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  3. Synac R Tablet

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Synac R Tablet, Pack of 10 TabletS
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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Synac R Tablet is used to reduce pain and swelling in conditions like osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. It works by inhibiting the production of certain chemical substances that cause pain and inflammation. Besides this, it also reduces acidity. In some cases, this medicine may cause side effects such as indigestion, stomach pain, constipation, dizziness, nausea, and diarrhoea. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Composition :

ACECLOFENAC-100MG + PARACETAMOL-325MG + RABEPRAZOLE-10MG

Manufacturer/Marketer :

Synergy Pharmaceuticals

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Synac R Tablet

Synac R Tablet belongs to a class of drugs called analgesics (pain relievers) used to reduce pain and swelling in conditions such as osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis (pain and stiffness in the backbone). Arthritis is a condition that causes swelling of one or more joints resulting in pain and stiffness of joints that worsen over time. The symptoms of arthritis include joint pain, stiffness, redness, tenderness, swelling in and around joints, and reduced movement of joints.

Synac R Tablet is a combination of three drugs, namely: Aceclofenac (nonsteroidal anti-inflammatory drug), Paracetamol (analgesic and antipyretic), and Rabeprazole (proton pump inhibitor).  Aceclofenac and Paracetamol work by inhibiting the production of certain chemical substances such as prostaglandins that cause pain and swelling. Thereby, it helps in relieving pain and swelling associated with different types of arthritis. Rabeprazole works by blocking the action of proton pumps that are involved in producing stomach acid. Thereby, it reduces the amount of acid produced by the stomach and prevents excess acid from flowing back into the food pipe.

Take Synac R Tablet as prescribed by your doctor. You are advised to take Synac R Tablet for as long as your doctor has prescribed it for you based on your medical condition. In some cases, you may experience indigestion, stomach pain, constipation, dizziness, nausea, and diarrhea. Most of these side effects of Synac R Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Synac R Tablet or any other medicines, please tell your doctor. If you are pregnant or planning for pregnancy, please inform your doctor before taking Synac R Tablet as it may cause adverse effects in the baby if taken during the last 3 months of pregnancy. Synac R Tablet may be excreted in breast milk. Therefore, avoid breastfeeding and consult a doctor. Synac R Tablet is not recommended for children below 18 years of age as the safety and effectiveness were not established. Avoid consumption of alcohol with Synac R Tablet as it may increase the risk of stomach bleeding. Drive only if you are alert as Synac R Tablet may cause dizziness, tiredness, drowsiness, or vision problems.

Uses of Synac R Tablet

Treatment of Osteoarthritis, Rheumatoid arthritis and Ankylosing spondylitis.

Directions for Use

• Synac R Tablet can be taken with food to avoid stomach upset or as advised by your doctor. • Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.• Swallow Synac R Tablet as a whole with a glass of water.• Do not chew, crush or break it.

Medicinal Benefits

Synac R Tablet contains Aceclofenac, Paracetamol and Rabeprazole.  Aceclofenac and Paracetamol inhibit the production of certain chemical substances such as prostaglandins that cause pain and swelling. Thereby, it helps in relieving pain and swelling associated with different types of arthritis such as osteoarthritis, rheumatoid arthritis and ankylosing spondylitis (pain and stiffness in the backbone). Rabeprazole blocks the action of proton pumps that are involved in producing stomach acid. Thereby, it reduces the amount of acid produced by the stomach and prevents excess acid from flowing back into the food pipe.

How Synac R Tablet Works

Synac R Tablet is a combination of three drugs, namely: Aceclofenac (nonsteroidal anti-inflammatory drug), Paracetamol (analgesic and antipyretic), and Rabeprazole (proton pump inhibitor).  Aceclofenac and Paracetamol work by inhibiting the production of certain chemical substances such as prostaglandins that cause pain and swelling. Thereby, it helps in relieving pain and swelling associated with different types of arthritis. Rabeprazole works by blocking the action of proton pumps that are involved in producing stomach acid. Thereby, it reduces the amount of acid produced by the stomach and prevents excess acid from flowing back into the food pipe.

Storage

Keep Synac R Tablet out of reach and sight of children.

What if I have taken an overdose of Synac R Tablet

Take Synac R Tablet only as prescribed by the physician. Do not exceed the recommended dose, as it might cause an overdose. If you suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

If you are allergic to Synac R Tablet or any other medicines, please tell your doctor. If you are pregnant or planning for pregnancy, please inform your doctor before taking Synac R Tablet as it may cause adverse effects in the baby if taken during the last 3 months of pregnancy. Synac R Tablet may be excreted in breast milk. Therefore, avoid breastfeeding and consult a doctor. Synac R Tablet is not recommended for children below 18 years of age as the safety and effectiveness were not established. Avoid consumption of alcohol with Synac R Tablet as it may increase the risk of stomach bleeding. Drive only if you are alert as Synac R Tablet may cause dizziness, tiredness, drowsiness or vision problems.

Drug-Drug Interactions

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RabeprazoleErlotinib
Critical
RabeprazoleRilpivirine
Critical

Drug-Drug Interactions

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RabeprazoleErlotinib
Critical
How does the drug interact with Synac R Tablet:
When used in combination with erlotinib, Synac R Tablet may prevent the absorption of erlotinib into the circulation, which might make erlotinib less effective in treating cancer.

How to manage the interaction:
Taking Synac R Tablet with Erlotinib is not recommended as it can result in an interaction, it should be taken only if a doctor has advised it. Do not stop using any medications without consulting a doctor.
RabeprazoleRilpivirine
Critical
How does the drug interact with Synac R Tablet:
Co-administration of Synac R Tablet can make Rilpivirine less effective by reducing its absorption in the body.

How to manage the interaction:
Taking Synac R Tablet with Rilpivirine is not recommended, but can be taken if prescribed by the doctor. Do not discontinue the medications without consulting a doctor.
RabeprazoleClopidogrel
Severe
How does the drug interact with Synac R Tablet:
Taking Clopidogrel with Synac R Tablet can reduce the effectiveness of Clopidogrel.

How to manage the interaction:
Taking Clopidogrel and Synac R Tablet together possibly has an interaction, but you can take these medications together if a doctor has advised it. Do not stop using any medications without talking to a doctor.
RabeprazoleAtazanavir
Severe
How does the drug interact with Synac R Tablet:
Co-administration of Atazanavir's blood levels and absorption can both be affected by Synac R Tablet, which decreases the atazanavir's ability to treat HIV.

How to manage the interaction:
Although taking Synac R Tablet and atazanavir together can result in an interaction, it can be taken if a doctor has prescribed it. Do not discontinue any medications without a doctor's advice.
RabeprazoleIdelalisib
Severe
How does the drug interact with Synac R Tablet:
When Synac R Tablet and Idelalisib are taken in combination, Idelalisib may increase the level or impact of Synac R Tablet.

How to manage the interaction:
Although taking Synac R Tablet and Idelalisib together can result in an interaction, it can be taken if a doctor has prescribed it. Do not discontinue any medications without a doctor's advice.
RabeprazolePazopanib
Severe
How does the drug interact with Synac R Tablet:
Taking Synac R Tablet together with Pazopanib can result in a decreased effectiveness of Pazopanib in treating the disease.

How to manage the interaction:
Although taking Synac R Tablet and Pazopanib together can result in an interaction, but can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without talking to a doctor.
RabeprazoleMethotrexate
Severe
How does the drug interact with Synac R Tablet:
Co-administration of Methotrexate with Synac R Tablet can increase the blood levels and side effects of Methotrexate.

How to manage the interaction:
Although there is a possible interaction between Synac R Tablet and Methotrexate, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without consulting a doctor.
RabeprazoleGefitinib
Severe
How does the drug interact with Synac R Tablet:
Taking Synac R Tablet together with Gefitinib results in decreased levels of gefitinib in your blood. This can result in a decreased effectiveness of gefitinib in treating the disease.

How to manage the interaction:
Although taking Synac R Tablet and Gefitinib together can possibly result in an interaction, it can be taken if your doctor has prescribed it. To lessen the effects of the interaction, it is advised that you take gefitinib 12 hours before or 12 hours after Synac R Tablet. Do not discontinue any medications without a doctor's advice.
RabeprazolePhenytoin
Severe
How does the drug interact with Synac R Tablet:
When Phenytoin and Synac R Tablet are taken in combination, Phenytoin will reduce the concentration or impact of Synac R Tablet.

How to manage the interaction:
Although taking Phenytoin and Synac R Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. Do not discontinue any medications without a doctor's advice.
RabeprazoleDasatinib
Severe
How does the drug interact with Synac R Tablet:
Taking Synac R Tablet together with Dasatinib results in decreased levels of Dasatinib and its effectiveness.

How to manage the interaction:
Although taking Synac R Tablet and Dasatinib together can result in an interaction, it can be taken if a doctor has prescribed it. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle activities like 20-30minutes of walking or swimming would be helpful.
  • Performing yoga may also help in improving joint flexibility and pain management.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Get adequate sleep as resting the muscles can help in reducing inflammation and swelling.
  • Follow heat or cold therapy, apply a cold or hot compress on the joints for 15-20minutes regularly.
  • Acupuncture, massage and physical therapy may also be helpful.
  • Eat foods rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
  • Foods containing flavonoids such as soy, berries, broccoli, grapes and green tea help in reducing inflammation.
  • Avoid smoking and alcohol consumption.

Habit Forming

No

Therapeutic Class

ANALGESICS

Synac R Tablet Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

Avoid consumption of alcohol with Synac R Tablet as it may increase the risk of stomach bleeding. Please consult a doctor before consuming alcohol with Synac R Tablet.

bannner image

Pregnancy

Unsafe

Synac R Tablet is not recommended for pregnant women especially in the third trimester as it may cause adverse effects in the baby. However, please consult a doctor if you are pregnant or planning for pregnancy before taking Synac R Tablet.

bannner image

Breast Feeding

Unsafe

Avoid breastfeeding while taking Synac R Tablet as it may be excreted in breast milk and cause adverse effects in the baby. Please consult a doctor if you are breastfeeding.

bannner image

Driving

Caution

Synac R Tablet may cause dizziness, tiredness, drowsiness or vision problems in some people. So, drive only if you are alert after taking Synac R Tablet.

bannner image

Liver

Caution

Take Synac R Tablet with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required.

bannner image

Kidney

Caution

Take Synac R Tablet with caution, especially if you have a history of Kidney diseases/conditions. The dose may be adjusted by your doctor as required. Avoid taking Synac R Tablet if you have severe kidney disease.

bannner image

Children

Unsafe

Synac R Tablet is not recommended for children below 18 years of age as the safety and effectiveness were not established.

Have a query?

FAQs

Synac R Tablet contains Aceclofenac, Paracetamol and Rabeprazole. Aceclofenac and Paracetamol work by inhibiting the production of certain chemical substances such as prostaglandins that cause pain and swelling. Thereby, helps in relieving pain and swelling associated with different types of arthritis. Rabeprazole works by blocking the action of proton pumps that are involved in producing stomach acid. Thereby, it reduces the amount of acid produced by the stomach and prevents excess acid from flowing back into the food pipe.

Synac R Tablet may increase the risk of heart problems such as heart attack, especially when used in high doses or for prolonged duration and in patients who are smokers, have high blood pressure, diabetes or high cholesterol. It is advised to inform your doctor if you have any of these conditions or have a history of heart problems or stroke before taking Synac R Tablet. However, it is recommended to take Synac R Tablet in the dose and for a duration as prescribed by your doctor.

You are not recommended to take Synac R Tablet with warfarin as it may increase the risk of bleeding more easily. However, if you notice blood in urine or stools, dizziness, unusual bleeding or bruising, vomiting, weakness or headache, please consult a doctor immediately. If you are supposed to use these medicines together, you are advised to contact your doctor so that the dose may be adjusted appropriately to use safely.

Synac R Tablet may impair fertility in females and make it more difficult to conceive. Therefore, if you are pregnant, planning for pregnancy or have difficulties conceiving, please consult your doctor before taking Synac R Tablet.

Synac R Tablet is not recommended for asthma patients as it may worsen the condition. Therefore, please inform your doctor if you have asthma or a history of asthma due to the use of aspirin or any other non-steroidal drugs.

Synac R Tablet does not cure arthritis. Synac R Tablet is only used to relieve symptoms of arthritis such as joint pain, swelling and stiffness.

Synac R Tablet typically starts to work within a few hours after taking it. However, response time may vary by individual health conditions and severity of symptoms. Always follow your doctor's instructions and complete the full prescribed course to have optimal results.

Yes, Synac R Tablet may cause tiredness and drowsiness in some individuals. However, these symptoms vanish as your body adjusts to the medication. If these symptoms worsen, please consult a doctor for relief.

The duration of Synac R Tablet intake may vary based on individual health status. Continue taking Synac R Tablet as long as prescribed by your doctor to have complete recovery without side effects. If you are having any concerns please inform your doctor.

Synac R Tablet already contains paracetamol. Taking extra paracetamol could increase the risk of liver and kidney damage due to excessive intake. To ensure safety, it is best to discuss this with your doctor before taking any medication while using Synac R Tablet.

Synac R Tablet is a combination of three drugs, namely: Aceclofenac, Paracetamol, and Rabeprazole belongs to a class of analgesics (pain relievers). It is used to reduce pain and swelling in conditions such as osteoarthritis, rheumatoid arthritis, and spondylitis (pain and stiffness in the backbone).

Do not stop taking Synac R Tablet without consulting your doctor, even if your pain is relieved. Stopping it suddenly without completing the full prescribed course can lead to negative effects or worsen the condition. Instead, report your progress to your doctor and follow their advice. They will guide you on how to stop the medication safely after ensuring the infection is fully cleared.

Synac R Tablet may cause nausea and vomiting in some individuals as they are reported side effects. However, these symptoms vanish over time as your body adjusts to the medication. If these symptoms worsen, please consult a doctor for relief.

Synac R Tablet may cause dizziness in some individuals as it is a reported side effect. However, this symptom vanishes over time as your body adjusts to the medication. If dizziness worsens, please consult a doctor for relief.

The long-term use of Synac R Tablet can cause kidney damage. It should be used with caution, especially if you have a history of kidney disease. Inform your doctor if you have any kidney conditions, as your dose may need to be adjusted accordingly.

No, do not take higher than the recommended dose of Synac R Tablet. The appropriate dose is carefully determined and given based on individual patient needs. Using more than the recommended dose can increase the risk of serious side effects. If you are having any concerns with the present dose please talk to your doctor and they will assess your condition and adjust the dose if necessary.

Store Synac R Tablet at room temperature, away from moisture and heat. Make sure to keep it out of reach of children and pets.

Synac R Tablet is used to reduce pain and swelling in conditions such as osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis (pain and stiffness in the backbone).

Do not take another medication along with Synac R Tablet without consulting your doctor. Synac R Tablet may interact with other medications, leading to side effects or reduced effectiveness. To avoid this, discuss it with your doctor beforehand. They will assess your situation and guide you on safe usage.

Follow your doctor's advice and take the right amount of medicine. Be aware of side effects and take care of yourself. If you are pregnant while on treatment, inform your doctor immediately. Do not take other medications unless instructed by the doctor. Alcohol consumption should be avoided. By following these precautions, you'll benefit most from your medicine and stay safe.

The common side effects of Synac R Tablet that may occur in some individuals are indigestion, stomach pain, constipation, dizziness, nausea, and diarrhoea. Most of these side effects of Synac R Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

No, it is advised not to drink alcohol while taking Synac R Tablet. Drinking alcohol during treatment may cause an increase in dizziness, drowsiness, and risk of stomach bleeding.

Synac R Tablet is not recommended for pregnant women especially in the third trimester as it may cause adverse effects in the foetus. However, please consult a doctor if you are pregnant or planning for pregnancy before taking Synac R Tablet.

Country of origin

India

Manufacturer/Marketer address

D.NO. 76-12-1/1, FIRST FLOOR DHOLPHIN BAR ROAD BHAVANIPURAM VIJAYAWADA 520012 (A.P)
Other Info - SYN0169

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Author Details

Veda MaddalaDoctor badge

Written By

Veda Maddala

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 6:52 AM IST

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Reference

  1. https://www.medicines.org.uk/emc/files/pil.4240.pdf
  2. https://www.medicines.org.uk/emc/files/pil.11899.pdf
  3. https://www.medicines.org.uk/emc/files/pil.2842.pdf

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