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Taftrio Tablet is an antiretroviral medicine used in the treatment of HIV. It contains Bictegravir, Emtricitabine and Tenofovir. It works by inhibiting the HIV reverse transcriptase enzymes necessary for the virus's DNA reproduction. This causes inhibition of DNA replication and thereby prevents further spread of infection. This medicine helps reduce the symptoms, control the infection, and prevent opportunistic infections effectively. It also helps in improving the quality of life of a patient with HIV.

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Written By Dr. Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

BICTEGRAVIR-50MG+EMTRICITABINE-200MG+TENOFOVIR ALAFENAMIDE-25MG

Manufacturer/Marketer :

Hetero Healthcare Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Taftrio Tablet

Taftrio Tablet is a prescription medicine used to treat Human Immunodeficiency Virus type 1 (HIV-1) in adults and children weighing at least 25 kg. It helps reduce the amount of HIV (viral load) in your body, allowing your immune system to function more effectively. Although it does not cure HIV, taking it consistently helps control the infection and supports long-term health.

To achieve the best results, you must take Taftrio Tablet consistently every single day at the same time. You can take this tablet with or without food, making it easy to fit into your daily routine. Incorporating a nutrient-rich diet, staying hydrated, and avoiding smoking can further support your immune system during treatment.

Many people taking this medication experience only mild side effects, such as headaches, diarrhoea, or mild stomach upset. However, you should consult your doctor immediately if you experience serious side effects, such as signs of a severe allergic reaction, dark urine, or yellowing of your skin and eyes. These could be signs of serious underlying health issues that require medical attention.

Before starting Taftrio Tablet , it is essential to tell your doctor if you have a history of liver conditions, such as hepatitis B, or any kidney problems. Do not take this if you are currently taking other medications that can cause severe interactions, which your healthcare provider will check. Your medical history helps determine if this is the safest treatment option for you.

This medicine can interact with antacids, iron supplements, and certain prescription drugs, which can reduce its effectiveness or increase your risk of side effects. It is also important to talk to your doctor about how alcohol or smoking might affect your liver function while on this therapy. If you are pregnant, planning to breastfeed, or are an older adult, consult your doctor or pharmacist to discuss your specific care plan.

Uses of Taftrio Tablet

Taftrio Tablet is used to treat HIV-1 Infection. The detailed uses of Taftrio Tablet are as follows:

  • HIV-1 Infection: Taftrio Tablet is prescribed to treat Human Immunodeficiency Virus type 1 (HIV-1) by reducing the amount of virus in the body to extremely low levels, helping you maintain a stronger immune system.
  • Immune System Support: By controlling the replication of the virus, Taftrio Tablet helps preserve CD4+ cells (immune cells), reducing the risk of opportunistic infections and illness.

Key Benefits

Taftrio Tablet is a combination antiretroviral medicine used to treat HIV-1 infection. When taken consistently as prescribed, it helps control the virus, supports immune function, and reduces the risk of HIV-related complications.

Benefits may include:

  • Helps lower the amount of HIV (viral load) in the blood. In many people who take the medicine consistently, the viral load can become undetectable, helping the immune system function more effectively.
  • By controlling HIV, it helps protect and maintain the immune system, reducing the risk of HIV-related infections and complications.
  • Combines three antiretroviral medicines into a single once-daily tablet, making it easier for many people to follow their prescribed treatment regimen.
  • Consistent use as prescribed helps maintain viral suppression and supports long-term management of HIV infection as part of comprehensive medical care.
Side effects of Taftrio Tablet
Here are the 7 step-by-step strategies to manage the side effect of "inability to sleep" caused by medication usage:
  • Prepare for a restful night's sleep: Develop a calming pre-sleep routine, like reading or meditation, to help your body relax and prepare for sleep.
  • Create a sleep-conducive Environment: Make bedroom a sleep haven by ensuring it is quiet, dark and calm.
  • Follow a Sleep Schedule: Go to bed and get up at the same time every day to help regulate your body's internal clock and increase sleep quality.
  • Try relaxing techniques like deep breathing, mindfulness meditation and any others.
  • Limit stimulating activities before bedtime: Avoid stimulating activities before bedtime to improve sleep quality.
  • Monitor Progress: Keep track of your sleep patterns to identify areas for improvement.
  • Consult a doctor if needed: If these steps don't improve your sleep, consult a doctor for further guidance and therapy.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
Managing depression as a side effect of medication: a comprehensive guide.
  • Remember, managing depression as a side effect of medication requires patience, persistence, and collaboration with your healthcare team.
  • Tell your doctor about your depression symptoms to adjust medication.
  • Consult a therapist or counsel for emotional support.
  • Engage in regular exercise to release endorphins (neurotransmitters).
  • Practice stress-reducing techniques like meditation and deep breathing.
  • Build a support network of friends, family, and support groups.
  • Establish a consistent sleep schedule.
  • Eat a nutritious diet rich in fruits, vegetables, and whole grains.
  • Limit or avoid alcohol and recreational substances.
  • Keep a mood journal to track symptoms and progress.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.

Directions for Use

  • Take Taftrio Tablet with or without food or as advised by a doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication, to ensure the safety.
  • Swallow the medicine as a whole with a glass of water.
  • Do not crush, break, or chew it.

How Taftrio Tablet Works

Taftrio Tablet contains three active ingredients that work together to prevent HIV-1 from multiplying and infecting healthy immune cells. Bictegravir: HIV uses a protein called integrase to insert its genetic material into your immune cells so it can make more copies of itself. Bictegravir is an integrase inhibitor that blocks this protein, preventing the virus from establishing infection in new cells. Emtricitabine: It is a nucleoside reverse transcriptase inhibitor (NRTI). It mimics the natural building blocks of viral genetic material, causing the virus to stop copying itself. Think of it as inserting the wrong building block into a chain, preventing the virus from completing its genetic material. Tenofovir alafenamide: It is also an NRTI and works in a similar way by interfering with viral replication. It enters immune cells efficiently at lower doses, helping reduce viral replication while limiting exposure to the rest of the body.
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Alcohol

Unsafe

Avoid alcohol consumption while on treatment with Taftrio Tablet . Alcohol intake might increase the risk of stomach or intestine bleeding.

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Pregnancy

Caution

If you are pregnant or suspect you may be pregnant, inform your doctor before taking Taftrio Tablet . Your doctor will prescribe a suitable dose of this medicine to prevent maternal-fetal HIV transmission.

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Breast Feeding

Unsafe

Taftrio Tablet is excreted in milk. If you have HIV or are taking Taftrio Tablet , you should not breastfeed your baby.

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Driving

Unsafe

Avoid driving vehicles or operating machines after taking Taftrio Tablet as it may cause fatigue.

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Liver

Caution

Taftrio Tablet can result in serious, sometimes fatal, liver damage. Inform your doctor if you have or have had a liver illness, particularly hepatitis B or C. Your doctor will most likely advise you not to take Taftrio Tablet .

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Kidney

Caution

Before using Taftrio Tablet , inform your doctor if you have or have ever had kidney disease, particularly if you are on dialysis treatment.

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Children

Consult your doctor

Please consult your doctor. Your doctor will decide the dose of this medicine based on the age and condition of your child.

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Heart

Caution

Exercise caution before using Taftrio Tablet in case of heart problems. Please consult your doctor if you have any concerns.

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Geriatrics

Safe if prescribed

Taftrio Tablet is generally safe for elderly patients. However, please consult your doctor if you have any concerns.

What if I have taken an overdose of Taftrio Tablet

If you take too much of this medicine, seek immediate medical attention or call your local poison control centre right away.

Diet & Lifestyle Advise

  • Manage calcium and iron supplements: Calcium or iron supplements can reduce the absorption of bictegravir. Take these supplements at least 2 hours apart from Taftrio Tablet .
  • Support your immune system: Eat a balanced diet rich in fruits, vegetables, and lean proteins to support your immune system while undergoing antiviral therapy.
  • Limit alcohol intake: Excessive alcohol use can strain your liver, which is already processing your daily medications. Talk to your doctor about safe limits.
  • Stay hydrated: Drink plenty of water throughout the day to help your kidneys filter and process the medication efficiently.
  • Support bone health: Maintain adequate calcium and vitamin D intake, engage in regular weight-bearing exercise, and avoid smoking to help support healthy bones.
health query

Have a query?

How Soon It Starts Working

The time required for Taftrio Tablet to start to work: The time required for Taftrio Tablet to show its action is unknown. The time for which the effects of Taftrio Tablet last: The duration of action for Taftrio Tablet is unknown.

What if you forget to take Taftrio Tablet

If you miss a dose, take it as soon as you remember, unless it is close to the time for your next dose. If it is almost time for your next dose, skip the missed dose and resume your regular schedule. Do not take two doses at the same time to make up for a missed one.

Storage

• Store Taftrio Tablet at room temperature between 20°C and 25°C (68°F to 77°F).

Drug Warnings

  • Check the Packaging Before Use: Check the packaging before use; do not take the medication if the seal on the bottle is broken when you first open it.
  • Separate Antacids from Your Dose: Do not take antacids containing aluminium or magnesium at the same time as Taftrio Tablet . Take this medicine at least 2 hours before or 6 hours after these antacids to help ensure proper absorption.
  • Do Not Stop Treatment Suddenly if You Have Hepatitis B: If you have hepatitis B, stopping Taftrio Tablet suddenly can cause a severe flare-up of your hepatitis infection. Never stop taking this medication without discussing it with your doctor first.
  • Keep an Updated Medication List: Keep a complete list of all medications, herbs, and supplements you use, and share it with your healthcare provider at every visit to prevent dangerous interactions.
  • Attend Regular Monitoring Appointments: Keep all scheduled follow-up appointments. Your doctor may regularly monitor your HIV viral load, CD4 cell count, kidney function, and liver function to ensure the medicine is working effectively and to check for possible side effects.

Drug-Drug Interactions

verifiedApollotooltip
  • Anti-seizure medicines (e.g., carbamazepine and phenytoin): May lower the amount of Taftrio Tablet in your body, which may make it less effective at controlling HIV infection.
  • Tuberculosis medicines (e.g., rifampin): May substantially reduce the levels of Taftrio Tablet , making it less effective.
  • Herbal supplement (e.g., St. John's Wort): May reduce the levels of Taftrio Tablet in your body and should generally be avoided during treatment.
  • Antacids containing magnesium or aluminium: May reduce the absorption of bictegravir. Take Taftrio Tablet at least 2 hours before or 6 hours after these antacids.
  • Multivitamins containing calcium, iron, magnesium, or aluminium: May interfere with the absorption of bictegravir. Separate them by at least 2 hours.
Tenofovir alafenamide + EmtricitabineLamivudine
Critical
Tenofovir alafenamide + EmtricitabineCidofovir
Critical

Drug-Drug Interactions

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Tenofovir alafenamide + EmtricitabineLamivudine
Critical
How does the drug interact with Taftrio Tablet:
Combining Taftrio Tablet with Lamivudine may significantly reduce the blood levels of both the medications.

How to manage the interaction:
Although there is a possibility of interaction between Taftrio Tablet and Lamivudine, it can be taken if prescribed by a doctor. In case you experience any unusual symptoms, consult a doctor. Do not stop using any medications without a doctor's advice.
Tenofovir alafenamide + EmtricitabineCidofovir
Critical
How does the drug interact with Taftrio Tablet:
Taking Cidofovir with Taftrio Tablet may increase the risk of kidney problems.

How to manage the interaction:
Although taking Cidofovir with Taftrio Tablet can result in an interaction, it can be taken if prescribed by a doctor. However, if you experience symptoms such as nausea, vomiting, loss of hunger, increased or decreased urine, swelling in hands or legs, shortness of breath, muscle pain, tiredness, weakness, confusion, or slow or rapid heart rate, consult a doctor. Do not discontinue any medication without consulting a doctor.
Tenofovir alafenamide + EmtricitabineMesalazine
Severe
How does the drug interact with Taftrio Tablet:
Taking Mesalazine with Taftrio Tablet may increase the risk of kidney problems.

How to manage the interaction:
Although taking Mesalazine with Taftrio Tablet can result in an interaction, it can be taken if prescribed by a doctor. However, if you experience symptoms such as nausea, vomiting, loss of hunger, increased or decreased urine, swelling in hands or legs, shortness of breath, muscle pain, tiredness, weakness, confusion, or slow or rapid heart rate, consult a doctor. Do not discontinue any medication without consulting a doctor.
Tenofovir alafenamide + EmtricitabineCelecoxib
Severe
How does the drug interact with Taftrio Tablet:
Taking Celecoxib with Taftrio Tablet may increase the risk of kidney problems.

How to manage the interaction:
Although taking Celecoxib with Taftrio Tablet can result in an interaction, it can be taken if prescribed by a doctor. However, if you experience symptoms such as nausea, vomiting, loss of hunger, increased or decreased urine, swelling in hands or legs, shortness of breath, muscle pain, tiredness, weakness, confusion, or slow or rapid heart rate, consult a doctor. Do not discontinue any medication without consulting a doctor.
Tenofovir alafenamide + EmtricitabineAdefovir dipivoxil
Severe
How does the drug interact with Taftrio Tablet:
Taking Adefovir dipivoxil with Taftrio Tablet may increase the risk of kidney problems.

How to manage the interaction:
Although taking Adefovir dipivoxil with Taftrio Tablet can result in an interaction, it can be taken if prescribed by a doctor. However, if you experience symptoms such as nausea, vomiting, loss of hunger, increased or decreased urine, swelling in hands or legs, shortness of breath, muscle pain, tiredness, weakness, confusion, or slow or rapid heart rate, consult a doctor. Do not discontinue any medication without consulting a doctor.
Tenofovir alafenamide + EmtricitabineRifampicin
Severe
How does the drug interact with Taftrio Tablet:
Combining Taftrio Tablet with Rifampicin may significantly reduce the blood levels of Taftrio Tablet.

How to manage the interaction:
Although there is a possibility of interaction between Taftrio Tablet and Rifampicin, it can be taken if prescribed by a doctor. In case you experience any unusual symptoms, consult a doctor. Do not stop using any medications without a doctor's advice.
Tenofovir alafenamide + EmtricitabineCyclophosphamide
Severe
How does the drug interact with Taftrio Tablet:
Taking Cyclophosphamide with Taftrio Tablet may increase the risk of kidney problems.

How to manage the interaction:
Although taking Cyclophosphamide with Taftrio Tablet can result in an interaction, it can be taken if prescribed by a doctor. However, if you experience symptoms such as nausea, vomiting, loss of hunger, increased or decreased urine, swelling in hands or legs, shortness of breath, muscle pain, tiredness, weakness, confusion, or slow or rapid heart rate, consult a doctor. Do not discontinue any medication without consulting a doctor.
Tenofovir alafenamide + EmtricitabineGentamicin
Severe
How does the drug interact with Taftrio Tablet:
Taking Gentamicin with Taftrio Tablet may increase the risk of kidney problems.

How to manage the interaction:
Although taking Gentamicin with Taftrio Tablet can result in an interaction, it can be taken if prescribed by a doctor. However, if you experience symptoms such as nausea, vomiting, loss of hunger, increased or decreased urine, swelling in hands or legs, shortness of breath, muscle pain, tiredness, weakness, confusion, or slow or rapid heart rate, consult a doctor. Do not discontinue any medication without consulting a doctor.
Tenofovir alafenamide + EmtricitabineSulfasalazine
Severe
How does the drug interact with Taftrio Tablet:
Taking Sulfasalazine with Taftrio Tablet may increase the risk of kidney problems.

How to manage the interaction:
Although taking Sulfasalazine with Taftrio Tablet can result in an interaction, it can be taken if prescribed by a doctor. However, if you experience symptoms such as nausea, vomiting, loss of hunger, increased or decreased urine, swelling in hands or legs, shortness of breath, muscle pain, tiredness, weakness, confusion, or slow or rapid heart rate, consult a doctor. Do not discontinue any medication without consulting a doctor.
Tenofovir alafenamide + EmtricitabineMefenamic acid
Severe
How does the drug interact with Taftrio Tablet:
Taking Mefenamic acid with Taftrio Tablet may increase the risk of kidney problems.

How to manage the interaction:
Although taking Mefenamic acid with Taftrio Tablet can result in an interaction, it can be taken if prescribed by a doctor. However, if you experience symptoms such as nausea, vomiting, loss of hunger, increased or decreased urine, swelling in hands or legs, shortness of breath, muscle pain, tiredness, weakness, confusion, or slow or rapid heart rate, consult a doctor. Do not discontinue any medication without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • No clinically significant food interactions are known with Taftrio Tablet when used as directed.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTIVIRALS]

FAQs

Taftrio Tablet is used to treat HIV Infection.
Taftrio Tablet works by inhibiting the HIV reverse transcriptase enzymes necessary for the virus's DNA reproduction.
Yes, you can take Taftrio Tablet with or without food. However, if you are taking calcium or iron supplements at the same time, you should take Taftrio Tablet with food to ensure proper absorption. Talk to your doctor or pharmacist if you have questions.
If you vomit within 1 hour of taking Taftrio Tablet , contact your doctor or pharmacist promptly. They may advise you to take another dose depending on your situation. If you vomit more than 1 hour after taking the medicine, another dose is usually not needed, and you can continue with your next scheduled dose. Follow the advice of your healthcare provider.
No, you must not stop taking Taftrio Tablet even if your viral load is undetectable. Stopping the medication can cause the virus to multiply rapidly and become resistant to treatment. Always talk to your doctor before making any changes.
No, Taftrio Tablet does not cure HIV. It is a highly effective treatment that keeps the virus under control, helps protect your immune system, and lowers the risk of serious illness, but it must be taken continuously. Talk to your doctor or pharmacist for more information.
Moderate alcohol consumption does not directly stop Taftrio Tablet from working. However, heavy drinking can damage your liver and kidneys, making it harder for your body to process the medication safely. Talk to your doctor or pharmacist about what is safe for you.
You should avoid taking antacids containing magnesium or aluminium at the same time as Taftrio Tablet . Take your HIV medicine at least 2 hours before or 6 hours after these antacids. If you have frequent heartburn or acid reflux, talk to your doctor or pharmacist about suitable treatment options.
Clinical data regarding the use of Taftrio Tablet during pregnancy is limited. If you are pregnant, planning to become pregnant, or breastfeeding, talk to your doctor or pharmacist to weigh the benefits and risks of this treatment.
Many people see a significant drop in their viral load within a few weeks of starting Taftrio Tablet , but it can take several months to reach undetectable levels. Regular blood tests will help your healthcare provider monitor your progress. Talk to your doctor or pharmacist if you have questions about your lab results.

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Country of origin

India

Manufacturer/Marketer address

7-2-A2, Hetero Corporate, Industrial Estates, Sanath Nagar, Hyderabad - 500 018. Telangana, India
Other Info - TAF0029
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