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compositionComposition:OSIMERTINIB-80MG
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Tagrisso 80Mg Tablet is primarily used to manage or treat lung cancer. It contains Osimertinib, which blocks proteins in cancer cells that encourage cancer growth. Thus, it reduces or stops the progression of advanced cancer. Sometimes, Tagrisso 80Mg Tablet may cause side effects such as diarrhoea, rash, dry skin, nail toxicity, stomatitis (inflammation of the oral mucosa), fatigue (feeling overtired), decreased appetite, and low blood cell counts.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

OSIMERTINIB-80MG

Manufacturer/Marketer :

Astra Zeneca Pharma India Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Tagrisso 80Mg Tablet

Tagrisso 80Mg Tablet is a prescription medicine used to treat a specific type of lung cancer called non-small cell lung cancer, particularly when the cancer cells have certain abnormal proteins. This medicine is prescribed to help prevent the cancer from returning after surgery or to control its spread when it is at an advanced stage.

You will typically take this medicine once a day. For it to work best, it is important to take it consistently at the same time every day, either with or without food. While taking this medicine, incorporating simple lifestyle changes such as staying well-hydrated and protecting your skin from the sun can help manage common treatment effects.

Like all prescription medications, Tagrisso 80Mg Tablet can cause side effects. Many people experience manageable issues like dry skin or mild diarrhoea, but it is important to contact your doctor immediately if you experience severe symptoms, such as new or worsening breathing problems, coughing, fever, or changes in your heart rate.

Do not take this if you are allergic to it or any of its ingredients. Before starting this treatment, tell your doctor if you have a history of lung inflammation, heart rhythm problems, or electrolyte imbalances, as these conditions may require special monitoring.

This medicine can interact with other substances, including certain prescription drugs, over-the-counter products, and herbal supplements like St. John's wort, which can lower its effectiveness. If you are pregnant, planning to become pregnant, or breastfeeding, do not take this medicine, as it can harm an unborn baby or nursing infant. Talk to your doctor or pharmacist if you fall into any of these groups.

Uses of Tagrisso 80Mg Tablet

Your doctor may prescribe Tagrisso 80Mg Tablet to treat the following conditions to help control the disease, reduce the risk of recurrence, and improve treatment outcomes:

  • Non-Small Cell Lung Cancer (NSCLC) with specific gene mutations: Tagrisso 80Mg Tablet is used to treat adults with certain types of lung cancer that have abnormal epidermal growth factor receptor (EGFR) genes. It may be prescribed after your tumour has been surgically removed to help lower the risk of the cancer returning, or as a primary treatment if the cancer has spread to other parts of the body.

Key Benefits

Using Tagrisso 80Mg Tablet as prescribed helps target cancer cells with specific EGFR gene mutations, slow disease progression, and reduce the risk of cancer recurrence. Here are the key benefits you can expect:

  • Slows tumour growth: Blocks the signals that allow cancer cells to grow and multiply, helping slow or stop the progression of non-small cell lung cancer.
  • Relieves cancer-related symptoms: Helps reduce symptoms such as coughing, chest discomfort, and shortness of breath, improving your quality of life and ability to carry out daily activities.
  • Reduces the risk of cancer recurrence: When taken after surgery, it helps lower the chances of the cancer returning in the lungs or spreading to other parts of the body, including the brain.
Side effects of Tagrisso 80Mg Tablet
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
  • Apply moisturizer immediately after showering or bathing.
  • Use a moisturizer containing lanolin, petroleum jelly, glycerine, hyaluronic acid or jojoba oil.
  • Do not use hot water for bathing. Instead use warm water and limit showers and bath to 5 to 10 minutes.
  • Apply a sunscreen with SPF-30 or higher.
  • Avoid harsh soaps, detergents and perfumes.
  • Do not scratch or rub the skin.
  • Drink adequate water to prevent dehydration.
  • Wear pants, full sleeves and a wide-brimmed hat while going out in the sun.
  • Soak the infected nail in warm water for 10 to 20 minutes, a few times a day.
  • Apply topical antibiotic ointment as advised by the doctor.
  • Avoid irritants and excessive moisture.
Here are the few steps for dealing with itching caused by drug use:
  • Report the itching to your doctor immediately; they may need to change your medication or dosage.
  • Use a cool, damp cloth on the itchy area to help soothe and calm the skin, reducing itching and inflammation.
  • Keep your skin hydrated and healthy with gentle, fragrance-free moisturizers.
  • Try not to scratch, as this can worsen the itching and irritate your skin.
  • If your doctor prescribes, you can take oral medications or apply topical creams or ointments to help relieve itching.
  • Track your itching symptoms and follow your doctor's guidance to adjust your treatment plan if needed. If the itching persists, consult your doctor for further advice.
  • Consult a hematologist or doctor to identify the cause of thrombocytopenia (Decreased Platelet Count) and plan treatment.
  • Foods rich in vitamins B12, C, folate, and iron may help boost platelet count.
  • Avoid heavy lifting, bending, or straining to reduce bleeding risk.
  • Stay hydrated by drinking plenty of water to help prevent bleeding.
  • Avoid alcohol and tobacco to prevent lowering platelet count and reduce bleeding risk.
  • Regular blood tests help monitor platelet count and detect any changes.

Directions for Use

  • Tagrisso 80Mg Tablet can be taken with or without food.
  • Take Tagrisso 80Mg Tablet at about the same time every day, to ensure consistent levels of medicine in your body, or as advised by a doctor.
  • Swallow the tablet as a whole with a glass of water.
  • Do not break, chew or crush Tagrisso 80Mg Tablet .

How Tagrisso 80Mg Tablet Works

Tagrisso 80Mg Tablet contains osimertinib, a tyrosine kinase inhibitor that targets abnormal epidermal growth factor receptor (EGFR) proteins found in certain types of non-small cell lung cancer (NSCLC). These mutated EGFR proteins send continuous signals that cause cancer cells to grow and divide uncontrollably. Tagrisso 80Mg Tablet works by selectively blocking the activity of these abnormal EGFR proteins, preventing them from sending growth signals to cancer cells. This slows or stops the growth and spread of the tumour and may cause cancer cells to die. Because it primarily targets cancer cells with specific EGFR mutations, it has less effect on healthy cells with normal EGFR proteins.
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Alcohol

Unsafe

Avoid alcohol consumption while on treatment with Tagrisso 80Mg Tablet .

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Pregnancy

Unsafe

Tagrisso 80Mg Tablet should not be used during pregnancy. So, inform your doctor if you are pregnant or suspect pregnancy. You or your partner must use a reliable form of contraception to prevent pregnancy while taking these medications.

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Breast Feeding

Unsafe

You should not breastfeed for two weeks after your last dose while taking this medication.

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Driving

Caution

Tagrisso 80Mg Tablet may cause fatigue (feeling overtired), impacting the ability to drive or use machines.

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Liver

Caution

Tagrisso 80Mg Tablet should be used with caution if you have liver disease. Inform your doctor before taking the Tagrisso 80Mg Tablet if you have had a liver impairment/disorder history. Your doctor will prescribe only if the benefits outweigh the risks.

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Kidney

Caution

Tagrisso 80Mg Tablet should be used with caution if you have kidney disease. Inform your doctor before taking the Tagrisso 80Mg Tablet if you have had a kidney impairment/disorder history. Your doctor will prescribe only if the benefits outweigh the risks.

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Children

Unsafe

Safety and effectiveness in patients below the age of 18 years have not been established. Hence, use is not recommended.

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Heart

Caution

Take Tagrisso 80Mg Tablet with caution, especially if you have a history of heart diseases/conditions. The dose may be adjusted by your doctor as required.

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Geriatrics

Caution

Tagrisso 80Mg Tablet can be used in the elderly when prescribed by a doctor. If you have any concerns about using Tagrisso 80Mg Tablet , please consult a doctor.

What if I have taken an overdose of Tagrisso 80Mg Tablet

If you take more than your prescribed dose, seek emergency medical attention immediately, even if you do not have any symptoms. Take the medicine pack with you so healthcare professionals know exactly what was taken.

Diet & Lifestyle Advise

  • Keep your skin moisturised: Use thick, fragrance-free moisturizers regularly to help manage dry skin and protect your skin barrier.
  • Protect yourself from the sun: This medicine can make your skin more sensitive to sunlight. Wear protective clothing, hats, and apply broad-spectrum sunscreen (SPF 30 or higher) when going outdoors.
  • Stay hydrated: Drink plenty of water and clear fluids throughout the day, especially if you experience diarrhoea, to prevent dehydration.
  • Practice gentle nail care: Keep your fingernails and toenails clean and trimmed short to avoid painful cracking or infections. Avoid harsh chemicals or biting your nails.
health query

Have a query?

How Soon It Starts Working

The time required for Tagrisso 80Mg Tablet to start to work: The time required for Tagrisso 80Mg Tablet to show its action is unknown. The time for which the effects of Tagrisso 80Mg Tablet last: The duration of action for Tagrisso 80Mg Tablet is unknown.

What if you forget to take Tagrisso 80Mg Tablet

If you miss a dose, take it as soon as you remember. However, if your next scheduled dose is due in less than 12 hours, skip the missed dose entirely and take your next dose at your usual scheduled time. Do not take two doses at once to make up for a missed one.

Storage

•Store Tagrisso 80Mg Tablet tablets at room temperature between 20°C and 25°C (68°F and 77°F).

Drug Warnings

  • Inspect the tablet before use: Check the tablet before taking it. Do not use it if it is cracked, discoloured, or if the packaging is damaged.
  • Use effective contraception: Use a highly effective method of birth control during treatment and for the recommended period after your last dose, as Tagrisso 80Mg Tablet can cause serious harm to an unborn baby.
  • Check before taking new medicines: Do not start any new prescription medicines, over-the-counter medicines, or herbal supplements without consulting your healthcare team.
  • Take care when driving: Avoid driving or operating machinery if you feel dizzy, tired, or experience changes in your vision while taking this medicine.
  • Monitor breathing symptoms: Contact your doctor immediately if you develop a new or worsening cough, shortness of breath, fever, or difficulty breathing, as these may be signs of a rare but serious lung condition (interstitial lung disease/pneumonitis).
  • Attend all monitoring appointments: Keep all scheduled ECGs, blood tests, and other follow-up appointments so your doctor can monitor your heart rhythm, liver function, electrolyte levels, and overall response to treatment.
  • Report vision changes promptly: Tell your doctor if you develop blurred vision, eye pain, redness, excessive tearing, or increased sensitivity to light, as eye problems may require prompt evaluation.

Drug-Drug Interactions

verifiedApollotooltip
  • Heart rhythm medicines: Combining Tagrisso 80Mg Tablet with other medicines that can affect your heart rhythm may increase the risk of abnormal heart beats.
  • Seizure and tuberculosis medicines: Certain drugs, such as phenytoin, carbamazepine, or rifampicin, can lower the amount of Tagrisso 80Mg Tablet in your body, making it less effective against cancer.

Drug-Drug Interactions

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How does the drug interact with Tagrisso 80Mg Tablet:
Using Dasatinib together with Tagrisso 80Mg Tablet can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Tagrisso 80Mg Tablet with Dasatinib together can result in an interaction, but it can be taken if a doctor has advised it. Consult a doctor if you experience dizziness, breathlessness, or heart palpitations. Do not stop using any medications without talking to a doctor.
How does the drug interact with Tagrisso 80Mg Tablet:
The combined use of Tagrisso 80Mg Tablet and Disopyramide can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Co-administration of Tagrisso 80Mg Tablet and Disopyramide can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhea, or vomiting, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
How does the drug interact with Tagrisso 80Mg Tablet:
Coadministration of Amiodarone together with Tagrisso 80Mg Tablet may raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Even though Amiodarone and Tagrisso 80Mg Tablet interact, they can be used if prescribed by a doctor. If you have cardiac problems or electrolyte imbalances, you may be at greater risk. If you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, get medical attention. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Tagrisso 80Mg Tablet:
Taking Idarubicin and Tagrisso 80Mg Tablet together can increase the chance of a serious abnormal heart rhythm. If you suffer from any cardiac conditions, or electrolyte disturbances (such as magnesium or potassium deficiency brought on by severe or prolonged diarrhea or vomiting), you may be at higher risk.

How to manage the interaction:
Taking Idarubicin and Tagrisso 80Mg Tablet together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Tagrisso 80Mg Tablet:
Use of atomoxetine with Tagrisso 80Mg Tablet can increase the risk of abnormal heart rhythm.

How to manage the interaction:
Although taking Atomoxetine and Tagrisso 80Mg Tablet together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Tagrisso 80Mg Tablet:
When Etanercept is used with Tagrisso 80Mg Tablet, the likelihood or severity of infection may increase.

How to manage the interaction:
Co-administration of Etanercept with Tagrisso 80Mg Tablet can result in an interaction, but it can be taken if a doctor has advised it. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Tagrisso 80Mg Tablet:
Taking Promethazine and Tagrisso 80Mg Tablet together can raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Although there is an interaction between promethazine and Tagrisso 80Mg Tablet, you can take these medicines together if prescribed by your doctor. However, contact a doctor if you experience dizziness, lightheadedness, fainting, shortness of breath, or an irregular heartbeat. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Tagrisso 80Mg Tablet:
Using Tagrisso 80Mg Tablet with Pazopanib can increase the risk of an irregular heart rhythm

How to manage the interaction:
There may be a possibility of interaction between Pazopanib and Tagrisso 80Mg Tablet, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Tagrisso 80Mg Tablet:
Taking Ondansetron with Tagrisso 80Mg Tablet increases the risk of an abnormal heart rhythm.

How to manage the interaction:
Co-administration of Ondansetron along with Tagrisso 80Mg Tablet can result in an interaction, it can be taken if a doctor has advised it. However, consult a doctor if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Tagrisso 80Mg Tablet:
Taking Primaquine and Tagrisso 80Mg Tablet together can increase the chance of a serious abnormal heart rhythm.

How to manage the interaction:
Taking Primaquine and Tagrisso 80Mg Tablet together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, consult a doctor immediately. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • St. John's Wort: Avoid taking herbal supplements containing St. John's wort, as they can significantly reduce the levels of Tagrisso 80Mg Tablet in your blood.
     
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[KINASE INHIBITORS]

FAQs

Tagrisso 80Mg Tablet is used to treat Lung cancer.
Tagrisso 80Mg Tablet contains Osimertinib, a protein kinase inhibitor that works by blocking the abnormal protein which can cause uncontrolled cell growth and cancer; thus, it slows or stops cancer growth.
This medicine may reduce the quantity of platelets in your blood significantly. Platelets are cells that aid in the clotting of blood. If your platelet count is low, you may bruise or bleed easily. Inform your doctor if you experience any unexplained bruises or bleeding. You may require a drip to receive more platelets. This is referred to as a platelet transfusion.
Tagrisso 80Mg Tablet may cause infertility. Discuss with your doctor all the risks of taking this medication.
Non-small cell lung cancer (NSCLC) is a type of lung cancer that begins at the cellular level and causes abnormal cells in the lungs to reproduce rapidly and out of control.
The common side effects of Tagrisso 80Mg Tablet are diarrhoea, rash, dry skin, nail toxicity, stomatitis (inflammation of the oral mucosa), fatigue (feeling overtired), decreased appetite (hunger), and low blood cell counts. If any of these side effects persist or worsen, please consult your doctor.
No, you should not crush, split, or chew the tablets. If you have trouble swallowing, you can disperse the tablet in a glass of still water. Stir until it breaks into small pieces and drink it immediately. Talk to your doctor or pharmacist for detailed instructions on how to do this safely.
Yes, you can take Tagrisso 80Mg Tablet with or without food. It is most important to take your dose at the same time every day to keep a steady amount of the medicine in your body. Talk to your doctor if you have questions.
diarrhoea is a common side effect of this medicine. Start drinking plenty of clear fluids right away to stay hydrated. Contact your doctor, as they may recommend taking an over-the-counter anti-diarrhoeal medicine or adjusting your treatment plan.
No, you should not take this medicine if you are pregnant or breastfeeding, as it can cause serious harm to a developing baby or a nursing infant. You must use effective birth control during treatment. Talk to your doctor for guidance.
Some patients may experience thinning of the hair or changes in hair texture while taking this medicine, though this is less common than other skin-related side effects. If you are concerned about hair changes, talk to your doctor.
There is no direct interaction between alcohol and Tagrisso 80Mg Tablet , but drinking alcohol can worsen side effects like dehydration, dry skin, and diarrhoea. It is best to talk to your doctor or pharmacist about whether alcohol is safe for you.
The length of your treatment depends on how well your cancer responds to the medicine and how well you tolerate any side effects. Your doctor will regularly monitor your progress and tell you how long to continue. Always talk to your doctor before stopping.
Yes, this medicine can make your skin highly sensitive to sunlight, increasing your risk of severe sunburn. Avoid prolonged sun exposure, wear protective clothing, and apply a broad-spectrum sunscreen daily. Talk to your doctor if you develop a severe skin reaction.
Tagrisso 80Mg Tablet works best in people whose tumour has specific EGFR mutations, particularly exon 19 deletion or exon 21 L858R substitution mutations. Genetic testing helps determine whether this medicine is likely to be effective for your cancer.
Tagrisso 80Mg Tablet can occasionally affect your heart rhythm, liver function, and electrolyte levels. Your doctor may arrange ECGs and blood tests during treatment to monitor for these changes and help ensure the medicine remains safe for you.

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Country of origin

INDIA

Manufacturer/Marketer address

Corporate & Registered Office, Block N1, 12th Floor, Manyata Embassy Business Park, Rachenahalli, Outer Ring Road, 560045, Bangalore
Other Info - TAG0030
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