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compositionComposition:CARBIDOPA-12.5MG+ENTACAPONE-200MG+LEVODOPA-50MG
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Syncapone 50 Tablet is used in treating Parkinson's disease. It helps control movement and provides greater relief from the symptoms of Parkinson's disease. It may cause common side effects such as nausea, vomiting, loss of appetite, light-headedness, lowered blood pressure, confusion, and dyskinesia (uncontrolled/involuntary muscle movement). Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

CARBIDOPA-12.5MG+ENTACAPONE-200MG+LEVODOPA-50MG

Manufacturer/Marketer :

Sun Pharmaceutical Industries Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Syncapone 50 Tablet

Syncapone 50 Tablet is a combination prescription medicine used to treat the symptoms of Parkinson’s disease, particularly when standard treatments begin to lose their effectiveness between doses. It helps manage movement difficulties by restoring chemical balance in the brain. This oral tablet is designed to provide more consistent relief from tremors, stiffness, and slow movement.

To get the best results, you must take Syncapone 50 Tablet consistently at the precise times prescribed by your doctor. You can take Syncapone 50 Tablet with or without food, but it is best to avoid eating high-protein meals right before or after your dose, as protein can interfere with how the medicine is absorbed. Combining this treatment with regular physical therapy and a balanced diet can help improve your daily mobility and overall physical function.

While taking Syncapone 50 Tablet , some people may experience mild side effects like nausea, dizziness, or a harmless change in urine color. However, you should contact your doctor immediately if you develop more serious issues, such as involuntary muscle movements, severe watery diarrhea, or unusual changes in your mental state, including hallucinations.

Before starting Syncapone 50 Tablet , tell your doctor if you have a history of liver damage, kidney disease, heart problems, or depression. Do not take this if you are currently taking non-selective monoamine oxidase (MAO) inhibitors, or if you have narrow-angle glaucoma.

This medication can interact with other substances. For example, taking iron supplements at the same time can reduce how much medicine your body absorbs, while alcohol can increase your risk of severe dizziness. If you are pregnant, planning to breastfeed, or are an older adult, consult your doctor or pharmacist to discuss the risks and benefits before starting treatment.

Uses of Syncapone 50 Tablet

Syncapone 50 Tablet is used in the treatment of Parkinson's disease. The detailed use of Syncapone 50 Tablet is as follows:

  • Parkinson’s Disease: Syncapone 50 Tablet is used to treat the symptoms of Parkinson's disease, specifically helping to manage the 'wearing-off' periods when previous doses of other medications begin to lose their effect before the next dose is due.

Key Benefits

Syncapone 50 Tablet helps improve movement and reduce the symptoms of Parkinson's disease, allowing for better control of daily activities. By supporting more consistent symptom management throughout the day, it helps maintain mobility, independence, and overall quality of life. Benefits may include:

  • Helps improve movement, coordination, and physical function.
  • Reduces stiffness, slowness of movement, and muscle rigidity.
  • Helps decrease off periods when Parkinson's symptoms may temporarily worsen.
  • Supports smoother performance of daily activities such as walking, eating, and writing.
  • Promotes greater independence and confidence in everyday life.
  • Provides more consistent symptom control throughout the day.
Side effects of Syncapone 50 Tablet
  • Uncontrolled and involuntary movements need immediate medical attention.
  • Observe your movements and try to understand and control the particular movement.
  • Regularly do strengthening exercises to improve blood flow throughout the body and avoid involuntary movements.
  • Implement massage techniques to enhance blood flow to organs.
  • Take a balanced diet and quit smoking.
  • Practice yoga and meditation to improve thought processes and reduce uncontrolled and involuntary movements.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Talk to your doctor about identifying the cause of the discoloration, adjusting your dose, or switching to a different medication.
  • Keep an eye on your urine colour and let your doctor know if you notice any unusual changes.
  • Increase your intake of water or other liquids to dilute your urine and restore its normal colour.
  • Avoid foods that can change your urine colour, such as beets, rhubarb, and berries.
Managing Medication-Triggered Anxiety: A Comprehensive Approach:
  • Inform your doctor about your anxiety symptoms so that you doctor may explore potential drug interactions and alter your treatment plan.
  • Work with your doctor to adjust your medication regimen or dosage to minimize anxiety symptoms.
  • Reduce anxiety symptoms by practicing relaxation techniques like meditation, deep breathing, or yoga.
  • Regular self-care activities, such as exercise, healthy food, and adequate sleep, can assist control anxiety.
  • Surround yourself with a supportive network of friends, family, or a support group to help manage anxiety and stay motivated.
  • Regularly track anxiety symptoms and report any changes to your doctor to ensure your treatment plan is effective and adjusted as needed.
  • Manage stress by practising deep breathing, yoga or meditation.
  • Participating in activities you enjoy, or exercising may also help manage agitation.
  • Get enough sleep. Maintain a regular sleep cycle.
  • Exercise regularly. Try physical activities like walking, running, or dancing.
Managing depression as a side effect of medication: a comprehensive guide.
  • Remember, managing depression as a side effect of medication requires patience, persistence, and collaboration with your healthcare team.
  • Tell your doctor about your depression symptoms to adjust medication.
  • Consult a therapist or counsel for emotional support.
  • Engage in regular exercise to release endorphins (neurotransmitters).
  • Practice stress-reducing techniques like meditation and deep breathing.
  • Build a support network of friends, family, and support groups.
  • Establish a consistent sleep schedule.
  • Eat a nutritious diet rich in fruits, vegetables, and whole grains.
  • Limit or avoid alcohol and recreational substances.
  • Keep a mood journal to track symptoms and progress.

Directions for Use

  • Take Syncapone 50 Tablet with or without food, or as advised by a doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
  • Swallow the medicine as a whole with a glass of water.
  • Do not crush, break, or chew it.

How Syncapone 50 Tablet Works

Syncapone 50 Tablet contains Carbidopa, Levodopa, and Entacapone. • Carbidopa: It helps Levodopa reach the brain more effectively by preventing it from breaking down too early in the body. It also helps reduce side effects such as nausea and vomiting. • Levodopa: It is converted into dopamine in the brain, helping improve control of body movements. This helps reduce symptoms of Parkinson's disease such as stiffness, slowness, and difficulty moving. • Entacapone: It helps Levodopa stay active in the body for a longer time, allowing its effects to last longer and helping provide more consistent control of Parkinson's symptoms.
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Alcohol

Caution

Avoid consumption of alcohol with Syncapone 50 Tablet as it may increase the risk of adverse effects such as drowsiness, dizziness, or difficulty in concentrating.

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Pregnancy

Caution

Syncapone 50 Tablet is a pregnancy Category C medicine. It is unknown whether Syncapone 50 Tablet will affect pregnant women or the fetus. Hence, the intake of Syncapone 50 Tablet should be avoided if you are pregnant or planning to become pregnant, as it may harm the baby.

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Breast Feeding

Caution

Syncapone 50 Tablet is excreted in human milk, but the effect of Syncapone 50 Tablet on an infant is unknown. So, Syncapone 50 Tablet is given to a breastfeeding mother only if the doctor thinks the benefits outweigh the risks.

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Driving

Unsafe

Syncapone 50 Tablet may cause drowsiness and make you fall asleep suddenly. Therefore, avoid driving if you feel drowsy after taking Syncapone 50 Tablet .

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Liver

Caution

Take Syncapone 50 Tablet with caution if you have a history of liver diseases/conditions. The dose may be adjusted by your doctor as required.

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Kidney

Caution

Take Syncapone 50 Tablet with caution if you have a history of kidney diseases/conditions. The dose may be adjusted by your doctor as required.

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Children

Caution

Syncapone 50 Tablet is not recommended for use in children, as safety and effectiveness have not been established.

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Heart

Caution

Syncapone 50 Tablet should be taken with extreme caution in patients with heart disease. Please consult your physician.

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Geriatrics

Safe if prescribed

Syncapone 50 Tablet can be given in elderly patients if prescribed by the doctor.

What if I have taken an overdose of Syncapone 50 Tablet

In case of an accidental overdose, seek immediate medical attention or call emergency services right away.

Diet & Lifestyle Advise

  • Manage protein timing: Avoid eating high-protein meals (such as meat, eggs, or cheese) at the same time you take your medication, as protein can block the medicine from being absorbed properly.
  • Stay well hydrated: Drink plenty of water throughout the day to help manage dry mouth and prevent constipation, which are common issues.
  • Move slowly when standing: To prevent dizziness or fainting from a sudden drop in blood pressure, take your time when moving from a sitting or lying position to standing.
  • Keep a symptom diary: Write down the times you take your medicine and when your symptoms return or worsen. Sharing this with your doctor helps them fine-tune your treatment plan.

Health Queries

My father has Parkinson's disease and is experiencing extreme tiredness and weakness. What medications can help manage these symptoms?

Vikas Singh

Vikas Singh

M Pharmacy

Fatigue and weakness are very common in Parkinson's disease. First, his doctor should review his current medications, as adjusting his primary treatment (like carbidopa-levodopa) can often help. If the fatigue is a direct symptom of the disease, wakefulness-promoting medications like modafinil or drugs like amantadine may be prescribed. If poor sleep or depression is contributing to his tiredness, low-dose antidepressants or sleep aids might be suggested. Please consult his neurologist to safely evaluate his symptoms and tailor his treatment plan.
health query

Have a query?

How Soon It Starts Working

The time required for Syncapone 50 Tablet to start to work: Syncapone 50 Tablet ideally shows its action within 1 to 2 hours after administration.

The time for which the effects of Syncapone 50 Tablet last: The effect of Syncapone 50 Tablet lasts for 3 to 6 hours.

What if you forget to take Syncapone 50 Tablet

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • Do not stop treatment abruptly: Never stop taking Syncapone 50 Tablet suddenly, as this may cause a serious reaction with symptoms such as high fever, severe muscle stiffness, confusion, and changes in consciousness.
  • Use caution during activities requiring alertness: Syncapone 50 Tablet may cause dizziness, drowsiness, or sudden episodes of sleep. Avoid driving, operating machinery, or performing hazardous tasks until you know how the medicine affects you.
  • Separate iron supplements from your dose: Do not take iron supplements or multivitamins containing iron at the same time as Syncapone 50 Tablet . Leave a gap of at least 2 hours, as iron can reduce the absorption and effectiveness of the treatment.
  • Monitor your blood pressure regularly: Syncapone 50 Tablet may cause a drop in blood pressure when standing up. Check your blood pressure as advised by your doctor and rise slowly from sitting or lying positions to help prevent dizziness or fainting.

Drug-Drug Interactions

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Drug-Drug Interactions

  • Iron supplements: Can bind to the medicine in your digestive tract and significantly lower its absorption.
  • Certain antidepressants (MAO inhibitors): Combining these can lead to dangerously high blood pressure.
  • Blood pressure medications: May increase the risk of dizziness or fainting when standing up due to low blood pressure.

Drug-Food Interactions

  • High-protein foods: Can compete with the absorption of the active ingredients in your gut, reducing the effectiveness of your dose.

Drug-Disease Interactions

  • Narrow-angle glaucoma: May increase pressure inside the eye, making this condition worse.
  • Liver damage: Reduced liver function can cause the medicine to build up in your body, increasing the risk of side effects.
  • Psychiatric disorders: May worsen symptoms of psychosis, confusion, or severe depression.
Entacapone + Carbidopa + LevodopaLinezolid
Critical
Entacapone + Carbidopa + LevodopaPhenelzine
Critical

Drug-Drug Interactions

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Entacapone + Carbidopa + LevodopaLinezolid
Critical
How does the drug interact with Syncapone 50 Tablet:
Using levodopa together with linezolid can increase blood pressure and increase the risk of side effects.

How to manage the interaction:
Taking levodopa together with linezolid is not recommended, but it can be taken if your doctor has suggested it. However, if you experience a sudden and severe headache, blurred vision, confusion, seizures, chest pain, nausea or vomiting, sudden numbness or weakness (especially on one side of the body), speech difficulties, fever, sweating, lightheadedness, and/or fainting, you should seek immediate medical attention. Do not stop using any medications without talking to a doctor.
Entacapone + Carbidopa + LevodopaPhenelzine
Critical
How does the drug interact with Syncapone 50 Tablet:
Using levodopa together with phenelzine can increase blood pressure and increase the risk of side effects.

How to manage the interaction:
Taking Levodopa with Phenelzine is not recommended, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience severe headache, blurred vision, confusion, seizures, chest pain, nausea or vomiting, sudden numbness or weakness (especially on one side of the body), speech difficulties, fever, sweating, lightheadedness and fainting. Do not discontinue any medications without consulting your doctor.
Entacapone + Carbidopa + LevodopaMethylene blue
Critical
How does the drug interact with Syncapone 50 Tablet:
Combining Entacapone with Methylene Blue can increase the risk of increased blood pressure.

How to manage the interaction:
Taking Entacapone and Methylene Blue together is not recommended as it can result in an interaction, but it can be taken if your doctor has advised it. If you notice any of these signs—sudden and severe headache, blurred vision, confusion, seizures, chest pain, nausea or vomiting, sudden numbness or weakness (especially on one side of the body), speech difficulties, fever, sweating, lightheadedness, and/or fainting—make sure to call a doctor right away. Do not discontinue any medications without consulting a doctor.
Entacapone + Carbidopa + LevodopaFurazolidone
Critical
How does the drug interact with Syncapone 50 Tablet:
Taking levodopa and furazolidone together can lead to increased blood pressure.

How to manage the interaction:
Using levodopa and furazolidone together is not recommended. It can be taken if your doctor has suggested it. If you experience any symptoms like sudden and severe headache, blurred vision, confusion, seizures, chest pain, nausea or vomiting, sudden numbness or weakness (especially on one side of the body), speech difficulties, fever, sweating, lightheadedness, and/or fainting, contact the doctor immediately. Do not discontinue any medications without consulting your doctor.
Entacapone + Carbidopa + LevodopaIsocarboxazid
Critical
How does the drug interact with Syncapone 50 Tablet:
Using levodopa together with isocarboxazid can increase blood pressure and increase the risk of side effects.

How to manage the interaction:
Taking isocarboxazid and levodopa together is not recommended as it can possibly result in an interaction, but it can be taken if your doctor has advised it. Contact your doctor right away if you experience symptoms like a severe headache, confusion, chest pain, or sudden weakness. Do not stop using any medications without a doctor's advice.
Entacapone + Carbidopa + LevodopaProcarbazine
Critical
How does the drug interact with Syncapone 50 Tablet:
Combining Levodopa with Procarbazine can increase the risk of increased blood pressure.

How to manage the interaction:
Taking Levodopa and Procarbazine together is not recommended as it can result in an interaction, but it can be taken if your doctor has advised it. If you notice any of these signs—sudden and severe headache, blurred vision, confusion, seizures, chest pain, nausea or vomiting, sudden numbness or weakness (especially on one side of the body), speech difficulties, fever, sweating, lightheadedness, and/or fainting—make sure to call a doctor right away. Do not discontinue any medications without consulting a doctor.
Entacapone + Carbidopa + LevodopaEsketamine
Severe
How does the drug interact with Syncapone 50 Tablet:
Combining Entacapone+Levodopa with Esketamine can increase the risk and severity of side effects (drowsiness, confusion, difficulty concentrating, and impairment in thinking, judgment, reaction speed, and motor coordination).

How to manage the interaction:
Although taking Entacapone+Levodopa and Esketamine together can cause an interaction, it can be taken if your doctor has suggested it. If you're having any of these symptoms, like feeling sleepy, having trouble concentrating, or feeling confused, it's important to let a doctor know right away. Do not stop using any medications without talking to a doctor.
Entacapone + Carbidopa + LevodopaAmisulpride
Severe
How does the drug interact with Syncapone 50 Tablet:
Coadministration of levodopa with amisulpride may increase the risk and severity of side effects and also reduce the effectiveness of both drugs.

How to manage the interaction:
Although taking amisulpride and levodopa can result in an interaction, it can be taken if a doctor has advised it. However, consult a doctor if you experience drowsiness, low blood pressure, dizziness, and lightheadedness. Do not discontinue any medications without consulting a doctor.
Entacapone + Carbidopa + LevodopaSodium oxybate
Severe
How does the drug interact with Syncapone 50 Tablet:
Taking Entacapone+Levodopa with sodium oxybate can increase the risk or severity of side effects like decreased rate of breathing, decreased heart rate, and loss of consciousness.

How to manage the interaction:
Although taking Entacapone+Levodopa and Sodium Oxybate together can cause an interaction, it can be taken if your doctor has suggested it. If you notice any symptoms like fatigue, dizziness, lightheadedness, drowsiness, confusion, shortness of breath, chest pain, or tightness, make sure to call a doctor right away. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTIPARKINSON AGENTS]

FAQs

Syncapone 50 Tablet is used in the treatment of Parkinson's disease and helps relieve symptoms, including tremors, spasms, muscle stiffness and poor muscle control.
Syncapone 50 Tablet works by maintaining the levels of dopamine in the brain. Thereby, it helps reduce symptoms of Parkinson's disease, such as tremors and stiffness.
Take Syncapone 50 Tablet at the same time every day, as this will help you remember to take the medicine.
In some cases, prolonged intake of Syncapone 50 Tablet may lead to autoimmune haemolytic anaemia (red blood cells in the blood are destroyed earlier than normal). Levodopa in Syncapone 50 Tablet can cause the immune system to mistake your own red blood cells for foreign substances. The body responds by making antibodies to attack the body's own red blood cells. The antibodies attach to red blood cells and cause them to break down too early. So, your doctor might recommend regular blood tests while using Syncapone 50 Tablet .
You are recommended to avoid taking protein-rich food (such as chicken, beef, pork, eggs, meats, fish, dairy products, seeds, and nuts), iron supplements, or multivitamin tablets while taking Syncapone 50 Tablet as it may delay and reduce the absorption of levodopa. Thus, it reduces the effectiveness of Syncapone 50 Tablet . Please consult your doctor and do as advised for the best results.
Yes, orthostatic hypotension could be a side-effect of Syncapone 50 Tablet . Orthostatic hypotension is a sudden lowering of blood pressure leading to dizziness on standing. If you experience this, do not try to stand up suddenly or start walking; instead, lie down and get up slowly only when you feel better. People taking Syncapone 50 Tablet are advised to regularly monitor their blood pressure levels to avoid unpleasant events.
Consult your doctor before taking Syncapone 50 Tablet if you have glaucoma. Syncapone 50 Tablet is contraindicated in patients with narrow-angle glaucoma. Syncapone 50 Tablet may cause blindness on long-term use in the case of patients with narrow-angle glaucoma.
Hallucination is a medical condition in which a person may feel, hear, or believe things that are not true, see things that are not there, or feel unusually suspicious or confused. Syncapone 50 Tablet may cause hallucinations in some cases if taken for a prolonged time. So, if you experience hallucinations while taking Syncapone 50 Tablet , please talk to your doctor immediately.
It is advised not to stop taking Syncapone 50 Tablet without consulting your doctor, as it may lead to a severe condition called withdrawal-emergent hyperpyrexia with symptoms such as confusion, fever, muscle stiffness, changes in heartbeat, and breathing. Therefore, take Syncapone 50 Tablet for as long as your doctor has prescribed it, and if you experience any of these symptoms while taking Syncapone 50 Tablet , please consult your doctor so that the dose may be gradually reduced.
Syncapone 50 Tablet can be taken with or without food as advised by your doctor. Stay away from protein meals as it can delay the action of Syncapone 50 Tablet .
Yes, Syncapone 50 Tablet can turn the colour of your urine, sweat and saliva dark (brown, red, or black). Although it not harmful, it can sometimes stain your bedding and clothes.
No, you should swallow the tablet whole. Crushing, chewing, or splitting the tablet can ruin its special design and alter how the medicine is absorbed. If you struggle to swallow tablets, talk to your doctor.
Syncapone 50 Tablet can cause sudden sleepiness or even cause you to fall asleep without warning. Avoid driving or operating machinery if this happens, and talk to your doctor right away.
If your multivitamin contains iron, it can prevent your body from absorbing Syncapone 50 Tablet . You should separate your multivitamin and your dose of Syncapone 50 Tablet by at least 2 hours. Talk to your pharmacist for guidance.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Drugs.com Clinical Review Team. Levodopa Carbidopa And Entacapone Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  2. Electronic Medicines Compendium (EMC). Pil.6518 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  3. U.S. Food and Drug Administration (FDA). 021485S028S029Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  4. Levodopa+Carbidopa+Entacapone. 2010. [Accessed on 23 Apr. 2019]Check here
  5. David J. Brooks. Optimizing levodopa therapy for Parkinson’s disease with levodopa/carbidopa/entacapone: implications from a clinical and patient perspective. Neuropsychiatric disease and treatment. [Revised in February 2008] [Accessed on 14th June 2022]Check here
  6. Orion Pharma (UK) Ltd. Electronic Medicines Compendium (EMC). [Revised in January 2021] [Accessed on 14th June 2022]Check here
  7. European Medicine Agency European Medicine Agency. 2014. [Accessed on 23 Apr. 2019]Check here

Country of origin

India

Manufacturer/Marketer address

Sun Pharmaceutical Industries Ltd., SUN HOUSE, CTS No. 201 B/1, Western Express Highway, Goregaon (E), Mumbai 400063
Other Info - SYN0015

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