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  3. Sysret 20 mg Tablet 10's

Sysret 20 mg Tablet 10's, Pack of 10 TABLETS
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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Sysret 20 mg Tablet is used to treat a severe form of acne known as nodular acne when other treatments are ineffective. It contains Isotretinoin, which works by stopping the sebaceous glands from producing too much sebum and slowing the production of certain natural substances that can cause acne. Some people may experience dry skin and headaches. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Composition :

ISOTRETINOIN-20MG

Manufacturer/Marketer :

Kaizen Pharmaceuticals Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Sysret 20 mg Tablet

Sysret 20 mg Tablet belongs to a class of drugs called retinoids, primarily used to treat a severe form of acne known as nodular acne that has not responded to other treatments, including antibiotics.

Sysret 20 mg Tablet contains 'isotretinoin', which works by stopping the sebaceous glands from producing too much sebum and slowing the production of certain natural substances that can cause acne.

In some cases, Sysret 20 mg Tablet may cause side effects like dry skin, headache, cold symptoms, and vision problems. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Do not take Sysret 20 mg Tablet if you are allergic to any of its components, are pregnant or breastfeeding. Wear protective clothing and use sunscreen while going out to protect your skin from sunburn.

Uses of Sysret 20 mg Tablet

Sysret 20 mg Tablet used in the treatment of nodular acne. The detailed uses of Sysret 20 mg Tablet are as follows:

  • Treatment for nodular acne: Sysret 20 mg Tablet reduces acne lesions and treats severe nodular acne that is not responding to other treatments.
  • Sebum Reduction: Sysret 20 mg Tablet prevents acne by reducing oil production, avoiding the growth of acne, and shrinking the sebaceous gland.
  • Enhancement of Skin Texture: By encouraging the removal of dead skin cells and avoiding clogged pores, Sysret 20 mg Tablet helps to improve skin texture.

Directions for Use

  • Take Sysret 20 mg Tablet with food or as advised by your doctor.
  • It is advised to take Sysret 20 mg Tablet twice a day; however, follow your doctor’s recommendation regarding the dosage and duration.
  • Swallow Sysret 20 mg Tablet as a whole with a glass of water.
  • Do not crush, chew or break it.

Medicinal Benefits

  • Sysret 20 mg Tablet used to treat severe nodular acne, especially when other treatments (like antibiotics) have failed.
  • It reduces oil (sebum) production by shrinking the sebaceous glands, helping to prevent clogged pores.
  • Sysret 20 mg Tablet reduces the buildup of dead skin cells and bacteria in pores. Thereby, prevents the formation of new acne.
  • Helps reduce redness, swelling, and tenderness of acne lesions.
  • By controlling severe breakouts, it helps reduce the risk of permanent scarring.
  • It often provides sustained acne clearance even after treatment ends.

How Sysret 20 mg Tablet Works

Sysret 20 mg Tablet contains 'isotretinoin', which works by stopping the sebaceous glands from producing too much sebum and slowing the production of certain natural substances that can cause acne.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Sysret 20 mg Tablet
Managing Medication-Triggered Epistaxis (Nosebleed): A Step-by-Step Guide:
  • If you experience nosebleeds or unusual bleeding after taking medication, seek medical attention right away and schedule an appointment to discuss your symptoms with your doctor.
  • Your doctor may adjust your treatment plan by changing the dosage, switching to a different medication, or stopping the medication.
  • If your doctor advises, take steps to manage bleeding and promote healing, such as applying pressure, using saline nasal sprays, or applying a cold compress, using humidifiers, avoiding blowing or picking your nose, and applying petroleum jelly to the nostrils.
  • Schedule follow-up appointments with your doctor to monitor progress, adjust treatment plans, and prevent future episodes.
  • Managing a low platelet count (thrombocytopenia) caused by medication usage requires a multi-step approach. Here are some steps to help manage the condition:
  • Inform your doctor about your low platelet count and medication usage. They will assess the situation and guide the best course of action.
  • Your doctor may recommend adjusting or stopping the medication that is causing a low platelet count. This could involve switching to alternative medication or reducing the dosage.
  • Monitor your platelet count regularly through blood tests to track any changes. This will help the doctor determine the effectiveness of the treatment plan.
  • If an underlying condition, such as infection or inflammation, contributes to the low platelet count, your doctor will treat it.
  • In some cases, alternative treatments like platelet transfusions or medications that stimulate platelet production may be necessary.
  • Avoid risky activities and certain medications; eat a balanced diet with plenty of water to reduce bleeding risk and boost overall health.
  • If you experience severe bleeding or bruising, seek emergency medical attention immediately.
  • Exercise and a healthy diet can help manage high cholesterol, but consult your doctor about medication if lifestyle changes are not enough.
  • Avoid foods high in cholesterol, saturated fat, and trans fats, such as egg yolks, cheese, fried foods, pastries, ice cream, and red meat.
  • Increase your intake of vegetables, fruits, oats, whole grains, lentils, and beans to boost fibre consumption.
  • Include foods rich in monounsaturated fats, like nuts, avocados, olive oil, and oily fish.
  • Exercise regularly for 30 minutes and maintain a healthy weight.
  • Quit smoking and limit excessive alcohol consumption, as both can negatively impact your cholesterol levels.

What if I have taken an overdose of Sysret 20 mg Tablet

Do not take more than the prescribed dose of Sysret 20 mg Tablet as it may cause an overdose. The symptoms of overdose include vomiting, dizziness, headache, stomach pain, loss of balance or coordination, warmth or tingling in your face and swollen or cracked lips. If you suspect you have taken an overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

  • Do not take Sysret 20 mg Tablet if you are allergic to any of its components, are pregnant or breastfeeding.
  • Inform your doctor if you have asthma, diabetes, hypervitaminosis A (high levels of vitamin A), liver or heart problems, weak bones, osteoporosis (bone loss), anorexia nervosa (an eating disorder where people eat too little), any mental problems such as psychosis (loss of contact with reality) or depression before taking Sysret 20 mg Tablet .
  • If you have depression or any suicidal thoughts while taking Sysret 20 mg Tablet or after stopping treatment with Sysret 20 mg Tablet , please consult your doctor.
  • Do not undergo any cosmetic procedures while taking Sysret 20 mg Tablet and for a minimum of 6 months after stopping treatment with Sysret 20 mg Tablet , as it may increase the risk of scarring.
  • Stop taking Sysret 20 mg Tablet and call your doctor right away if you think you are pregnant, miss a menstrual period, or have had sex without using two forms of birth control.

Drug-Drug Interactions

verifiedApollotooltip
IsotretinoinDemeclocycline
Critical
IsotretinoinOxytetracycline
Critical

Drug-Drug Interactions

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IsotretinoinDemeclocycline
Critical
How does the drug interact with Sysret 20 mg Tablet:
Taking Sysret 20 mg Tablet with Demeclocycline may increase the risk of a rare and serious condition called pseudotumor cerebri (increased pressure in the brain).

How to manage the interaction:
Although taking Sysret 20 mg Tablet and Demeclocycline together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as headache, nausea, vomiting, and visual disturbances, consult a doctor. Do not stop using any medications without consulting doctor.
IsotretinoinOxytetracycline
Critical
How does the drug interact with Sysret 20 mg Tablet:
Co-administration of Sysret 20 mg Tablet with Oxytetracycline can increase the risk of pseudotumor cerebri (caused by increased pressure in the brain).

How to manage the interaction:
Taking Sysret 20 mg Tablet and Oxytetracycline together is not recommended as it can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as headache, nausea, vomiting, and visual disturbances, consult a doctor. Do not stop using any medications without consulting doctor.
IsotretinoinDoxycycline
Critical
How does the drug interact with Sysret 20 mg Tablet:
Taking Sysret 20 mg Tablet with Doxycycline may increase the risk of a rare condition called pseudotumor cerebri (increased pressure in the brain).

How to manage the interaction:
Although taking Sysret 20 mg Tablet and Doxycycline together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as headache, nausea, vomiting, and visual disturbances, consult a doctor. Do not stop using any medications without consulting doctor.
IsotretinoinTeriflunomide
Severe
How does the drug interact with Sysret 20 mg Tablet:
Taking Sysret 20 mg Tablet with teriflunomide may affect liver and causes liver problems.

How to manage the interaction:
Although taking Sysret 20 mg Tablet and teriflunomide together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of hunger, fatigue, nausea, vomiting, abdominal pain, dark-coloured urine, light-coloured stools, and/or yellowing of the skin or eyes. Do not stop using any medications without consulting doctor.
IsotretinoinTretinoin
Severe
How does the drug interact with Sysret 20 mg Tablet:
Taking Sysret 20 mg Tablet together with tretinoin may increase the risk of hypervitaminosis A (excessive vitamin A-related effects).

How to manage the interaction:
Although taking Sysret 20 mg Tablet and tretinoin together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as increased pressure in the brain (headache, nausea, vomiting, visual disturbances) or liver damage (fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, yellowing of the skin or eyes). Do not stop using any medications without consulting doctor.
IsotretinoinLomitapide
Severe
How does the drug interact with Sysret 20 mg Tablet:
Taking Sysret 20 mg Tablet with lomitapide may affect liver and cause liver problems.

How to manage the interaction:
Although taking Sysret 20 mg Tablet and lomitapide together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of hunger, fatigue, nausea, vomiting, abdominal pain, dark urine, pale stools, and/or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
IsotretinoinMinocycline
Severe
How does the drug interact with Sysret 20 mg Tablet:
Taking Sysret 20 mg Tablet with minocycline may increase the risk of a rare and serious condition called pseudotumor cerebri (increased pressure in the brain).

How to manage the interaction:
Although taking Sysret 20 mg Tablet and minocycline together can result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as headache, nausea, vomiting, and visual disturbances, consult a doctor. Do not stop using any medications without consulting a doctor.
IsotretinoinAminolevulinic acid
Severe
How does the drug interact with Sysret 20 mg Tablet:
Taking Sysret 20 mg Tablet with aminolevulinic acid may increase the risk of a severe sunburn.

How to manage the interaction:
Although taking Sysret 20 mg Tablet and aminolevulinic acid together can possibly result in an interaction, it can be taken if your doctor has prescribed it. After taking you should avoid exposure of the eyes and skin to sunlight or bright indoor lights for 48 hours. Incase you experience any unusual symptoms, consult a doctor. Do not stop using any medications without consulting doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Regular exercise can improve your mood and self-esteem, though it doesn't clear acne. Take a shower immediately after finishing exercise as sweat may irritate acne.
  • Avoid sun exposure while using Sysret 20 mg Tablet as it may make the skin more sensitive to sunlight and cause sunburn. Wear protective clothing and use sunscreen while going out to protect your skin from sunburn.
  • Regular hair washing is also recommended, and hair contact with the face should be avoided.
  • Remove the makeup completely before going to bed.

Habit Forming

No

Therapeutic Class

RETINOIDS

Sysret 20 mg Tablet Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

Avoid consumption of alcohol with Sysret 20 mg Tablet as it may increase the risk of liver damage and cause a rise in cholesterol levels.

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Pregnancy

Unsafe

Sysret 20 mg Tablet is a Category X pregnancy drug and is considered unsafe for pregnant women as it may cause severe birth defects. Please consult a doctor if you are pregnant or planning to become pregnant.

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Breast Feeding

Unsafe

Sysret 20 mg Tablet may be excreted in breast milk and cause adverse effects in the baby. Please consult a doctor before using Sysret 20 mg Tablet while breastfeeding.

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Driving

Caution

Sysret 20 mg Tablet may reduce night vision in some patients. Therefore, drive only if you are alert after taking Sysret 20 mg Tablet .

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Liver

Unsafe

Sysret 20 mg Tablet is usually not recommended for patients with impaired liver function. If you have any concerns regarding the use of Sysret 20 mg Tablet in patients with liver problems, please consult a doctor.

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Kidney

Consult your doctor

If you have any concerns regarding the use of Sysret 20 mg Tablet in patients with kidney problems, please consult a doctor.

bannner image

Children

Unsafe

Sysret 20 mg Tablet is not recommended for children below 12 years of age.

bannner image

Heart

Consult your doctor

If you have any concerns regarding the use of Sysret 20 mg Tablet in patients with heart problems, please consult a doctor.

bannner image

Geriatrics

Consult your doctor

Limited information is available. Please consult your doctor.

Have a query?

FAQs

Sysret 20 mg Tablet is used to treat a severe form of acne known as nodular acne that cannot be cleared by any other treatments, including antibiotics.

Sysret 20 mg Tablet may cause decreased night vision temporarily or permanently in some patients. It is not necessary for everyone taking Sysret 20 mg Tablet to experience this side effect. Avoid driving after taking Sysret 20 mg Tablet if you are unable to see in the dark, and consult a doctor if you notice any changes in vision or have painful or persistent dry eyes.

Sysret 20 mg Tablet may increase the skin sensitivity to sunlight. Therefore, avoid or limit exposure to sunlight and sunlamps. You are advised to use sunscreen and wear protective clothing while going out to prevent sunburn.

No, you are not recommended to undergo any cosmetic procedures to smoothen your skin, including waxing, laser procedures or dermabrasion (an exfoliating technique to remove outer layers of skin with a rotating instrument) while taking Sysret 20 mg Tablet and for a minimum of 6 months after stopping treatment with Sysret 20 mg Tablet , as it may increase the risk of scarring.

You are not recommended to take vitamin A supplements with Sysret 20 mg Tablet as it may cause hypervitaminosis A (excessive levels of vitamin A in the body), leading to an increased risk of adverse effects. However, please consult a doctor before taking other medicines or supplements with Sysret 20 mg Tablet .

No, Sysret 20 mg Tablet is not recommended for use during pregnancy as it may cause severe birth defects. Also, it is advised to use effective contraceptive measures before, while taking Sysret 20 mg Tablet and after 1 month of stopping treatment with Sysret 20 mg Tablet . However, please inform your doctor if you are pregnant, planning for pregnancy or breastfeeding before taking Sysret 20 mg Tablet .

Sysret 20 mg Tablet is safe to use if prescribed by the doctor. Use Sysret 20 mg Tablet exactly as advised by the doctor as it is associated with adverse effects.

Sysret 20 mg Tablet is not a steroid. It is a retinoid used to treat severe nodular acne.

Pregnancy tests, lipid profile tests, liver function tests, blood glucose tests, and creatine phosphokinase (CPK) tests are recommended tests during Sysret 20 mg Tablet treatment.

In most cases, the effect of Sysret 20 mg Tablet is permanent. Isotretinoin is a clinically effective anti-acne therapy that shows significant improvement in many patients.

Sysret 20 mg Tablet does not cause cancer. In fact, isotretinoin slows the growth of cancer cells by activating protein receptors in cells, including cancer cells.

Long-term use of Sysret 20 mg Tablet , even in low doses, has not been studied and is not recommended. Hence, long-term side effects of Sysret 20 mg Tablet have not been established.

Sysret 20 mg Tablet is not known to affect male fertility.

Sysret 20 mg Tablet might elevate liver enzymes. Therefore, regular liver function tests are advised.

Side effects of Sysret 20 mg Tablet include chapped lips and dry skin, eyes, nose, or lips. These side effects may not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Country of origin

India

Manufacturer/Marketer address

Old No:22, New No:20 East Club Road, Shenoy Nagar, Chennai, Tamil Nadu-600030
Other Info - SYS0062

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Author Details

Veda MaddalaDoctor badge

Written By

Veda Maddala

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Aug 6, 2025 | 12:40 PM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2002/18662s051lbl.pdf
  2. https://www.drugs.com/mtm/isotretinoin.html
  3. https://www.nhs.uk/medicines/isotretinoin-capsules/

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