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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
SYNTHIVAN TABLET is used to treat HIV infection. It contains Atazanavir and Ritonavir which work by inhibiting the protease enzyme production that is required by the HIV-infected cells to make new viruses. In some cases, this medicine may cause side effects such as stomachache, diarrhoea, nausea, vomiting, headache, dizziness, indigestion, and tiredness. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Whats That

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Manufacturer/Marketer :

Cipla Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About SYNTHIVAN TABLET

SYNTHIVAN TABLET belongs to the class of medications called ‘antiretroviral agents’ used to treat HIV infection. HIV is a virus that attacks the immune cells of the body leading to decreased immunity. It spreads through body fluids such as semen, vaginal fluid, and blood. Symptoms include fever, chills, rash, night sweats, muscle aches, tiredness, and sore throat that usually last for days to several weeks.

SYNTHIVAN TABLET is a combination of Atazanavir and Ritonavir. These drugs belong to the class of protease inhibitors. They work by inhibiting the protease enzyme production, which is required by the HIV-infected cells to make new viruses. This effect helps to inhibit viral replication.

Take SYNTHIVAN TABLET exactly as prescribed by the doctor. SYNTHIVAN TABLET may cause side effects such as stomach ache, diarrhoea, feeling sick (nausea), vomiting (being sick), flushing (reddening of the skin), headache, dizziness, pain in the throat, cough, upset stomach, a tingling sensation or numbness in the hands, feet or around the lips and mouth, bad taste in the mouth, damage to the nerves that can cause weakness and pain, itching, rash, joint pain and back pain, dyspepsia (indigestion), and fatigue (tiredness). Inform your doctor if any of these side effects persist or get worse.

It is not recommended to take SYNTHIVAN TABLET if you are allergic to any contents of it. Before taking SYNTHIVAN TABLET , inform your doctor if you have any liver disease, hepatitis B or C (liver infections), hemophilia (bleeding disorder), erectile dysfunction, diabetes, gall stones, and kidney disease. Inform your doctor if you are pregnant or breastfeeding. Consult your doctor before using this medicine for children. SYNTHIVAN TABLET should be used with caution in elderly patients. Alcohol consumption may increase the risk of side effects. SYNTHIVAN TABLET may cause dizziness, so do not drive or operate heavy machinery if you feel dizzy.

Uses of SYNTHIVAN TABLET

Treatment of HIV infection

Directions for Use

• SYNTHIVAN TABLET should be taken with food.• Follow your doctor's instructions on the dosage and timing of this medication.• Swallow SYNTHIVAN TABLET as a whole with a glass of water.• Do not crush, break, or chew it.

Medicinal Benefits

SYNTHIVAN TABLET belongs to the group of medicines called antiretroviral therapy (ART). SYNTHIVAN TABLET is a fixed-dose combination (FDC) and contains atazanavir and ritonavir. FDC helps decrease drug resistance (reduction in medication effectiveness) as HIV can easily develop drug resistance. SYNTHIVAN TABLET helps reduce the symptoms, control the infection, and prevent opportunistic infections effectively. It further helps in improving the quality of life of a patient with HIV. 

How SYNTHIVAN TABLET Works

SYNTHIVAN TABLET is a combination of Atazanavir and Ritonavir. These drugs belong to the class of protease inhibitors. They work by inhibiting the protease enzyme production, which is required by the HIV-infected cells to make new viruses. This effect helps to inhibit viral replication.

Storage

Keep this medicine out of the sight and reach of children.

What if I have taken an overdose of SYNTHIVAN TABLET

Take SYNTHIVAN TABLET only as prescribed by the physician. Do not exceed the recommended dose, as it might cause an overdose. If you suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Inform your doctor if you develop persistent diarrhoea or vomiting, as it may affect the effectiveness of SYNTHIVAN TABLET . SYNTHIVAN TABLET may cause pancreatitis, so inform your doctor if you develop symptoms such as nausea (feeling sick), vomiting, or stomach pain. SYNTHIVAN TABLET may lead to opportunistic infections (infections that occur frequently or severely in patients with weak immune systems), so inform your doctor immediately if you experience symptoms of infection such as muscle weakness, weakness beginning in the hands and feet that progress towards the trunk, palpitations (pounding heartbeat), and tremors. SYNTHIVAN TABLET may destroy bone leading to symptoms such as joint stiffness or pain. It may also cause muscle pain, tenderness, or weakness. SYNTHIVAN TABLET may also cause dizziness and abnormal heartbeat. Inform your doctor immediately if you notice any significant changes in the electrocardiogram (ECG).

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Synthivan Tablet:
Taking Nimodipine with Synthivan Tablet can increase the blood levels of Synthivan Tablet, which may lead to increased side effects.

How to manage the interaction:
Taking Nimodipine with Synthivan Tablet is not recommended as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience irregular heart rhythm, swelling, and lightheadedness, contact a doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Synthivan Tablet:
Co-administration of Eplerenone and Synthivan Tablet may significantly increase the blood levels of Eplerenone.

How to manage the interaction:
Taking Synthivan Tablet and Eplerenone together is not recommended as it can lead to an interaction. However, it can be taken if a doctor advises it. If you experience any unusual symptoms like headaches, irritation, confusion, edema (swelling caused by too much fluid accumulation), weakness, palpitations, or constipation, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
RitonavirErgotamine
Critical
How does the drug interact with Synthivan Tablet:
Taking ergotamine with Synthivan Tablet may significantly increase the blood levels and effects of ergotamine.

How to manage the interaction:
Taking Ergotamine with Synthivan Tablet is not recommended as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience abdominal pain, nausea, vomiting, numbness or tingling, muscle pain or weakness, blue or purple discoloration of fingers or toes, pale or cold skin, chest pain or tightness, irregular heartbeat, severe headache, shortness of breath, blurred vision, confusion, and/or slurred speech, contact a doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Synthivan Tablet:
Taking Ticagrelor with Synthivan Tablet may significantly increase the blood levels of Ticagrelor.

How to manage the interaction:
Taking Ticagrelor with Synthivan Tablet is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience any unusual bleeding or bruising, swelling, vomiting, blood in your urine or stools, headache, dizziness, or weakness. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Synthivan Tablet:
Taking Synthivan Tablet and Tolvaptan may significantly increase the blood levels of tolvaptan.

How to manage the interaction:
Taking Tolvaptan with Synthivan Tablet is not recommended as it can possibly result in an interaction, it can be taken if a doctor has advised it. If you notice any of these symptoms like difficulty swallowing, trouble speaking, muscle weakness, trouble controlling body movements, confusion, mood changes, fits, contact a doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Synthivan Tablet:
Coadministration of Synthivan Tablet and Sildenafil may significantly increase the blood levels of sildenafil.

How to manage the interaction:
Taking Sildenafil with Synthivan Tablet together is generally avoided as it can possibly result in an interaction, it can be taken only if your doctor has advised it. If you notice any of these symptoms like nausea, shortness of breath, dizziness, lightheadedness, fainting, visual disturbances, ringing in the ears, vision or hearing loss, chest pain or tightness, irregular heartbeat, and/or priapism (prolonged and painful erection unrelated to sexual activity), contact a doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Synthivan Tablet:
The combination of Amiodarone and Synthivan Tablet may significantly increase the blood levels of Amiodarone.

How to manage the interaction:
Despite the fact that Amiodarone and Synthivan Tablet interact, it can be taken if prescribed by a doctor. If you get dizziness, shortness of breath, weakness, or chest tightness, consult a doctor. Do not stop taking any medications without visiting a doctor.
How does the drug interact with Synthivan Tablet:
Taking Synthivan Tablet and Simvastatin may increase the risk of side effects.

How to manage the interaction:
Taking Simvastatin with Synthivan Tablet is not recommended as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of hunger, tiredness, nausea, vomiting, dark colored urine, and/or yellowing of the skin or eyes, contact a doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Synthivan Tablet:
Taking Synthivan Tablet and Ranolazine may significantly increase the blood levels and effects of Ranolazine.

How to manage the interaction:
Co-administration of Ranolazine with Synthivan Tablet can possibly result in an interaction, but it can be taken if a doctor has advised it. In case you experience any symptoms like feeling lightheaded, fainting, or rapid heartbeats, consult a doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Synthivan Tablet:
Taking Isavuconazole with Synthivan Tablet may significantly increase the blood levels of Isavuconazole, which may increase the risk of side effects.

How to manage the interaction:
Taking Isavuconazole with Synthivan Tablet is not recommended as it can possibly result in an interaction, it can be taken if a doctor has advised it. If you notice any of these symptoms like nausea, vomiting, loose stools, light color stools or dark urine, consult a doctor. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat a healthy and balanced diet. Eat vitamin and nutrient-rich food such as dark-green, yellow, orange, and red vegetables and fruit as it helps to boost your immune system. Option for lean protein and whole grains.
  • Avoid eating raw meat and eggs. Consume properly boiled and cooked meat, poultry, or seafood.
  • Eat bland and low-fat foods and avoid spicy or oily foods if you experience nausea or vomiting.
  • Try to reduce emotional and physical stress by spending time with family or whatever makes you happy.
  • Drink more fluids and avoid alcoholic beverages to prevent dehydration.  
  • Wash your hands properly before and after eating.
  • Make sure you sleep at least 8 hours a day.

Habit Forming

No

Therapeutic Class

ANTIRETROVIRAL AGENTS
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Alcohol

Caution

Consumption of alcohol may increase the risk of side-effects.

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Pregnancy

Caution

SYNTHIVAN TABLET should be used with caution in pregnant women. It is given only if clinically needed and when benefits outweigh the risk.

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Breast Feeding

Caution

If SYNTHIVAN TABLET is prescribed during breastfeeding, the doctor may advise you to stop breastfeeding as this medicine can pass into breastmilk.

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Driving

Caution

SYNTHIVAN TABLET may cause dizziness, so do not drive or operate heavy machinery if you feel dizzy.

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Liver

Caution

SYNTHIVAN TABLET should be used with caution in patients with liver diseases. The dose may have to be adjusted by your doctor.

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Kidney

Caution

SYNTHIVAN TABLET should be used with caution in patients with kidney diseases. The dose may have to be adjusted by your doctor.

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Children

Caution

This medicine is not recommended for children below 3 months. However, please consult your doctor for more information.

Have a query?

FAQs

SYNTHIVAN TABLET is used to treat HIV infection.

SYNTHIVAN TABLET is a combination of two medicines: Atazanavir and Ritonavir. These two drugs work by inhibiting the protease enzyme production, which is required by the HIV-infected cells to make new viruses. Thereby preventing viral replication and controlling the infection.

SYNTHIVAN TABLET should be taken with food (after a meal or substantial snack) as this helps in effective absorption of the medicine.

SYNTHIVAN TABLET may cause side-effects such as stomach ache, diarrhoea, feeling sick (nausea), vomiting (being sick), flushing (reddening of the skin), headache, dizziness, pain in the throat, cough, upset stomach, a tingling sensation or numbness in the hands, feet or around the lips and mouth, bad taste in the mouth, damage to the nerves that can cause weakness and pain, itching, rash, joint pain and back pain, dyspepsia (indigestion), and fatigue (tiredness). Inform your doctor if any of these side-effects persist or get worse.

SYNTHIVAN TABLET should not be used in patients with liver disease, hepatitis B or C (liver infections), haemophilia (bleeding disorder), erectile dysfunction, diabetes, gall stones, and kidney disease as it may worsen these conditions.

SYNTHIVAN TABLET doesn’t cure HIV infection. However, it helps to control the disease and prevent opportunistic infections.

Country of origin

India

Manufacturer/Marketer address

Cipla House, Peninsula Business Park, Ganpatrao Kadam Marg, Lower Parel, Mumbai-400013
Other Info - SYN0117

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