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  3. TALECELM PLUS TABLET

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TALECELM PLUS TABLET, Pack of 10 TABLETS
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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
TALECELM PLUS TABLET is used to treat depression. It contains Alprazolam and Fluoxetine which improve mood and suppress the abnormal activity of the nerve cells in the brain. In some cases, this medicine may cause side effects such as nausea, vomiting, diarrhoea, confusion, drowsiness, tiredness, and low sexual desire. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Composition :

ALPRAZOLAM-0.5MG + FLUOXETINE-20MG

Manufacturer/Marketer :

Talent India Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About TALECELM PLUS TABLET

TALECELM PLUS TABLET belongs to the class of medications called ‘antidepressants' primarily used for the treatment of depression, which is a mood disorder that causes a persistent feeling of sadness and loss of interest. Depression is also called a major depressive disorder or clinical depression, it affects how you feel, think and behave and can lead to various emotional and physical problems.

TALECELM PLUS TABLET contains a combination of two medicines called alprazolam and fluoxetine. Alprazolam is a benzodiazepine (BZD) that increases the action of GABA (gamma-aminobutyric acid), a chemical messenger that suppresses the abnormal activity of the nerve cells in the brain. Fluoxetine is a selective serotonin reuptake inhibitor (SSRI) that increases serotonin levels, a chemical messenger that improves mood.

Take this TALECELM PLUS TABLET in the dose and duration as advised by your doctor. Swallow it as a whole with a glass of water. Do not chew, crush or break it. TALECELM PLUS TABLET may be taken with or without food, but it is better to take it at a fixed time. TALECELM PLUS TABLET may cause common side effects like nausea, vomiting, diarrhoea, confusion, memory impairment, drowsiness, tiredness, low sexual desire, and uncoordinated body movements. These side effects do not require any medical attention and resolve on their own. If any of these effects persist, contact your doctor immediately.

If you are known to be allergic to TALECELM PLUS TABLET or any other medicines, please tell your doctor. Do not take TALECELM PLUS TABLET if you are pregnant or breastfeeding as it may cause adverse effects in the baby. Inform your doctor if you have liver or kidney problems, closed-angle glaucoma, cardiac diseases, bleeding disorders, epilepsy and electro-convulsive therapy before taking TALECELM PLUS TABLET. Also, inform your doctor about diabetes and pulmonary insufficiency before taking TALECELM PLUS TABLET.

Uses of TALECELM PLUS TABLET

Treatment of Depression.

Directions for Use

• TALECELM PLUS TABLET can be taken with or without food, but it is better to take it at a fixed time.• Follow your doctor's instructions on the dosage and timing of this medication.• Swallow TALECELM PLUS TABLET as a whole with a glass of water.• Do not crush, chew, or break it.

Medicinal Benefits

TALECELM PLUS TABLET contains a combination of two medicines called alprazolam and fluoxetine belongs to the class of medications called antidepressants, primarily used for the treatment of depression. Alprazolam is a benzodiazepine (BZD) that increases the action of GABA (gamma-aminobutyric acid), a chemical messenger that suppresses the abnormal activity of the nerve cells in the brain. Fluoxetine is a selective serotonin reuptake inhibitor (SSRI) that increases serotonin levels, a chemical messenger that improves mood.

How TALECELM PLUS TABLET Works

TALECELM PLUS TABLET contains a combination of two medicines called alprazolam and fluoxetine. Alprazolam is a benzodiazepine (BZD) that increases the action of GABA (gamma-aminobutyric acid), a chemical messenger that suppresses the abnormal activity of the nerve cells in the brain. Fluoxetine is a selective serotonin reuptake inhibitor (SSRI) that increases serotonin levels, a chemical messenger that improves mood.

Storage

stored at room temperature below 30°C
Side effects of Talecelm Plus Tablet
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Here are the steps to manage medication-triggered Nervousness:
  • Tell your doctor immediately if you experience symptoms of Nervousness, such as anxiety, jitteriness, or an increased heart rate, after taking medication or adjusting your medication regimen.
  • Your doctor may adjust your medication regimen to alleviate symptoms of Nervousness. This can include switching to a different medication, reducing the dosage, or temporarily stopping the medication. Your doctor may also recommend alternative techniques like relaxation, mindfulness meditation, or journaling. These techniques can help reduce anxiety and Nervousness.
  • Practice stress-reducing techniques, such as deep breathing exercises, yoga, or journaling, to help manage Nervousness.
  • Engage in regular physical activity, such as walking or jogging, to help reduce anxiety and improve mood.
  • Your doctor may advise considering cognitive-behavioural therapy (CBT) or other forms of talk therapy to address underlying anxiety or Nervousness.
  • You should maintain regular follow-up appointments with your doctor to monitor nervousness symptoms, adjust treatment plans as needed, and discuss any concerns or questions.
  • Avoid driving or operating machinery or activities that require high focus until you know how the medication affects you.
  • Maintain a fixed sleeping schedule, create a relaxing bedtime routine and ensure your sleeping space is comfortable to maximize your sleep quality.
  • Limit alcohol and caffeine as these may worsen drowsiness and disturb sleep patterns.
  • Drink plenty of water as it helps with alertness and keeps you hydrated and for overall well-being.
  • Moderate physical activity can improve energy levels, but avoid intense workouts right before bedtime.
  • Do pelvic floor exercises (Kegel exercises) to gain more control over urinary sphincters (muscles used to control flow of urine out of the bladder).
  • Drink fluids only at certain times to control when you will urinate.
  • If you feel frequent urge to urinate or have problems starting to urinate or if your urine stream is weak or starts and stops, or feel pain in your genitals, lower abdomen or lower back, consult your doctor.
  • Do not stand up suddenly. Lie down and get up slowly only when you feel better.
  • Avoid alcohol and large meals.
  • Drink enough water before standing for long periods.
  • Exercise regularly; however, avoid exercising in extreme heat.
  • Eat small, low-carb meals.
  • Wear compression stockings.

What if I have taken an overdose of TALECELM PLUS TABLET

Take TALECELM PLUS TABLET only as prescribed by the doctor. Do not exceed the recommended dose, as it might cause an overdose. If you suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

If you are known to be allergic to TALECELM PLUS TABLET or any other medicines, please tell your doctor. Do not take TALECELM PLUS TABLET if you are pregnant or breastfeeding, as it may cause adverse effects on the baby. Inform your doctor if you have liver or kidney problems, closed-angle glaucoma, cardiac diseases, bleeding disorders, epilepsy, and electro-convulsive therapy before taking TALECELM PLUS TABLET. Also, inform your doctor if you have diabetes and pulmonary insufficiency before taking TALECELM PLUS TABLET. Inform your doctor if you have a history of depression or any other mental disorder or have been hospitalized for mental illnesses or drug or alcohol addiction before taking TALECELM PLUS TABLET.

Drug-Drug Interactions

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TrifluoperazineMetoclopramide
Critical
TrifluoperazineZiprasidone
Critical

Drug-Drug Interactions

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TrifluoperazineMetoclopramide
Critical
How does the drug interact with Talecelm Plus Tablet:
Co-administration of Metoclopramide with Talecelm Plus Tablet can increase the risk of side effects like uncontrolled movement disorder.

How to manage the interaction:
Taking Metoclopramide with Talecelm Plus Tablet is generally avoided as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience muscle spasms or movements that you can't stop or control, such as lip smacking, chewing, puckering, frowning or scowling, tongue thrusting, teeth clenching, jaw twitching, blinking, eye-rolling, shaking or jerking of arms and legs, tremor, jitteriness, restlessness, pacing, and foot tapping., contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
TrifluoperazineZiprasidone
Critical
How does the drug interact with Talecelm Plus Tablet:
Co-administration of Talecelm Plus Tablet with Ziprasidone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Talecelm Plus Tablet with Ziprasidone together can possibly result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor immediately if you experience any symptoms such as sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not discontinue any medications without consulting a doctor.
TrihexyphenidylPotassium citrate
Critical
How does the drug interact with Talecelm Plus Tablet:
Co-administration of Talecelm Plus Tablet with potassium citrate may increase the risk of stomach ulcers, bleeding, and gastrointestinal injury.

How to manage the interaction:
Taking Talecelm Plus Tablet with potassium citrate is not recommended as it can possibly result in an interaction, it can be taken if prescribed by a doctor. However, if you experience abdominal pain, bloating, sudden dizziness or lightheadedness, nausea, vomiting (especially with blood), loss of appetite, or black stools contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
TrihexyphenidylPotassium chloride
Critical
How does the drug interact with Talecelm Plus Tablet:
Co-administration of Talecelm Plus Tablet with potassium chloride can increase the risk of stomach ulcers, bleeding, and gastrointestinal injury.

How to manage the interaction:
Taking Talecelm Plus Tablet with potassium chloride is not recommended as it can possibly result in an interaction, it can be taken if prescribed by a doctor. However, if you experience abdominal pain, bloating, sudden dizziness or lightheadedness, nausea, vomiting (especially with blood), loss of appetite, black stools contact a doctor immediately. Do not discontinue any medications without consulting to a doctor.
TrifluoperazineSotalol
Severe
How does the drug interact with Talecelm Plus Tablet:
Using sotalol together with Talecelm Plus Tablet can increase the risk or severity of irregular heart rhythms which can be severe. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Although there is a possible interaction between Sotalol and Talecelm Plus Tablet, you can take these medicines together if prescribed by a doctor. If you experience dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations consult a doctor. Do not stop using any medications without talking to a doctor.
TrifluoperazineDisopyramide
Severe
How does the drug interact with Talecelm Plus Tablet:
The combined use of Talecelm Plus Tablet and Disopyramide can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Co-administration of Talecelm Plus Tablet and Disopyramide can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhea, or vomiting, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
TrifluoperazineMoxifloxacin
Severe
How does the drug interact with Talecelm Plus Tablet:
Using moxifloxacin together with Talecelm Plus Tablet can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Although there is a possible interaction between Moxifloxacin and Talecelm Plus Tablet, you can take these medicines together if prescribed by your doctor. If you notice any of these symptoms - an irregular heart rhythm, severe or prolonged diarrhea, vomiting, complications, sudden dizziness, feeling lightheaded, fainting, difficulty breathing, or heart palpitations - call your doctor right away. Do not discontinue any medications without first consulting your doctor.
TrifluoperazineMorphine
Severe
How does the drug interact with Talecelm Plus Tablet:
Using Morphine together with Talecelm Plus Tablet can increase the risk of central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Co-administration of Morphine with Talecelm Plus Tablet can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience any symptoms like trouble breathing, feeling tired, or having a cough, dizziness, drowsiness, difficulty concentrating, impaired judgment, reaction speed, and motor coordination, make sure to contact a doctor immediately. Do not stop using any medications without consulting a doctor.
TrihexyphenidylKetamine
Severe
How does the drug interact with Talecelm Plus Tablet:
Taking Talecelm Plus Tablet with Ketamine can increase the risk of side effects.

How to manage the interaction:
Although there is a interaction between Talecelm Plus Tablet and ketamine, but it can be taken together if prescribed by your doctor. However, if you experience drowsiness, confusion, difficulty concentrating, and impairment in thinking contact your doctor right away. Do not stop using any medications without talking to your doctor.
TrihexyphenidylEsketamine
Severe
How does the drug interact with Talecelm Plus Tablet:
Taking Talecelm Plus Tablet with esketamine can increase the risk of other side effects.

How to manage the interaction:
Although there is a interaction between Talecelm Plus Tablet and esketamine, but can be taken together if prescribed by your doctor. However, if you experience drowsiness, confusion, difficulty concentrating, and impairment in thinking contact your doctor right away. Do not stop using any medications without talking to your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Follow a regular sleep pattern. Do not take a nap during day time.

  • Avoid watching TV and using mobiles or laptops just before bedtime.

  • Maintain a diet rich in fruits, vegetables, and whole grains. Avoid fried foods, high-fat dairy products, pastries, and processed foods, as they may worsen anxiety.

  • To boost your mental health, dark green leafy vegetables, in particular, are brain protective. Nuts, seeds, and legumes, such as beans and lentils, are also excellent brain foods.

  • Do regular exercise 

  • Avoid the consumption of alcohol as it may increase drowsiness.

Habit Forming

Yes

Therapeutic Class

ANTIDEPRESSANT

TALECELM PLUS TABLET Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

Avoid consumption of alcohol with TALECELM PLUS TABLET as it may increase the risk of drowsiness and other adverse effects.

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Pregnancy

Unsafe

TALECELM PLUS TABLET is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. If the benefits are more than the potential risks, a doctor may rarely prescribe it in some life-threatening situations. Please consult your doctor. 

bannner image

Breast Feeding

Unsafe

Avoid breastfeeding while taking TALECELM PLUS TABLET as it may be excreted in breast milk and cause adverse effects in the baby.

bannner image

Driving

Caution

TALECELM PLUS TABLET may cause dizziness or drowsiness in some people. It is an offence to drive if TALECELM PLUS TABLET affects you. Therefore, avoid driving if you feel drowsy, dizzy or experience any vision problems after taking TALECELM PLUS TABLET.

bannner image

Liver

Caution

Take TALECELM PLUS TABLET with caution, especially if you have a history of liver diseases/conditions. Your doctor may adjust the dose if necessary based on your condition.

bannner image

Kidney

Caution

Take TALECELM PLUS TABLET with caution, especially if you have a pre-existing or a history of kidney disease. Please consult your doctor before taking TALECELM PLUS TABLET. Your doctor may adjust the dose if necessary based on your condition.

bannner image

Children

Caution

TALECELM PLUS TABLET should not be used by children, as efficacy and safety have not been established.

Have a query?

FAQs

TALECELM PLUS TABLET is used to treat depression, a mood disorder that causes a persistent feeling of sadness and loss of interest.

TALECELM PLUS TABLET contains a combination of two medicines called alprazolam and fluoxetine. Alprazolam is a benzodiazepine (BZD) that increases the action of GABA (gamma-aminobutyric acid), a chemical messenger that suppresses the abnormal activity of the nerve cells in the brain. Fluoxetine is a selective serotonin reuptake inhibitor (SSRI) that increases serotonin levels, a chemical messenger that improves mood.

TALECELM PLUS TABLET may cause common side effects like nausea, vomiting, diarrhea, confusion, memory impairment, drowsiness, tiredness, low sexual desire, and uncoordinated body movements. These side effects do not require any medical attention it resolves on their own. If it persists, contact your doctor immediately.

Yes, TALECELM PLUS TABLET may cause mental or physical dependence if used for a prolonged time. Therefore, take TALECELM PLUS TABLET only in dose and duration as advised by your doctor.

No, you are not recommended to take TALECELM PLUS TABLET with codeine as co-administration of these medicines may cause breathing problems, drowsiness, and coma. However, before using TALECELM PLUS TABLET with codeine and other opioids, you are advised to contact your doctor so that the dosage may be adjusted accordingly to use safely.

Inform your doctor if you have liver or kidney problems, closed-angle glaucoma, cardiac diseases, diabetes, pulmonary insufficiency, bleeding disorders, epilepsy and electro-convulsive therapy before taking TALECELM PLUS TABLET.

Country of origin

INDIA

Manufacturer/Marketer address

1601, Karnavati Estate, GIDC, Phase III, Vatva, Ahmedabad 382445, Gujarat, India.
Other Info - TAL0015

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 6:47 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.medicines.org.uk/emc/product/1657/smpc
  2. https://www.drugs.com/drug-interactions/alprazolam-index.html
  3. https://www.medicineindia.org/pharmacology-for-generic/844/fluoxetine-alprazolam?__cf_chl_captcha_tk__=ecd6c2923f63ac697d2c04ec539962719a5bd393-161199975
  4. https://medlineplus.gov/druginfo/meds/a689006.html
  5. https://www.medicines.org.uk/emc/medicine/25737?__cf_chl_captcha_tk__=462f8ffae499ab071a8edc7b5fc42020e67922ef-1612002540-0-ASWRGc-3j3qIE8dikdGz_rP97UOqJgqx9aaTrplIfXYiPksfhGz2Ys2fXjshHuBUYJ7uc9u8qJApC_ACtRdEiUPrfZA6W64BL42ZLn1o--R221RENVRXktL0-WUkSrKOEKGXtzvBReTv4RTPWctVXQdnD7LjqwtDKXsXSDGIL-JuMTfWqmiLvzBxYNeoZzQf5DpWZD67AGmAEB-Lvicf-KI4UK6JYmQdRenpzSYIZl-5rlzUyqWaOkhMnoQqCb1FE8rvWXa6syqtLi4AyVkxswBG4mOMLzdKshGNR9Z74GWlH1lFfkYl9tlXALRip8immFwgRCKbA9HeH9OtJg4xDMkLNWiN-DH2MJJ0ATz_-08k5KZvS4fjTC6_RYIQbDIUCIFzxj40_c1A9KJSRNZ4mxJlSAvxlLBqhzTByiyzeo08edeqSREFePFc4wnx1pT7r1p_x2HxtfWuA036mmnw12Pmq19F2sH10mPvlTX9RaoXysX7eL7nsVxDbznfW_LeSP8vNz7Je0xim__yP8k_R35az_BbmiZ0EexUq1eb2Em3#PRODUCTINFO

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