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compositionComposition:TRAMADOL-100MG
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SUPRIDOL 100MG SUPPOSITORY is used to treat moderate to severe pain. It contains Tramadol, which provides pain relief by altering the transmission of pain signals from nerves to the brain and spinal cord. In some cases, it may cause common side effects such as nausea, vomiting, dry mouth, constipation, dizziness, drowsiness, headache, fatigue, and sweating. Before taking this medication, inform your doctor if you are pregnant or breastfeeding, taking any other medications, or have any pre-existing medical conditions.

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Written By ,
Reviewed By Praneetha Akunuri , M.Pharmacy
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More about the Product

Composition :

TRAMADOL-100MG

Manufacturer/Marketer :

Neon Laboratories Ltd

Consume Type :

Rectal

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About SUPRIDOL 100MG SUPPOSITORY

SUPRIDOL 100MG SUPPOSITORY is a prescription pain reliever designed to manage moderate to severe pain in patients who require constant, around-the-clock treatment. This medication works directly on the central nervous system to alter how your brain perceives and responds to discomfort. It is typically prescribed when other, non-opioid pain relievers have not provided sufficient relief.

For optimal relief, this medicine must be used exactly as prescribed by your doctor, keeping the intervals between doses consistent. Because this is a rectal suppository, it can be used without regard to food, making it highly useful for patients experiencing nausea. To help improve your recovery and general well-being, incorporating low-impact physical therapy and gentle stretching can support your pain management plan.

While this medicine is highly effective, some patients may experience mild side effects like drowsiness, dizziness, or nausea. However, you must seek immediate medical attention if you experience serious issues, such as slow or shallow breathing, severe confusion, or signs of an allergic reaction. Your safety is a priority, so monitoring how your body responds to this medication is essential.

Before starting this treatment, tell your doctor if you have a history of breathing disorders, head injuries, seizures, or kidney and liver problems. Do not take this if you have severe asthma, a blockage in your stomach or intestines, or if you have recently taken certain antidepressants. Always share your complete medical history to ensure this therapy is safe for you.

This medication can interact dangerously with other drugs that cause drowsiness, as well as alcohol, which can lead to life-threatening breathing difficulties. Additionally, smoking may affect how your body processes this medicine, so it is important to discuss your habits with your healthcare provider. If you are pregnant, breastfeeding, or an elderly patient, consult your doctor before using this medicine to discuss the potential risks.

SUPRIDOL 100MG SUPPOSITORY suppositories are generally not recommended for children unless specifically prescribed by a doctor, and any paediatric dose must be determined by a paediatrician based on the child's age, weight, and medical condition.

Uses of SUPRIDOL 100MG SUPPOSITORY

Your doctor may prescribe SUPRIDOL 100MG SUPPOSITORY for the following conditions:

  • Moderate to severe pain: It acts on the brain and spinal cord to reduce intense pain signals caused by surgeries, injuries, or chronic medical conditions.
  • Pain control when oral medication is not possible: It provides a reliable alternative for pain relief when patients are unable to swallow tablets due to severe nausea, vomiting, or throat complications.

Key Benefits

Using SUPRIDOL 100MG SUPPOSITORY as prescribed can help provide effective pain relief, particularly when oral medicines are not suitable. Here are the key benefits:

  • Gentle on the stomach: By delivering the active medicine through the rectum, it bypasses the digestive tract, significantly reducing the stomach upset or irritation often associated with oral pain medications.
  • Rapid and consistent relief: The blood vessels in the rectum absorb the medication efficiently, allowing it to start working quickly to ease discomfort and provide steady, long-lasting comfort.
  • Improved daily function: Effective pain control helps you sleep more soundly, move with greater ease, and engage in daily activities or physical recovery exercises more comfortably.
Side effects of Supridol 100mg Suppository

Directions for Use

  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Insert the suppository into the rectum using your finger. Keep lying down for about 15 minutes after insertion to prevent the suppository from sliding.
  • Wash your hands before and after using SUPRIDOL 100MG SUPPOSITORY.

How SUPRIDOL 100MG SUPPOSITORY Works

SUPRIDOL 100MG SUPPOSITORY contains tramadol, which works by targeting the way the brain and nervous system process pain signals. After administration, the medicine is absorbed into the bloodstream and reaches the brain and spinal cord, where it helps reduce the transmission and perception of pain. SUPRIDOL 100MG SUPPOSITORY acts on specific opioid receptors called mu-opioid receptors (special proteins in the brain and nervous system that help control pain). By activating these receptors, it reduces the transmission of pain signals from the body to the brain, helping decrease the intensity of moderate to severe pain. SUPRIDOL 100MG SUPPOSITORY also increases the levels of two natural chemical messengers in the nervous system, norepinephrine and serotonin, by keeping them active in the nervous system for longer. This strengthens the body's natural pain-inhibiting pathways and contributes to its pain-relieving effect. Together, these actions provide pain relief through opioid receptor activity and by increasing the activity of norepinephrine and serotonin, two natural chemical messengers that help control pain.
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Alcohol

Unsafe

Avoid alcohol consumption while using SUPRIDOL 100MG SUPPOSITORY, as it may cause increased drowsiness and dizziness.

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Pregnancy

Unsafe

SUPRIDOL 100MG SUPPOSITORY is a Category C pregnancy drug and is considered unsafe for pregnant women. Long-term use of SUPRIDOL 100MG SUPPOSITORY during pregnancy may cause withdrawal symptoms in your baby.

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Breast Feeding

Unsafe

Avoid breastfeeding while taking SUPRIDOL 100MG SUPPOSITORY, as it may be excreted in breast milk and cause adverse effects in the baby.

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Driving

Unsafe

SUPRIDOL 100MG SUPPOSITORY may cause drowsiness, and dizziness. Therefore, avoid driving until your vision is clear and you are mentally alert.

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Liver

Caution

You are not recommended to use SUPRIDOL 100MG SUPPOSITORY if you have severe liver impairment. If you have mild to moderate liver disease, please inform your doctor before taking SUPRIDOL 100MG SUPPOSITORY. Your doctor may suggest extending the time between the doses.

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Kidney

Caution

You are not recommended to use SUPRIDOL 100MG SUPPOSITORY if you have severe kidney impairment. If you have mild to moderate kidney disease, please inform your doctor before taking SUPRIDOL 100MG SUPPOSITORY. Your doctor may suggest extending the time between the doses.

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Children

Unsafe

SUPRIDOL 100MG SUPPOSITORY is not recommended for children below 12 years of age.

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Heart

Caution

SUPRIDOL 100MG SUPPOSITORY should be used with caution in patients with heart disease, as it may increase the risk of side effects.

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Geriatrics

Caution

SUPRIDOL 100MG SUPPOSITORY should be used with caution in elderly patients, as it may increase the risk of dizziness and other side effects.

What if I have taken an overdose of SUPRIDOL 100MG SUPPOSITORY

If you suspect an overdose, seek emergency medical attention immediately. Signs of an overdose can include extremely slow or shallow breathing, severe sleepiness, cold and clammy skin, pinpoint pupils, muscle weakness, or loss of consciousness.

Diet & Lifestyle Advise

  • Increase dietary fibre: To combat the risk of constipation, include high-fibre foods such as whole grains, beans, oats, fresh vegetables, and fruits in your daily meals.
  • Stay well-hydrated: Drink plenty of water throughout the day to help soften stools and prevent constipation, as well as to help manage dry mouth.
  • Avoid sudden physical movements: Stand up slowly from a sitting or lying position to prevent dizziness and protect yourself from accidental falls.
  • Incorporate light physical activity: If your doctor approves, short walks can help stimulate digestion, reduce joint stiffness, and support overall pain recovery.
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Have a query?

How Soon It Starts Working

The time required for SUPRIDOL 100MG SUPPOSITORY to start to work: The time required for SUPRIDOL 100MG SUPPOSITORY to show its action is unknown. The time for which the effects of SUPRIDOL 100MG SUPPOSITORY last: The duration of action for SUPRIDOL 100MG SUPPOSITORY is unknown.

What if you forget to take SUPRIDOL 100MG SUPPOSITORY

If you are using this medication on a regular schedule and miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed one and continue with your regular schedule. Do not use a double dose to make up for a missed one.

Storage

•Store SUPRIDOL 100MG SUPPOSITORY suppositories in a cool place, ideally at a temperature below 25°C (77°F) or in the refrigerator as indicated on the product packaging.•Do not freeze the suppositories, as this can damage their structure.

Drug Warnings

  • Inspect the wrapping: Always check the foil or plastic wrap before opening. Do not use the suppository if the wrapper is torn, damaged, or has been pre-opened.
  • Do not cut or split: Use the suppository whole as designed. Cutting or splitting the suppository can lead to an incorrect dose of the medicine.
  • Avoid driving and hazardous activities: This medicine can significantly slow your reaction times and cause heavy sleepiness. Do not drive or operate machinery until you know exactly how it affects you.
  • Understand dependency risks: This medication has the potential to cause physical dependence and habit-forming behaviour, even when used correctly. Strictly follow your doctor's dosing instructions.
  • Consult before using other sleeping aids: Avoid taking over-the-counter sleep aids, muscle relaxants, or antihistamines without checking with your doctor first, as these can dangerously increase drowsiness.
  • Understand dependency and prescription requirements: SUPRIDOL 100MG SUPPOSITORY can cause physical dependence, tolerance, and habit-forming behaviour even when used correctly. In India, SUPRIDOL 100MG SUPPOSITORY is a prescription-controlled medicine, so use it only when prescribed by a qualified doctor and obtain it through a valid prescription. Never share it with anyone else.

Drug-Drug Interactions

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  • Benzodiazepines and sleeping pills: Combining these with SUPRIDOL 100MG SUPPOSITORY can cause dangerously slow or stopped breathing, extreme drowsiness, coma, or other life-threatening breathing problems.
  • Antidepressants (SSRIs, SNRIs, and MAOIs): Using these medications together significantly increases the risk of a rare, serious condition called serotonin syndrome, which causes high blood pressure, rapid heart rate, tremors, and confusion.

Drug-Drug Interactions

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How does the drug interact with Supridol 100mg Suppository:
Combining Tranylcypromine with Supridol 100mg Suppository can increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Tranylcypromine with Supridol 100mg Suppository is not recommended, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting your doctor.
How does the drug interact with Supridol 100mg Suppository:
Co-administration of Linezolid with Supridol 100mg Suppository can increase the risk of serotonin syndrome and seizures.

How to manage the interaction:
Taking Linezolid with Supridol 100mg Suppository is not recommended, consult a doctor before taking it. Consult a doctor if you experience confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea. Do not stop using any medications without talking to a doctor.
TramadolAlvimopan
Critical
How does the drug interact with Supridol 100mg Suppository:
Co-administration of Supridol 100mg Suppository with Alvimopan can make the side effects worse or more dangerous.

How to manage the interaction:
Taking Alvimopan with Supridol 100mg Suppository is not recommended, please consult your doctor before taking it.
TramadolPhenelzine
Critical
How does the drug interact with Supridol 100mg Suppository:
Combining Phenelzine with Supridol 100mg Suppository can increase the risk of serotonin syndrome and seizures.

How to manage the interaction:
Taking Supridol 100mg Suppository with Phenelzine is not recommended, please consult your doctor before taking it.
How does the drug interact with Supridol 100mg Suppository:
Taking Safinamide with Supridol 100mg Suppository can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Safinamide with Supridol 100mg Suppository is not recommended as it can possibly result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting your doctor.
How does the drug interact with Supridol 100mg Suppository:
Taking rasagiline with Supridol 100mg Suppository can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Supridol 100mg Suppository with Rasagiline is not recommended, as it can lead to an interaction, but can be taken if advised by your doctor. However, if you experience any symptoms like severe headache, blurred vision, confusion, seizures, chest pain, nausea or vomiting, sudden numbness or weakness (especially on one side of the body), speech difficulties, fever, sweating, lightheadedness, and fainting, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
How does the drug interact with Supridol 100mg Suppository:
Co-administration of Ziprasidone with Supridol 100mg Suppository can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Supridol 100mg Suppository with Ziprasidone together can possibly result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Supridol 100mg Suppository:
The combined use of Supridol 100mg Suppository with fluvoxamine can make Supridol 100mg Suppository less effective as a treatment.

How to manage the interaction:
Taking fluvoxamine with Supridol 100mg Suppository together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience any symptoms such as confusion, hallucination, seizure, increased heart rate, blurred vision, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Supridol 100mg Suppository:
Co-administration of citalopram with Supridol 100mg Suppository may increase the risk and severity of the seizure.

How to manage the interaction:
Taking citalopram with Supridol 100mg Suppository together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience any symptoms such as confusion, hallucination, seizure, increased heart rate, blurred vision, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Supridol 100mg Suppository:
Coadministration of Lorazepam with Supridol 100mg Suppository can increase the risk and severity of side effects like dizziness, decreased breathing rate, and irregular heart rates.

How to manage the interaction:
Taking Lorazepam with Supridol 100mg Suppository together is generally avoided as it can result in an interaction, it can be taken if your doctor has advised it. However, if you notice any symptoms of dizziness, lightheadedness, severe headache, weakness, difficulty concentrating, or impairment in judgment, and motor coordination you should contact a doctor immediately. Avoid driving or using hazardous machines. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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  • Alcohol: Avoid consuming any alcohol during your treatment, as it can dangerously intensify the sedative effects of the medication, leading to extreme sleepiness, low blood pressure, and slowed breathing.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

Yes

Therapeutic Class

[NARCOTIC (OPIOID) ANALGESIC]

FAQs

SUPRIDOL 100MG SUPPOSITORY belongs to a group of medications called "opioid analgesics," primarily used to treat moderate to severe pain.
SUPRIDOL 100MG SUPPOSITORY contains Tramadol, an analgesic medication that acts in the brain and spinal cord. It helps relieve pain by stimulating the body's natural opioid receptors. By binding to these receptors, Tramadol mimics the effects of endorphins (pain-reducing chemicals), thereby reducing the sensation of pain. It also increases the levels of serotonin and noradrenaline (chemical messengers) in the brain and spinal cord, which alters the transmission of pain signals from nerves to the brain, further providing relief from pain.
SUPRIDOL 100MG SUPPOSITORY may cause withdrawal symptoms, such as nervousness, anxiety, shakiness, agitation, difficulty in sleeping, hallucinations, unusual sensations (like numbness, tingling, or ringing in the ears), confusion, altered perception, and paranoia (persistent fear of others), when you stop taking SUPRIDOL 100MG SUPPOSITORY suddenly. Your doctor will gradually reduce the dose to avoid withdrawal symptoms.
SUPRIDOL 100MG SUPPOSITORY may cause seizures, especially when taken in high doses or if you have a history of seizures. Therefore, it is recommended to inform your doctor if you have a history of seizures, as this may increase the risk of getting seizures.
You are not recommended to take SUPRIDOL 100MG SUPPOSITORY with antidepressants (medicines used to treat depression), especially if you are currently taking or have taken monoamine oxidase (MAO) inhibitors (such as isocarboxazid, phenelzine, and selegiline) within the last 14 days. Co-administration of these medicines with SUPRIDOL 100MG SUPPOSITORY may significantly increase the risk of seizures and serotonin syndrome (a condition where serotonin buildup in the brain, leading to symptoms like agitation, muscle spasms, and high fever).
The common side effects of SUPRIDOL 100MG SUPPOSITORY include nausea, vomiting, dry mouth, constipation, dizziness, drowsiness, headache, fatigue, and sweating. Most of these side effects will gradually resolve over time without the need for medical attention. However, if the side effects persist or worsen, please consult your doctor.
SUPRIDOL 100MG SUPPOSITORY may cause both mental and physical addiction. Avoid taking SUPRIDOL 100MG SUPPOSITORY large doses or for extended periods, as this may reduce its effectiveness and lead to tolerance, where your body requires higher doses over time. Your doctor will prescribe SUPRIDOL 100MG SUPPOSITORY for shorter durations, with regular breaks in between, to reduce the risk of developing addiction.
You should not use SUPRIDOL 100MG SUPPOSITORY more often than once every 4 hours. Its pain-relieving effects will last between 4 to 8 hours, depending on the severity of your pain. Please consult your doctor for further advice.
No, SUPRIDOL 100MG SUPPOSITORY may harm the unborn baby. If you are pregnant or planning to become pregnant, use SUPRIDOL 100MG SUPPOSITORY only if prescribed by your doctor, and limit it to single doses. Long-term use of SUPRIDOL 100MG SUPPOSITORY during pregnancy may cause withdrawal symptoms in your baby.
No, you should not cut or split the suppository unless your doctor specifically instructs you to do so. Cutting it can cause an uneven distribution of the medicine, leading to an incorrect dose. Talk to your doctor or pharmacist if you feel your dose needs adjustment.
If the suppository feels soft or melted inside the wrapper, hold it under cold running water or place it in the refrigerator for a few minutes until it hardens. Once it is solid, you can peel open the wrapper and insert it. Talk to your doctor or pharmacist if you have questions about storage.
It is generally not recommended to use this medication while breastfeeding, as the active drug can pass into breast milk and cause serious side effects, such as unusual sleepiness or breathing difficulties, in your baby. Talk to your doctor to explore safer pain management options.
If you are experiencing diarrhoea, using a rectal suppository is not ideal because the medicine may not be absorbed properly before leaving your body. In this situation, it is best to seek an alternative option. Talk to your doctor or pharmacist for advice.
This medication is typically prescribed for short-term pain relief. Prolonged use can lead to physical dependence or tolerance, meaning you might need higher doses to achieve the same pain relief. Talk to your doctor about the appropriate duration for your treatment.
If a suppository is accidentally swallowed, contact a poison control center or seek emergency medical attention immediately. While the medicine is designed for rectal use, swallowing it can still cause serious systemic side effects. Talk to your doctor or pharmacist for immediate guidance.

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Country of origin

INDIA

Manufacturer/Marketer address

140, Damji Samji Industrial Complex, Mahakali Caves Rd., Andheri(East), Mumbai-93.
Other Info - SUP0145
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