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Written By Veda Maddala , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy

Tacvido Forte Oral Gel is used to prevent rejection of a transplanted organ, such as a liver, kidney, or heart. It contains Tacrolimus, which works by suppressing the activity of T and B lymphocytes (cells in the immune system) that usually attack foreign invaders and defend the body against foreign cells and infection. Thus, it prevents organ rejection in transplanted patients and helps the body to accept the new organ.

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Composition :

TACROLIMUS-0.1%W/V

Manufacturer/Marketer :

Mohrish Pharmaceuticals Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Tacvido Forte Oral Gel

Tacvido Forte Oral Gel is used to prevent rejection of a transplanted organ, such as a liver, kidney, or heart. Organ rejection occurs when a patient’s immune system recognises the donor organ as foreign and tries to eliminate it.

Tacvido Forte Oral Gel contains Tacrolimus, which works by suppressing the activity of T and B lymphocytes (cells in the immune system) that usually attack foreign invaders and defend the body against foreign cells and infection. Thus, it prevents organ rejection in transplanted patients and helps the body to accept the new organ.

Take Tacvido Forte Oral Gel as prescribed. You are advised to use Tacvido Forte Oral Gel for as long as your doctor has recommended it for you based on your medical condition. Some people may experience nausea, diarrhoea, headache, kidney problems, infection, fever, constipation or high blood pressure. Most of these side effects of Tacvido Forte Oral Gel do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Tacrolimus or any other medicines, please tell your doctor. If you are pregnant or a breastfeeding mother, it is advised to consult a doctor before using Tacvido Forte Oral Gel. Avoid alcohol consumption with Tacvido Forte Oral Gel. Drive only if you are alert, as Tacvido Forte Oral Gel may cause some people vision problems or nervous disturbances. If you are about to get vaccinated, inform your doctor before taking Tacvido Forte Oral Gel. Tacvido Forte Oral Gel may increase the risk of infections or skin cancer as it lowers the body’s immune defence system.

Uses of Tacvido Forte Oral Gel

Tacvido Forte Oral Gel is used to treat various medical conditions. The detailed uses are as follows:

  • Prevention of Organ Transplant Rejection: Tacvido Forte Oral Gel is used to stop the body from rejecting a transplanted kidney, liver, heart, or lung. It works by lowering the activity of certain immune cells that could attack the new organ. It is usually given along with other anti-rejection medicines.
  • Other Off-Label Uses: In some cases, Tacvido Forte Oral Gel may be used for graft-versus-host disease (after bone marrow or stem cell transplant), autoimmune liver diseases (autoimmune hepatitis, lupus nephritis), autoimmune eye conditions (uveitis, scleritis), and other immune-related disorders such as rheumatoid arthritis, Crohn’s disease, or myasthenia gravis, particularly when standard treatments are not effective.

Directions for Use

  • Take Tacvido Forte Oral Gel at least 1 hour before or 2 to 3 hours after a meal or as advised by your doctor.
  • Strictly follow your doctor's recommendation regarding the dosage and duration.
  • Swallow it as a whole with water.
  • Do not crush, break or chew it.

Medicinal Benefits

  • Tacvido Forte Oral Gel belongs to the class of medicines called immunosuppressants, which reduce the activity of the body's immune system, and it contains Tacrolimus as the active ingredient.
  • It works by lowering the activity of certain white blood cells (T-lymphocytes) that trigger immune reactions, helping to prevent the body from attacking transplanted organs and reducing harmful immune responses.
  • It is used to prevent rejection of kidney, liver, heart, or lung transplants, usually along with other anti-rejection medicines.
  • It may also be used for graft-versus-host disease, autoimmune liver conditions, autoimmune eye inflammation, and certain severe autoimmune diseases (such as rheumatoid arthritis, Crohn's disease, or myasthenia gravis) when other treatments are not effective.
  • It provides several benefits, including protecting transplanted organs from rejection, improving long-term transplant survival, reducing the need for high-dose steroids, managing severe immune reactions in certain diseases, and improving quality of life for transplant patients.

How Tacvido Forte Oral Gel Works

Tacvido Forte Oral Gel contains Tacrolimus, which works by suppressing the activity of T and B lymphocytes (cells in the immune system) that usually attack foreign invaders and defend the body against foreign cells and infection. Thus, it prevents organ rejection in transplanted patients and helps the body to accept the new organ.

Storage

• Store in a cool and dry place away from sunlight.• Keep Tacvido Forte Oral Gel out of the sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Tacvido Forte Oral Gel 25 ml
  • Eat foods rich in vitamin B like leafy greens and fortified cereals.
  • Avoid spicy and acidic food.
  • Stay hydrated by drinking enough fluids.
  • Brush your teeth using a soft-bristle toothbrush and floss regularly.
  • Manage stress with relaxation techniques like deep breathing, yoga and meditation.
  • Talk to the doctor if the tingling sensation persists or worsens.

What if I have taken an overdose of Tacvido Forte Oral Gel

Do not take more than the prescribed dose. Using more medication will not improve your symptoms; rather, it may cause poisoning or serious side effects. If you suspect that you may have overdosed of Tacvido Forte Oral Gel or if you experience any adverse events, please go to the emergency department of the closest hospital.

Drug Warnings

  • Inform your doctor if you are allergic to Tacrolimus or any other medicines before starting Tacvido Forte Oral Gel.
  • If you are pregnant or breastfeeding, consult your doctor before using Tacvido Forte Oral Gel to ensure it is safe for you and your baby.
  • Avoid alcohol consumption while taking Tacvido Forte Oral Gel, as it may increase side effects.
  • Drive or operate machinery only if you feel alert, since Tacvido Forte Oral Gel may occasionally cause vision problems, dizziness, or nervous system disturbances.
  • Inform your doctor before receiving any vaccines, as Tacvido Forte Oral Gel suppresses the immune system and may reduce the effectiveness of certain vaccines.
  • Tacvido Forte Oral Gel can increase the risk of infections and skin cancer due to lowered immune defence; use protective clothing and sunscreen while outdoors.
  • When preparing the oral suspension, use glass or metal containers only, as the granules can stick to plastic (PVC) and result in an incomplete dose.
  • Avoid inhaling the granules or letting them, or the prepared suspension, come into contact with your skin or eyes. If accidental contact occurs, wash the area thoroughly with soap and water or rinse eyes with plain water.

Drug-Drug Interactions

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TacrolimusSaquinavir
Critical

Drug-Drug Interactions

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How does the drug interact with Tacvido Forte Oral Gel 25 ml:
Taking Tacvido Forte Oral Gel 25 ml with Mifepristone may significantly increase the blood levels of Tacvido Forte Oral Gel 25 ml, which may increase the risk and/or severity of side effects.

How to manage the interaction:
Taking Tacvido Forte Oral Gel 25 ml with Mifepristone is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience unusual symptoms. Do not discontinue any medications without consulting a doctor.
TacrolimusSaquinavir
Critical
How does the drug interact with Tacvido Forte Oral Gel 25 ml:
Taking Tacvido Forte Oral Gel 25 ml with saquinavir can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Tacvido Forte Oral Gel 25 ml with Saquinavir is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Tacvido Forte Oral Gel 25 ml:
Taking Tacvido Forte Oral Gel 25 ml with dronedarone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Tacvido Forte Oral Gel 25 ml with Dronedarone is not recommended, but can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Tacvido Forte Oral Gel 25 ml:
Combining Tacvido Forte Oral Gel 25 ml with Thioridazine can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Tacvido Forte Oral Gel 25 ml with Thioridazine is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Tacvido Forte Oral Gel 25 ml:
Taking cidofovir with Tacvido Forte Oral Gel 25 ml can increase the risk of kidney problems.

How to manage the interaction:
Taking Tacvido Forte Oral Gel 25 ml with Cidofovir is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor immediately if you experience nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not stop using any medications without first talking to your doctor.
How does the drug interact with Tacvido Forte Oral Gel 25 ml:
Taking Tacvido Forte Oral Gel 25 ml with Ziprasidone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Tacvido Forte Oral Gel 25 ml with Ziprasidone together can possibly result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor immediately if you experience any symptoms such as sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Tacvido Forte Oral Gel 25 ml:
Taking Tacvido Forte Oral Gel 25 ml with capreomycin can increase the risk of kidney problems.

How to manage the interaction:
Although taking Tacvido Forte Oral Gel 25 ml and capreomycin together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Tacvido Forte Oral Gel 25 ml:
Taking Tacvido Forte Oral Gel 25 ml with cisplatin can increase the risk of kidney problems.

How to manage the interaction:
Although taking Tacvido Forte Oral Gel 25 ml and cisplatin together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Tacvido Forte Oral Gel 25 ml:
Taking Tacvido Forte Oral Gel 25 ml with netilmicin may increase risk of kidney problems.

How to manage the interaction:
Although taking Tacvido Forte Oral Gel 25 ml and netilmicin together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not discontinue any medications without consulting a doctor.
TacrolimusOxaprozin
Severe
How does the drug interact with Tacvido Forte Oral Gel 25 ml:
Taking Tacvido Forte Oral Gel 25 ml with oxaprozin may increase the risk of kidney problems.

How to manage the interaction:
Although taking Tacvido Forte Oral Gel 25 ml and oxaprozin together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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TACROLIMUS-0.1%W/VGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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TACROLIMUS-0.1%W/VGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Taking of grapefruit or grapefruit juice while on Tacvido Forte Oral Gel 25 ml treatment may lead to increased Tacvido Forte Oral Gel 25 ml levels in blood. Avoid or limit grapefruit or grapefruit juice intake during treatment with Tacvido Forte Oral Gel 25 ml.

Diet & Lifestyle Advise

  • Eat a balanced diet rich in fruits, vegetables, whole grains, lean proteins, and healthy fats to support immune system balance and overall recovery after transplant.
  • Limit salt intake to help manage blood pressure, which can be affected by Tacrolimus and other transplant medications.
  • Avoid grapefruit and grapefruit juice, as they can increase Tacrolimus levels in the blood and raise the risk of side effects.
  • Stay hydrated by drinking enough water daily to support kidney function and prevent dehydration.
  • Limit alcohol consumption or avoid it entirely, as it can stress the liver and interfere with medication effectiveness.
  • Avoid undercooked or raw meat, seafood, and unpasteurised dairy products to reduce the risk of infections that can compromise your immune system.
  • Practice good hand hygiene and food safety to minimise exposure to harmful bacteria or viruses.
  • Maintain a healthy weight through a balanced diet and light physical activity, as recommended by your doctor.
  • Avoid herbal supplements or over-the-counter medicines without medical advice, as they can interact with Tacrolimus and other immunosuppressants.
  • Manage stress and get adequate rest, as this supports immune health and overall well-being during long-term transplant recovery.

Habit Forming

No

Therapeutic Class

IMMUNOSUPPRESSANTS
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Alcohol

Unsafe

Avoid alcohol consumption with Tacvido Forte Oral Gel as it may increase the risk of adverse effects. Please consult a doctor before consuming alcohol with Tacvido Forte Oral Gel.

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Pregnancy

Caution

Using Tacrolimus during pregnancy may cause kidney dysfunction or neonatal hyperkalemia (high potassium levels in the blood). Therefore, please consult a doctor if you are pregnant before taking Tacvido Forte Oral Gel and if you are a woman of childbearing age, use effective contraceptive methods while using Tacvido Forte Oral Gel.

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Breast Feeding

Consult your doctor

Tacvido Forte Oral Gel may be excreted in breast milk. Therefore, please inform your doctor if you are a breastfeeding mother before taking Tacvido Forte Oral Gel. You should avoid taking Tacvido Forte Oral Gel during breastfeeding or avoid breastfeeding while on treatment with Tacvido Forte Oral Gel.

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Driving

Caution

Tacvido Forte Oral Gel may cause vision problems or nervous disturbances in a few people. Therefore, avoid driving if you experience any of these symptoms after taking Tacvido Forte Oral Gel.

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Liver

Consult your doctor

Please consult a doctor if you have liver diseases/conditions before taking Tacvido Forte Oral Gel.

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Kidney

Consult your doctor

Please consult a doctor if you have Kidney diseases/conditions before taking Tacvido Forte Oral Gel.

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Children

Safe if prescribed

Tacvido Forte Oral Gel should be used in children in doses as advised by a doctor only.

Have a query?

FAQs

Tacvido Forte Oral Gel is used to prevent rejection of a transplanted organ, such as a liver, kidney, or heart.

Tacvido Forte Oral Gel contains Tacrolimus, an immunosuppressant that works by inhibiting the activity of T and B lymphocytes (cells in the immune system) that usually attack foreign invaders and defend the body against foreign cells and infection. As a result, it helps the body accept the new organ and prevents organ rejection in patients who have had organ transplants.

Tacvido Forte Oral Gel may increase the risk of infections as it may weaken the immune system. Therefore, consult a doctor immediately if you have any signs of infection, such as a sore throat or fever.

Tacvido Forte Oral Gel may increase the risk of skin cancer. Therefore, avoid or limit exposure to the sun for extended periods or artificial light such as tanning beds. Wear protective clothing and use sunscreen before going out in the sun.

If you are about to receive any vaccinations, especially live vaccines such as measles, mumps, rubella (MMR), oral polio, varicella, yellow fever, intranasal influenza, BCG and TY21a typhoid vaccines, inform your doctor that you are taking Tacvido Forte Oral Gel because it may reduce the effectiveness of the vaccine and increase your risk of contracting the infection that the vaccine is meant to protect against.

Using Tacvido Forte Oral Gel with Sirolimus is not recommended in patients who have had heart or liver transplants. It is unknown if kidney transplant recipients can use it safely. Hence, please seek medical advice before combining Tacvido Forte Oral Gel with other medications.

Tacvido Forte Oral Gel may cause tremors, trembling and shaking of hands. Consult the doctor if this becomes bothersome.

Tacvido Forte Oral Gel is usually taken on an empty stomach or 2 to 3 hours after a meal. Wait at least 1 hour until the next meal.

Tacvido Forte Oral Gel is a macrolide antibiotic with immunosuppressant properties.

Tacvido Forte Oral Gel should not be taken by people who are allergic to any of its components, allergic to sirolimus or any macrolide-antibiotic, during breastfeeding, and receiving live vaccines.

Let the doctor know if you have long QT syndrome, low or high levels of potassium, low levels of calcium or magnesium, an irregular heartbeat, high blood pressure, high cholesterol levels, cystic fibrosis (an inborn disease), heart, kidney, or liver disease. Inform the doctor if you have a weak immune system or if you are due to undergo any vaccination.

Tacvido Forte Oral Gel decreases the activity of your immune system, increasing the risk of serious infection and cancer (lymphoma cancer). Consult the doctor if you experience symptoms of infection (sore throat, extreme tiredness, cough, flu-like symptoms, fever,) or cancer (weight loss, swollen lymph nodes in the neck, armpits, or groin, fever, excessive tiredness or weakness, night sweats, cough, chest pain, trouble breathing, or pain, swelling, or fullness in the stomach area).

No, Tacvido Forte Oral Gel does not have an abuse potential as it is not a controlled substance.

Side effects of Tacvido Forte Oral Gel include nausea, diarrhoea, headache, kidney problems, infection, fever, constipation or high blood pressure. If the side effects persist or worsen, please consult your doctor.

Country of origin

INDIA

Manufacturer/Marketer address

59/1, First Floor, Kalu Sarai, Aurobindo Marg, New Delhi - 110016
Other Info - TAC0103

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