TABLET affects you. Therefore, avoid driving if you feel drowsy, dizzy or experience any vision problems after taking TALECELM PLUS TABLET.

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Liver

Caution

Take TALECELM PLUS TABLET with caution, especially if you have a history of liver diseases/conditions. Your doctor may adjust the dose if necessary based on your condition.

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Kidney

Caution

Take TALECELM PLUS TABLET with caution, especially if you have a pre-existing or a history of kidney disease. Please consult your doctor before taking TALECELM PLUS TABLET. Your doctor may adjust the dose if necessary based on your condition.

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Children

Caution

TALECELM PLUS TABLET should not be used by children, as efficacy and safety have not been established.

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Heart

Caution

TALECELM PLUS TABLET should be used with extreme caution due to the risk of cardiovascular problems. Please inform your physician if you have any concerns.

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Geriatrics

Caution

TALECELM PLUS TABLET can be given in elderly patients with extreme caution, due to the cause of adverse effects.

What if I have taken an overdose of TALECELM PLUS TABLET

If you suspect an overdose, seek immediate emergency medical attention. Symptoms of an overdose may include extreme drowsiness, confusion, slow reflexes, shallow breathing, or loss of consciousness.

Diet & Lifestyle Advise

  • Avoid alcohol: Do not drink alcohol while taking TALECELM PLUS TABLET, as it can dangerously increase drowsiness, dizziness, and coordination problems.
  • Limit caffeine: Reduce your consumption of coffee, tea, and energy drinks, as caffeine can trigger anxiety and counteract the calming effects of this medicine.
  • Avoid grapefruit: Do not consume grapefruit or grapefruit juice, as it can interfere with how your body processes the medicine and increase the risk of side effects.
  • Prioritise sleep: Maintain a consistent sleep schedule to help manage fatigue and support your brain's recovery process.
health query

Have a query?

How Soon It Starts Working

The time required for TALECELM PLUS TABLET to start to work: The time required for TALECELM PLUS TABLET to show its action is unknown. The time for which the effects of TALECELM PLUS TABLET last: The duration of action for TALECELM PLUS TABLET is clinically unknown.

What if you forget to take TALECELM PLUS TABLET

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.

Storage

• Store TALECELM PLUS TABLET according to the storage instructions on your medicine pack. Unless otherwise stated on the label, store it at room temperature, ideally between 20°C and 25°C (68°F to 77°F).

Drug Warnings

  • Do not stop treatment suddenly: Keep taking TALECELM PLUS TABLET as prescribed. Stopping it suddenly can cause withdrawal symptoms, so your doctor will gradually reduce the dose when it is time to stop.
  • Attend regular follow-up visits: Keep all your scheduled appointments so your doctor can monitor your symptoms, check for side effects, and review whether your treatment needs to be continued or adjusted.
  • Watch for mood changes: During the first few weeks of treatment, especially in the first month, contact your doctor immediately if you notice worsening depression, unusual behaviour, or thoughts of self-harm.
  • Avoid activities requiring alertness: Do not drive, operate machinery, or perform tasks that require full attention until you know how this medicine affects you.
  • Check your tablets before use: Make sure the tablets are intact and not discoloured or damaged by moisture. If they do not look normal, ask your pharmacist before taking them.
  • Tell your healthcare providers: Inform your doctor, dentist, or surgeon that you are taking TALECELM PLUS TABLET before any medical or dental procedure or before starting a new medicine.

Drug-Drug Interactions

verifiedApollotooltip
  • Monoamine oxidase inhibitors/Drugs used to treat depression (e.g., Phenelzine, Tranylcypromine): Taking these medicines with TALECELM PLUS TABLET or within 14 days of stopping them may cause severe, life-threatening reactions.
  • Medications that increase or affect serotonin activity (e.g, other antidepressants, tramadol, or triptans): Taking these medicines alongside TALECELM PLUS TABLET may increase the risk of serotonin syndrome and requires close monitoring.
  • Sleeping pills, muscle relaxants, or narcotic pain relievers (e.g., Zolpidem, Diazepam, Morphine): These medicines may increase drowsiness, dizziness, and breathing problems when taken with TALECELM PLUS TABLET.
  • Blood thinners and NSAIDs (e.g., Warfarin, Ibuprofen): Taking these medicines alongside TALECELM PLUS TABLET may increase the risk of bleeding.
Trifluoperazine + TrihexyphenidylAstemizole
Critical
Trifluoperazine + TrihexyphenidylTerfenadine
Critical

Drug-Drug Interactions

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Trifluoperazine + TrihexyphenidylAstemizole
Critical
How does the drug interact with Talecelm Plus Tablet:
Coadministration of Trifluoperazine and Trihexyphenidyl with Astemizole increases the risk of irregular heart rhythms. The risk is higher if you have a previous history of heart problems and electrolyte disturbances.

How to manage the interaction:
Although taking Trifluoperazine and Trihexyphenidyl with Astemizole can possibly result in an interaction, they can be taken together if prescribed by a doctor. However, consult your doctor immediately if you experience sudden dizziness, lightheadedness, shortness of breath, or heart palpitations. Do not discontinue using any medications without consulting a doctor.
Trifluoperazine + TrihexyphenidylTerfenadine
Critical
How does the drug interact with Talecelm Plus Tablet:
Coadministration of Trifluoperazine and Trihexyphenidyl with Terfenadine increases the risk of irregular heart rhythms. The risk is higher if you have a previous history of heart problems and electrolyte disturbances.

How to manage the interaction:
Although taking Trifluoperazine and Trihexyphenidyl with Terfenadine can result in an interaction, they can be taken together if prescribed by a doctor. However, consult your doctor immediately if you experience sudden dizziness, lightheadedness, shortness of breath, or heart palpitations. Do not discontinue using any medications without consulting a doctor.
Trifluoperazine + TrihexyphenidylCisapride
Critical
How does the drug interact with Talecelm Plus Tablet:
Coadministration of Trifluoperazine and Trihexyphenidyl with Cisapride increases the risk of irregular heart rhythms. The risk is higher if you have a previous history of heart problems and electrolyte disturbances.

How to manage the interaction:
Taking Trifluoperazine and Trihexyphenidyl with Cisapride together will result in an interaction, but they can be taken together if prescribed by a doctor. However, consult your doctor immediately if you experience sudden dizziness, lightheadedness, shortness of breath, or heart palpitations. Do not discontinue using any medications without consulting a doctor.
Trifluoperazine + TrihexyphenidylIbutilide
Critical
How does the drug interact with Talecelm Plus Tablet:
Coadministration of Trifluoperazine and Trihexyphenidyl with Ibutilide increases the risk of irregular heart rhythms. The risk is higher if you have a previous history of heart problems and electrolyte disturbances.

How to manage the interaction:
Although taking Trifluoperazine and Trihexyphenidyl with Ibutilidee can result in an interaction, they can be taken together if prescribed by a doctor. However, consult your doctor immediately if you experience sudden dizziness, lightheadedness, shortness of breath, or heart palpitations. Do not discontinue using any medications without consulting a doctor.
Trifluoperazine + TrihexyphenidylQuinidine
Critical
How does the drug interact with Talecelm Plus Tablet:
Coadministration of Trifluoperazine and Trihexyphenidyl with Quinidine increases the risk of irregular heart rhythms. The risk is higher if you have a previous history of heart problems and electrolyte disturbances.

How to manage the interaction:
Although taking Trifluoperazine and Trihexyphenidyl with Quinidine possibly results in an interaction, they can be taken together if prescribed by a doctor. However, consult your doctor immediately if you experience sudden dizziness, lightheadedness, shortness of breath, or heart palpitations. Do not discontinue using any medications without consulting a doctor.
Trifluoperazine + TrihexyphenidylPotassium chloride
Critical
How does the drug interact with Talecelm Plus Tablet:
Co-administration of Trifluoperazine and Trihexyphenidyl with potassium chloride can increase the risk of stomach ulcers, bleeding, and gastrointestinal injury.

How to manage the interaction:
Taking Trifluoperazine and Trihexyphenidyl with potassium chloride is not recommended as it can result in an interaction, but it can be taken if a doctor prescribes it. However, contact a doctor immediately if you experience abdominal pain, bloating, sudden dizziness or lightheadedness, nausea, vomiting (especially with blood), loss of appetite, or black stools. Do not discontinue any medications without consulting a doctor.
Trifluoperazine + TrihexyphenidylPotassium citrate
Critical
How does the drug interact with Talecelm Plus Tablet:
Co-administration of Trifluoperazine and Trihexyphenidyl with potassium citrate may increase the risk of stomach ulcers, bleeding, and gastrointestinal injury.

How to manage the interaction:
Taking Trifluoperazine and Trihexyphenidyl with potassium citrate is not recommended as it can result in an interaction, but it can be taken if prescribed by a doctor. However, contact a doctor immediately if you experience abdominal pain, bloating, sudden dizziness or lightheadedness, nausea, vomiting (especially with blood), loss of appetite, or black stools. Do not discontinue any medications without consulting a doctor.
Trifluoperazine + TrihexyphenidylZiprasidone
Critical
How does the drug interact with Talecelm Plus Tablet:
Co-administration of Trifluoperazine and Trihexyphenidyl with Ziprasidone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Trifluoperazine and Trihexyphenidyl with Ziprasidone can possibly result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not discontinue any medications without consulting a doctor.
Trifluoperazine + TrihexyphenidylPethidine
Severe
How does the drug interact with Talecelm Plus Tablet:
Coadministration of Trifluoperazine and Trihexyphenidyl with Pethidine can increase the risk of CNS depression.

How to manage the interaction:
Although there is an interaction between Talecelm Plus Tablet and Pethidine, it can be taken together if prescribed by your doctor. However, contact your doctor immediately if you experience drowsiness, confusion, difficulty concentrating, and impaired thinking. Do not stop using any medications without talking to your doctor.
Trifluoperazine + TrihexyphenidylTopiramate
Severe
How does the drug interact with Talecelm Plus Tablet:
Taking Trifluoperazine and Trihexyphenidyl with topiramate can increase the risk of increased body temperature and reduced sweating.

How to manage the interaction:
Co-administration of Trifluoperazine and Trihexyphenidyl with Topiramate can result in an interaction, but it can be taken if your doctor has advised it. However, contact your doctor immediately if you experience dizziness, lightheadedness, or increased body temperature. Do not discontinue any medications without first consulting your doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Alcohol: Consuming alcohol while taking TALECELM PLUS TABLET may greatly increase drowsiness, poor coordination, and breathing problems.
  • Grapefruit juice: Consuming grapefruit juice while taking this medication may increase the amount of alprazolam in the body and raise the risk of side effects.
     
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

Yes

Therapeutic Class

[ANTIDEPRESSANT]

FAQs

Yes. Because TALECELM PLUS TABLET contains alprazolam, it can cause physical and psychological dependence, especially if taken for a long time or at higher doses than prescribed. Take it exactly as directed by your doctor and do not increase the dose or stop taking it suddenly, as this can lead to withdrawal symptoms. If treatment needs to be stopped, your doctor will gradually reduce the dose.
TALECELM PLUS TABLET is generally not recommended during pregnancy as it may cause harm to the developing baby. If you are pregnant or planning to become pregnant, talk to your doctor to discuss safer alternatives.
No, you should never stop taking TALECELM PLUS TABLET suddenly, even if you feel fine. Stopping abruptly can cause severe withdrawal symptoms. Always talk to your doctor first, as they will create a plan for gradually decreasing the dose.
Yes, drowsiness is a common side effect of TALECELM PLUS TABLET. Avoid driving or operating machinery until you know how this medicine affects you. If daytime sleepiness is severe, talk to your doctor about adjusting your dosing schedule.
Some pain relievers, such as ibuprofen or aspirin, can increase the risk of bleeding when taken with TALECELM PLUS TABLET. Talk to your doctor or pharmacist to find a safe pain management option.
It is best to limit your caffeine intake while taking TALECELM PLUS TABLET. Caffeine is a stimulant that can trigger anxiety and interfere with the relaxing effects of your medication. Talk to your doctor for personalised dietary advice.
Take the missed dose as soon as you remember. If your next scheduled dose is only a few hours away, skip the missed dose and continue with your regular schedule. Never double the dose. Talk to your doctor or pharmacist if you are unsure.
This medicine should not be used in children or teenagers, as its safety and effectiveness have not been established. It should only be used if specifically prescribed by a doctor and under close medical supervision, due to the risk of changes in mood or behaviour.
Yes. Your doctor may schedule regular follow-up visits to check how well the medicine is working, monitor for side effects, assess your mood, and decide when it is safe to reduce or stop alprazolam. Depending on your health, your doctor may also recommend blood tests, such as liver function tests, if clinically needed.

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Country of origin

INDIA

Manufacturer/Marketer address

1601, Karnavati Estate, GIDC, Phase III, Vatva, Ahmedabad 382445, Gujarat, India.
Other Info - TAL0015

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